The Collagen Protein

Bookmark this page

Sequence Alignment of the Collagen Protein (Homo sapiens)  (with Clustalw) ^a

Fibrillar Collagens Isoform Sequence Alignment

alpha1B(XI)     -----MEPWSSRWKTKRWLWDFT--VTTLALTFLFQAREVRGAAPVDVLKALDFHN---- 49
alpha1C(XI)     -----MEPWSSRWKTKRWLWDFT--VTTLALTFLFQAREVRGAAPVDVLKALDFHN---- 49
alpha1A(XI)     -----MEPWSSRWKTKRWLWDFT--VTTLALTFLFQAREVRGAAPVDVLKALDFHN---- 49
alpha1(V)       ------MDVHTRWKARSALRPGAPLLPPLLLLLLWAPPPSRAAQPADLLKVLDFHN---- 50
alpha2-1(XI)    ------MERCSRCHRLLLLLPLV--------LGLSAAPGWAGAPPVDVLRALRFPS---- 42
alpha2-2(XI)    ------MERCSRCHRLLLLLPLV--------LGLSAAPGWAGAPPVDVLRALRFPS---- 42
alpha2-3(XI)    ------MERCSRCHRLLLLLPLV--------LGLSAAPGWAGAPPVDVLRALRFPS---- 42
alph3(V)        -----MGNRRDLGQPRAGLCLLL--------AALQLLPG-TQADPVDVLKALGVQG---- 42
alpha1-1(II)    ------------------------------------------------------------
alpha1-2(II)    ------------------------------------------------------------
alpha1(I)       ------------------------------------------------------------
alpha2(V)       ------------------------------------------------------------
alpha2(I)       ------------------------------------------------------------
alpha1(III)     ------------------------------------------------------------
alpha1(XXIV)    MHLRAHRTRRGKVSPTAKTKS--LLHFIVLCVAGVVVHAQ--EQGIDILHQLGLGGKDVR 56
alpha1(XXVII)   MGAGSARGARGTAAAAAARGGGFLFSWILVSFACHLASTQGAPEDVDILQRLGLS----- 55
                                                                               

alpha1B(XI)     -SPEGISKTTGFCTNRKNSKGSDTAYRVSKQAQLSAPTKQLFPGGTFPEDFSILFTVKPK 108
alpha1C(XI)     -SPEGISKTTGFCTNRKNSKGSDTAYRVSKQAQLSAPTKQLFPGGTFPEDFSILFTVKPK 108
alpha1A(XI)     -SPEGISKTTGFCTNRKNSKGSDTAYRVSKQAQLSAPTKQLFPGGTFPEDFSILFTVKPK 108
alpha1(V)       -LPDGITKTTGFCATRRSSKGPDVAYRVTKDAQLSAPTKQLYPASAFPEDFSILTTVKAK 109
alpha2-1(XI)    -LPDGVRRAKGICP-------ADVAYRVARPAQLSAPTRQLFPGG-FPKDFSLLTVVRTR 93
alpha2-2(XI)    -LPDGVRRAKGICP-------ADVAYRVARPAQLSAPTRQLFPGG-FPKDFSLLTVVRTR 93
alpha2-3(XI)    -LPDGVRRAKGICP-------ADVAYRVARPAQLSAPTRQLFPGG-FPKDFSLLTVVRTR 93
alph3(V)        -GQAGVPEGPGFCPQR--TPEGDRAFRIGQASTLGIPTWELFPEGHFPENFSLLITLRGQ 99
alpha1-1(II)    ------------------------------------------------------------
alpha1-2(II)    ------------------------------------------------------------
alpha1(I)       ------------------------------------------------------------
alpha2(V)       ------------------------------------------------------------
alpha2(I)       ------------------------------------------------------------
alpha1(III)     ------------------------------------------------------------
alpha1(XXIV)    HSSPATAVPSASTPLPQGVHLTESGVIFKNDAYIETPFVKILPVN-LGQPFTILTGLQSH 115
alpha1(XXVII)   -------WTKAGSPAPPGVIPFQSGFIFTQRARLQAPTGTVIPAA-LGTELALVLSLCSH 107
                                                                               

alpha1B(XI)     KGIQSFLLSIYNEHGIQQIGVEVGRSPVFLFEDHTGKPAPEDYPLFRTVNIADGKWHRVA 168
alpha1C(XI)     KGIQSFLLSIYNEHGIQQIGVEVGRSPVFLFEDHTGKPAPEDYPLFRTVNIADGKWHRVA 168
alpha1A(XI)     KGIQSFLLSIYNEHGIQQIGVEVGRSPVFLFEDHTGKPAPEDYPLFRTVNIADGKWHRVA 168
alpha1(V)       KGSQAFLVSIYNEQGIQQIGLELGRSPVFLYEDHTGKPGPEDYPLFRGINLSDGKWHRIA 169
alpha2-1(XI)    PGLQAPLLTLYSAQGVRQLGLELGRPVRFLYEDQTGRPQPPSQPVFRGLSLADGKWHRVA 153
alpha2-2(XI)    PGLQAPLLTLYSAQGVRQLGLELGRPVRFLYEDQTGRPQPPSQPVFRGLSLADGKWHRVA 153
alpha2-3(XI)    PGLQAPLLTLYSAQGVRQLGLELGRPVRFLYEDQTGRPQPPSQPVFRGLSLADGKWHRVA 153
alph3(V)        PANQSVLLSIYDERGARQLGLALGPALGLLGDPFR--------PLPQQVNLTDGRWHRVA 151
alpha1-1(II)    -----------------------------------------------MIRLGAPQTLVLL 13
alpha1-2(II)    -----------------------------------------------MIRLGAPQTLVLL 13
alpha1(I)       --------------------------------------------------MFSFVDLRLL 10
alpha2(V)       ----------------------------------------------MMANWAEARPLLIL 14
alpha2(I)       -----------------------------------------------MLSFVDTRTLLLL 13
alpha1(III)     -----------------------------------------------MMSFVQKGSWLLL 13
alpha1(XXIV)    RVNNAFLFSIRNKNR-LQLGVQLLPKKLVVHIRGK-------QPAVFNYSVHDEQWHSFA 167
alpha1(XXVII)   RVNHAFLFAVRSQKRKLQLGLQFLPGKTVVHLGSR-------RSVAFDLDMHDGRWHHLA 160
                                                                             . 

alpha1B(XI)     ISVEKKTVTMIVDCKKKTTKPLD-RSERAIVDTNGITVFGTRILDEEVFEGDIQQFLITG 227
alpha1C(XI)     ISVEKKTVTMIVDCKKKTTKPLD-RSERAIVDTNGITVFGTRILDEEVFEGDIQQFLITG 227
alpha1A(XI)     ISVEKKTVTMIVDCKKKTTKPLD-RSERAIVDTNGITVFGTRILDEEVFEGDIQQFLITG 227
alpha1(V)       LSVHKKNVTLILDCKKKTTKFLD-RSDHPMIDINGIIVFGTRILDEEVFEGDIQQLLFVS 228
alpha2-1(XI)    VAVKGQSVTLIVDCKKRVTRPLP-RSARPVLDTHGVIIFGARILDEEVFEGDVQELAIVP 212
alpha2-2(XI)    VAVKGQSVTLIVDCKKRVTRPLP-RSARPVLDTHGVIIFGARILDEEVFEGDVQELAIVP 212
alpha2-3(XI)    VAVKGQSVTLIVDCKKRVTRPLP-RSARPVLDTHGVIIFGARILDEEVFEGDVQELAIVP 212
alph3(V)        VSIDGEMVTLVADCEAQP--PVL-GHGPRFISIAGLTVLGTQDLGEKTFEGDIQELLISP 208
alpha1-1(II)    TLLVAAVLRCQGQDVQEAG---------------SCVQDGQRYNDKDVWKPEPCRICVCD 58
alpha1-2(II)    TLLVAAVLRCQGQDVR-------------------------------------------- 29
alpha1(I)       LLLAATALLTHGQEEGQVEGQDE-D-----IPPITCVQNGLRYHDRDVWKPEPCRICVCD 64
alpha2(V)       IVLLGQFVSIKAQEEDEDEGYG---------EEIACTQNGQMYLNRDIWKPAPCQICVCD 65
alpha2(I)       AVTLCLATCQSLQEETVR------------------------------------------ 31
alpha1(III)     ALLHPTIILAQQEAVEGG-----------------CSHLGQSYADRDVWKPEPCQICVCD 56
alpha1(XXIV)    ITIRNQSVSMFVECGKKYFSTET-IPEVQTFDSNSVFTLGSMNNNSIHFEGIVCQLDIIP 226
alpha1(XXVII)   LELRGRTVTLVTACGQRRVPVLLPFHRDPALDPGGSFLFGKMNPHAVQFEGALCQFSIYP 220
                                                                               

alpha1B(XI)     DPKAAYDYCEHYSPDCDSSAPKAAQAQEPQIDEKKKS-----NFKKKMRTVATKSKEKSK 282
alpha1C(XI)     DPKAAYDYCEHYSPDCDSSAPKAAQAQEPQIDE--------------------------- 260
alpha1A(XI)     DPKAAYDYCEHYSPDCDSSAPKAAQAQEPQIDEYAPE-----DIIEYDYEYGEAEYKEAE 282
alpha1(V)       DHRAAYDYCEHYSPDCDTAVPDTPQSQDPNPDEYYTEGDGEGETYYYEYPYYEDPEDLGK 288
alpha2-1(XI)    GVQAAYESCEQKELECEGGQRERPQNQQPHRAQRSPQ----------------------- 249
alpha2-2(XI)    GVQAAYESCEQKELECEGGQRERPQNQQPHRAQRSPQ----------------------- 249
alpha2-3(XI)    GVQAAYESCEQKELECEGGQRERPQNQQPHRAQRSPQ----------------------- 249
alph3(V)        DPQAAFQACERYLPDCDNLAPAATVAPQGEPETPRPR----------------------- 245
alpha1-1(II)    TGTVLCDDIICEDVKDCLSPEIPFGECCPICPTDLAT----------------------- 95
alpha1-2(II)    ------------------------------------------------------------
alpha1(I)       NGKVLCDDVICDETKN-------------------------------------------- 80
alpha2(V)       NGAILCDKIECQDVLDCADPVTPPGECCPVCSQTPGG----------------------- 102
alpha2(I)       ------------------------------------------------------------
alpha1(III)     SGSVLCDDIICDD----------------------------------------------- 69
alpha1(XXIV)    SAEASADYCRYVKQQCRQADKYQP------------------------------------ 250
alpha1(XXVII)   VTQVAHNYCTHLRKQCGQADTYQSPLGPLFSQDSGRPFTFQSDLALLGLENLTTATPALG 280
                                                                               

alpha1B(XI)     KFTPPKSEKFSSKKKKSYQASAKAKLGVKANIVDDFQ-----------EYNYGTMESYQT 331
alpha1C(XI)     -----------------------------ANIVDDFQ-----------EYNYGTMESYQT 280
alpha1A(XI)     SVTEG------------PTVTEETIAQTEANIVDDFQ-----------EYNYGTMESYQT 319
alpha1(V)       EPTPSKKPVEAAKETTEVPEELTPTPTEAAPMPETSEGAGKEEDVGIGDYDYVPSEDYYT 348
alpha2-1(XI)    --------------------QQPSRLHRPQNQEPQSQPT---------ESLYYDYEPPYY 280
alpha2-2(XI)    --------------------QQPSRLHRPQNQEPQSQ----------------------- 266
alpha2-3(XI)    --------------------QQPSRLHRPQNQEPQSQ----------------------- 266
alph3(V)        --------------------RKGKGKGRKKGRGRKGK-------------GRKKNKEIWT 272
alpha1-1(II)    ------------------------------------------------------------
alpha1-2(II)    ------------------------------------------------------------
alpha1(I)       ------------------------------------------------------------
alpha2(V)       ------------------------------------------------------------
alpha2(I)       ------------------------------------------------------------
alpha1(III)     ------------------------------------------------------------
alpha1(XXIV)    ---------ETSIPCTTLIPTKIPEHSP---------------PPKLFAEKVLS------ 280
alpha1(XXVII)   SLPAGRGPRGTVAPATPTKPQRTSPTNPHQHMAVGGPAQTPLLPAKLSASNALDPMLPAS 340
                                                                               

alpha1B(XI)     EAPR--HVSGTNEPNPVEEIFTEEYLTGEDYDSQRKNSEDTLYENKEIDGRDSDLLVDGD 389
alpha1C(XI)     EAPR--HVSGTNEPNPVEEIFTEEYLTGEDYDSQRKNSEDTLYENKEIDGRDSDLLVDGD 338
alpha1A(XI)     EAPR--HVSGTNEPNPVEEIFTEEYLTGEDYDSQRKNSEDTLYENKEIDGRDSDLLVDGD 377
alpha1(V)       PSPYDDLTYGEGEENPDQPTDPGAGAEIPTSTADTSNSSNPAPPPGEGADDLEGEFTEET 408
alpha2-1(XI)    DVMTTGTTPDYQDPTPGEEEEILESSLLPPLEEEQTDLQVPPTADRFQAEEYGEGGTDPP 340
alpha2-2(XI)    ------------DPTPGEEEEILESSLLPPLEE--------------------------- 287
alpha2-3(XI)    ------------------------------------------------------------
alph3(V)        SSPPP-DSAENQTSTDIPKTETPAPNLPPTPTPLVVTSTVTTGLNATILERSLDPDSGTE 331
alpha1-1(II)    ------------------------------------------------------------
alpha1-2(II)    ------------------------------------------------------------
alpha1(I)       ------------------------------------------------------------
alpha2(V)       ------------------------------------------------------------
alpha2(I)       ------------------------------------------------------------
alpha1(III)     ------------------------------------------------------------
alpha1(XXIV)    --------------EDTFTEGKSIPNIIKND-----SETVYKRQEHQISRSQLSSLQSGN 321
alpha1(XXVII)   VGGSTRTPRPAAAQPSQKITATKIPKSLPTKPSAPSTSIVPIKSPHPTQKTAPSSFTKSA 400
                                                                               

alpha1B(XI)     LGEYDFYEYKEYEDKPTSPPNEEFGPGVPAETDITETSINGHGAYGEKGQKGEPAVVEPG 449
alpha1C(XI)     LGEYDFYEYKEYEDKPTSPPNEEFGPGVPAETDITETSINGHGAYGEKGQKGEPAVVEPG 398
alpha1A(XI)     LGEYDFYEYKEYEDKPTSPPNEEFGPGVPAETDITETSINGHGAYGEKGQKGEPAVVEPG 437
alpha1(V)       IRNLDENYYDPYYDPTSSPS--EIGPGMPANQDTIYEGIG--GPRGEKGQKGEPAIIEPG 464
alpha2-1(XI)    EGPYDYTYGYGDDYRE------ETELGPALSAETAHSGAAAHGPRGLKGEKGEPAVLEPG 394
alpha2-2(XI)    ---------------------------------------AAHGPRGLKGEKGEPAVLEPG 308
alpha2-3(XI)    ---------------------------------------AAHGPRGLKGEKGEPAVLEPG 287
alph3(V)        LGTLETKAAREDEEGDDS----TMGPDFRAAEYPSRTQFQIFPGAGEKGAKGEPAVIEKG 387
alpha1-1(II)    --------------------------------------ASG--QPGPKGQKGEPGDIKDI 115
alpha1-2(II)    -------------------------------------------QPGPKGQKGEPGDIKDI 46
alpha1(I)       -------------------------------------------CPGAEVPEGE----CCP 93
alpha2(V)       --------------------------------------GNTNFGRGRKGQKGEPGLVPVV 124
alpha2(I)       ------------------------------------------------------------
alpha1(III)     -------------------------------------------QELDCPNPEIPFGECCA 86
alpha1(XXIV)    VS---AVDLTNHGIQAKEMITEED-TQTNFSLS----VTTHRISEAKMNTKEKFSSLLNM 373
alpha1(XXVII)   LPTQKQVPPTSRPVPARVSRPAEKPIQRNPGMPRPPPPSTRPLPPTTSSSKKPIPTLART 460
                                                                               

alpha1B(XI)     MLVEGPPGP-------------------------AGPAGIMGPPGLQGPTGPPGDPGDRG 484
alpha1C(XI)     MLVEGPPGP-------------------------AGPAGIMGPPGLQGPTGPPGDPGDRG 433
alpha1A(XI)     MLVEGPPGP-------------------------AGPAGIMGPPGLQGPTGPPGDPGDRG 472
alpha1(V)       MLIEGPPGP-------------------------EGPAGLPGPPGTMGPTGQVGDPGERG 499
alpha2-1(XI)    MLVEGPPGP-------------------------EGPAGLIGPPGIQGNPGPVGDPGERG 429
alpha2-2(XI)    MLVEGPPGP-------------------------EGPAGLIGPPGIQGNPGPVGDPGERG 343
alpha2-3(XI)    MLVEGPPGP-------------------------EGPAGLIGPPGIQGNPGPVGDPGERG 322
alph3(V)        QQFEGPPGA-------------------------PGPQGVVGPSGPPGPPGFPGDPGPPG 422
alpha1-1(II)    VGPKGPPGP-------------------------QGPAGEQGPRGDRGDKGEKGAPGPRG 150
alpha1-2(II)    VGPKGPPGP-------------------------QGPAGEQGPRGDRGDKGEKGAPGPRG 81
alpha1(I)       VCPDGSESPT-----------------------DQETTGVEGPKGDTGPRGPRGPAGPPG 130
alpha2(V)       TGIRGRPGP-------------------------AGPPGSQGPRGERGPKGRPGPRGPQG 159
alpha2(I)       ----------------------------------------KGPAGDRGPRGERGPPGPPG 51
alpha1(III)     VCPQPPTAP----------------------------TRPPNGQGPQGPKGDPGPPGIPG 118
alpha1(XXIV)    SDNITQHDDR-----------------------VTGLSLFKKMPSILPQIKQDTITNLKK 410
alpha1(XXVII)   EAKITSHASKPASARTSTHKPPPFTALSSSPAPTPGSTRSTRPPATMVPPTSGTSTPRTA 520
                                                               .               

