Hypolipidemic and hypocholesterolemic effect of argan oil (Argania spinosa L.) in Meriones shawi rats
- PMID: 14522427
- DOI: 10.1016/s0378-8741(03)00176-4
Hypolipidemic and hypocholesterolemic effect of argan oil (Argania spinosa L.) in Meriones shawi rats
Abstract
The potential health benefits of various dietary oils in relation to cardiovascular disease and cancer are recently receiving considerable attention. The main proposal of this study is to investigate the effect of dietary argan oil, obtained from seeds of Argania spinosa L. (Sapotaceae) endemic from Morocco, on serum lipids composition. Hyperlipidemia was induced by high calorie and cholesterol (HCC) diet administration in 16 rats (Meriones shawi, a rodent of the Gerbillideae family). Eight rats were treated with argan oil (1ml/100g weight) daily by oral route during 7 weeks (treated group). Control animals were also fed with HCC diet for 7 weeks. After 7-week treatment with argan oil, blood lipoproteins were significantly reduced. Total cholesterol decreased with 36.67% (P<0.01), low density lipoprotein (LDL)-cholesterol in 67.70% (P<0.001), triglycerides in 30.67% (P<0.05) and body weight in 12.7% (P<0.05). High density lipoprotein (HDL)-cholesterol concentration remained unaltered. These results indicate the beneficial effect of argan oil in the treatment of the hyperlipidemia and hypercholesterolemia. This effect will be related with the polyunsaturated fatty acids and other constituents of studied oil.
Similar articles
-
[Experimental evidence of an antihypertensive and hypocholesterolemic effect of oil of argan, Argania sideroxylon].Therapie. 2000 May-Jun;55(3):375-8. Therapie. 2000. PMID: 10967715 French.
-
Evidence of hypolipemiant and antioxidant properties of argan oil derived from the argan tree (Argania spinosa).Clin Nutr. 2004 Oct;23(5):1159-66. doi: 10.1016/j.clnu.2004.03.003. Clin Nutr. 2004. PMID: 15380909
-
Physicochemical characteristics, nutritional properties, and health benefits of argan oil: a review.Crit Rev Food Sci Nutr. 2014;54(11):1401-14. doi: 10.1080/10408398.2011.638424. Crit Rev Food Sci Nutr. 2014. PMID: 24580537 Review.
-
Ethnobotany, phytochemistry and biological properties of Argan tree (Argania spinosa (L.) Skeels) (Sapotaceae) - A review.J Ethnopharmacol. 2021 Dec 5;281:114528. doi: 10.1016/j.jep.2021.114528. Epub 2021 Aug 18. J Ethnopharmacol. 2021. PMID: 34418509 Review.
-
Phenolic-extract from argan oil (Argania spinosa L.) inhibits human low-density lipoprotein (LDL) oxidation and enhances cholesterol efflux from human THP-1 macrophages.Atherosclerosis. 2006 Feb;184(2):389-96. doi: 10.1016/j.atherosclerosis.2005.05.018. Epub 2005 Jul 12. Atherosclerosis. 2006. PMID: 16019008
Cited by
-
Data insights from a Moroccan phytochemical database (MPDB) derived from aromatic & medicinal plants.Bioinformation. 2023 Dec 31;19(12):1217-1224. doi: 10.6026/973206300191217. eCollection 2023. Bioinformation. 2023. PMID: 38250527 Free PMC article.
-
Onosma hispidum L. extract reverses hyperlipidemia, hypertension, and associated vascular dysfunction in rats.Saudi J Biol Sci. 2023 Aug;30(8):103712. doi: 10.1016/j.sjbs.2023.103712. Epub 2023 Jun 16. Saudi J Biol Sci. 2023. PMID: 37405138 Free PMC article.
-
Creaming behavior prediction of argan oil in water emulsion stabilized by lacto-fermentation: creaming index.BMC Biotechnol. 2021 Sep 18;21(1):53. doi: 10.1186/s12896-021-00711-9. BMC Biotechnol. 2021. PMID: 34537028 Free PMC article.
-
In Vitro & In Vivo Anti-Hyperglycemic Potential of Saponins Cake and Argan Oil from Argania spinosa.Foods. 2021 May 13;10(5):1078. doi: 10.3390/foods10051078. Foods. 2021. PMID: 34068075 Free PMC article.
-
Floristic biodiversity, biogeographical significance, and importance of Morocco's Arganeraie Biosphere Reserve.Environ Sci Pollut Res Int. 2021 Dec;28(45):64156-64165. doi: 10.1007/s11356-020-11936-0. Epub 2021 Jan 6. Environ Sci Pollut Res Int. 2021. PMID: 33405131 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
