Development and validation of the Charcot-Marie-Tooth Disease Infant Scale
Mandarakas et al. present a reliable and sensitive 15-item functional outcome measure for early-onset Charcot-Marie-Tooth disease and related neuropathies.
Neurobiological substrates underlying the predictive effect of genomic risk for depression on the conversion of amnestic mild cognitive impairment
Depression increases the risk of conversion from amnestic mild cognitive impairment (MCI) to Alzheimer’s disease. Xu et al. show that the polygenic risk score for major depressive disorder-specific variants predicts conversion from non-depressed amnestic MCI to Alzheimer’s disease, via effects on hippocampal development and amyloid-β binding.
Focused ultrasound thalamotomy location determines clinical outcomes in essential tremor patients
MR-guided focused ultrasound thalamotomy is a novel and minimally invasive ablative treatment for essential tremor. Boutet et al. examine the relationship between the size and location of therapeutic lesions and clinical outcomes.
HCN1 mutation spectrum: from neonatal epileptic encephalopathy to benign generalized epilepsy and beyond
HCN channels are activated by hyperpolarization and help to control neuronal excitability. Marini et al. show that de novo or inherited missense variants leading to loss or gain of function of HCN1 are associated with multiple seizure disorders
Brain structural alterations are distributed following functional, anatomic and genetic connectivity
By conducting a transdiagnostic search of voxel-based morphometry studies in a wide range of brain disorders, Cauda et al. explore how different types of brain connectivity guide the spread of structural alterations and constrain co-alteration patterns.
Dysfunctional effort-based decision-making underlies apathy in genetic cerebral small vessel disease
Using behavioural, physiological and imaging techniques, Le Heron et al. present converging evidence that reduced reward sensitivity underlies apathy in patients with a monogenic form of cerebral small vessel disease.
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New brain imaging technology answers questions about the spread of Alzheimer's
Recently published in Brain: Tau burden and the functional connectome in Alzheimer’s disease and progressive supranuclear palsy
Can electrical stimulation of the brain enhance mind?
Stimulating networks of brain cells at a set of parameters, which match their physiological activity when memories are encoded, can reverberate a memory trace and result in its conscious experience.
What are the critical brain networks for creativity?
The concept of creativity is imbued with two contradictory notions. The first notion usually considers that a creative production is the result of high-level control functions such as inhibition, mental manipulation, or planning. These functions are known to depend on the anterior part of the brain: the prefrontal cortex.
What can brain research offer people who stutter?
Brain imaging studies of adults who stutter do reveal differences in both the structure and the function of the circuits involved in speech production. For example, a number of studies show that the bundle of nerve fibers connecting the sensory and motor brain areas involved in speech production is less organized in people who stutter.
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