alpha1B(XI)     PPGRPGLPGADGLPGPPGTMLMLPFRYGGDG---SKGPTISAQE--AQAQAILQQARIAL 539
alpha1C(XI)     PPGRPGLPGADGLPGPPGTMLMLPFRYGGDG---SKGPTISAQE--AQAQAILQQARIAL 488
alpha1A(XI)     PPGRPGLPGADGLPGPPGTMLMLPFRYGGDG---SKGPTISAQE--AQAQAILQQARIAL 527
alpha1(V)       PPGRPGLPGADGLPGPPGTMLMLPFRFGGGGDAGSKGPMVSAQE--SQAQAILQQARLAL 557
alpha2-1(XI)    PPGRAGLPGSDGAPGPPGTSLMLPFRFGSGG--GDKGPVVAAQE--AQAQAILQQARLAL 485
alpha2-2(XI)    PPGRAGLPGSDGAPGPPGTSLMLPFRFGSGG--GDKGPVVAAQE--AQAQAILQQARLAL 399
alpha2-3(XI)    PPGRAGLPGSDGAPGPPGTSLMLPFRFGSGG--GDKGPVVAAQE--AQAQAILQQARLAL 378
alph3(V)        PAGLPGIPGIDGIRGPPGTVIMMPFQFAGGS---FKGPPVSFQQ--AQAQAVLQQTQLSM 477
alpha1-1(II)    RDGEPGTPGNPGPPGPPGP----PGPPGLGGNFAAQMAGGFDEK-AGGAQLGVMQGPMGP 205
alpha1-2(II)    RDGEPGTPGNPGPPGPPGP----PGPPGLGGNFAAQMAGGFDEK-AGGAQLGVMQGPMGP 136
alpha1(I)       RDGIPGQPGLPGPPGPPGP----PGPPGLGGNFAPQLSYGYDEK-STGGIS--VPGPMGP 183
alpha2(V)       IDGEPGVPGQPGAPGPPGHP-SHPGPDGLSRPFSAQMAGLDEKS-GLGSQVGLMPGSVGP 217
alpha2(I)       RDGEDGPTGPPGPPGPPGP-------PGLGGNFAAQYD---------GKGVGLGPGPMGL 95
alpha1(III)     RNGDPGIPGQPGSPGSPGPPGICESCPTGPQNYSPQYDSYDVKSGVAVGGLAGYPGPAGP 178
alpha1(XXIV)    AITANLHTNELMEMQPILNTSLHRVTNEPSVDNHLDLR----------KEGEFYPDATYP 460
alpha1(XXVII)   PAVPTPGSAPTGSKKPIGSEASKKAGPKSSPRKPVPLRPGKAARDVPLSDLTTRPSPRQP 580
                          .       .                                            

alpha1B(XI)     RGPPGPM----------------------GLTGRPGPVGGPGSSGAKGESGDPGPQGPRG 577
alpha1C(XI)     RGPPGPM----------------------GLTGRPGPVGGPGSSGAKGESGDPGPQGPRG 526
alpha1A(XI)     RGPPGPM----------------------GLTGRPGPVGGPGSSGAKGESGDPGPQGPRG 565
alpha1(V)       RGPAGPM----------------------GLTGRPGPVGPPGSGGLKGEPGDVGPQGPRG 595
alpha2-1(XI)    RGPPGPM----------------------GYTGRPGPLGQPGSPGLKGESGDLGPQGPRG 523
alpha2-2(XI)    RGPPGPM----------------------GYTGRPGPLGQPGSPGLKGESGDLGPQGPRG 437
alpha2-3(XI)    RGPPGPM----------------------GYTGRPGPLGQPGSPGLKGESGDLGPQGPRG 416
alph3(V)        KGPPGPV----------------------GLTGRPGPVGLPGHPGLKGEEGAEGPQGPRG 515
alpha1-1(II)    MGPRGPP----------------------GPA---GAPGPQGFQGNPGEPGEPGVSGPMG 240
alpha1-2(II)    MGPRGPP----------------------GPA---GAPGPQGFQGNPGEPGEPGVSGPMG 171
alpha1(I)       SGPRGLP----------------------GPP---GAPGPQGFQGPPGEPGEPGASGPMG 218
alpha2(V)       VGPRGPQ----------------------GLQ---GQQGGAGPTGPPGEPGDPGPMGPIG 252
alpha2(I)       MGPRGPP----------------------GAA---GAPGPQGFQGPAGEPGEPGQTGPAG 130
alpha1(III)     PGPPGPP----------------------GTSGHPGSPGSPGYQGPPGEPGQAGPSGPPG 216
alpha1(XXIV)    IENSYET-------------------ELYDYYYYEDLNTMLEMEYLRGPKGDTGPPGPPG 501
alpha1(XXVII)   QPSQQTTPALVLAPAQFLSSSPRPTSSGYSIFHLAGSTPFPLLMGPPGPKGDCGLPGPPG 640
                                             .     .           *  *  *  ** *

alpha1B(XI)     VQGPPGPTGKPGKRGRPGADGGRGMPGEPGAKGDRGFDGLPGLPGDKGHRGERGPQGPPG 637
alpha1C(XI)     VQGPPGPTGKPGKRGRPGADGGRGMPGEPGAKGDRGFDGLPGLPGDKGHRGERGPQGPPG 586
alpha1A(XI)     VQGPPGPTGKPGKRGRPGADGGRGMPGEPGAKGDRGFDGLPGLPGDKGHRGERGPQGPPG 625
alpha1(V)       VQGPPGPAGKPGRRGRAGSDGARGMPGQTGPKGDRGFDGLAGLPGEKGHRGDPGPSGPPG 655
alpha2-1(XI)    PQGLTGPPGKAGRRGRAGADGARGMPGDPGVKGDRGFDGLPGLPGEKGHRGDTGAQGLPG 583
alpha2-2(XI)    PQGLTGPPGKAGRRGRAGADGARGMPGDPGVKGDRGFDGLPGLPGEKGHRGDTGAQGLPG 497
alpha2-3(XI)    PQGLTGPPGKAGRRGRAGADGARGMPGDPGVKGDRGFDGLPGLPGEKGHRGDTGAQGLPG 476
alph3(V)        LQGPHGPPGRVGKMGRPGADGARGLPGDTGPKGDRGFDGLPGLPGEKGQRGDFGHVGQPG 575
alpha1-1(II)    PRGPPGPPGKPGDDGEAGKPGKAGERGPPGPQGARGFPGTPGLPGVKGHRGYPGLDGAKG 300
alpha1-2(II)    PRGPPGPPGKPGDDGEAGKPGKAGERGPPGPQGARGFPGTPGLPGVKGHRGYPGLDGAKG 231
alpha1(I)       PRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGFSGLDGAKG 278
alpha2(V)       SRGPEGPPGKPGEDGEPGRNGNPGEVGFAGSPGARGFPGAPGLPGLKGHRGHKGLEGPKG 312
alpha2(I)       ARGPAGPPGKAGEDGHPGKPGRPGERGVVGPQGARGFPGTPGLPGFKGIRGHNGLDGLKG 190
alpha1(III)     PPGAIGPSGPAGKDGESGRPGRPGERGLPGPPGIKGPAGIPGFPGMKGHRGFDGRNGEKG 276
alpha1(XXIV)    PAGIPGPSGKRGPRGIPGPHGNPGLPGLPGPKGPKGDPGFSPGQPVPGEKGDQGLSGLMG 561
alpha1(XXVII)   LPGLPGIPGARGPRGPPGPYGNPGLPGPPGAKGQKGDPGLSPGKAHDGAKGDMGLPGLSG 700
                  *  * .*  *  * .*  *  *  *  *  * :*  * .      * :*  *  *  *

alpha1B(XI)     PPGDDGMRGEDGEIGPRGLPGEAGPRGLLGPRGTPGAPGQPGMAGVDGPPGPKGNMGPQG 697
alpha1C(XI)     PPGDDGMRGEDGEIGPRGLPGEAGPRGLLGPRGTPGAPGQPGMAGVDGPPGPKGNMGPQG 646
alpha1A(XI)     PPGDDGMRGEDGEIGPRGLPGEAGPRGLLGPRGTPGAPGQPGMAGVDGPPGPKGNMGPQG 685
alpha1(V)       PPGDDGERGDDGEVGPRGLPGEPGPRGLLGPKGPPGPPGPPGVTGMDGQPGPKGNVGPQG 715
alpha2-1(XI)    PPGEDGERGDDGEIGPRGLPGESGPRGLLGPKGPPGIPGPPGVRGMDGPQGPKGSLGPQG 643
alpha2-2(XI)    PPGEDGERGDDGEIGPRGLPGESGPRGLLGPKGPPGIPGPPGVRGMDGPQGPKGSLGPQG 557
alpha2-3(XI)    PPGEDGERGDDGEIGPRGLPGESGPRGLLGPKGPPGIPGPPGVRGMDGPQGPKGSLGPQG 536
alph3(V)        PPGEDGERGAEGPPGPTGQAGEPGPRGLLGPRGSPGPTGRPGVTGIDGAPGAKGNVGPPG 635
alpha1-1(II)    EAGAPGVKGESGSPGENGSPGPMGPRGLPGERGRTGPAGAAGARGNDGQPGPAGPPGPVG 360
alpha1-2(II)    EAGAPGVKGESGSPGENGSPGPMGPRGLPGERGRTGPAGAAGARGNDGQPGPAGPPGPVG 291
alpha1(I)       DAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTG 338
alpha2(V)       EVGAPGSKGEAGPTGPMGAMGPLGPRGMPGERGRLGPQGAPGQRGAHGMPGKPGPMGPLG 372
alpha2(I)       QPGAPGVKGEPGAPGENGTPGQTGARGLPGERGRVGAPGPAGARGSDGSVGPVGPAGPIG 250
alpha1(III)     ETGAPGLKGENGLPGENGAPGPMGPRGAPGERGRPGLPGAAGARGNDGARGSDGQPGPPG 336
alpha1(XXIV)    PPGMQGDKGLKGHPGLPGLPGEQGIPGFAGNIGSPGYPGRQGLAGPEGNPGPKGAQGFIG 621
alpha1(XXVII)   NPGPPGRKGHKGYPGPAGHPGEQGQPGPEGSPGAKGYPGRQGLPGPVGDPGPKGSRGYIG 760
                  *  * :*  *  *  *  *  *  *  *  *  *  *  *  *  *  *  *  *  *

alpha1B(XI)     EPGPPGQQGNPGPQGLPGPQGPIGPPGEKGPQGKPGLAGLPGADGPPGHPGKEGQSGEKG 757
alpha1C(XI)     EPGPPGQQGNPGPQGLPGPQGPIGPPGEKGPQGKPGLAGLPGADGPPGHPGKEGQSGEKG 706
alpha1A(XI)     EPGPPGQQGNPGPQGLPGPQGPIGPPGEKGPQGKPGLAGLPGADGPPGHPGKEGQSGEKG 745
alpha1(V)       EPGPPGQQGNPGAQGLPGPQGAIGPPGEKGPLGKPGLPGMPGADGPPGHPGKEGPPGEKG 775
alpha2-1(XI)    EPGPPGQQGTPGTQGLPGPQGAIGPHGEKGPQGKPGLPGMPGSDGPPGHPGKEGPPGTKG 703
alpha2-2(XI)    EPGPPGQQGTPGTQGLPGPQGAIGPHGEKGPQGKPGLPGMPGSDGPPGHPGKEGPPGTKG 617
alpha2-3(XI)    EPGPPGQQGTPGTQGLPGPQGAIGPHGEKGPQGKPGLPGMPGSDGPPGHPGKEGPPGTKG 596
alph3(V)        EPGPPGQQGNHGSQGLPGPQGLIGTPGEKGPPGNPGIPGLPGSDGPLGHPGHEGPTGEKG 695
alpha1-1(II)    PAGGPGFPGAPGAKGEAGPTGARGPEGAQGPRGEPGTPGSPGPAGASGNPGTDGIPGAKG 420
alpha1-2(II)    PAGGPGFPGAPGAKGEAGPTGARGPEGAQGPRGEPGTPGSPGPAGASGNPGTDGIPGAKG 351
alpha1(I)       PAGPPGFPGAVGAKGEAGPQGPRGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKG 398
alpha2(V)       IPGSSGFPGNPGMKGEAGPTGARGPEGPQGQRGETGPPGPVGSPGLPGAIGTDGTPGAKG 432
alpha2(I)       SAGPPGFPGAPGPKGEIGAVGNAGPAGPAGPRGEVGLPGLSGPVGPPGNPGANGLTGAKG 310
alpha1(III)     PPGTAGFPGSPGAKGEVGPAGSPGSNGAPGQRGEPGPQGHAGAQGPPGPPGINGSPGGKG 396
alpha1(XXIV)    SPGEAGQLGPEGERGIPGIRGKKGFKGRQGFPGDFGDRGPAGLDGSPGLVGGTGPPGFPG 681
alpha1(XXVII)   LPGLFGLPGSDGERGLPGVPGKRGKMGMPGFPGVFGERGPPGLDGNPGELGLPGPPGVPG 820
                 .*  *  *  * :*  *  *  *  *  *  *  *  *  *  *  *  *  * .*  *

alpha1B(XI)     ALGPPGPQGPIGYPGPRGVKGADGVRGLKGSKGEKGEDGFPGFKGDMGLKGDRGEVGQIG 817
alpha1C(XI)     ALGPPGPQGPIGYPGPRGVKGADGVRGLKGSKGEKGEDGFPGFKGDMGLKGDRGEVGQIG 766
alpha1A(XI)     ALGPPGPQGPIGYPGPRGVKGADGVRGLKGSKGEKGEDGFPGFKGDMGLKGDRGEVGQIG 805
alpha1(V)       GQGPPGPQGPIGYPGPRGVKGADGIRGLKGTKGEKGEDGFPGFKGDMGIKGDRGEIGPPG 835
alpha2-1(XI)    NQGPSGPQGPLGYPGPRGVKGVDGIRGLKGHKGEKGEDGFPGFKGDIGVKGDRGEVGVPG 763
alpha2-2(XI)    NQGPSGPQGPLGYPGPRGVKGVDGIRGLKGHKGEKGEDGFPGFKGDIGVKGDRGEVGVPG 677
alpha2-3(XI)    NQGPSGPQGPLGYPGPRGVKGVDGIRGLKGHKGEKGEDGFPGFKGDIGVKGDRGEVGVPG 656
alph3(V)        AQGPPGSAGPPGYPGPRGVKGTSGNRGLQGEKGEKGEDGFPGFKGDVGLKGDQGKPGAPG 755
alpha1-1(II)    SAGAPGIAGAPGFPGPRGPPGPQGATGPLGPKGQTGEPGIAGFKGEQGPKGEPGPAGPQG 480
alpha1-2(II)    SAGAPGIAGAPGFPGPRGPPGPQGATGPLGPKGQTGEPGIAGFKGEQGPKGEPGPAGPQG 411
alpha1(I)       ANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGEPGPVGVQG 458
alpha2(V)       PTGSPGTSGPPGSAGPPGSPGPQGSTGPQGIRGQPGDPGVPGFKGEAGPKGEPGPHGIQG 492
alpha2(I)       AAGLPGVAGAPGLPGPRGIPGPVGAAGATGARGLVGEPGPAGSKGESGNKGEPGSAGPQG 370
alpha1(III)     EMGPAGIPGAPGLMGARGPPGPAGANGAPGLRGGAGEPGKNGAKGEPGPRGERGEAGIPG 456
alpha1(XXIV)    LRGSVGPVGPIGPAGIPGPMGLSGNKGLPGIKGDKGEQGTAGELGEPGYPGDKGAVGLPG 741
alpha1(XXVII)   LIGDLGVLGPIGYPGPKGMKGLMGSVGEPGLKGDKGEQGVPGVSGDPGFQGDKGSQGLPG 880
                  *  *  *. *  *  *  *  *  *  * :*  *: *  *  *: *  *: *  *  *

alpha1B(XI)     PRGEDGPEGPKGRAGPTGDPGPSGQAGEKGKLGVPGLPGYPGRQGPKGSTGFPGFPGANG 877
alpha1C(XI)     PRGEDGPEGPKGRAGPTGDPGPSGQAGEKGKLGVPGLPGYPGRQGPKGSTGFPGFPGANG 826
alpha1A(XI)     PRGEDGPEGPKGRAGPTGDPGPSGQAGEKGKLGVPGLPGYPGRQGPKGSTGFPGFPGANG 865
alpha1(V)       PRGEDGPEGPKGRGGPNGDPGPLGPPGEKGKLGVPGLPGYPGRQGPKGSIGFPGFPGANG 895
alpha2-1(XI)    SRGEDGPEGPKGRTGPTGDPGPPGLMGEKGKLGVPGLPGYPGRQGPKGSLGFPGFPGASG 823
alpha2-2(XI)    SRGEDGPEGPKGRTGPTGDPGPPGLMGEKGKLGVPGLPGYPGRQGPKGSLGFPGFPGASG 737
alpha2-3(XI)    SRGEDGPEGPKGRTGPTGDPGPPGLMGEKGKLGVPGLPGYPGRQGPKGSLGFPGFPGASG 716
alph3(V)        PRGEDGPEGPKGQAGQAGEEGPPGSAGEKGKLGVPGLPGYPGRPGPKGSIGFPGPLGPIG 815
alpha1-1(II)    APGPAGEEGKRGARGEPGGVGPIGPPGERGAPGNRGFPGQDGLAGPKGAPGERGPSGLAG 540
alpha1-2(II)    APGPAGEEGKRGARGEPGGVGPIGPPGERGAPGNRGFPGQDGLAGPKGAPGERGPSGLAG 471
alpha1(I)       PPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAG 518
alpha2(V)       PIGPPGEEGKRGPRGDPGTVGPPGPVGERGAPGNRGFPGSDGLPGPKGAQGERGPVGSSG 552
alpha2(I)       PPGPSGEEGKRGPNGEAGSAGPPGPPGLRGSPGSRGLPGADGRAGVMGPPGSRGASGPAG 430
alpha1(III)     VPGAKGEDGKDGSPGEPGANGLPGAAGERGAPGFRGPAGPNGIPGEKGPAGERGAPGPAG 516
alpha1(XXIV)    PPGMRGKSGPSGQTGDPGLQGPSGPPGPEGFPGDIGIPGQNGPEGPKGLLGNRGPPGPPG 801
alpha1(XXVII)   FPGARGKPGPLGKVGDKGSIGFPGPPGPEGFPGDIGPPGDNGPEGMKGKPGARGLPGPRG 940
                  *  *  *  *  *  *  *  *  * .*  *  * .*  *  *  *  *  *  *  *

alpha1B(XI)     EKGARGVAGKPGPRGQRGPTGPRGSRGARGPTGKPGPKGTSGGDGPPGPPGERGPQGPQG 937
alpha1C(XI)     EKGARGVAGKPGPRGQRGPTGPRGSRGARGPTGKPGPKGTSGGDGPPGPPGERGPQGPQG 886
alpha1A(XI)     EKGARGVAGKPGPRGQRGPTGPRGSRGARGPTGKPGPKGTSGGDGPPGPPGERGPQGPQG 925
alpha1(V)       EKGGRGTPGKPGPRGQRGPTGPRGERGPRGITGKPGPKGNSGGDGPAGPPGERGPNGPQG 955
alpha2-1(XI)    EKGARGLSGKSGPRGERGPTGPRGQRGPRGATGKSGAKGTSGGDGPHGPPGERGLPGPQG 883
alpha2-2(XI)    EKGARGLSGKSGPRGERGPTGPRGQRGPRGATGKSGAKGTSGGDGPHGPPGERGLPGPQG 797
alpha2-3(XI)    EKGARGLSGKSGPRGERGPTGPRGQRGPRGATGKSGAKGTSGGDGPHGPPGERGLPGPQG 776
alph3(V)        EKGKSGKTGQPGLEGERGPPGSRGERGQPGATGQPGPKGDVGQDGAPGIPGEKGLPGLQG 875
alpha1-1(II)    PKGANGDPGRPGEPGLPGARGLTGRPGDAGPQGKVGPSGAPGEDGRPGPPGPQGARGQPG 600
alpha1-2(II)    PKGANGDPGRPGEPGLPGARGLTGRPGDAGPQGKVGPSGAPGEDGRPGPPGPQGARGQPG 531
alpha1(I)       PKGSPGEAGRPGEAGLPGAKGLTGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAG 578
alpha2(V)       PKGSQGDPGRPGEPGLPGARGLTGNPGVQGPEGKLGPLGAPGEDGRPGPPGSIGIRGQPG 612
alpha2(I)       VRGPNGDAGRPGEPGLMGPRGLPGSPGNIGPAGKEGPVGLPGIDGRPGPIGPAGARGEPG 490
alpha1(III)     PRGAAGEPGRDGVPGGPGMRGMPGSPGGPGSDGKPGPPGSQGESGRPGPPGPSGPRGQPG 576
alpha1(XXIV)    LKGTQGEEGPIGAFGELGPRGKPGQKGYAGEPGPEGLKGEVGDQGNIGKIGETGPVGLPG 861
alpha1(XXVII)   QLGPEGDEGPMGPPGAPGLEGQPGRKGFPGRPGLDGVKGEPGDPGRPGPVGEQGFMGFIG 1000
                  *  *  *  *  *  *  *  *  *  *  *  *  *  *  *  *  *  *  *  *

