Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children
- PMID: 9500320
- DOI: 10.1016/s0140-6736(97)11096-0
Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children
Erratum in
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Retraction of an interpretation.Lancet. 2004 Mar 6;363(9411):750. doi: 10.1016/S0140-6736(04)15715-2. Lancet. 2004. PMID: 15016483 No abstract available.
Retraction in
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Retraction--Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children.Lancet. 2010 Feb 6;375(9713):445. doi: 10.1016/S0140-6736(10)60175-4. Lancet. 2010. PMID: 20137807 No abstract available.
Expression of concern in
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The significance of ileo-colonic lymphoid nodular hyperplasia in children with autistic spectrum disorder: expression of concern.Eur J Gastroenterol Hepatol. 2011 Nov;23(11):1082. doi: 10.1097/MEG.0b013e328349d184. Eur J Gastroenterol Hepatol. 2011. PMID: 21971344 No abstract available.
Abstract
Background: We investigated a consecutive series of children with chronic enterocolitis and regressive developmental disorder.
Methods: 12 children (mean age 6 years [range 3-10], 11 boys) were referred to a paediatric gastroenterology unit with a history of normal development followed by loss of acquired skills, including language, together with diarrhoea and abdominal pain. Children underwent gastroenterological, neurological, and developmental assessment and review of developmental records. Ileocolonoscopy and biopsy sampling, magnetic-resonance imaging (MRI), electroencephalography (EEG), and lumbar puncture were done under sedation. Barium follow-through radiography was done where possible. Biochemical, haematological, and immunological profiles were examined.
Findings: Onset of behavioural symptoms was associated, by the parents, with measles, mumps, and rubella vaccination in eight of the 12 children, with measles infection in one child, and otitis media in another. All 12 children had intestinal abnormalities, ranging from lymphoid nodular hyperplasia to aphthoid ulceration. Histology showed patchy chronic inflammation in the colon in 11 children and reactive ileal lymphoid hyperplasia in seven, but no granulomas. Behavioural disorders included autism (nine), disintegrative psychosis (one), and possible postviral or vaccinal encephalitis (two). There were no focal neurological abnormalities and MRI and EEG tests were normal. Abnormal laboratory results were significantly raised urinary methylmalonic acid compared with age-matched controls (p=0.003), low haemoglobin in four children, and a low serum IgA in four children.
Interpretation: We identified associated gastrointestinal disease and developmental regression in a group of previously normal children, which was generally associated in time with possible environmental triggers.
Comment in
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Vaccine adverse events: causal or coincidental?Lancet. 1998 Feb 28;351(9103):611-2. doi: 10.1016/S0140-6736(05)78423-3. Lancet. 1998. PMID: 9500313 No abstract available.
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Autism, inflammatory bowel disease, and MMR vaccine.Lancet. 1998 Mar 21;351(9106):905; author reply 908-9. Lancet. 1998. PMID: 9525390 No abstract available.
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Autism, inflammatory bowel disease, and MMR vaccine.Lancet. 1998 Mar 21;351(9106):905-6; author reply 908-9. doi: 10.1016/S0140-6736(05)70316-0. Lancet. 1998. PMID: 9525391 No abstract available.
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Autism, inflammatory bowel disease, and MMR vaccine.Lancet. 1998 Mar 21;351(9106):906; author reply 908-9. doi: 10.1016/s0140-6736(05)70317-2. Lancet. 1998. PMID: 9525392 No abstract available.
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Autism, inflammatory bowel disease, and MMR vaccine.Lancet. 1998 Mar 21;351(9106):906-7; author reply 908-9. doi: 10.1016/S0140-6736(05)70318-4. Lancet. 1998. PMID: 9525393 No abstract available.
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Autism, inflammatory bowel disease, and MMR vaccine.Lancet. 1998 Mar 21;351(9106):907; author reply 908-9. doi: 10.1016/S0140-6736(05)70319-6. Lancet. 1998. PMID: 9525394 No abstract available.
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Autism, inflammatory bowel disease, and MMR vaccine.Lancet. 1998 Mar 21;351(9106):907; author reply 908-9. doi: 10.1016/S0140-6736(05)70320-2. Lancet. 1998. PMID: 9525395 No abstract available.
