Ambros, V. "Genetic basis for heterochronic
variation" in Heterochrony in Evolution, Michael L. McKinney, Ed. Plenum,
New York.
Ambros, V., and Moss, E. (1994) The heterochronic genes
and developmental timing in C. elegans. Trends in Genetics, 10,
123-127. ¥PDF¥
Ambros, V. R. (1997) Heterochronic genes. In "Caenorhabditis elegans" D. Riddle, Ed. Cold Spring Harbor Laboratory
Press, Cold Spring Harbor.
Ambros, V. (2000) Control of developmental timing in Caenorhabditis
elegans. Current Opinions in
Development and Genetics 10, 428-433. ¥PDF¥
Ambros, V. (2000) The temporal control of cell cycle
and cell fate in Caenorhabditis elegans. In Novartis Symposium on The Cell
Cycle in Development, Novartis Foundation P. Nurse, Ed.
Ambros, V. (2001) Dicing up RNAs. Science
(Perspectives) Aug 3;293(5531):811-3. ¥PDF¥
Ambros, V. (2001) MicroRNAs: Tiny regulators with
great potential. Cell 107, 823-826. ¥PDF¥
Ambros, V., and Lee, R.
(2003) Identification of microRNAs and other tiny noncoding RNAs by cDNA
cloning in RNA Interference,
Editing, and Modification, Methods and Protocols , J.Gott ,Ed.
Carrington, J., Ambros, V.
(2003) Roles of Small RNAs in Development of Plants and Animals. Science 301
July 18(5631):336-8 ¥PDF¥
Ambros V. (2003). MicroRNA
pathways in flies and worms: growth, death, fat, stress, and timing. Cell. 113,
673-676. ¥PDF¥
Lee, R. C., Feinbaum, R. and
Ambros, V. (2004). A short History of a Short RNA Cell, Vol. S116,
S89–S92 ¥PDF¥
Ambros, V.
(2004). The functions of animal microRNAs. Nature (Insight) 431, 350 –
355 ¥PDF¥
Karp, X. and Ambros,V
(2005) Encountering MicroRNAs in Cell Fate Signaling. Science 310(5752): 1288 -
1289 ¥PDF¥
Peer reviewed articles
Gruberg
ER, Ambros VR.( 1974 ) A forebrain visual projection in the frog (Rana
pipiens).
Exp
Neurol. Aug;44(2):187-197.
Ambros
VR, Chen LB, Buchanan JM(1975).Surface ruffles as markers for studies of cell
transformation by Rous sarcoma virus. Proc Natl Acad Sci U S A.
Aug;72(8):3144-8.
Flanegan
JB, Pettersson RF, Ambros V, Hewlett NJ, Baltimore D.( 1977)Covalent linkage of
a protein to a defined nucleotide sequence at the 5'-terminus of virion and
replicative intermediate RNAs of poliovirus. Proc Natl Acad Sci U S A.
Mar;74(3):961-5.
Hewlett
MJ, Rozenblatt S, Ambros V, Baltimore D.( 1977) Separation and quantitation of
intracellular forms of poliovirus RNA by agarose gel electrophoresis
Biochemistry.
Jun 14;16(12):2763-7.
Pettersson
RF, Ambros V, Baltimore D.(1978) Identification of a protein linked to nascent
poliovirus RNA and to the polyuridylic acid of negative-strand RNA.
J
Virol Aug;27(2):357-65.
Ambros
V, Baltimore D.(1978) Protein is linked to the 5' end of poliovirus RNA by a
phosphodiester linkage to tyrosine. J Biol Chem Aug 10;253(15):5263-6.
Ambros
V, Pettersson RF, Baltimore D. (1978) An enzymatic activity in uninfected cells
that cleaves the linkage between poliovirion RNA and the 5' terminal protein.
Cell.
Dec;15(4):1439-46.
Ambros
V, Baltimore D. (1980) Purification and properties of a HeLa cell enzyme able
to remove the 5'-terminal protein from poliovirus RNA. J Biol Chem. Jul
25;255(14):6739-44.