alpha1B(XI)     PVGFPGPKGPPGPPGKDGLPGHPGQRGETGFQGKTGPPGPGGVVGPQGPTGETGPIGERG 997
alpha1C(XI)     PVGFPGPKGPPGPPGKDGLPGHPGQRGETGFQGKTGPPGPGGVVGPQGPTGETGPIGERG 946
alpha1A(XI)     PVGFPGPKGPPGPPGKDGLPGHPGQRGETGFQGKTGPPGPGGVVGPQGPTGETGPIGERG 985
alpha1(V)       PTGFPGPKGPPGPPGKDGLPGHPGQRGETGFQGKTGPPGPPGVVGPQGPTGETGPMGERG 1015
alpha2-1(XI)    PNGFPGPKGPPGPPGKDGLPGHPGQRGEVGFQGKTGPPGPPGVVGPQGAAGETGPMGERG 943
alpha2-2(XI)    PNGFPGPKGPPGPPGKDGLPGHPGQRGEVGFQGKTGPPGPPGVVGPQGAAGETGPMGERG 857
alpha2-3(XI)    PNGFPGPKGPPGPPGKDGLPGHPGQRGEVGFQGKTGPPGPPGVVGPQGAAGETGPMGERG 836
alph3(V)        PPGFPGPKGPPGHQGKDGRPGHPGQRGELGFQGQTGPPGPAGVLGPQGKTGEVGPLGERG 935
alpha1-1(II)    VMGFPGPKGANGEPGKAGEKGLPGAPGLRGLPGKDGETGAAGPPGPAGPAGERGEQGAPG 660
alpha1-2(II)    VMGFPGPKGANGEPGKAGEKGLPGAPGLRGLPGKDGETGAAGPPGPAGPAGERGEQGAPG 591
alpha1(I)       VMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGERGEQGPAG 638
alpha2(V)       SMGLPGPKGSSGDPGKPGEAGNAGVPGQRGAPGKDGEVGPSGPVGPPGLAGERGEQGPPG 672
alpha2(I)       NIGFPGPKGPTGDPGKNGDKGHAGLAGARGAPGPDGNNGAQGPPGPQGVQGGKGEQGPPG 550
alpha1(III)     VMGFPGPKGNDGAPGKNGERGGPGGPGPQGPPGKNGETGPQGPPGPTGPGGDKGDTGPPG 636
alpha1(XXIV)    EVGMTGSIGEKGERGSPGPLGPQGEKGVMGYPGPPGVPGPIGPLGLPGHVGARGPPGSQG 921
alpha1(XXVII)   LVGEPGIVGEKGDRGMMGPPGVPGPKGSMGHPGMPGGMGTPGEPGPQGPPGSRGPPGMRG 1060
                  * .*  *  *  *  *  *  *  *  *  *  *  *. *  *  *  *  *  *  *

alpha1B(XI)     HPGPPGPPGEQGLPGAAGKEGAKGDPGPQGISGKDGPAGLRGFPGERGLPGAQGAPGLKG 1057
alpha1C(XI)     HPGPPGPPGEQGLPGAAGKEGAKGDPGPQGISGKDGPAGLRGFPGERGLPGAQGAPGLKG 1006
alpha1A(XI)     HPGPPGPPGEQGLPGAAGKEGAKGDPGPQGISGKDGPAGLRGFPGERGLPGAQGAPGLKG 1045
alpha1(V)       HPGPPGPPGEQGLPGLAGKEGTKGDPGPAGLPGKDGPPGLRGFPGDRGLPGPVGALGLKG 1075
alpha2-1(XI)    HPGPPGPPGEQGLPGTAGKEGTKGDPGPPGAPGKDGPAGLRGFPGERGLPGTAGGPGLKG 1003
alpha2-2(XI)    HPGPPGPPGEQGLPGTAGKEGTKGDPGPPGAPGKDGPAGLRGFPGERGLPGTAGGPGLKG 917
alpha2-3(XI)    HPGPPGPPGEQGLPGTAGKEGTKGDPGPPGAPGKDGPAGLRGFPGERGLPGTAGGPGLKG 896
alph3(V)        PPGPPGPPGEQGLPGLEGREGAKGELGPPGPLGKEGPAGLRGFPGPKGGPGDPGPTGLKG 995
alpha1-1(II)    PSGFQGLPGPPGPPGEGGKPGDQGVPGEAGAPGLVGPRGERGFPGERGSPGAQGLQGPRG 720
alpha1-2(II)    PSGFQGLPGPPGPPGEGGKPGDQGVPGEAGAPGLVGPRGERGFPGERGSPGAQGLQGPRG 651
alpha1(I)       SPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRG 698
alpha2(V)       PTGFQGLPGPPGPPGEGGKPGDQGVPGDPGAVGPLGPRGERGNPGERGEPGITGLPGEKG 732
alpha2(I)       PPGFQGLPGPSGPAGEVGKPGERGLHGEFGLPGPAGPRGERGPPGESGAAGPTGPIGSRG 610
alpha1(III)     PQGLQGLPGTGGPPGENGKPGEPGPKGDAGAPGAPGGKGDAGAPGERGPPGLAGAPGLRG 696
alpha1(XXIV)    PKGQRGSRGPDGLLGEQGIQGAKGEKGDQGKRGPHGLIGKTGNPGERGFQGKPGLQGLPG 981
alpha1(XXVII)   AKGRRGPRGPDGPAGEQGSRGLKGPPGPQGRPGRPGQQGVAGERGHLGSRGFPGIPGPSG 1120
                  *  *  *  *  *  *  *  *  *  *  *  *  *  *  *  *  *  *  *  *

alpha1B(XI)     GEGPQGPPGPVGSPGERGSAGTAGPIGLPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDG 1117
alpha1C(XI)     GEGPQGPPGPVGSPGERGSAGTAGPIGLPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDG 1066
alpha1A(XI)     GEGPQGPPGPVGSPGERGSAGTAGPIGLPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDG 1105
alpha1(V)       NEGPPGPPGPAGSPGERGPAGAAGPIGIPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDG 1135
alpha2-1(XI)    NEGPSGPPGPAGSPGERGAAGSGGPIGPPGRPGPQGPPGAAGEKGVPGEKGPIGPTGRDG 1063
alpha2-2(XI)    NEGPSGPPGPAGSPGERGAAGSGGPIGPPGRPGPQGPPGAAGEKGVPGEKGPIGPTGRDG 977
alpha2-3(XI)    NEGPSGPPGPAGSPGERGAAGSGGPIGPPGRPGPQGPPGAAGEKGVPGEKGPIGPTGRDG 956
alph3(V)        DKGPPGPVGANGSPGERGPLGPAGGIGLPGQSGSEGPVGPAGKKGSRGERGPPGPTGKDG 1055
alpha1-1(II)    LPGTPGTDGPKGASGPAGPPGAQGPPGLQGMPGERGAAGIAGPKGDRGDVGEKGPEGAPG 780
alpha1-2(II)    LPGTPGTDGPKGASGPAGPPGAQGPPGLQGMPGERGAAGIAGPKGDRGDVGEKGPEGAPG 711
alpha1(I)       ANGAPGNDGAKGDAGAPGAPGSQGAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGSPG 758
alpha2(V)       MAGGHGPDGPKGSPGPSGTPGDTGPPGLQGMPGERGIAGTPGPKGDRGGIGEKGAEGTAG 792
alpha2(I)       PSGPPGPDGNKGEPGVVGAVGTAGPSGPSGLPGERGAAGIPGGKGEKGEPGLRGEIGNPG 670
alpha1(III)     GAGPPGPEGGKGAAGPPGPPGAAGTPGLQGMPGERGGLGSPGPKGDKGEPGGPGADGVPG 756
alpha1(XXIV)    STGDRGLPGEPGLRGLQGDVGPPGEMGMEGPPGTEGESGLQGEPGAKGDVGTAGSVGGTG 1041
alpha1(XXVII)   PPGTKGLPGEPGPQGPQGPIGPPGEMGPKGPPGAVGEPGLPGEAGMKGDLGPLGTPGEQG 1180
                  *  *  *  *  *  *  *  *  *  * .*  *  *  *  *  *  *  *  *  *

alpha1B(XI)     VQGPVGLPGPAGPAGSPGEDGDKGEIGEPGQKGSKGDKGENGPPGPPGLQGPVGAPGIAG 1177
alpha1C(XI)     VQGPVGLPGPAGPAGSPGEDGDKGEIGEPGQKGSKGDKGENGPPGPPGLQGPVGAPGIAG 1126
alpha1A(XI)     VQGPVGLPGPAGPAGSPGEDGDKGEIGEPGQKGSKGDKGENGPPGPPGLQGPVGAPGIAG 1165
alpha1(V)       LQGPVGLPGPAGPVGPPGEDGDKGEIGEPGQKGSKGDKGEQGPPGPTGPQGPIGQPGPSG 1195
alpha2-1(XI)    VQGPVGLPGPAGPPGVAGEDGDKGEVGDPGQKGTKGNKGEHGPPGPPGPIGPVGQPGAAG 1123
alpha2-2(XI)    VQGPVGLPGPAGPPGVAGEDGDKGEVGDPGQKGTKGNKGEHGPPGPPGPIGPVGQPGAAG 1037
alpha2-3(XI)    VQGPVGLPGPAGPPGVAGEDGDKGEVGDPGQKGTKGNKGEHGPPGPPGPIGPVGQPGAAG 1016
alph3(V)        IPGPLGPLGPPGAAGPSGEEGDKGDVGAPGHKGSKGDKGDAGPPGQPGIRGPAGHPGPPG 1115
alpha1-1(II)    KDGGRGLTGPIGPPGPAGANGEKGEVGPPGPAGSAGARGAPGERGETGPPGPAGFAGPPG 840
alpha1-2(II)    KDGGRGLTGPIGPPGPAGANGEKGEVGPPGPAGSAGARGAPGERGETGPPGPAGFAGPPG 771
alpha1(I)       KDGVRGLTGPIGPPGPAGAPGDKGESGPSGPAGPTGARGAPGDRGEPGPPGPAGFAGPPG 818
alpha2(V)       NDGARGLPGPLGPPGPAGPTGEKGEPGPRGLVGPPGSRGNPGSRGENGPTGAVGFAGPQG 852
alpha2(I)       RDGARGAPGAVGAPGPAGATGDRGEAGAAGPAGPAGPRGSPGERGEVGPAGPNGFAGPAG 730
alpha1(III)     KDGPRGPTGPIGPPGPAGQPGDKGEGGAPGLPGIAGPRGSPGERGETGPPGPAGFPGAPG 816
alpha1(XXIV)    EPGLRGEPGAPGEEGLQGKDGLKGVPGGRGLPGEDGEKGEMGLPGIIGPLGRSGQTGLPG 1101
alpha1(XXVII)   LIGQRGEPGLEGDSGPMGPDGLKGDRGDPGPDGEHGEKGQEGLMGEDGPPGPPGVTGVRG 1240
                  *  *  *  *  *  *  * :*  *  *  *  * :*  *  *  *  *  * .*  *

alpha1B(XI)     GDGEPGPRGQQGMFGQKGDEGARGFPGPPGPIGLQGLPGPPGEKGENGDVGPMGPPGPPG 1237
alpha1C(XI)     GDGEPGPRGQQGMFGQKGDEGARGFPGPPGPIGLQGLPGPPGEKGENGDVGPMGPPGPPG 1186
alpha1A(XI)     GDGEPGPRGQQGMFGQKGDEGARGFPGPPGPIGLQGLPGPPGEKGENGDVGPMGPPGPPG 1225
alpha1(V)       ADGEPGPRGQQGLFGQKGDEGPRGFPGPPGPVGLQGLPGPPGEKGETGDVGQMGPPGPPG 1255
alpha2-1(XI)    ADGEPGARGPQGHFGAKGDEGTRGFNGPPGPIGLQGLPGPSGEKGETGDVGPMGPPGPPG 1183
alpha2-2(XI)    ADGEPGARGPQGHFGAKGDEGTRGFNGPPGPIGLQGLPGPSGEKGETGDVGPMGPPGPPG 1097
alpha2-3(XI)    ADGEPGARGPQGHFGAKGDEGTRGFNGPPGPIGLQGLPGPSGEKGETGDVGPMGPPGPPG 1076
alph3(V)        ADGAQGRRGPPGLFGQKGDDGVRGFVGVIGPPGLQGLPGPPGEKGEVGDVGSMGPHGAPG 1175
alpha1-1(II)    ADGQPGAKGEQGEAGQKGDAGAPGPQGPSGAPGPQGPTGVTGPKGARGAQGPPGATGFPG 900
alpha1-2(II)    ADGQPGAKGEQGEAGQKGDAGAPGPQGPSGAPGPQGPTGVTGPKGARGAQGPPGATGFPG 831
alpha1(I)       ADGQPGAKGEPGDAGAKGDAGPPGPAGPAGPPGPIGNVGAPGAKGARGSAGPPGATGFPG 878
alpha2(V)       PDGQPGVKGEPGEPGQKGDAGSPGPQGLAGSPGPHGPNGVPGLKGGRGTQGPPGATGFPG 912
alpha2(I)       AAGQPGAKGERGAKGPKGENGVVGPTGPVGAAGPAGPNGPPGPAGSRGDGGPPGMTGFPG 790
alpha1(III)     QNGEPGGKGERGAPGEKGEGGPPGVAGPPGGSGPAGPPGPQGVKGERGSPGGPGAAGFPG 876
alpha1(XXIV)    PEGIVGIPGQRGRPGKKGDKGQIGPTGEVGSRGPPGKIGKSGPKGARGTRGAVGHLGLMG 1161
alpha1(XXVII)   PEGKSGKQGEKGRTGAKGAKGYQGQLGEMGVPGDPGPPGTPGPKGSRGSLGPTGAPGRMG 1300
                  *  *  *  *  * **  *  *  *  *  *  *  *  *  *  *  *  *  *  *

alpha1B(XI)     PRGPQGPNGADGPQGPPGSVGSVGGVGEKGEPGEA----GNPGPPGEAGVGGPKGERGEK 1293
alpha1C(XI)     PRGPQGPNGADGPQGPPGSVGSVGGVGEKGEPGEA----GNPGPPGEAGVGGPKGERGEK 1242
alpha1A(XI)     PRGPQGPNGADGPQGPPGSVGSVGGVGEKGEPGEA----GNPGPPGEAGVGGPKGERGEK 1281
alpha1(V)       PRGPSGAPGADGPQGPPGGIGNPGAVGEKGEPGEA----GEPGLPGEGGPPGPKGERGEK 1311
alpha2-1(XI)    PRGPAGPNGADGPQGPPGGVGNLGPPGEKGEPGES----GSPGIQGEPGVKGPRGERGEK 1239
alpha2-2(XI)    PRGPAGPNGADGPQGPPGGVGNLGPPGEKGEPGES----GSPGIQGEPGVKGPRGERGEK 1153
alpha2-3(XI)    PRGPAGPNGADGPQGPPGGVGNLGPPGEKGEPGES----GSPGIQGEPGVKGPRGERGEK 1132
alph3(V)        PRGPQGPTGSEGTPGLPGGVGQPGAVGEKGERGDA----GDPGPPGAPGIPGPKGDIGEK 1231
alpha1-1(II)    AAGRVGPPGSNGNPGPPGPPGPSGKDGPKGARGDS----GPPGRAGEPGLQGPAGPPGEK 956
alpha1-2(II)    AAGRVGPPGSNGNPGPPGPPGPSGKDGPKGARGDS----GPPGRAGEPGLQGPAGPPGEK 887
alpha1(I)       AAGRVGPPGPSGNAGPPGPPGPAGKEGGKGPRGET----GPAGRPGEVGPPGPPGPAGEK 934
alpha2(V)       SAGRVGPPGPAGAPGPAGPLGEPGKEGPPGLRGDP----GSHGRVGDRGPAGPPGGPGDK 968
alpha2(I)       AAGRTGPPGPSGISGPPGPPGPAGKEGLRGPRGDQ----GPVGRTGEVGAVGPPGFAGEK 846
alpha1(III)     ARGLPGPPGSNGNPGPPGPSGSPGKDGPPGPAGNT----GAPGSPGVSGPKGDAGQPGEK 932
alpha1(XXIV)    PDGEPGIPGYRGHQGQPGPSGLPGPKGEKGYPGEDSTVLGPPGPRGEPGPVGDQGERGEP 1221
alpha1(XXVII)   AQGEPGLAGYDGHKGIVGPLGPPGPKGEKGEQGEDGKAEGPPGPPGDRGPVGDRGDRGEP 1360
                . *  *  *  *  *  *  *  *  *  *  *:     *  *  *  *  *  *  *: 

alpha1B(XI)     GEAGPPGAAGPPGAKGPPGDDGPKGNPGPVGFPGDPGPPGEPGPAGQDGVGGDKGEDGDP 1353
alpha1C(XI)     GEAGPPGAAGPPGAKGPPGDDGPKGNPGPVGFPGDPGPPGEPGPAGQDGVGGDKGEDGDP 1302
alpha1A(XI)     GEAGPPGAAGPPGAKGPPGDDGPKGNPGPVGFPGDPGPPGEPGPAGQDGVGGDKGEDGDP 1341
alpha1(V)       GESGPSGAAGPPGPKGPPGDDGPKGSPGPVGFPGDPGPPGEPGPAGQDGPPGDKGDDGEP 1371
alpha2-1(XI)    GESGQPGEPGPPGPKGPTGDDGPKGNPGPVGFPGDPGPPGEGGPRGQDGAKGDRGEDGEP 1299
alpha2-2(XI)    GESGQPGEPGPPGPKGPTGDDGPKGNPGPVGFPGDPGPPGEGGPRGQDGAKGDRGEDGEP 1213
alpha2-3(XI)    GESGQPGEPGPPGPKGPTGDDGPKGNPGPVGFPGDPGPPGEGGPRGQDGAKGDRGEDGEP 1192
alph3(V)        GDSGPSGAAGPPGKKGPPGEDGAKGSVGPTGLPGDLGPPGDPGVSGIDGSPGEKGDPGDV 1291
alpha1-1(II)    GEPGDDGPSGAEGPPGPQGLAGQRGIVGLPGQRGERGFPGLPGPSGEPGKQGAPGASGDR 1016
alpha1-2(II)    GEPGDDGPSGAEGPPGPQGLAGQRGIVGLPGQRGERGFPGLPGPSGEPGKQGAPGASGDR 947
alpha1(I)       GSPGADGPAGAPGTPGPQGIAGQRGVVGLPGQRGERGFPGLPGPSGEPGKQGPSGASGER 994
alpha2(V)       GDPGEDGQPGPDGPPGPAGTTGQRGIVGMPGQRGERGMPGLPGPAGTPGKVGPTGATGDK 1028
alpha2(I)       GPSGEAGTAGPPGTPGPQGLLGAPGILGLPGSRGERGLPGVAGAVGEPGPLGIAGPPGAR 906
alpha1(III)     GSPGAQGPPGAPGPLGIAGITGARGLAGPPGMPGPRGSPGPQGVKGESGKPGANGLSGER 992
alpha1(XXIV)    GAEGYKGHVGVPGLRGATGQQGPPGEPGDQGEQGLKGERGSEGNKGKKGAPGPSGKPGIP 1281
alpha1(XXVII)   GDPGYPGQEGVQGLRGKPGQQGQPGHPGPRGWPGPKGSKGAEGPKGKQGKAGAPGRRGVQ 1420
                *  *  *  *  *  *  *  *  *  *  *  *  *  *  *  *  *  *  *  *  

