|
(Circulation. 2005;111:920-925.)
© 2005 American Heart Association, Inc.
Valvular Heart Disease |
From the Baylor Heart and Vascular Institute and the Departments of Pathology and Medicine, Baylor University Medical Center, Dallas, Tex.
Correspondence to William C. Roberts, MD, Baylor Heart and Vascular Institute, Baylor University Medical Center, 3500 Gaston Ave, Dallas, TX 75246. E-mail wc.roberts{at}baylorhealth.edu
Received August 27, 2004; revision received November 22, 2004; accepted December 13, 2004.
Background Aortic valve stenosis (with or without aortic regurgitation and without associated mitral stenosis) in adults in the Western world has been considered in recent years to most commonly be the result of degenerative or atherosclerotic disease.
Methods and Results We examined operatively excised, stenotic aortic valves from 932 patients aged 26 to 91 years (mean±SD, 70±12), and none had associated mitral valve replacement or evidence of mitral stenosis: A total of 504 (54%) had congenitally malformed valves (unicuspid in 46 [unicommissural in 42; acommissural in 4] and bicuspid in 458); 417 (45%) had tricuspid valves (either absent or minimal commissural fusion); and 11 (1%) had valves of undetermined type. It is likely that the latter 11 valves also had been congenitally malformed. Of the 584 men, 343 (59%) had either a unicuspid or a bicuspid valve; of the 348 women, 161 (46%) had either a unicuspid or a bicuspid aortic valve.
Conclusions The data from this large study of adults having isolated aortic valve replacement for aortic stenosis (with or without associated aortic regurgitation) and without associated mitral stenosis or mitral valve replacement strongly suggest that an underlying congenitally malformed valve, at least in men, is more common than a tricuspid aortic valve.
Key Words: aorta heart defects, congenital valves regurgitation
Related Article:
Circulation 2005 111: 832-834.
This article has been cited by other articles:
|
R. Zegdi, V. Ciobotaru, M. Noghin, G. Sleilaty, A. Lafont, C. Latremouille, A. Deloche, and J.-N. Fabiani Is it reasonable to treat all calcified stenotic aortic valves with a valved stent? Results from a human anatomic study in adults. J. Am. Coll. Cardiol., February 5, 2008; 51(5): 579 - 584. [Abstract] [Full Text] [PDF] |
||||
|
R. Zegdi, G. Sleilaty, A. Lafont, and J.-N. Fabiani Percutaneous aortic valve replacement with the CoreValve prosthesis. J. Am. Coll. Cardiol., January 15, 2008; 51(2): 170 - 170. [Full Text] [PDF] |
||||
|
R. F. Padera Jr. and F. J. Schoen Pathology of Cardiac Surgery Card. Surg. Adult, January 1, 2008; 3(2008): 111 - 178. [Full Text] |
||||
|
R. B. Hinton Jr, L. J. Martin, M. E. Tabangin, M. L. Mazwi, L. H. Cripe, and D. W. Benson Hypoplastic Left Heart Syndrome Is Heritable J. Am. Coll. Cardiol., October 16, 2007; 50(16): 1590 - 1595. [Abstract] [Full Text] [PDF] |
||||
|
H. Dave and R. Pretre Pericardial patch reconstruction of the congenitally diseased aortic valve MMCTS, May 7, 2007; 2007(0507): 1354. [Abstract] [Full Text] [PDF] |
||||
|
H.-H. Sievers and C. Schmidtke A classification system for the bicuspid aortic valve from 304 surgical specimens J. Thorac. Cardiovasc. Surg., May 1, 2007; 133(5): 1226 - 1233. [Abstract] [Full Text] [PDF] |
||||
|
J. Aboulhosn and J. S. Child Left Ventricular Outflow Obstruction: Subaortic Stenosis, Bicuspid Aortic Valve, Supravalvar Aortic Stenosis, and Coarctation of the Aorta Circulation, November 28, 2006; 114(22): 2412 - 2422. [Full Text] [PDF] |
||||
|
R. O. Bonow, B. A. Carabello, K. Chatterjee, A. C. de Leon Jr, D. P. Faxon, M. D. Freed, W. H. Gaasch, B. W. Lytle, R. A. Nishimura, P. T. O'Gara, et al. ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1998 Guidelines for the Management of Patients With Valvular Heart Disease) Developed in Collaboration With the Society of Cardiovascular Anesthesiologists Endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons J. Am. Coll. Cardiol., August 1, 2006; 48(3): e1 - e148. [Full Text] [PDF] |
