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Volume 337:677-681 September 4, 1997 Number 10
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Multidrug Resistance in Yersinia pestis Mediated by a Transferable Plasmid
Marc Galimand, Ph.D., Annie Guiyoule, Guy Gerbaud, Bruno Rasoamanana, M.D., Suzanne Chanteau, Ph.D., Elisabeth Carniel, M.D., Ph.D., and Patrice Courvalin, M.D.

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Yersinia pestis is the causative agent of plague, a zoonotic disease transmitted to humans through flea bites and typically characterized by the appearance of a tender and swollen lymph node, the bubo. Human-to-human transmission can occur, through either the bite of fleas (bubonic plague) or respiratory droplets, causing an overwhelming infection called pneumonic plague.

The last plague pandemic began in Hong Kong in 1894 and spread throughout the world, establishing many endemic foci. Antibiotics and enforcement of public health measures significantly decreased the morbidity and mortality associated with the disease but did not allow its eradication. In fact, plague . . . (Click here for the full text of this article.)

Methods

      Patient and Strains

      Mediums and Resistance Studies

      Nucleic-Acid Techniques

Results

      Antibiotic Resistance of Y. pestis 17/95

      Characterization of Plasmid pIP1202

      Analysis of Plasmid DNA

Discussion

References

 

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