Ambros
V, Horvitz HR. (1984) Heterochronic mutants of the nematode Caenorhabditis
elegans. Science. Oct 26;226(4673):409-16.
Ambros
V, Horvitz HR. (1987) The lin-14 locus of Caenorhabditis elegans controls the
time of expression of specific postembryonic developmental events.
Genes
Dev. Jun;1(4):398-414.
Ruvkun
G, Ambros V, Coulson A, Waterston R, Sulston J, Horvitz HR.(1989)
Molecular
genetics of the Caenorhabditis elegans heterochronic gene lin-14.
Genetics.
Mar;121(3):501-516.
Ambros
V. (1989)A hierarchy of regulatory genes controls a larva-to-adult developmental
switch in C. elegans. Cell. Apr 7;57(1):49-57.
Hodgkin
J, Papp A, Pulak R, Ambros V, Anderson P. (1989) A new kind of informational
suppression in the nematode Caenorhabditis elegans. Genetics.
Oct;123(2):301-13.
Liu
ZC, Ambros V. (1989) Heterochronic genes control the stage-specific initiation
and expression of the dauer larva developmental program in Caenorhabditis
elegans.
Genes
Dev. Dec;3(12B):2039-49. ¥PDF¥
Papp
A, Rougvie AE, Ambros V. (1991) Molecular cloning of lin-29, a heterochronic
gene required for the differentiation of hypodermal cells and the cessation of
molting in C.elegans. Nucleic Acids Res. Feb 11;19(3):623-30.
Liu, Z and Ambos, V (1991). Alternative temporal
control systems for hypodermal cell differentiation in Caenorhabditis elegans.
Nature 350, 162-165.
Mello
CC, Kramer JM, Stinchcomb D, Ambros V. (1991) Efficient gene transfer in
C.elegans: extrachromosomal maintenance and integration of transforming
sequences.
EMBO
J. Dec;10(12):3959-70. ¥PDF¥
Lee, R., Feinbaum, R., and Ambros, V. (1993). The heterochronic gene lin-4 of C. elegans encodes small RNAs with antisense complementarity to lin-14. Cell,
75, 843-854. ¥PDF¥
Liu, Z., Kirch, S., and Ambros, V. R. (1995) The C. elegans heterochronic gene pathway controls the
stage-specific transcription of collagen genes. Development, 121, 2471-2478. ¥PDF¥
Rougvie, A. and Ambros, V. R. (1995) The lin-29 locus of C. elegans encodes a Zn-finger protein that regulates a
stage-specific transcriptional switch. Development, 121, 2491-2500. ¥PDF¥
Euling, S., and Ambros, V. R. (1996) Heterochronic genes control cell cycle
progress and developmental competence of C. elegans vulva precursor cells. Cell 84, 667-676. ¥PDF¥
Euling, S., and Ambros, V. R. (1996) Reversibility of vulval cell
determination in C. elegans.
Development 122, 2507-2515. ¥PDF¥
Moss, E., Lee, R., and Ambros, V. (1997) Control of
developmental timing by the cold shock domain protein Lin-28 and its regulation
by the lin-4 RNA. Cell 88,
637-646. ¥PDF¥
Hong, Y., Roy, R. and Ambros, V. (1998) Developmental
regulation of a cyclin-dependent kinase inhibitor controls postembryonic cell
cycle progression in C. elegans. Development 125, 3585-3597. ¥PDF¥
Ambros, V. (1999) Cell cycle-dependent sequencing of
cell fate decisions in Caenorhabditis elegans. Development 126, 1947-1956. ¥PDF¥
Feinbaum,
R. and Ambros, V. (1999) The timing of lin-4 RNA accumulation controls
the
timing of postembryonic developmental events in C. elegans.
Develop. Biol. 210, 87-95. ¥PDF¥
Olsen, P. H. and Ambros, V. (1999) The lin-4 regulatory RNA controls developmental timing in C.
elegans by blocking LIN-14 protein synthesis after the initiation of
translation. Develop Biol.
216,671-680 ¥PDF¥
Hong, Y., Lee, R. C. and Ambros, V. (2000) Structure and function analysis if
LIN-14, a temporal regulator of postembryonic developmental events in C.
elegans. Molecular and Cell. Biol.