||||
|
R. O. Bonow, B. A. Carabello, K. Chatterjee, A. C. de Leon Jr, D. P. Faxon, M. D. Freed, W. H. Gaasch, B. W. Lytle, R. A. Nishimura, P. T. O'Gara, et al. ACC/AHA 2006 Practice Guidelines for the Management of Patients With Valvular Heart Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1998 Guidelines for the Management of Patients With Valvular Heart Disease) Developed in Collaboration With the Society of Cardiovascular Anesthesiologists Endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons J. Am. Coll. Cardiol., August 1, 2006; 48(3): 598 - 675. [Full Text] [PDF] |
||||
|
K. D. O'Brien Pathogenesis of Calcific Aortic Valve Disease: A Disease Process Comes of Age (and a Good Deal More) Arterioscler. Thromb. Vasc. Biol., August 1, 2006; 26(8): 1721 - 1728. [Abstract] [Full Text] [PDF] |
||||
|
W. C. Roberts, J. M. Ko, T. R. Moore, and W. H. Jones III Causes of Pure Aortic Regurgitation in Patients Having Isolated Aortic Valve Replacement at a Single US Tertiary Hospital (1993 to 2005) Circulation, August 1, 2006; 114(5): 422 - 429. [Abstract] [Full Text] [PDF] |
||||
|
R. B. Hinton Jr, J. Lincoln, G. H. Deutsch, H. Osinska, P. B. Manning, D. W. Benson, and K. E. Yutzey Extracellular Matrix Remodeling and Organization in Developing and Diseased Aortic Valves Circ. Res., June 9, 2006; 98(11): 1431 - 1438. [Abstract] [Full Text] [PDF] |
||||
|
C. M. Otto Valvular Aortic Stenosis: Disease Severity and Timing of Intervention J. Am. Coll. Cardiol., June 6, 2006; 47(11): 2141 - 2151. [Abstract] [Full Text] [PDF] |
||||
|
T. Ichihara, G. Fujii, M. Sasaki, O. Kawaguchi, and Y. Ueda Clinical Characteristics of Bicuspid Aortic Valves in Surgical Patients Asian Cardiovasc Thorac Ann, June 1, 2006; 14(3): 210 - 212. [Abstract] [Full Text] [PDF] |
||||
|
R. Pretre, A. Kadner, H. Dave, D. Bettex, and M. Genoni Tricuspidisation of the aortic valve with creation of a crown-like annulus is able to restore a normal valve function in bicuspid aortic valves. Eur. J. Cardiothorac. Surg., June 1, 2006; 29(6): 1001 - 1006. [Abstract] [Full Text] [PDF] |
||||
|
A. K. Agnihotri, S. C. Desai, Y.-Q. Lai, M. G. Fitzsimons, A. D. Hilgenberg, and G. J. Vlahakes Two distinct clinical presentations in adult unicuspid aortic valve J. Thorac. Cardiovasc. Surg., May 1, 2006; 131(5): 1169 - 1170. [Full Text] [PDF] |
||||
|
F. C. Caira, S. R. Stock, T. G. Gleason, E. C. McGee, J. Huang, R. O. Bonow, T. C. Spelsberg, P. M. McCarthy, S. H. Rahimtoola, and N. M. Rajamannan Human Degenerative Valve Disease Is Associated With Up-Regulation of Low-Density Lipoprotein Receptor-Related Protein 5 Receptor-Mediated Bone Formation J. Am. Coll. Cardiol., April 18, 2006; 47(8): 1707 - 1712. [Abstract] [Full Text] [PDF] |
||||
|
P. A. Grayburn Assessment of Low-Gradient Aortic Stenosis With Dobutamine Circulation, February 7, 2006; 113(5): 604 - 606. [Full Text] [PDF] |
||||
|
W. C. Roberts, J. M. Ko, and C. Hamilton Comparison of Valve Structure, Valve Weight, and Severity of the Valve Obstruction in 1849 Patients Having Isolated Aortic Valve Replacement for Aortic Valve Stenosis (With or Without Associated Aortic Regurgitation) Studied at 3 Different Medical Centers in 2 Different Time Periods Circulation, December 20, 2005; 112(25): 3919 - 3929. [Abstract] [Full Text] [PDF] |
||||
|
K. L. Chan, K. Teo, D. E. Newby, D. B. Northridge, and N. A. Boon Lipid-Lowering Therapy in Calcific Aortic Stenosis N. Engl. J. Med., September 8, 2005; 353(10): 1066 - 1067. [Full Text] [PDF] |
||||
|
M. B. Lewin and C. M. Otto The Bicuspid Aortic Valve: Adverse Outcomes From Infancy to Old Age Circulation, February 22, 2005; 111(7): 832 - 834. [Full Text] [PDF] |
||||
Circulation Home | Subscriptions | Archives | Feedback | Authors | Help | AHA Journals Home | Search Copyright © 2005 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited. |