alpha1B(XI)     GQPGPPGPSGEAGPPGPPGKRGPPGAAGAEGRQG---EKGAKGEAGAEGPPGKTGPVGPQ 1410
alpha1C(XI)     GQPGPPGPSGEAGPPGPPGKRGPPGAAGAEGRQG---EKGAKGEAGAEGPPGKTGPVGPQ 1359
alpha1A(XI)     GQPGPPGPSGEAGPPGPPGKRGPPGAAGAEGRQG---EKGAKGEAGAEGPPGKTGPVGPQ 1398
alpha1(V)       GQTGSPGPTGEPGPSGPPGKRGPPGPAGPEGRQG---EKGAKGEAGLEGPPGKTGPIGPQ 1428
alpha2-1(XI)    GQPGSPGPTGENGPPGPLGKRGPAGSPGSEGRQG---GKGAKGDPGAIGAPGKTGPVGPA 1356
alpha2-2(XI)    GQPGSPGPTGENGPPGPLGKRGPAGSPGSEGRQG---GKGAKGDPGAIGAPGKTGPVGPA 1270
alpha2-3(XI)    GQPGSPGPTGENGPPGPLGKRGPAGSPGSEGRQG---GKGAKGDPGAIGAPGKTGPVGPA 1249
alph3(V)        GGPGPPGASGEPGAPGPPGKRGPSGHMGREGREG---EKGAKGEPGPDGPPGRTGPMGAR 1348
alpha1-1(II)    GPPGPVGPPGLTGPAGEPGREGSPGADGPPGRDGAAGVKGDRGETGAVGAPGAPGPPGSP 1076
alpha1-2(II)    GPPGPVGPPGLTGPAGEPGREGSPGADGPPGRDGAAGVKGDRGETGAVGAPGAPGPPGSP 1007
alpha1(I)       GPPGPMGPPGLAGPPGESGREGAPGAEGSPGRDGSPGAKGDRGETGPAGPPGAPGAPGAP 1054
alpha2(V)       GPPGPVGPPGSNGPVGEPGPEGPAGNDGTPGRDGAVGERGDRGDPGPAGLPGSQGAPGTP 1088
alpha2(I)       GPPGAVGSPGVNGAPGEAGRDGNPGNDGPPGRDGQPGHKGERGYPGNIGPVGAAGAPGPH 966
alpha1(III)     GPPGPQGLPGLAGTAGEPGRDGNPGSDGLPGRDGSPGGKGDRGENGSPGAPGAPGHPGPP 1052
alpha1(XXIV)    GLQGLLGPKGIQGYHGADGISGNPGKIGPPGKQGLPGIRGGPGRTGLAGAPGPPGVKGSS 1341
alpha1(XXVII)   GLQGLPGPRGVVGRQGLEGIAGPDGLPGRDGQAGQQGEQGDDGDPGPMGPAGKRGNPGVA 1480
                *  *  *  *  *  *  *  *  *  *  *: *    :*  *  *  *  *  *  *  

alpha1B(XI)     GPAGKPGPEGLRGIPGPVGEQGLPGAAGQDGPPGPMGPPGLPGLKGDPGSKGEKGHPGLI 1470
alpha1C(XI)     GPAGKPGPEGLRGIPGPVGEQGLPGAAGQDGPPGPMGPPGLPGLKGDPGSKGEKGHPGLI 1419
alpha1A(XI)     GPAGKPGPEGLRGIPGPVGEQGLPGAAGQDGPPGPMGPPGLPGLKGDPGSKGEKGHPGLI 1458
alpha1(V)       GAPGKPGPDGLRGIPGPVGEQGLPGSPGPDGPPGPMGPPGLPGLKGDSGPKGEKGHPGLI 1488
alpha2-1(XI)    GPAGKPGPDGLRGLPGSVGQQGRPGATGQAGPPGPVGPPGLPGLRGDAGAKGEKGHPGLI 1416
alpha2-2(XI)    GPAGKPGPDGLRGLPGSVGQQGRPGATGQAGPPGPVGPPGLPGLRGDAGAKGEKGHPGLI 1330
alpha2-3(XI)    GPAGKPGPDGLRGLPGSVGQQGRPGATGQAGPPGPVGPPGLPGLRGDAGAKGEKGHPGLI 1309
alph3(V)        GPPGRVGPEGLRGIPGPVGEPGLLGAPGQMGPPGPLGPSGLPGLKGDTGPKGEKGHIGLI 1408
alpha1-1(II)    GPAGPTGKQGDRGEAGAQGPMGPSGPAGARGIQGPQGPRGDKGEAGEPGERGLKGHRGFT 1136
alpha1-2(II)    GPAGPTGKQGDRGEAGAQGPMGPSGPAGARGIQGPQGPRGDKGEAGEPGERGLKGHRGFT 1067
alpha1(I)       GPVGPAGKSGDRGETGPAGPAGPVGPVGARGPAGPQGPRGDKGETGEQGDRGIKGHRGFS 1114
alpha2(V)       GPVGAPGDAGQRGDPGSRGPIGPPGRAGKRGLPGPQGPRGDKGDHGDRGDRGQKGHRGFT 1148
alpha2(I)       GPVGPAGKHGNRGETGPSGPVGPAGAVGPRGPSGPQGIRGDKGEPGEKGPRGLPGLKGHN 1026
alpha1(III)     GPVGPAGKSGDRGESGPAGPAGAPGPAGSRGAPGPQGPRGDKGETGERGAAGIKGHRGFP 1112
alpha1(XXIV)    GLPGSPGIQGPKGEQGLPGQPGIQGKRGHRGAQGDQGPCGDPGLKGQPGEYGVQGLTGFQ 1401
alpha1(XXVII)   GLPGAQGPPGFKGESGLPGQLGPPGKRGTEGRTGLPGNQGEPGSKGQPGDSGEMGFPGMA 1540
                   *  *  *  * :*  *  *  *  *  *  *  *  *  *  *  *: *  *  *  *  

alpha1B(XI)     GLIGPPGEQGEKGDRGLPGTQGSPGAKGDGGIPGPAGPLGPPGPPGLPGPQGPKGNKGST 1530
alpha1C(XI)     GLIGPPGEQGEKGDRGLPGTQGSPGAKGDGGIPGPAGPLGPPGPPGLPGPQGPKGNKGST 1479
alpha1A(XI)     GLIGPPGEQGEKGDRGLPGTQGSPGAKGDGGIPGPAGPLGPPGPPGLPGPQGPKGNKGST 1518
alpha1(V)       GLIGPPGEQGEKGDRGLPGPQGSSGPKGEQGITGPSGPIGPPGPPGLPGPPGPKGAKGSS 1548
alpha2-1(XI)    GLIGPPGEQGEKGDRGLPGPQGSPGQKGEMGIPGASGPIGPGGPPGLPGPAGPKGAKGAT 1476
alpha2-2(XI)    GLIGPPGEQGEKGDRGLPGPQGSPGQKGEMGIPGASGPIGPGGPPGLPGPAGPKGAKGAT 1390
alpha2-3(XI)    GLIGPPGEQGEKGDRGLPGPQGSPGQKGEMGIPGASGPIGPGGPPGLPGPAGPKGAKGAT 1369
alph3(V)        GLIGPPGEAGEKGDQGLPGVQGPPGPKGDPGPPGPIGSLGHPGPPGVAGPLGQKGSKGSP 1468
alpha1-1(II)    GLQGLPGPPGPSGDQGASGPAGPSGPRGPPGPVGPSGKDGANGIPGPIGPPGPRGRSGET 1196
alpha1-2(II)    GLQGLPGPPGPSGDQGASGPAGPSGPRGPPGPVGPSGKDGANGIPGPIGPPGPRGRSGET 1127
alpha1(I)       GLQGPPGPPGSPGEQGPSGASGPAGPRGPPGSAGAPGKDGLNGLPGPIGPPGPRGRTGDA 1174
alpha2(V)       GLQGLPGPPGPNGEQGSAGIPGPFGPRGPPGPVGPSGKEGNPGPLGPIGPPGVRGSVGEA 1208
alpha2(I)       GLQGLPGIAGHHGDQGAPGSVGPAGPRGPAGPSGPAGKDGRTGHPGTVGPAGIRGPQGHQ 1086
alpha1(III)     GNPGAPGSPGPAGQQGAIGSPGPAGPRGPVGPSGPPGKDGTSGHPGPIGPPGPRGNRGER 1172
alpha1(XXIV)    GFPGPKGPEGDAGIVGISGPKGPIGHRGNTGPLGREGIIGPTGRTGPRGEKGFRG----- 1456
alpha1(XXVII)   GLFGPKGPPGDIGFKGIQGPRGPPGLMGKEGIVGPLGILGPSGLPGPKGDKGSRGDWGLQ 1600
                *  *  *  *  *  *  *  *. *  *  *  *  *  *  *  *  *  * :*     

alpha1B(XI)     GPAGQKGDSGLPGPPGSPGPPGEVIQPLPILSSKKTRRHTEGMQADADDN------ILDY 1584
alpha1C(XI)     GPAGQKGDSGLPGPPGSPGPPGEVIQPLPILSSKKTRRHTEGMQADADDN------ILDY 1533
alpha1A(XI)     GPAGQKGDSGLPGPPGSPGPPGEVIQPLPILSSKKTRRHTEGMQADADDN------ILDY 1572
alpha1(V)       GPTGPKGEAGHPGPPGPPGPPGEVIQPLPIQASR-TRRNIDASQLLDDGNGE---NYVDY 1604
alpha2-1(XI)    GPGGPKGEKGVQGPPGHPGPPGEVIQPLPIQMPKKTRRSVDGSRLMQEDEAIPTGGAPGS 1536
alpha2-2(XI)    GPGGPKGEKGVQGPPGHPGPPGEVIQPLPIQMPKKTRRSVDGSRLMQEDEAIPTGGAPGS 1450
alpha2-3(XI)    GPGGPKGEKGVQGPPGHPGPPGEVIQPLPIQMPKKTRRSVDGSRLMQEDEAIPTGGAPGS 1429
alph3(V)        GSMGPRGDTGPAGPPGPPGAPAELHG------LRRRRRFVPVP-------------LPVV 1509
alpha1-1(II)    GPAGPPGNPGPPGPPGPPGP-GIDMSAFAGLGPREKGPDPLQYMRADQAAG-----GLRQ 1250
alpha1-2(II)    GPAGPPGNPGPPGPPGPPGP-GIDMSAFAGLGPREKGPDPLQYMRADQAAG-----GLRQ 1181
alpha1(I)       GPVGPPGPPGPPGPPGPPSA-GFDFSFLP-QPPQEKAHDGGRYYRADDAN------VVRD 1226
alpha2(V)       GPEGPPGEPGPPGPPGPPGH-LTAALGDIMGHYDESMPDPLPEFTEDQAAP-----DDKN 1262
alpha2(I)       GPAGPPGPPGPPGPPGVSGG-GYDFGYDGDFYRADQ----------PRSAP-----SLRP 1130
alpha1(III)     GSEGSPGHPGQPGPPGPPGAPGPCCGGVGAAAIAGIGGEKAGGFAPYYGDE-----PMDF 1227
alpha1(XXIV)    -ETGPQGPRGQPGPPGPPGAPGPRKQMDINAAIQALIESNTALQMESYQNT-----EVTL 1510
alpha1(XXVII)   GPRGPPGPRGRPGPPGPPGGPIQLQQDDLGAAFQTWMDTSGALRPESYSYP-----DRLV 1655
                   *  *  *  **** ..                                         

alpha1B(XI)     SDGMEEIFGSLNSLKQDIEHMKFPMGTQTNPARTCKDLQLSHPDFPDGEYWIDPNQGCSG 1644
alpha1C(XI)     SDGMEEIFGSLNSLKQDIEHMKFPMGTQTNPARTCKDLQLSHPDFPDGEYWIDPNQGCSG 1593
alpha1A(XI)     SDGMEEIFGSLNSLKQDIEHMKFPMGTQTNPARTCKDLQLSHPDFPDGEYWIDPNQGCSG 1632
alpha1(V)       ADGMEEIFGSLNSLKLEIEQMKRPLGTQQNPARTCKDLQLCHPDFPDGEYWVDPNQGCSR 1664
alpha2-1(XI)    PGGLEEIFGSLDSLREEIEQMRRPTGTQDSPARTCQDLKLCHPELPDGEYWVDPNQGCAR 1596
alpha2-2(XI)    PGGLEEIFGSLDSLREEIEQMRRPTGTQDSPARTCQDLKLCHPELPDGEYWVDPNQGCAR 1510
alpha2-3(XI)    PGGLEEIFGSLDSLREEIEQMRRPTGTQDSPARTCQDLKLCHPELPDGEYWVDPNQGCAR 1489
alph3(V)        EGGLEEVLASLTSLSLELEQLRRPPGTAERPGLVCHELHRNHPHLPDGEYWIDPNQGCAR 1569
alpha1-1(II)    H--DAEVDATLKSLNNQIESIRSPEGSRKNPARTCRDLKLCHPEWKSGDYWIDPNQGCTL 1308
alpha1-2(II)    H--DAEVDATLKSLNNQIESIRSPEGSRKNPARTCRDLKLCHPEWKSGDYWIDPNQGCTL 1239
alpha1(I)       R--DLEVDTTLKSLSQQIENIRSPEGSRKNPARTCRDLKMCHSDWKSGEYWIDPNQGCNL 1284
alpha2(V)       KT-DPGVHATLKSLSSQIETMRSPDGSKKHPARTCDDLKLCHSAKQSGEYWIDPNQGSVE 1321
alpha2(I)       K--DYEVDATLKSLNNQIETLLTPEGSRKNPARTCRDLRLSHPEWSSGYYWIDPNQGCTM 1188
alpha1(III)     KINTDEIMTSLKSVNGQIESLISPDGSRKNPARNCRDLKFCHPELKSGEYWVDPNQGCKL 1287
alpha1(XXIV)    IDHSEEIFKTLNYLSNLLHSIKNPLGTRDNPARICKDLLNCEQKVSDGKYWIDPNLGCPS 1570
alpha1(XXVII)   LDQGGEIFKTLHYLSNLIQSIKTPLGTKENPARVCRDLMDCEQKMVDGTYWVDPNLGCSS 1715
                      :  :*  :   :. :  * *:   *.  * :*   .    .* **:*** *.  

alpha1B(XI)     DSFKVYCNFTSGGETCIYPDKKSEGVRISSWPKE----KPGSWFSEFKRGKLLSYLDVEG 1700
alpha1C(XI)     DSFKVYCNFTSGGETCIYPDKKSEGVRISSWPKE----KPGSWFSEFKRGKLLSYLDVEG 1649
alpha1A(XI)     DSFKVYCNFTSGGETCIYPDKKSEGVRISSWPKE----KPGSWFSEFKRGKLLSYLDVEG 1688
alpha1(V)       DSFKVYCNFTAGGSTCVFPDKKSEGARITSWPKE----NPGSWFSEFKRGKLLSYVDAEG 1720
alpha2-1(XI)    DAFRVFCNFTAGGETCVTPRDD---------------------------VTQFSYVDSEG 1629
alpha2-2(XI)    DAFRVFCNFTAGGETCVTPRDD---------------------------VTQFSYVDSEG 1543
alpha2-3(XI)    DAFRVFCNFTAGGETCVTPRDD---------------------------VTQFSYVDSEG 1522
alph3(V)        DSFRVFCNFTAGGETCLYPDKKFEIVKLASWSKE----KPGGWYSTFRRGKKFSYVDADG 1625
alpha1-1(II)    DAMKVFCNMETG-ETCVYPNPANVPKKNWWSSKS-KEKKHIWFGETINGGFHFSYGDDNL 1366
alpha1-2(II)    DAMKVFCNMETG-ETCVYPNPANVPKKNWWSSKS-KEKKHIWFGETINGGFHFSYGDDNL 1297
alpha1(I)       DAIKVFCNMETG-ETCVYPTQPSVAQKNWYISKNPKDKRHVWFGESMTDGFQFEYGGQGS 1343
alpha2(V)       DAIKVYCNMETG-ETCISANPSSVPRKTWWASKS-PDNKPVWYGLDMNRGSQFAYGDHQS 1379
alpha2(I)       DAIKVYCDFSTG-ETCIRAQPENIPAKNWYRSSK--DKKHVWLGETINAGSQFEYNVEGV 1245
alpha1(III)     DAIKVFCNMETG-ETCISANPLNVPRKHWWTDSS-AEKKHVWFGESMDGGFQFSYGNPEL 1345
alpha1(XXIV)    DAIEVFCNFSAGGQTCLPPVSVT----------------------------KLEFG---- 1598
alpha1(XXVII)   DTIEVSCNFTHGGQTCLKPITAS----------------------------KVEFA---- 1743
                *::.* *::  * .**: .                                 . :     

alpha1B(XI)     -NSINMVQMTFLKLLTASARQNFTYHCHQSAAWYD-VSSGSYDKALRFLGSNDEEMSYDN 1758
alpha1C(XI)     -NSINMVQMTFLKLLTASARQNFTYHCHQSAAWYD-VSSGSYDKALRFLGSNDEEMSYDN 1707
alpha1A(XI)     -NSINMVQMTFLKLLTASARQNFTYHCHQSAAWYD-VSSGSYDKALRFLGSNDEEMSYDN 1746
alpha1(V)       -NPVGVVQMTFLRLLSASAHQNVTYHCYQSVAWQD-AATGSYDKALRFLGSNDEEMSYDN 1778
alpha2-1(XI)    -SPVGVVQLTFLRLLSVSAHQDVSYPCSG----------AARDGPLRLRGANEDELSPET 1678
alpha2-2(XI)    -SPVGVVQLTFLRLLSVSAHQDVSYPCSG----------AARDGPLRLRGANEDELSPET 1592
alpha2-3(XI)    -SPVGVVQLTFLRLLSVSAHQDVSYPCSG----------AARDGPLRLRGANEDELSPET 1571
alph3(V)        -SPVNVVQLNFLKLLSATARQNFTYSCQNAAAWLD-EATGDYSHSARFLGTNGEELSFNQ 1683
alpha1-1(II)    APNTANVQMTFLRLLSTEGSQNITYHCKNSIAYLD-EAAGNLKKALLIQGSNDVEIRAEG 1425
alpha1-2(II)    APNTANVQMTFLRLLSTEGSQNITYHCKNSIAYLD-EAAGNLKKALLIQGSNDVEIRAEG 1356
alpha1(I)       DPADVAIQLTFLRLMSTEASQNITYHCKNSVAYMD-QQTGNLKKALLLQGSNEIEIRAEG 1402
alpha2(V)       -PNTAITQMTFLRLLSKEASQNITYICKNSVGYMD-DQAKNLKKAVVLKGANDLDIKAEG 1437
alpha2(I)       TSKEMATQLAFMRLLANYASQNITYHCKNSIAYMD-EETGNLKKAVILQGSNDVELVAEG 1304
alpha1(III)     PEDVLDVQLAFLRLLSSRASQNITYHCKNSIAYMD-QASGNVKKALKLMGSNEGEFKAEG 1404
alpha1(XXIV)    ---VGKVQMNFLHLLSSEATHIITIHCLNTPRWTS-TQTSGPGLPIGFKGWNGQIFKVNT 1654
alpha1(XXVII)   ---ISRVQMNFLHLLSSEVTQHITIHCLNMTVWQEGTGQTPAKQAVRFRAWNGQIFEAGG 1800
                       *: *::*::    : .:  *                 .  : . *   :    