20, 2285-95 ¥PDF¥
Slack, F. J., Basson, M., Liu, Z., Ambros, V.,
Horvitz, H. R. and Ruvkun, G. (2000) The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor.
Molecular Cell 5, 659-669. ¥PDF¥
Lee, R. C. and Ambros, V. (2001) An extensive class
of small RNAs in Caenorhabditis elegans. Science 294, 862-864 ¥PDF¥
Sempere, L. F., Dubrovsky, E. B., Dubrovskaya, V.A.,
Berger, E. M., and Ambros, V. (2002). The expression of the let-7 small
regulatory RNA is controlled by ecdysone during metamorphosis in Drosophila
melanogaster" Develop. Biol. 244, 170-179 ¥PDF¥
Ambros V, Bartel B, Bartel DP, Burge CB, Carrington JC, Chen
X, Dreyfuss G, Eddy SR, Griffiths-Jones S, Marshall M, Matzke M, Ruvkun G,
Tuschl T (2003). A uniform
system for microRNA annotation. RNA
9, 277-279 ¥PDF¥
Ambros,
V., Lee, R.C., Lavanway, A., Williams, P.T. and Jewell, D. (2003) microRNAs and
other tiny endogenous RNAs in C. elegans. Current Biology 13,
807-818. ¥PDF¥
Sempere, L.F., Sokol, N.S., Dubrovsky, E.B., Berger,
E.M., and Ambros, V. (2003) Temporal Regulation of microRNA Expression in Drosophila
melanogaster mediated by Hormonal
Signals and Broad-Complex gene activity. Develop Biol
259, 9-18. ¥PDF¥
Pepper,
A. S-R., McCane, J. E., Kemper, K., Yeung, D. A. Y., Lee, R. C., Ambros, V.,
Moss, E. (2004) The C. elegans heterochronic
gene lin-46 affects developmental
timing at two larval stages and encodes a relative of the scaffolding protein
gephyrin. Development 131(9):2049-59 ¥PDF¥
Sempere, L. F., Freemantle, S., Pitha-Rowe, I., Moss,
E., Dmitrovsky, E., Ambros, V. (2004). Expression profiling of mammalian microRNAs
uncovers a subset of brain-expressed microRNAs with possible roles in murine
and human neuronal differentiation. Genome Biology 5(3):R13. Epub 2004 Feb 16. ¥PDF¥
Sokol, N. S. and
Ambros, V. (2005) Mesodermally expressed Drosophila microRNA-1 is regulated by Twist and is required in muscles
during larval growth. Genes and Development 19:
2343-2354 ¥PDF¥
Abbott, A. L.,
Alvarez-Saavedra, E., Miska, E. A., Lau, N. C., Bartel, D. P., Horvitz, H. R. and Ambros, V. (2005). The let-7 MicroRNA Family Members mir-48, mir-84,
and mir-241 Function Together to
Regulate Developmental Timing in Caenorhabditis elegans.
Developmental Cell, Vol. 9, 1-12 ¥PDF¥
Kuhlmann,
M., Borisova,
B. E., Kaller, M., Larsson, P., Stach, D., Na, J. Eichinger, L., Lyko, F., Ambros, V., Sšderbom, F., Hammann, C. and Nellen, W. (2005) Silencing
of retrotransposons in Dictyostelium by DNA methylation and RNAi.
Nucl. Acids
Res. Nov 10;33(19):6405-17 ¥PDF¥
Hristova,
M., Birse, D., Hong, Y. and Ambros, V. (2005) The C. elegans heterochronic regulator LIN-14 is a novel
transcription factor that controls the developmental timing of transcription
from the insulin/IGF gene ins-33
by direct DNA binding. Mol CellBiol. 2005 Dec;25(24):11059-72 ¥PDF¥
Lee,
R.C., Hammell C.H., Ambros V.R. (2006) Interacting endogenous and exogenous
RNAi pathways in C. elegans. RNA,
Apr;12(4):589-97 ¥PDF¥