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Autism, inflammatory bowel disease, and MMR vaccine.Lancet. 1998 Mar 21;351(9106):907-8; author reply 908-9. doi: 10.1016/S0140-6736(05)70321-4. Lancet. 1998. PMID: 9525396 No abstract available.
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Autism, inflammatory bowel disease, and MMR vaccine.Lancet. 1998 May 2;351(9112):1355; author reply 1356. Lancet. 1998. PMID: 9643815 No abstract available.
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Autism, inflammatory bowel disease, and MMR vaccine.Lancet. 1998 May 2;351(9112):1355; author reply 1356. doi: 10.1016/S0140-6736(05)79080-2. Lancet. 1998. PMID: 9643816 No abstract available.
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Autism, inflammatory bowel disease, and MMR vaccine.Lancet. 1998 May 2;351(9112):1355-6; author reply 1356. doi: 10.1016/S0140-6736(05)79081-4. Lancet. 1998. PMID: 9643817 No abstract available.
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Autism, inflammatory bowel disease, and MMR vaccine.Lancet. 1998 May 2;351(9112):1356. doi: 10.1016/S0140-6736(05)79082-6. Lancet. 1998. PMID: 9643818 No abstract available.
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Autism, inflammatory bowel disease, and MMR vaccine.Lancet. 1998 May 2;351(9112):1357. doi: 10.1016/S0140-6736(05)79085-1. Lancet. 1998. PMID: 9643820 No abstract available.
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Autism, inflammatory bowel disease, and MMR vaccine.Lancet. 1998 May 2;351(9112):1357. doi: 10.1016/s0140-6736(05)79087-5. Lancet. 1998. PMID: 9643821 No abstract available.
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Autism, inflammatory bowel disease, and MMR vaccine.Lancet. 1998 May 2;351(9112):1357-8. doi: 10.1016/S0140-6736(05)79088-7. Lancet. 1998. PMID: 9643822 No abstract available.
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Autism, inflammatory bowel disease, and MMR vaccine.Lancet. 1998 May 2;351(9112):1358. doi: 10.1016/s0140-6736(05)79089-9. Lancet. 1998. PMID: 9643823 No abstract available.
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Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children.Lancet. 1998 Jul 18;352(9123):234-5. doi: 10.1016/S0140-6736(05)77837-5. Lancet. 1998. PMID: 9683237 No abstract available.
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The MMR question.Lancet. 2000 Jul 8;356(9224):160-1. doi: 10.1016/s0140-6736(05)73169-x. Lancet. 2000. PMID: 10963264 No abstract available.
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The MMR question.Lancet. 2000 Jul 8;356(9224):161. doi: 10.1016/S0140-6736(05)73171-8. Lancet. 2000. PMID: 10963266 No abstract available.
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The MMR question.Lancet. 2000 Jul 8;356(9224):161-2. doi: 10.1016/S0140-6736(05)73172-X. Lancet. 2000. PMID: 10963267 No abstract available.
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MMR vaccination, ileal lymphoid nodular hyperplasia, and pervasive develop-mental disorder.Lancet. 2002 Jun 15;359(9323):2051-2. doi: 10.1016/S0140-6736(02)08948-1. Lancet. 2002. PMID: 12086756 No abstract available.
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The lessons of MMR.Lancet. 2004 Mar 6;363(9411):747-9. doi: 10.1016/S0140-6736(04)15714-0. Lancet. 2004. PMID: 15016482 No abstract available.
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A statement by the editors of The Lancet.Lancet. 2004 Mar 6;363(9411):820-1. doi: 10.1016/S0140-6736(04)15699-7. Lancet. 2004. PMID: 15022645 No abstract available.
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A statement by Dr Simon Murch. Allegations concerning our 1998 study.Lancet. 2004 Mar 6;363(9411):821-2. doi: 10.1016/s0140-6736(04)15708-5. Lancet. 2004. PMID: 15022648 No abstract available.
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A statement by Professor John Walker-Smith.Lancet. 2004 Mar 6;363(9411):822-3. doi: 10.1016/S0140-6736(04)15709-7. Lancet. 2004. PMID: 15022649 No abstract available.
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A statement by Dr Andrew Wakefield.Lancet. 2004 Mar 6;363(9411):823-4. doi: 10.1016/S0140-6736(04)15710-3. Lancet. 2004. PMID: 15022650 No abstract available.
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