alpha1B(XI)     N--PFIKTLYDGCASRKGYE-KTVIEINTPKIDQVPIVDVMINDFGDQNQKFGFEVGPVC 1815
alpha1C(XI)     N--PFIKTLYDGCASRKGYE-KTVIEINTPKIDQVPIVDVMINDFGDQNQKFGFEVGPVC 1764
alpha1A(XI)     N--PFIKTLYDGCASRKGYE-KTVIEINTPKIDQVPIVDVMINDFGDQNQKFGFEVGPVC 1803
alpha1(V)       N--PYIRALVDGCATKKGYQ-KTVLEIDTPKVEQVPIVDIMFNDFGEASQKFGFEVGPAC 1835
alpha2-1(XI)    S--PYVKEFRDGCQTQQG---RTVLEVRTPVLEQLPVLDASFSDLGAPPRRGGVLLGPVC 1733
alpha2-2(XI)    S--PYVKEFRDGCQTQQG---RTVLEVRTPVLEQLPVLDASFSDLGAPPRRGGVLLGPVC 1647
alpha2-3(XI)    S--PYVKEFRDGCQTQQG---RTVLEVRTPVLEQLPVLDASFSDLGAPPRRGGVLLGPVC 1626
alph3(V)        TTAATVSVPQDGCRLRKGQT-KTLFEFSSSRAGFLPLWDVAATDFGQTNQKFGFELGPVC 1742
alpha1-1(II)    NSRFTYTALKDGCTKHTGKWGKTVIEYRSQKTSRLPIIDIAPMDIGGPEQEFGVDIGPVC 1485
alpha1-2(II)    NSRFTYTALKDGCTKHTGKWGKTVIEYRSQKTSRLPIIDIAPMDIGGPEQEFGVDIGPVC 1416
alpha1(I)       NSRFTYSVTVDGCTSHTGAWGKTVIEYKTTKTSRLPIIDVAPLDVGAPDQEFGFDVGPVC 1462
alpha2(V)       NIRFRYIVLQDTCSKRNGNVGKTVFEYRTQNVARLPIIDLAPVDVGGTDQEFGVEIGPVC 1497
alpha2(I)       NSRFTYTVLVDGCSKKTNEWGKTIIEYKTNKPSRLPFLDIAPLDIGGADQEFFVDIGPVC 1364
alpha1(III)     NSKFTYTVLEDGCTKHTGEWSKTVFEYRTRKAVRLPIVDIAPYDIGGPDQEFGVDVGPVC 1464
alpha1(XXIV)    L--LEPKVLSDDCKIQDGSWHKATFLFHTQEPNQLPVIEVQKLPHLKTERKYYIDSSSVC 1712
alpha1(XXVII)   Q--FRPEVSMDGCKVQDGRWHQTLFTFRTQDPQQLPIISVDNLPPASSGKQYRLEVGPAC 1858
                          * *  : .   :: :   :     :*. .          :.  .  ...*

alpha1B(XI)     FLG 1818
alpha1C(XI)     FLG 1767
alpha1A(XI)     FLG 1806
alpha1(V)       FMG 1838
alpha2-1(XI)    FMG 1736
alpha2-2(XI)    FMG 1650
alpha2-3(XI)    FMG 1629
alph3(V)        FSS 1745
alpha1-1(II)    FL- 1487
alpha1-2(II)    FL- 1418
alpha1(I)       FL- 1464
alpha2(V)       FV- 1499
alpha2(I)       FK- 1366
alpha1(III)     FL- 1466
alpha1(XXIV)    FL- 1714
alpha1(XXVII)   FL- 1860
                *  

Fibrillar Collagens Accession numbers:
NP_000079 - (COL1A1; alpha1(I)) alpha 1 type I collagen ;
NP_000080 - (COL1A2; alpha2(I)) alpha 2 type I collagen;
NP_149162 - (COL2A1-2; alpha1(II)) alpha 1 type II collagen isoform 2;
NP_001835 - (COL2A1-1; alpha1(II)) alpha 1 type II collagen isoform 1;
NP_000081 - (COL3A1; alpha1(III)) collagen, type III, alpha 1 ;
NP_000084 - (COL5A1; alpha1(V)) alpha 1 type V collagen;
NP_000384 - (COL5A2; alpha2(V)) alpha 2 type V collagen;
NP_056534 - (COL5A3; alpha3(V)) collagen, type V, alpha 3;
NP_001845 - (COL11A1-A; alpha1A(XI)) alpha 1 type XI collagen isoform A ;
NP_542196 - (COL11A1-B; alpha1B(XI)) alpha 1 type XI collagen isoform B ;
NP_542197 - (COL11A1-C; alpha1C(XI)) alpha 1 type XI collagen isoform C ;
NP_542411 - (COL11A2-1; alpha2-1(XI)) collagen, type XI, alpha 2 isoform 1 ;
NP_542412 - (COL11A2-2; alpha2-2(XI)) collagen, type XI, alpha 2 isoform 2 ;
NP_542410 - (COL11A2-3; alpha2-3(XI)) collagen, type XI, alpha 2 isoform 3 ;
NP_690850 - (COL24A1; alpha1(XXIV)) collagen, type XXIV, alpha 1;
NP_116277 - (COL27A1; alpha1(XXVII)) collagen, type XXVII, alpha 1

Basement Membrane Collagen IV Isoform Sequence Alignment

alpha5-2(IV)   ------------------MKLRGVSLAAGLFLLALSLWGQPAEAAACYGCSPG--SKCDC 40
alpha5-3(IV)   ------------------MKLRGVSLAAGLFLLALSLWGQPAEAAACYGCSPG--SKCDC 40
alpha5-1(IV)   ------------------MKLRGVSLAAGLFLLALSLWGQPAEAAACYGCSPG--SKCDC 40
alpha1(IV)     ------------------MGPR-LSVWLLLLPAALLLHEEHSRAAAKGGCAGSGCGKCDC 41
alpha6A(IV)    -----------MLINKLWLLL-----VTLCLTEELAAAGEKSYGKPCGGQDCSG--SCQC 42
alpha6B(IV)    ------------MHPGLWLLL-----VTLCLTEELAAAGEKSYGKPCGGQDCSG--SCQC 41
alpha2(IV)     MGRDQRAVAGPALRRWLLLGT-----VTVGFLAQSVLAGVKKFDVPCGGRDCSG--GCQC 53
alpha4(IV)     MWSLHIVLMRCSFRLTKSLATGPWSLILILFSVQYVYGSGKKYIGPCGGRDCS---VCHC 57
alpha3-2(IV)   ----------------MSARTAPRPQVLLLPLLLVLLAAAPAASKGCVCKDKG---QCFC 41
alpha3-4(IV)   ----------------MSARTAPRPQVLLLPLLLVLLAAAPAASKGCVCKDKG---QCFC 41
alpha3-5(IV)   ----------------MSARTAPRPQVLLLPLLLVLLAAAPAASKGCVCKDKG---QCFC 41
alpha3-1(IV)   ----------------MSARTAPRPQVLLLPLLLVLLAAAPAASKGCVCKDKG---QCFC 41
                                                                   .    * *

alpha5-2(IV)   SGIKGEKGERGFPGLEGHPGLPGFPGPEGPPGPRGQKGDDGIPGPPGPKGIRGPPGLPGF 100
alpha5-3(IV)   SGIKGEKGERGFPGLEGHPGLPGFPGPEGPPGPRGQKGDDGIPGPPGPKGIRGPPGLPGF 100
alpha5-1(IV)   SGIKGEKGERGFPGLEGHPGLPGFPGPEGPPGPRGQKGDDGIPGPPGPKGIRGPPGLPGF 100
alpha1(IV)     HGVKGQKGERGLPGLQGVIGFPGMQGPEGPQGPPGQKGDTGEPGLPGTKGTRGPPGASGY 101
alpha6A(IV)    FPEKGARGRPGPIGIQGPTGPQGFTGSTGLSGLKGERGFPGLLGPYGPKGDKGPMGVPGF 102
alpha6B(IV)    FPEKGARGRPGPIGIQGPTGPQGFTGSTGLSGLKGERGFPGLLGPYGPKGDKGPMGVPGF 101
alpha2(IV)     YPEKGGRGQPGPVGPQGYNGPPGLQGFPGLQGRKGDKGERGAPGVTGPKGDVGARGVSGF 113
alpha4(IV)     VPEKGSRGPPGPPGPQGPIGPLGAPGPIGLSGEKGMRGDRGPPGAAGDKGDKGPTGVPGF 117
alpha3-2(IV)   DGAKGEKGEKGFPGPPGSPGQKGFTGPEGLPGPQGPKGFPGLPGLTGSKGVRGISGLPGF 101
alpha3-4(IV)   DGAKGEKGEKGFPGPPGSPGQKGFTGPEGLPGPQGPKGFPGLPGLTGSKGVRGISGLPGF 101
alpha3-5(IV)   DGAKGEKGEKGFPGPPGSPGQKGFTGPEGLPGPQGPKGFPGLPGLTGSKGVRGISGLPGF 101
alpha3-1(IV)   DGAKGEKGEKGFPGPPGSPGQKGFTGPEGLPGPQGPKGFPGLPGLTGSKGVRGISGLPGF 101
                  ** :*  *  *  *  *  *  *  *  *  * :*  *  *  * **  *  * .*:

alpha5-2(IV)   PGTPGLPGMPGHDGAPGPQGIPGCNGTKGERGFPGSPGFPGLQGPPGPPGIPGMKGEPGS 160
alpha5-3(IV)   PGTPGLPGMPGHDGAPGPQGIPGCNGTKGERGFPGSPGFPGLQGPPGPPGIPGMKGEPGS 160
alpha5-1(IV)   PGTPGLPGMPGHDGAPGPQGIPGCNGTKGERGFPGSPGFPGLQGPPGPPGIPGMKGEPGS 160
alpha1(IV)     PGNPGLPGIPGQDGPPGPPGIPGCNGTKGERGPLGPPGLPGFAGNPGPPGLPGMKGDPG- 160
alpha6A(IV)    LGINGIPGHPGQPGPRGPPGLDGCNGTQGAVGFPGPDGYPGLLGPPGLPGQKGSKGDPVL 162
alpha6B(IV)    LGINGIPGHPGQPGPRGPPGLDGCNGTQGAVGFPGPDGYPGLLGPPGLPGQKGSKGDPVL 161
alpha2(IV)     PGADGIPGHPGQGGPRGRPGYDGCNGTQGDSGPQGPPGSEGFTGPPGPQGPKGQKGEPYA 173
alpha4(IV)     PGLDGIPGHPGPPGPRGKPGMSGHNGSRGDPGFPGGRGALGPGGPLGHPGEKGEKGNSVF 177
alpha3-2(IV)   SGSPGLPGTPGNTGPYGLVGVPGCSGSKGEQGFPGLPGTLGYPGIPGAAGLKGQKGAPAK 161
alpha3-4(IV)   SGSPGLPGTPGNTGPYGLVGVPGCSGSKGEQGFPGLPGTLGYPGIPGAAGLKGQKGAPAK 161
alpha3-5(IV)   SGSPGLPGTPGNTGPYGLVGVPGCSGSKGEQGFPGLPGTLGYPGIPGAAGLKGQKGAPAK 161
alpha3-1(IV)   SGSPGLPGTPGNTGPYGLVGVPGCSGSKGEQGFPGLPGTLGYPGIPGAAGLKGQKGAPAK 161
                *  *:** **  *. *  *  * .*::*  *  *  *  *  *  *  *  * ** .  

alpha5-2(IV)   IIMSSLPG--PKGNPGYPGPPGIQGLPGPTGIPGPIGPPGPPGLMGPPGPPGLPGPKGNM 218
alpha5-3(IV)   IIMSSLPG--PKGNPGYPGPPGIQGLPGPTGIPGPIGPPGPPGLMGPPGPPGLPGPKGNM 218
alpha5-1(IV)   IIMSSLPG--PKGNPGYPGPPGIQGLPGPTGIPGPIGPPGPPGLMGPPGPPGLPGPKGNM 218
alpha1(IV)     EILGHVPGMLLKGERGFPGIPGTPGPPGLPGLQGPVGPPGFTGPPGPPGPPGPPGEKGQM 220
alpha6A(IV)    APGSFKG---MKGDPGLPGLDGITGPQGAPGFPGAVGPAGPPGLQGPPGPPGPLGPDGNM 219
alpha6B(IV)    APGSFKG---MKGDPGLPGLDGITGPQGAPGFPGAVGPAGPPGLQGPPGPPGPLGPDGNM 218
alpha2(IV)     LPKEERDR--YRGEPGEPGLVGFQGPPGRPGHVGQMGPVGAPGRPGPPGPPGPKGQQGNR 231
alpha4(IV)     ILGAVKG---IQGDRGDPGLPGLPGSWGAGGPAGPTGYPGEPGLVGPPGQPGRPGLKGNP 234
alpha3-2(IV)   EEDIELDA---KGDPGLPGAPGPQGLPGPPGFPGPVGPPGPPGFFGFPGAMGPRGPKGHM 218
alpha3-4(IV)   EEDIELDA---KGDPGLPGAPGPQGLPGPPGFPGPVGPPGPPGFFGFPGAMGPRGPKGHM 218
alpha3-5(IV)   EEDIELDA---KGDPGLPGAPGPQGLPGPPGFPGPVGPPGPPGFFGFPGAMGPRGPKGHM 218
alpha3-1(IV)   EEDIELDA---KGDPGLPGAPGPQGLPGPPGFPGPVGPPGPPGFFGFPGAMGPRGPKGHM 218
                          :*: * **  *  *  *  *  *  *  * .*  * **  *  * .*: 

alpha5-2(IV)   GLNFQGPKGEKGEQGLQGPPGPPGQISEQKRPIDVEFQKGDQGLPGDRGPPGPPGIRGPP 278
alpha5-3(IV)   GLNFQGPKGEKGEQGLQGPPGPPGQISEQKRPIDVEFQKGDQGLPGDRGPPGPPGIRGPP 278
alpha5-1(IV)   GLNFQGPKGEKGEQGLQGPPGPPGQISEQKRPIDVEFQKGDQGLPGDRGPPGPPGIRGPP 278
alpha1(IV)     GLSFQGPKGDKGDQGVSGPPGVPGQAQVQ--------EKGDFATKGEKGQKGEPGFQGMP 272
alpha6A(IV)    GLGFQGEKGVKGDVGLPGPAGPP-PSTG--ELEFMGFPKGKKGSKGEPGPKGFPGISGPP 276
alpha6B(IV)    GLGFQGEKGVKGDVGLPGPAGPP-PSTG--ELEFMGFPKGKKGSKGEPGPKGFPGISGPP 275
alpha2(IV)     GLGFYGVKGEKGDVGQPGPNGIP-SDTLHPIIAPTGVTFHPDQYKGEKGSEGEPGIRG-- 288
alpha4(IV)     GVGVKGQMGDPGEVGQQGSPGPT-LLVE---------PPDFCLYKGEKGIKGIPGMVGLP 284
alpha3-2(IV)   GERVIGHKGERGVKGLTGPPGPPGTVIVT--LTGPDNRTDLKGEKGDKGAMGEPGPPGPS 276
alpha3-4(IV)   GERVIGHKGERGVKGLTGPPGPPGTVIVT--LTGPDNRTDLKGEKGDKGAMGEPGPPGPS 276
alpha3-5(IV)   GERVIGHKGERGVKGLTGPPGPPGTVIVT--LTGPDNRTDLKGEKGDKGAMGEPGPPGPS 276
alpha3-1(IV)   GERVIGHKGERGVKGLTGPPGPPGTVIVT--LTGPDNRTDLKGEKGDKGAMGEPGPPGPS 276
               *  . *  *  *  *  *. * .                      *: *  * **  *  

alpha5-2(IV)   GPPG-------GEKGEKGEQGEPGKRGKPGKDGENGQPGIPGLPGDPGYPGEPGRDGEKG 331
alpha5-3(IV)   GPPG-------GEKGEKGEQGEPGKRGKPGKDGENGQPGIPGLPGDPGYPGEPGRDGEKG 331
alpha5-1(IV)   GPPG-------GEKGEKGEQGEPGKRGKPGKDGENGQPGIPGLPGDPGYPGEPGRDGEKG 331
alpha1(IV)     G------------VGEKGEPGKPGPRGKPGKDGDKGEKGSPGFPGEPGYPGLIGRQGPQG 320
alpha6A(IV)    GFPGLGTTGEKGEKGEKGIPGLPGPRGPMGSEGVQGPPGQQGKKGTLGFPGLNGFQGIEG 336
alpha6B(IV)    GFPGLGTTGEKGEKGEKGIPGLPGPRGPMGSEGVQGPPGQQGKKGTLGFPGLNGFQGIEG 335
alpha2(IV)     ----------ISLKGEEGIMGFPGLRGYPGLSGEKGSPGQKGSRGLDGYQGPDGPRGPKG 338
alpha4(IV)     GPPGRKGESGIGAKGEKGIPGFPGPRGDPGSYGSPGFPGLKGELGLVGDPGLFGLIGPKG 344
alpha3-2(IV)   GLPG------ESYGSEKGAPGDPGLQGKPGKDGVPGFPGSEGVKGNRGFPGLMGEDGIKG 330
alpha3-4(IV)   GLPG------ESYGSEKGAPGDPGLQGKPGKDGVPGFPGSEGVKGNRGFPGLMGEDGIKG 330
alpha3-5(IV)   GLPG------ESYGSEKGAPGDPGLQGKPGKDGVPGFPGSEGVKGNRGFPGLMGEDGIKG 330
alpha3-1(IV)   GLPG------ESYGSEKGAPGDPGLQGKPGKDGVPGFPGSEGVKGNRGFPGLMGEDGIKG 330
                             .*:*  * ** :*  *  *  *  *  *  *  *  *  *  * :*

alpha5-2(IV)   QKGDTGPPGPPGLVIPRPGTGITIGEKGNIGLPGLPGEKGERGFPGIQGPPGLPGPPGAA 391
alpha5-3(IV)   QKGDTGPPGPPGLVIPRPGTGITIGEKGNIGLPGLPGEKGERGFPGIQGPPGLPGPPGAA 391
alpha5-1(IV)   QKGDTGPPGPPGLVIPRPGTGITIGEKGNIGLPGLPGEKGERGFPGIQGPPGLPGPPGAA 391
alpha1(IV)     EKGEAGPPGPPGIVIGTG----PLGEKGERGYPGTPGPRGEPGPKGFPGLPGQPGPPGLP 376
alpha6A(IV)    QKGDIGLPGPDVFIDIDG--AVISGNPGDPGVPGLPGLKGDEGIQGLRGPSGVPGLPALS 394
alpha6B(IV)    QKGDIGLPGPDVFIDIDG--AVISGNPGDPGVPGLPGLKGDEGIQGLRGPSGVPGLPALS 393
alpha2(IV)     EAGDPGPPGLPAYSPHP---SLAKGARGDPGFPGAQGEPGSQGEPGDPGLPGPPGLSIGD 395
alpha4(IV)     DPGNRGHPGPPGVLVTPP--LPLKGPPGDPGFPGRYGETGDVGPPGPPGLLGRPGE-ACA 401
alpha3-2(IV)   QKGDIGPPGFRGPTEYYD----TYQEKGDEGTPGPPGPRGARGPQGPSGPPGVPGSPGSS 386
alpha3-4(IV)   QKGDIGPPGFRGPTEYYD----TYQEKGDEGTPGPPGPRGARGPQGPSGPPGVPGSPGSS 386
alpha3-5(IV)   QKGDIGPPGFRGPTEYYD----TYQEKGDEGTPGPPGPRGARGPQGPSGPPGVPGSPGSS 386
alpha3-1(IV)   QKGDIGPPGFRGPTEYYD----TYQEKGDEGTPGPPGPRGARGPQGPSGPPGVPGSPGSS 386
               : *: * **                  *: * **  *  *  *  *  *  * **     

