Embryonic stem cell lines derived from human blastocysts
- PMID: 9804556
- DOI: 10.1126/science.282.5391.1145
Embryonic stem cell lines derived from human blastocysts
Erratum in
- Science 1998 Dec 4;282(5395):1827
Abstract
Human blastocyst-derived, pluripotent cell lines are described that have normal karyotypes, express high levels of telomerase activity, and express cell surface markers that characterize primate embryonic stem cells but do not characterize other early lineages. After undifferentiated proliferation in vitro for 4 to 5 months, these cells still maintained the developmental potential to form trophoblast and derivatives of all three embryonic germ layers, including gut epithelium (endoderm); cartilage, bone, smooth muscle, and striated muscle (mesoderm); and neural epithelium, embryonic ganglia, and stratified squamous epithelium (ectoderm). These cell lines should be useful in human developmental biology, drug discovery, and transplantation medicine.
Comment in
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A versatile cell line raises scientific hopes, legal questions.Science. 1998 Nov 6;282(5391):1014-5. doi: 10.1126/science.282.5391.1014. Science. 1998. PMID: 9841438 No abstract available.
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Publishing controversial research.Science. 1998 Nov 6;282(5391):1045. doi: 10.1126/science.282.5391.1045. Science. 1998. PMID: 9841446 No abstract available.
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New potential for human embryonic stem cells.Science. 1998 Nov 6;282(5391):1061-2. doi: 10.1126/science.282.5391.1061. Science. 1998. PMID: 9841453 No abstract available.
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