alpha5-2(IV)   V------MGPPGPPGFPGERGQKGDEGPPGISIPGPPGLDGQPGAPGLPGPPGPAGPHIP 445
alpha5-3(IV)   V------MGPPGPPGFPGERGQKGDEGPPGISIPGPPGLDGQPGAPGLPGPPGPAGPHIP 445
alpha5-1(IV)   V------MGPPGPPGFPGERGQKGDEGPPGISIPGPPGLDGQPGAPGLPGPPGPAGPHIP 445
alpha1(IV)     V------PGQAGAPGFPGERGEKGDRGFPGTSLPGPSGRDGLPGPPGSPGPPGQPG--YT 428
alpha6A(IV)    G-----VPGALGPQGFPGLKGDQGNPGRTTIGAAGLPGRDGLPGPPGPPGPPSPEFETET 449
alpha6B(IV)    G-----VPGALGPQGFPGLKGDQGNPGRTTIGAAGLPGRDGLPGPPGPPGPPSPEFETET 448
alpha2(IV)     GDQRRGLPGEMGPKGFIGDPGIPALYG----GPPGPDGKRGPPGPPGLPGPPGPDGFLFG 451
alpha4(IV)     G-----MIGPPGPQGFPGLPGLPGEAG-IPGRPDSAPGKPGKPGSPGLPGAPGLQGLPGS 455
alpha3-2(IV)   R------PGLRGAPGWPGLKGSKGERGRPGKDAMGTPGSPGCAGSPGLPGSPGPPGPPGD 440
alpha3-4(IV)   R------PGLRGAPGWPGLKGSKGERGRPGKDAMGTPGSPGCAGSPGLPGSPGPPGPPGD 440
alpha3-5(IV)   R------PGLRGAPGWPGLKGSKGERGRPGKDAMGTPGSPGCAGSPGLPGSPGPPGPPGD 440
alpha3-1(IV)   R------PGLRGAPGWPGLKGSKGERGRPGKDAMGTPGSPGCAGSPGLPGSPGPPGPPGD 440
                       *  *. *: *  *  .  *       .  *  * .*.** **.*.       

alpha5-2(IV)   PSDEICEPGPPG---PPGSPGDKGLQGEQGVKGDKGDTCFNCIGTGISGPPGQPGLPGLP 502
alpha5-3(IV)   PSDEICEPGPPG---PPGSPGDKGLQGEQGVKGDKGDTCFNCIGTGISGPPGQPGLPGLP 502
alpha5-1(IV)   PSDEICEPGPPG---PPGSPGDKGLQGEQGVKGDKGDTCFNCIGTGISGPPGQPGLPGLP 502
alpha1(IV)     NGIVECQPGPPGDQGPPGIPGQPGFIGEIGEKGQKGESCLICDIDGYRGPPGPQ------ 482
alpha6A(IV)    ---LHNKE--SG---FPGLRGEQGPKGNLGLKGIKGDSGFCACDGG-VPNTGPPGEPGPP 500
alpha6B(IV)    ---LHNKE--SG---FPGLRGEQGPKGNLGLKGIKGDSGFCACDGG-VPNTGPPGEPGPP 499
alpha2(IV)     ---LKGAKGRAG---FPGLPGSPGAR---GPKGWKGDAGECRCTEGDEAIKGLPGLPGPK 502
alpha4(IV)     SV-IYCSVGNPG---PQGIKGKVGPPGGRGPKGEKGNEGLCACEPGPMGPPGPPGLPGRQ 511
alpha3-2(IV)   IVFRKGPPGDHG---LPGYLGSPGIPGVDGPKGEPG--LLCTQCPYIPGPPGLPGLPGLH 495
alpha3-4(IV)   IVFRKGPPGDHG---LPGYLGSPGIPGVDGPKGEPG--LLCTQCPYIPGPPGLPGLPGLH 495
alpha3-5(IV)   IVFRKGPPGDHG---LPGYLGSPGIPGVDGPKGEPG--LLCTQCPYIPGPPGLPGLPGLH 495
alpha3-1(IV)   IVFRKGPPGDHG---LPGYLGSPGIPGVDGPKGEPG--LLCTQCPYIPGPPGLPGLPGLH 495
                          *     *  *. *     * **  *               *        

alpha5-2(IV)   GPPGSLGFPGQKGEKGQAGATGPKGLPGIPGAPGAP---GFPGSKGEPGDILTFPGMKGD 559
alpha5-3(IV)   GPPGSLGFPGQKGEKGQAGATGPKGLPGIPGAPGAP---GFPGSKGEPGDILTFPGMKGD 559
alpha5-1(IV)   GPPGSLGFPGQKGEKGQAGATGPKGLPGIPGAPGAP---GFPGSKGEPGDILTFPGMKGD 559
alpha1(IV)     GPPGEIGFPGQPGAKGDRGLPGRDGVAGVPGPQGTPGLIGQPGAKGEPGEFYFDLRLKGD 542
alpha6A(IV)    GPWGLIGLPGLKGARGDRGSGGAQGPAGAPGLVGPL---GPSGPKGKKGEPILST-IQGM 556
alpha6B(IV)    GPWGLIGLPGLKGARGDRGSGGAQGPAGAPGLVGPL---GPSGPKGKKGEPILST-IQGM 555
alpha2(IV)     GFAGINGEPGRKGDRGDPGQHGLPGFPGLKGVPGNI---GAPGPKGAKGDSRTIT-TKGE 558
alpha4(IV)     GSKGDLGLPGWLGTKGDPGPPGAEGPPGLPGKHGAS---GPPGNKGAKGDMVVSR-VKGH 567
alpha3-2(IV)   GVKGIPGRQGAAGLKGSPGSPGNTGLPGFPGFPGAQ---GDPGLKGEKGETLQPEGQVGV 552
alpha3-4(IV)   GVKGIPGRQGAAGLKGSPGSPGNTGLPGFPGFPGAQ---GDPGLKGEKGETLQPEGQVGV 552
alpha3-5(IV)   GVKGIPGRQGAAGLKGSPGSPGNTGLPGFPGFPGAQ---GDPGLKGEKGETLQPEGQVGV 552
alpha3-1(IV)   GVKGIPGRQGAAGLKGSPGSPGNTGLPGFPGFPGAQ---GDPGLKGEKGETLQPEGQVGV 552
               *  *  *  *  * :*. *  *  * .*  *  *     * .* **  *:        * 

alpha5-2(IV)   KGELGSPGAPGLPGLPGTPGQDGLPGLPGPKGEPGGITFKGERGPPGNPGLPGLPGNIGP 619
alpha5-3(IV)   KGELGSPGAPGLPGLPGTPGQDGLPGLPGPKGEPGGITFKGERGPPGNPGLPGLPGNIGP 619
alpha5-1(IV)   KGELGSPGAPGLPGLPGTPGQDGLPGLPGPKGEPGGITFKGERGPPGNPGLPGLPGNIGP 619
alpha1(IV)     KGDPGFPGQPGMTGRAGSPGRDGHPGLPGPKGSPGSVGLKGERGPPGGVGFPGSRGDTGP 602
alpha6A(IV)    PGDRGDSGSQGFRGVIGEPGKDGVPGLPGLPGLPG-DGGQGFPGEKGLPGLPGEKGHPGP 615
alpha6B(IV)    PGDRGDSGSQGFRGVIGEPGKDGVPGLPGLPGLPG-DGGQGFPGEKGLPGLPGEKGHPGP 614
alpha2(IV)     RGQPGVPGVPGMKGDDGSPGRDGLDGFPGLPGPPG-DGIKGPPGDPGYPGIPGTKGTPGE 617
alpha4(IV)     KGERGPDGPPGFPGQPGSHGRDGHAGEKGDPGPPG-DHEDATPGGKGFPGPLGPPGKAGP 626
alpha3-2(IV)   PGDPGLRGQPGRKGLDGIPGTPGVKGLPGPKGELALSGEKGDQGPPGDPGSPGSPGPAGP 612
alpha3-4(IV)   PGDPGLRGQPGRKGLDGIPGTPGVKGLPGPKGELALSGEKGDQGPPGDPGSPGSPGPAGP 612
alpha3-5(IV)   PGDPGLRGQPGRKGLDGIPGTPGVKGLPGPKGELALSGEKGDQGPPGDPGSPGSPGPAGP 612
alpha3-1(IV)   PGDPGLRGQPGRKGLDGIPGTPGVKGLPGPKGELALSGEKGDQGPPGDPGSPGSPGPAGP 612
                *: *  *  *  *  *  *  *  *  *  *  .    ..  *  *  *  *  *  * 

alpha5-2(IV)   MGPPGFGPPGPVGEKGIQGVAGNPGQPGIPGPKGDPGQTIT------------------- 660
alpha5-3(IV)   MGPPGFGPPGPVGEKGIQGVAGNPGQPGIPGPKGDPGQTIT------------------- 660
alpha5-1(IV)   MGPPGFGPPGPVGEKGIQGVAGNPGQPGIPGPKGDPGQTIT------------------- 660
alpha1(IV)     PGPPGYGPAGPIGDKGQAGFPGGPGSPGLPGPKGEPGKIVP------------------- 643
alpha6A(IV)    PGLPGNGLPGLPGPRGLPGDKGKDGLPGQQGLPGSKGIT-----------------LPCI 658
alpha6B(IV)    PGLPGNGLPGLPGPRGLPGDKGKDGLPGQQGLPGSKGIT-----------------LPCI 657
alpha2(IV)     MGPPGLGLPGLKGQRGFPGDAGLPGPPGFLGPPGPAGTPGQIDCDTDVKRAVGGDRQEAI 677
alpha4(IV)     VGPPGLGFPGPPGERGHPGVPGHPGVRGPDGLKGQKGDTIS---------------CNVT 671
alpha3-2(IV)   AGPPGYGPQGEPGLQGTQGVPGAPGPPGEAGPRGELSVSTP------------------- 653
alpha3-4(IV)   AGPPGYGPQGEPGLQGTQGVPGAPGPPGEAGPRGELSVSTP------------------- 653
alpha3-5(IV)   AGPPGYGPQGEPGLQGTQGVPGAPGPPGEAGPRGELSVSTP------------------- 653
alpha3-1(IV)   AGPPGYGPQGEPGLQGTQGVPGAPGPPGEAGPRGELSVSTP------------------- 653
                * ** *  *  * :*  *  *  *  *  *  *  .                       

alpha5-2(IV)   QPGKPG-LPGNPGRDGDVGLPGDPGLPGQP---GLPGIPGSKGEPGIPG-IGLPGPPGPK 715
alpha5-3(IV)   QPGKPG-LPGNPGRDGDVGLPGDPGLPGQP---GLPGIPGSKGEPGIPG-IGLPGPPGPK 715
alpha5-1(IV)   QPGKPG-LPGNPGRDGDVGLPGDPGLPGQP---GLPGIPGSKGEPGIPG-IGLPGPPGPK 715
alpha1(IV)     LPGPPG-AEGLPGSPGFPGPQGDRGFPGTP---GRPGLPGEKGAVGQPG-IGFPGPPGPK 698
alpha6A(IV)    IPGSYG-PSGFPGTPGFPGPKGSRGLPGTP---GQPGSSGSKGEPGSPGLVHLPELPGFP 714
alpha6B(IV)    IPGSYG-PSGFPGTPGFPGPKGSRGLPGTP---GQPGSSGSKGEPGSPGLVHLPELPGFP 713
alpha2(IV)     QPGCIGGPKGLPGLPGPPGPTGAKGLRGIPGFAGADGGPGPRGLPGDAGREGFPGPPGFI 737
alpha4(IV)     YPGRHG----PPGFDGPPGPKGFPGPQGAP---GLSGSDGHKGRPGTPGTAEIPGPPGFR 724
alpha3-2(IV)   VPGPPG----PPGPPGHPGPQGPPGIPGSLGKCGDPGLPGPDGEPGIPG-IGFPGPPGPK 708
alpha3-4(IV)   VPGPPG----PPGPPGHPGPQGPPGIPGSLGKCGDPGLPGPDGEPGIPG-IGFPGPPGPK 708
alpha3-5(IV)   VPGPPG----PPGPPGHPGPQGPPGIPGSLGKCGDPGLPGPDGEPGIPG-IGFPGPPGPK 708
alpha3-1(IV)   VPGPPG----PPGPPGHPGPQGPPGIPGSLGKCGDPGLPGPDGEPGIPG-IGFPGPPGPK 708
                **  *     **  *  *  *  *  *     *  *  *  *  * .*   :*  **  

alpha5-2(IV)   GFPGIPGPPGAPGTPGRIGLEGPPGPPGFPGPKGEPGFALPGPPGPPGLPGFKGALGPKG 775
alpha5-3(IV)   GFPGIPGPPGAPGTPGRIGLEGPPGPPGFPGPKGEPGFALPGPPGPPGLPGFKGALGPKG 775
alpha5-1(IV)   GFPGIPGPPGAPGTPGRIGLEGPPGPPGFPGPKGEPGFALPGPPGPPGLPGFKGALGPKG 775
alpha1(IV)     GVDGLPGDMGPPGTPGRPGFNGLPGNPGVQGQKGEPGVGLPGLKGLPGLPGIPGTPGEKG 758
alpha6A(IV)    GPRGEKGLPGFPGLPGKDGLPGMIGSPGLPGSKGATGDIFGAENGAPGEQGLQGLTGHKG 774
alpha6B(IV)    GPRGEKGLPGFPGLPGKDGLPGMIGSPGLPGSKGATGDIFGAENGAPGEQGLQGLTGHKG 773
alpha2(IV)     GPRGSKGAVGLPGPDGSPGPIGLPGPDGPPGERGLPGEVLGAQPGPRGDAGVPGQPGLKG 797
alpha4(IV)     GDMGDPGFGGEKG-SSPVGPPGPPGSPGVNGQKGIPGDPAFGHLGPPGKRGLSGVPGIKG 783
alpha3-2(IV)   GDQGFPGTKGSLGCPGKMGEPGLPGKPGLPGAKGEPAVAMPGGPGTPGFPGERGNSGEHG 768
alpha3-4(IV)   GDQGFPGTKGSLGCPGKMGEPGLPGKPGLPGAKGEPAVAMPGGPGTPGFPGERGNSGEHG 768
alpha3-5(IV)   GDQGFPGTKGSLGCPGKMGEPGLPGKPGLPGAKGEPAVAMPGGPGTPGFPGERGNSGEHG 768
alpha3-1(IV)   GDQGFPGTKGSLGCPGKMGEPGLPGKPGLPGAKGEPAVAMPGGPGTPGFPGERGNSGEHG 768
               *  *  *  *  *  .  *  *  *  *  * :* ..    .  *  *  *  *  * :*

alpha5-2(IV)   DRGFPGPPGPPGRTGLDGLPGPKGDVGPNGQPGPMGPPGLPG----IGVQGPPGPPGIPG 831
alpha5-3(IV)   DRGFPGPPGPPGRTGLDGLPGPKGDVGPNGQPGPMGPPGLPG----IGVQGPPGPPGIPG 831
alpha5-1(IV)   DRGFPGPPGPPGRTGLDGLPGPKGDVGPNGQPGPMGPPGLPG----IGVQGPPGPPGIPG 831
alpha1(IV)     SIGVPGVPGEHGAIGPPGLQGIRGEPGPPGLPGSVGSPGVPG----IGPPGARGPPGGQG 814
alpha6A(IV)    FLGDSGLPGLKGVHGKPGLLGPKGERGSPGTPGQVGQPGTPGSSGPYGIKGKSGLPGAPG 834
alpha6B(IV)    FLGDSGLPGLKGVHGKPGLLGPKGERGSPGTPGQVGQPGTPGSSGPYGIKGKSGLPGAPG 833
alpha2(IV)     LPGDRGPPGFRGSQGMPGMPGLKGQPGLPGPSGQPGLYGPPGLHGFPGAPGQEGPLGLPG 857
alpha4(IV)     PRGDPGCPGAEGPAGIPGFLGLKGPKGREGHAGFPGVPGPPGHSCERGAPGIPGQPGLPG 843
alpha3-2(IV)   EIGLPGLPGLPGTPGNEGLDGPRGDPGQPGPPGEQGPPGRCIE----GPRGAQGLPGLNG 824
alpha3-4(IV)   EIGLPGLPGLPGTPGNEGLDGPRGDPGQPGPPGEQGPPGRCIE----GPRGAQGLPGLNG 824
alpha3-5(IV)   EIGLPGLPGLPGTPGNEGLDGPRGDPGQPGPPGEQGPPGRCIE----GPRGAQGLPGLNG 824
alpha3-1(IV)   EIGLPGLPGLPGTPGNEGLDGPRGDPGQPGPPGEQGPPGRCIE----GPRGAQGLPGLNG 824
                 *  * **  *  *  *: * :*  *  * .*  *  *        *  *  *  *  *

alpha5-2(IV)   PIGQPGLHGIPGEKGDPGPPG-LDVPGPPGERGSPGIPGAPGPIGPPGSPGLPGKAGASG 890
alpha5-3(IV)   PIGQPGLHGIPGEKGDPGPPG-LDVPGPPGERGSPGIPGAPGPIGPPGSPGLPGKAGASG 890
alpha5-1(IV)   PIGQPGLHGIPGEKGDPGPPG-LDVPGPPGERGSPGIPGAPGPIGPPGSPGLPGKAGASG 890
alpha1(IV)     PPGLSGPPGIKGEKGFPGFPG-LDMPGPKGDKGAQGLPGITGQSGLPGLPGQQGAPGIPG 873
alpha6A(IV)    FPGISGHPGKKGTRGKKGPPGSIVKKGLPGLKGLPGNPGLVGLKGSPGSPGVAGLPALSG 894
alpha6B(IV)    FPGISGHPGKKGTRGKKGPPGSIVKKGLPGLKGLPGNPGLVGLKGSPGSPGVAGLPALSG 893
alpha2(IV)     IPGREGLPGDRGDPGDTGAPGPVGMKGLSGDRGDAGFTGEQGHPGSPGFKGIDGMPGTPG 917
alpha4(IV)     YPGSPGAPGGKGQPGDVGPPGPAGMKGLPGLPGRPGAHGPPGLPGIPGPFGDDGLPGPPG 903
alpha3-2(IV)   LKGQQGRRGKTGPKGDPGIPG-LDRSGFPGETGSPGIPGHQGEMGPLGQRGYPGNPGILG 883
alpha3-4(IV)   LKGQQGRRGKTGPKGDPGIPG-LDRSGFPGETGSPGIPGHQGEMGPLGQRGYPGNPGILG 883
alpha3-5(IV)   LKGQQGRRGKTGPKGDPGIPG-LDRSGFPGETGSPGIPGHQGEMGPLGQRGYPGNPGILG 883
alpha3-1(IV)   LKGQQGRRGKTGPKGDPGIPG-LDRSGFPGETGSPGIPGHQGEMGPLGQRGYPGNPGILG 883
                 *  *  *  *  *  * **     *  *  *  *  *  *  *  *  *  * ..  *

alpha5-2(IV)   FPGTKGEMGMMGPPGPPGPLGIPGRSGVPGLKGDDGLQGQPGLPGPTGEKGSKGEPGLPG 950
alpha5-3(IV)   FPGTKGEMGMMGPPGPPGPLGIPGRSGVPGLKGDDGLQGQPGLPGPTGEKGSKGEPGLPG 950
alpha5-1(IV)   FPGTKGEMGMMGPPGPPGPLGIPGRSGVPGLKGDDGLQGQPGLPGPTGEKGSKGEPGLPG 950
alpha1(IV)     FPGSKGEMGVMGTPGQPGSPGPVGAPGLPGEKGDHGFPGSSGPRGDPGLKGDKGDVGLPG 933
alpha6A(IV)    PKGEKGSVGFVGFPGIPGLPGIPGTRGLKGIPGSTGKMGPSGRAGTPGEKGDRGNPGPVG 954
alpha6B(IV)    PKGEKGSVGFVGFPGIPGLPGIPGTRGLKGIPGSTGKMGPSGRAGTPGEKGDRGNPGPVG 953
alpha2(IV)     LKGDRGSPGMDGFQGMPGLKGRPGFPGSKGEAGFFGIPGLKGLAGEPGFKGSRGDPGPPG 977
alpha4(IV)     PKGPRGLPGFPGFPGERGKPGAEGCPGAKGEP------GEKGMSGLPGDRGLRGAKGAIG 957
alpha3-2(IV)   PPGEDGVIGMMGFPGAIGPPGPPGNPGTPGQRGSPGIPGVKGQRGTPGAKGEQGDKGNPG 943
alpha3-4(IV)   PPGEDGVIGMMGFPGAIGPPGPPGNPGTPGQRGSPGIPGVKGQRGTPGAKGEQGDKGNPG 943
alpha3-5(IV)   PPGEDGVIGMMGFPGAIGPPGPPGNPGTPGQRGSPGIPGVKGQRGTPGAKGEQGDKGNPG 943
alpha3-1(IV)   PPGEDGVIGMMGFPGAIGPPGPPGNPGTPGQRGSPGIPGVKGQRGTPGAKGEQGDKGNPG 943
                 *  *  *. *  *  *  *  *  *  *        *  *  * .* :* :*  *  *

alpha5-2(IV)   PPGPMDPNLLGSK-GEKGEPGLPGIPGVSGPKGYQGLPGDPGQPGLSGQPGLPGPP-GPK 1008
alpha5-3(IV)   PPGPMDPNLLGSK-GEKGEPGLPGIPGVSGPKGYQGLPGDPGQPGLSGQPGLPGPP-GPK 1008
alpha5-1(IV)   PPGPMDPNLLGSK-GEKGEPGLPGIPGVSGPKGYQGLPGDPGQPGLSGQPGLPGPP-GPK 1008
alpha1(IV)     KPGSMDKVDMGSMKGQKGDQGEKGQIGPIGEKGSRGDPGTPGVPGKDGQAGQPGQP-GPK 992
alpha6A(IV)    IPSPRRPMSNLWLKGDKGSQGSAGSNGFPGPRGDKGEAGRPGPPGLPGAPGLPGIIKGVS 1014
alpha6B(IV)    IPSPRRPMSNLWLKGDKGSQGSAGSNGFPGPRGDKGEAGRPGPPGLPGAPGLPGIIKGVS 1013
alpha2(IV)     PPPVILPG-MKDIKGEKGDEGPMGLKGYLGAKGIQGMPGIPGLSGIPGLPGRPGHIKGVK 1036
alpha4(IV)     PPGDEGEMAIISQKGTPGEPGPPGDDGFPGERGDKGTPGMQGRRGEPGRYGPPGFHRGEP 1017
alpha3-2(IV)   PSE------ISHVIGDKGEPGLKGFAGNPGEKGNRGVPGMPGLKGLKGLPGPAGPP-GPR 996
alpha3-4(IV)   PSE------ISHVIGDKGEPGLKGFAGNPGEKGNRGVPGMPGLKGLKGLPGPAGPP-GPR 996
alpha3-5(IV)   PSE------ISHVIGDKGEPGLKGFAGNPGEKGNRGVPGMPGLKGLKGLPGPAGPP-GPR 996
alpha3-1(IV)   PSE------ISHVIGDKGEPGLKGFAGNPGEKGNRGVPGMPGLKGLKGLPGPAGPP-GPR 996
               .            *  *. *  *  *  * :* :* .*  *  *  *  * .*   *  

alpha5-2(IV)   GNPGLPGQPGLIGPPGLKGTIGDMGFPGPQGVEGPPGPSGVPGQPGSPGLPGQKGDKGDP 1068
alpha5-3(IV)   GNPGLPGQPGLIGPPGLKGTIGDMGFPGPQGVEGPPGPSGVPGQPGSPGLPGQKGDKGDP 1068
alpha5-1(IV)   GNPGLPGQPGLIGPPGLKGTIGDMGFPGPQGVEGPPGPSGVPGQPGSPGLPGQKGDKGDP 1068
alpha1(IV)     GDPGISGTPGAPGLPGPKGSVGGMGLPGTPGEKGVPGIPGPQGSPGLPGDKGAKGEKGQA 1052
alpha6A(IV)    GKPGPPGFMGIRGLPGLKGSSGITGFPGMPGESGSQGIRGSPGLPGASGLPGLKGDNGQT 1074
alpha6B(IV)    GKPGPPGFMGIRGLPGLKGSSGITGFPGMPGESGSQGIRGSPGLPGASGLPGLKGDNGQT 1073
alpha2(IV)     GDIGVPGIPGLPGFPGVAGPPGITGFPGFIGSRGDKGAPGRAGLYGEIGATGDFGDIGDT 1096
alpha4(IV)     GEKGQPGPPGPPGPPGSTGLRGFIGFPGLPGDQGEPGSPGPPGFSGIDGARGPKGNKGDP 1077
alpha3-2(IV)   GDLGSTGNPGEPGLRGIPGSMGNMGMPGSKGKRGTLGFPGRAGRPGLPGIHGLQGDKGEP 1056
alpha3-4(IV)   GDLGSTGNPGEPGLRGIPGSMGNMGMPGSKGKRGTLGFPGRAGRPGLPGIHGLQGDKGEP 1056
alpha3-5(IV)   GDLGSTGNPGEPGLRGIPGSMGNMGMPGSKGKRGTLGFPGRAGRPGLPGIHGLQGDKGEP 1056
alpha3-1(IV)   GDLGSTGNPGEPGLRGIPGSMGNMGMPGSKGKRGTLGFPGRAGRPGLPGIHGLQGDKGEP 1056
               *. * .*  *  *  *  *  *  *:**  *  *  *  *  *  *  *  *  *: *:.

alpha5-2(IV)   GISSIGLPGLPGPKGEPGLPGYPGNPGIKGSVGDPGLPGLPGTPGAKGQPGLPGFPGTPG 1128
alpha5-3(IV)   GISSIGLPGLPGPKGEPGLPGYPGNPGIKGSVGDPGLPGLPGTPGAKGQPGLPGFPGTPG 1128
alpha5-1(IV)   GISSIGLPGLPGPKGEPGLPGYPGNPGIKGSVGDPGLPGLPGTPGAKGQPGLPGFPGTPG 1128
alpha1(IV)     GPPGIGIPGLRGEKGDQGIAGFPGSPGEKGEKGSIGIPGMPGSPGLKGSPGSVGYPGSPG 1112
alpha6A(IV)    -VEISGSPGPKGQPGESGFKGTK---GRDGLIGNIGFPGNKGEDGKVGVSGDVGLPGAPG 1130
alpha6B(IV)    -VEISGSPGPKGQPGESGFKGTK---GRDGLIGNIGFPGNKGEDGKVGVSGDVGLPGAPG 1129
alpha2(IV)     -INLPGRPGLKGERGTTGIPGLKGFFGEKGTEGDIGFPGITG---VTGVQGPPGLKGQTG 1152
alpha4(IV)     -ASHFGPPGPKGEPGSPGCPGHFGASGEQGLPGIQGPRGSPGRPGPPGSSGPPGCPGDHG 1136
alpha3-2(IV)   GYSEGTRPGPPGPTGDPGLPGDMGKKGEMGQPGPPGHLGPAGPEGAPGSPGSPGLPGKPG 1116
alpha3-4(IV)   GYSEGTRPGPPGPTGDPGLPGDMGKKGEMGQPGPPGHLGPAGPEGAPGSPGSPGLPGKPG 1116
alpha3-5(IV)   GYSEGTRPGPPGPTGDPGLPGDMGKKGEMGQPGPPGHLGPAGPEGAPGSPGSPGLPGKPG 1116
alpha3-1(IV)   GYSEGTRPGPPGPTGDPGLPGDMGKKGEMGQPGPPGHLGPAGPEGAPGSPGSPGLPGKPG 1116
                      **  *  *  *  *     *  *  *  *  *  *     *  *  *  *  *

alpha5-2(IV)   PPGPKGISGPPGNPGLPGEPGPVGGGGHPGQPGPPGEKGKPGQDGIPGPAGQKGEPGQPG 1188
alpha5-3(IV)   PPGPKGISGPPGNPGLPGEPGPVGGGGHPGQPGPPGEKGKPGQDGIPGPAGQKGEPGQPG 1188
alpha5-1(IV)   PPGPKGISGPPGNPGLPGEPGPVGGGGHPGQPGPPGEKGKPGQDGIPGPAGQKGEPGQPG 1188
alpha1(IV)     LPGEKGDKGLPGLDGIPGVKGEAGLPGTPGPTGPAGQKGEPGSDGIPGSAGEKGEPGLPG 1172
alpha6A(IV)    FPGVAGMRGEPGLPGSSGHQGAIGPLGSPGLIGPKGFPGFPGLHGLNGLPGTKGTHGTPG 1190
alpha6B(IV)    FPGVAGMRGEPGLPGSSGHQGAIGPLGSPGLIGPKGFPGFPGLHGLNGLPGTKGTHGTPG 1189
alpha2(IV)     FPGLTGPPGSQGELGRIGLPGGKGDDGWPGAPGLPGFPGLRGIRGLHGLPGTKGFPGSPG 1212
alpha4(IV)     MPGLRGQPGEMGDPGPRGLQ---GDPGIPGPPGIKGPSGSPGLNGLHGLKGQKGTKGASG 1193
alpha3-2(IV)   PHGDLGFKGIKGLLGPPGIRGPPGLPGFPGSPGPMGIRGDQGRDGIPGPAGEKGETGLLR 1176
alpha3-4(IV)   PHGDLGFKGIKGLLGPPGIRGPPGLPGFPGSPGPMGIRGDQGRDGIPGPAGEKGETGLLR 1176
alpha3-5(IV)   PHGDLGFKGIKGLLGPPGIRGPPGLPGFPGSPGPMGIRGDQGRDGIPGPAGEKGETGLLR 1176
alpha3-1(IV)   PHGDLGFKGIKGLLGPPGIRGPPGLPGFPGSPGPMGIRGDQGRDGIPGPAGEKGETGLLR 1176
                 *  *  *  *  *  *     *  * **  *  *  *  *  *: *  * **  *   

alpha5-2(IV)   FGNPGPPGLPGLSGQKGDGGLPGIP-GNPGLPGPKGEPGFHGFPGVQGPPGPPGSPGP-A 1246
alpha5-3(IV)   FGNPGPPGLPGLSGQKGDGGLPGIP-GNPGLPGPKGEPGFHGFPGVQGPPGPPGSPGP-A 1246
alpha5-1(IV)   FGNPGPPGLPGLSGQKGDGGLPGIP-GNPGLPGPKGEPGFHGFPGVQGPPGPPGSPGP-A 1246
alpha1(IV)     RGFPGFPGAKGDKGSKGEVGFPGLA-GSPGIPGSKGEQGFMGPPGPQGQPGLPGSPGH-A 1230
alpha6A(IV)    PSITGVPGPAGLPGPKGEKGYPGIGIGAPGKPGLRGQKGDRGFPGLQGPAG---LPGAPG 1247
alpha6B(IV)    PSITGVPGPAGLPGPKGEKGYPGIGIGAPGKPGLRGQKGDRGFPGLQGPAG---LPGAPG 1246
alpha2(IV)     SDIHGDP---GFPGPPGERGDPGEANTLPGPVGVPGQKGDQGAPGERGPPGSPGLQGFPG 1269
alpha4(IV)     LHDVGPPGPVGIPGLKGERGDPGSPGISP--PGPRGKKGPPGPPGSSGPPGPAGATGRAP 1251
alpha3-2(IV)   AP-PGPRGNPGAQGAKGDRGAPGFP-GLPGRKGAMGDAGPRGPTGIEGFPGPPGLPGA-I 1233
alpha3-4(IV)   AP-PGPRGNPGAQGAKGDRGAPGFP-GLPGRKGAMGDAGPRGPTGIEGFPGPPGLPGA-I 1233
alpha3-5(IV)   AP-PGPRGNPGAQGAKGDRGAPGFP-GLPGRKGAMGDAGPRGPTGIEGFPGPPGLPGA-I 1233
alpha3-1(IV)   AP-PGPRGNPGAQGAKGDRGAPGFP-GLPGRKGAMGDAGPRGPTGIEGFPGPPGLPGA-I 1233
                   *     *  *  *: * **     *   *  *. *  * .*  * .*     *   

alpha5-2(IV)   LEGPKGNPGPQGPPGRPGPTGFQGLPGPEGPPGLPGNGGIKGEKGNPGQPGLPGLPGLKG 1306
alpha5-3(IV)   LEGPKGNPGPQGPPGRPG---FQGLPGPEGPPGLPGNGGIKGEKGNPGQPGLPGLPGLKG 1303
alpha5-1(IV)   LEGPKGNPGPQGPPGRPG------LPGPEGPPGLPGNGGIKGEKGNPGQPGLPGLPGLKG 1300
alpha1(IV)     TEGPKGDRGPQGQPGLPG------LPGPMGPPGLPGIDGVKGDKGNPGWPGAPGVPGPKG 1284
alpha6A(IV)    ISLPSLIAGQPGDPGRPGLDGERGRPGPAGPPGPPGPSSNQGDTGDPGFPGIPGPKGPKG 1307
alpha6B(IV)    ISLPSLIAGQPGDPGRPGLDGERGRPGPAGPPGPPGPSSNQGDTGDPGFPGIPGPKGPKG 1306
alpha2(IV)     ITPPSNISGAPGDKGAPGIFGLKGYRGPPGPPGSAALPGSKGDTGNPGAPGTPGTKGWAG 1329
alpha4(IV)     KDIPD--PGPPGDQGPPGPDGPRGAPGPPGLPGSVDLLR--GEPGDCGLPGPPGPPGPPG 1307
alpha3-2(IV)   IPGQTGNRGPPGSRGSPG------APGPPGPPGS-HVIGIKGDKGSMGHPGPKGPPGTAG 1286
alpha3-4(IV)   IPGQTGNRGPPGSRGSPG------APGPPGPPGS-HVIGIKGDKGSMGHPGPKGPPGTAG 1286
alpha3-5(IV)   IPGQTGNRGPPGSRGSPG------APGPPGPPGS-HVIGIKGDKGSMGHPGPKGPPGTAG 1286
alpha3-1(IV)   IPGQTGNRGPPGSRGSPG------APGPPGPPGS-HVIGIKGDKGSMGHPGPKGPPGTAG 1286
                       *  *  * **        ** * **        *: *. * **  *  *  *

alpha5-2(IV)   DQGPPGLQGNPGRPGLNGMKGDPGLPGVPGFPGMKGPSGVPGSAGPEGEPGLIGPPGPPG 1366
alpha5-3(IV)   DQGPPGLQGNPGRPGLNGMKGDPGLPGVPGFPGMKGPSGVPGSAGPEGEPGLIGPPGPPG 1363
alpha5-1(IV)   DQGPPGLQGNPGRPGLNGMKGDPGLPGVPGFPGMKGPSGVPGSAGPEGEPGLIGPPGPPG 1360
alpha1(IV)     DPGFQGMPGIGGSPGITGSKGDMGPPGVPGFQGPKGLPGLQGIKGDQGDQGVPGAKGLPG 1344
alpha6A(IV)    DQGIPGFSGLPGELGLKGMRGEPGFMGTPGKVGPPGDPGFPGMKGKAGPRGSSGLQGDPG 1367
alpha6B(IV)    DQGIPGFSGLPGELGLKGMRGEPGFMGTPGKVGPPGDPGFPGMKGKAGPRGSSGLQGDPG 1366
alpha2(IV)     DSGPQGRPGVFGLPGEKGPRGEQGFMGNTGPTGAVGDRGPKGPKGDPGFPGAPGTVGAPG 1389
alpha4(IV)     PPGYKGFPGCDGKDGQKGPVGFPGPQGPHGFPGPPGEKGLPGPPGRKGPTGLPGPRGEPG 1367
alpha3-2(IV)   DMGPPGRLGAPGTPGLPGPRGDPGFQGFPGVKGEKGNPGFLGSIGPPGPIGPKGPPGVRG 1346
alpha3-4(IV)   DMGPPGRLGAPGTPGLPGPRGDPGFQGFPGVKGEKGNPGFLGSIGPPGPIGPKGPPGVRG 1346
alpha3-5(IV)   DMGPPGRLGAPGTPGLPGPRGDPGFQGFPGVKGEKGNPGFLGSIGPPGPIGPKGPPGVRG 1346
alpha3-1(IV)   DMGPPGRLGAPGTPGLPGPRGDPGFQGFPGVKGEKGNPGFLGSIGPPGPIGPKGPPGVRG 1346
                 *  *  *  *  *  *  *  *  *  *  *  *  *  *  *  *  *  *  *  *

alpha5-2(IV)   LPGPSGQSIIIKGDAGPPGIPGQPGLKGLPGPQGPQGLPGPTGPPGDPGRNGLPGFDGAG 1426
alpha5-3(IV)   LPGPSGQSIIIKGDAGPPGIPGQPGLKGLPGPQGPQGLPGPTGPPGDPGRNGLPGFDGAG 1423
alpha5-1(IV)   LPGPSGQSIIIKGDAGPPGIPGQPGLKGLPGPQGPQGLPGPTGPPGDPGRNGLPGFDGAG 1420
alpha1(IV)     PPGPPGPYDIIKGEPGLPGPEGPPGLKGLQGLPGPKGQQGVTGLVGIPGPPGIPGFDGAP 1404
alpha6A(IV)    QTPTAEAVQVPPGPLGLPGIDGIPGLTGDPGAQGPVGLQGSKGLPGIPGKDGPSGLPGPP 1427
alpha6B(IV)    QTPTAEAVQVPPGPLGLPGIDGIPGLTGDPGAQGPVGLQGSKGLPGIPGKDGPSGLPGPP 1426
alpha2(IV)     IAGIPQKIAVQPGTVGPQGRRGPPGAPGEMGPQGPPGEPGFRGAPGKAGPQGRGGVSAVP 1449
alpha4(IV)     PPADVDDCPRIPGLPGAPGMRGPEGAMGLPGMRGPSG-PGCKGEPGLDGRRGVDGVPGSP 1426
alpha3-2(IV)   DPG-TLKIISLPGSPGPPGTPGEPGMQGEPGPPGPPGNLGPCGPRGKPGKDGKPGTPGPA 1405
alpha3-4(IV)   DPG-TLKIISLPGSPGPPGTPGEPGMQGEPGPPGPPGNLGPCGPRGKPGKDGKPGTPGPA 1405
alpha3-5(IV)   DPG-TLKIISLPGSPGPPGTPGEPGMQGEPGPPGPPGNLGPCGPRGKPGKDGKPGTPGPA 1405
alpha3-1(IV)   DPG-TLKIISLPGSPGPPGTPGEPGMQGEPGPPGPPGNLGPCGPRGKPGKDGKPGTPGPA 1405
                .          *  *  *  *  *  *  *  ** *  *  *  *  *  *  *  .  

alpha5-2(IV)   GRKGDPGLPGQPGTRGLDGPPGPDGLQGPPGPPGTSSVAHGFLITRHSQTTDAPQCPQGT 1486
alpha5-3(IV)   GRKGDPGLPGQPGTRGLDGPPGPDGLQGPPGPPGTSSVAHGFLITRHSQTTDAPQCPQGT 1483
alpha5-1(IV)   GRKGDPGLPGQPGTRGLDGPPGPDGLQGPPGPPGTSSVAHGFLITRHSQTTDAPQCPQGT 1480
alpha1(IV)     GQKGEMGPAGPTGPRGFPGPPGPDGLPGSMGPPGTPSVDHGFLVTRHSQTIDDPQCPSGT 1464
alpha6A(IV)    GALGDPGLPGLQGPPGFEGAPGQQGPFGMPGMPGQSMRVG-YTLVKHSQSEQVPPCPIGM 1486
alpha6B(IV)    GALGDPGLPGLQGPPGFEGAPGQQGPFGMPGMPGQSMRVG-YTLVKHSQSEQVPPCPIGM 1485
alpha2(IV)     GFRGDEGPIGHQGPIGQEGAPGRPGSPGLPGMPGRSVSIG-YLLVKHSQTDQEPMCPVGM 1508
alpha4(IV)     GPPGRKGDTGEDGYPGGPGPPGPIGDPGPKGF-GPGYLGG-FLLVLHSQTDQEPTCPLGM 1484
alpha3-2(IV)   GEKGNKGSKGEPGPAGSDGLPGLKGKRGDSGSPATWTTRG-FVFTRHSQTTAIPSCPEGT 1464
alpha3-4(IV)   GEKGNKGSKGEPGPAGSDGLPGLKGKRGDSGSPATWTTRG-FVFTRHSQTTAIPSCPEGT 1464
alpha3-5(IV)   GEKGNKGSKGEP------------------------------------------------ 1417
alpha3-1(IV)   GEKGNKGSKGEPGPAGSDGLPGLKGKRGDSGSPATWTTRG-FVFTRHSQTTAIPSCPEGT 1464
               *  *  *  *                                                  

alpha5-2(IV)   LQVYEGFSLLYVQGNKRAHGQDLGTAGSCLRRFSTMPFMFCNINNVCNFASRNDYSYWLS 1546
alpha5-3(IV)   LQVYEGFSLLYVQGNKRAHGQDLGTAGSCLRRFSTMPFMFCNINNVCNFASRNDYSYWLS 1543
alpha5-1(IV)   LQVYEGFSLLYVQGNKRAHGQDLGTAGSCLRRFSTMPFMFCNINNVCNFASRNDYSYWLS 1540
alpha1(IV)     KILYHGYSLLYVQGNERAHGQDLGTAGSCLRKFSTMPFLFCNINNVCNFASRNDYSYWLS 1524
alpha6A(IV)    SQLWVGYSLLFVEGQEKAHNQDLGFAGSCLPRFSTMPFIYCNINEVCHYARRNDKSYWLS 1546
alpha6B(IV)    SQLWVGYSLLFVEGQEKAHNQDLGFAGSCLPRFSTMPFIYCNINEVCHYARRNDKSYWLS 1545
alpha2(IV)     NKLWSGYSLLYFEGQEKAHNQDLGLAGSCLARFSTMPFLYCNPGDVCYYASRNDKSYWLS 1568
alpha4(IV)     PRLWTGYSLLYLEGQEKAHNQDLGLAGSCLPVFSTLPFAYCNIHQVCHYAQRNDRSYWLA 1544
alpha3-2(IV)   VPLYSGFSFLFVQGNQRAHGQDLGTLGSCLQRFTTMPFLFCNVNDVCNFASRNDYSYWLS 1524
alpha3-4(IV)   VPLYSGFSFLFVQGNQRAHGQDLESLFHQL------------------------------ 1494
alpha3-5(IV)   -----------------------ESLFHQL------------------------------ 1424
alpha3-1(IV)   VPLYSGFSFLFVQGNQRAHGQDLGTLGSCLQRFTTMPFLFCNVNDVCNFASRNDYSYWLS 1524
                                            *                              

alpha5-2(IV)   TPEPMPMSMQPLKGQSIQPFISRCAVCEAPAVVIAVHSQTIQIPHCPQGWDSLWIGYSFM 1606
alpha5-3(IV)   TPEPMPMSMQPLKGQSIQPFISRCAVCEAPAVVIAVHSQTIQIPHCPQGWDSLWIGYSFM 1603
alpha5-1(IV)   TPEPMPMSMQPLKGQSIQPFISRCAVCEAPAVVIAVHSQTIQIPHCPQGWDSLWIGYSFM 1600
alpha1(IV)     TPEPMPMSMAPITGENIRPFISRCAVCEAPAMVMAVHSQTIQIPPCPSGWSSLWIGYSFV 1584
alpha6A(IV)    TTAPIP--MMPVSQTQIPQYISRCSVCEAPSQAIAVHSQDITIPQCPLGWRSLWIGYSFL 1604
alpha6B(IV)    TTAPIP--MMPVSQTQIPQYISRCSVCEAPSQAIAVHSQDITIPQCPLGWRSLWIGYSFL 1603
alpha2(IV)     TTAPLP--MMPVAEDEIKPYISRCSVCEAPAIAIAVHSQDVSIPHCPAGWRSLWIGYSFL 1626
alpha4(IV)     SAAPLP--MMPLSEEAIRPYVSRCAVCEAPAQAVAVHSQDQSIPPCPQTWRSLWIGYSFL 1602
alpha3-2(IV)   TPALMPMNMAPITGRALEPYISRCTVCEGPAIAIAVHSQTTDIPPCPHGWISLWKGFSFI 1584
alpha3-4(IV)   ------------------------------------------------------------
alpha3-5(IV)   ------------------------------------------------------------
alpha3-1(IV)   TPALMPMNMAPITGRALEPYISRCTVCEGPAIAIAVHSQTTDIPPCPHGWISLWKGFSFI 1584
                                                                              

alpha5-2(IV)   MHTSAGAEGSGQALASPGSCLEEFRSAPFIECHG-RGTCNYYANSYSFWLATVDVSDMFS 1665
alpha5-3(IV)   MHTSAGAEGSGQALASPGSCLEEFRSAPFIECHG-RGTCNYYANSYSFWLATVDVSDMFS 1662
alpha5-1(IV)   MHTSAGAEGSGQALASPGSCLEEFRSAPFIECHG-RGTCNYYANSYSFWLATVDVSDMFS 1659
alpha1(IV)     MHTSAGAEGSGQALASPGSCLEEFRSAPFIECHG-RGTCNYYANAYSFWLATIERSEMFK 1643
alpha6A(IV)    MHTAAGAEGGGQSLVSPGSCLEDFRATPFIECSGARGTCHYFANKYSFWLTTVEERQQFG 1664
alpha6B(IV)    MHTAAGAEGGGQSLVSPGSCLEDFRATPFIECSGARGTCHYFANKYSFWLTTVEERQQFG 1663
alpha2(IV)     MHTAAGDEGGGQSLVSPGSCLEDFRATPFIECNGGRGTCHYYANKYSFWLTTIPE-QSFQ 1685
alpha4(IV)     MHTGAGDQGGGQALMSPGSCLEDFRAAPFLECQGRQGTCHFFANKYSFWLTTVKADLQFS 1662
alpha3-2(IV)   MKAYS-----------------------------------INCESWGIRKNNKSLSGVHE 1609
alpha3-4(IV)   ------------------------------------------------------------
alpha3-5(IV)   ------------------------------------------------------------
alpha3-1(IV)   MFTSAGSEGTGQALASPGSCLEEFRASPFLECHG-RGTCNYYSNSYSFWLASLNPERMFR 1643
                                                                              

alpha5-2(IV)   K-PQSETLKAG-DLRTRISRCQVCMKRT-- 1691
alpha5-3(IV)   K-PQSETLKAG-DLRTRISRCQVCMKRT-- 1688
alpha5-1(IV)   K-PQSETLKAG-DLRTRISRCQVCMKRT-- 1685
alpha1(IV)     K-PTPSTLKAG-ELRTHVSRCQVCMRRT-- 1669
alpha6A(IV)    ELPVSETLKAG-QLHTRVSRCQVCMKSL-- 1691
alpha6B(IV)    ELPVSETLKAG-QLHTRVSRCQVCMKSL-- 1690
alpha2(IV)     GSPSADTLKAG-LIRTHISRCQVCMKNL-- 1712
alpha4(IV)     SAPAPDTLKESQAQRQKISRCQVCVKYS-- 1690
alpha3-2(IV)   E-KTLKLKKTA-ELLFFILKNKVMTEHAVI 1637
alpha3-4(IV)   ------------------------------
alpha3-5(IV)   ------------------------------
alpha3-1(IV)   K-PIPSTVKAG-ELEKIISRCQVCMKKRH- 1670
                                              

Basement Membrane Collagen Accession Numbers:

NP_001836 - (COL4A1; alpha1(IV)) alpha 1 type IV collagen;
NP_001837 - (COL4A2; alpha2(IV)) alpha 2 type IV collagen ;
NP_000082 - (COL4A3-1; alpha3-1(IV)) alpha 3 type IV collagen isoform 1;
NP_112730 - (COL4A3-2; alpha3-1(IV)) alpha 3 type IV collagen isoform 2;
NP_112733 - (COL4A3-4; alpha3-4(IV)) alpha 3 type IV collagen isoform 4;
NP_112734 - (COL4A3-5; alpha3-5(IV)) alpha 3 type IV collagen isoform 5;
NP_000083 - (COL4A4; alpha4(IV)) alpha 4 type IV collagen;
NP_000486 - (COL4A5; alpha5-1(IV)) alpha 5 type IV collagen isoform 1;
NP_203699 - (COL4A5; alpha5-2(IV)) alpha 5 type IV collagen isoform 2;
NP_203700 - (COL4A5; alpha5-3(IV)) alpha 5 type IV collagen isoform 3;
NP_001838 - (COL4A6-A; alpha6A(IV)) type IV alpha 6 collagen isoform A;
NP_378667 - (COL4A6-B; alpha6B(IV)) type IV alpha 6 collagen isoform B

Membrane-Associated Collagens with Interrupted Triple helices (MACIT Collagens) Isoform Sequence Alignment

alpha1-13(XIII)   ------------------------------------------------------------
alpha1-15(XIII)   ------------------------------------------------------------
alpha1-6(XIII)    ------------------------------------------------------------
alpha1-19(XIII)   ------------------------------------------------------------
alpha1-7(XIII)    ------------------------------------------------------------
alpha1-12(XIII)   ------------------------------------------------------------
alpha1(XIII)      ------------------------------------------------------------
alpha1-8(XIII)    ------------------------------------------------------------
alpha1-11(XIII)   ------------------------------------------------------------
alpha1-9(XIII)    ------------------------------------------------------------
alpha1-16(XIII)   ------------------------------------------------------------
alpha1-3(XIII)    ------------------------------------------------------------
alpha1-17(XIII)   ------------------------------------------------------------
alpha1-2(XIII)    ------------------------------------------------------------
alpha1-5(XIII)    ------------------------------------------------------------
alpha1-10(XIII)   ------------------------------------------------------------
alpha1-14(XIII)   ------------------------------------------------------------
alpha1-18(XIII)   ------------------------------------------------------------
alpha1-4(XIII)    ------------------------------------------------------------
alpha1(XXIII)     ------------------------------------------------------------
alpha1-1(XXV)     ------------------------------------------------------------
alpha1(XVII)      MDVTKKNKRDGTEVTERIVTETVTTRLTSLPPKGGTSNGYAKTASLGGGSRLEKQSLTHG 60
                                                                                 

alpha1-13(XIII)   ------------------------------------------------------------
alpha1-15(XIII)   ------------------------------------------------------------
alpha1-6(XIII)    ------------------------------------------------------------
alpha1-19(XIII)   ------------------------------------------------------------
alpha1-7(XIII)    ------------------------------------------------------------
alpha1-12(XIII)   ------------------------------------------------------------
alpha1(XIII)      ------------------------------------------------------------
alpha1-8(XIII)    ------------------------------------------------------------
alpha1-11(XIII)   ------------------------------------------------------------
alpha1-9(XIII)    ------------------------------------------------------------
alpha1-16(XIII)   ------------------------------------------------------------
alpha1-3(XIII)    ------------------------------------------------------------
alpha1-17(XIII)   ------------------------------------------------------------
alpha1-2(XIII)    ------------------------------------------------------------
alpha1-5(XIII)    ------------------------------------------------------------
alpha1-10(XIII)   ------------------------------------------------------------
alpha1-14(XIII)   ------------------------------------------------------------
alpha1-18(XIII)   ------------------------------------------------------------
alpha1-4(XIII)    ------------------------------------------------------------
alpha1(XXIII)     ------------------------------------------------------------
alpha1-1(XXV)     ------------------------------------------------------------
alpha1(XVII)      SSGYINSTGSTRGHASTSSYRRAHSPASTLPNSPGSTFERKTHVTRHAYEGSSSGNSSPE 120
                                                                                 

alpha1-13(XIII)   ------------------------------------------------------------
alpha1-15(XIII)   ------------------------------------------------------------
alpha1-6(XIII)    ------------------------------------------------------------
alpha1-19(XIII)   ------------------------------------------------------------
alpha1-7(XIII)    ------------------------------------------------------------
alpha1-12(XIII)   ------------------------------------------------------------
alpha1(XIII)      ------------------------------------------------------------
alpha1-8(XIII)    ------------------------------------------------------------
alpha1-11(XIII)   ------------------------------------------------------------
alpha1-9(XIII)    ------------------------------------------------------------
alpha1-16(XIII)   ------------------------------------------------------------
alpha1-3(XIII)    ------------------------------------------------------------
alpha1-17(XIII)   ------------------------------------------------------------
alpha1-2(XIII)    ------------------------------------------------------------
alpha1-5(XIII)    ------------------------------------------------------------
alpha1-10(XIII)   ------------------------------------------------------------
alpha1-14(XIII)   ------------------------------------------------------------
alpha1-18(XIII)   ------------------------------------------------------------
alpha1-4(XIII)    ------------------------------------------------------------
alpha1(XXIII)     ------------------------------------------------------------
alpha1-1(XXV)     ------------------------------------------------------------
alpha1(XVII)      YPRKEFASSSTRGRSQTRESEIRVRLQSASPSTRWTELDDVKRLLKGSRSASVSPTRNSS 180
                                                                                 

alpha1-13(XIII)   ------------------------------------------------------------
alpha1-15(XIII)   ------------------------------------------------------------
alpha1-6(XIII)    ------------------------------------------------------------
alpha1-19(XIII)   ------------------------------------------------------------
alpha1-7(XIII)    ------------------------------------------------------------
alpha1-12(XIII)   ------------------------------------------------------------
alpha1(XIII)      ------------------------------------------------------------
alpha1-8(XIII)    ------------------------------------------------------------
alpha1-11(XIII)   ------------------------------------------------------------
alpha1-9(XIII)    ------------------------------------------------------------
alpha1-16(XIII)   ------------------------------------------------------------
alpha1-3(XIII)    ------------------------------------------------------------
alpha1-17(XIII)   ------------------------------------------------------------
alpha1-2(XIII)    ------------------------------------------------------------
alpha1-5(XIII)    ------------------------------------------------------------
alpha1-10(XIII)   ------------------------------------------------------------
alpha1-14(XIII)   ------------------------------------------------------------
alpha1-18(XIII)   ------------------------------------------------------------
alpha1-4(XIII)    ------------------------------------------------------------
alpha1(XXIII)     ------------------------------------------------------------
alpha1-1(XXV)     ------------------------------------------------------------
alpha1(XVII)      NTLPIPKKGTVETKIVTASSQSVSGTYDATILDANLPSHVWSSTLPAGSSMGTYHNNMTT 240
                                                                                 

alpha1-13(XIII)   ----MVAERTHKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLA 56
alpha1-15(XIII)   ----MVAERTHKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLA 56
alpha1-6(XIII)    ----MVAERTHKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLA 56
alpha1-19(XIII)   ----MVAERTHKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLA 56
alpha1-7(XIII)    ----MVAERTHKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLA 56
alpha1-12(XIII)   ----MVAERTHKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLA 56
alpha1(XIII)      ----MVAERTHKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLA 56
alpha1-8(XIII)    ----MVAERTHKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLA 56
alpha1-11(XIII)   ----MVAERTHKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLA 56
alpha1-9(XIII)    ----MVAERTHKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLA 56
alpha1-16(XIII)   ----MVAERTHKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLA 56
alpha1-3(XIII)    ----MVAERTHKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLA 56
alpha1-17(XIII)   ----MVAERTHKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLA 56
alpha1-2(XIII)    ----MVAERTHKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLA 56
alpha1-5(XIII)    ----MVAERTHKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLA 56
alpha1-10(XIII)   ----MVAERTHKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLA 56
alpha1-14(XIII)   ----MVAERTHKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLA 56
alpha1-18(XIII)   ----MVAERTHKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLA 56
alpha1-4(XIII)    ----MVAERTHKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLA 56
alpha1(XXIII)     ----MGPG--ERAGGGGDAGKGNAAGGGGGGRSATTAG-----SRAVSALCLLLSVGSAA 49
alpha1-1(XXV)     ----MLLK--KHAGKGGGREPRSEDPTPAEQHCARTMP-----PCAV--LAALLSVVAVV 47
alpha1(XVII)      QSSSLLNTNAYSAGSVFGVPNNMASCSPTLHPGLSTSSSVFGMQNNLAPSLTTLSHGTTT 300
                      :       *.                                       *:  : .

alpha1-13(XIII)   LSLLAHFRTAELQARVLR----------------------------LEAERG-------- 80
alpha1-15(XIII)   LSLLAHFRTAELQARVLR----------------------------LEAERG-------- 80
alpha1-6(XIII)    LSLLAHFRTAELQARVLR----------------------------LEAERG-------- 80
alpha1-19(XIII)   LSLLAHFRTAELQARVLR----------------------------LEAERG-------- 80
alpha1-7(XIII)    LSLLAHFRTAELQARVLR----------------------------LEAERG-------- 80
alpha1-12(XIII)   LSLLAHFRTAELQARVLR----------------------------LEAERG-------- 80
alpha1(XIII)      LSLLAHFRTAELQARVLR----------------------------LEAERG-------- 80
alpha1-8(XIII)    LSLLAHFRTAELQARVLR----------------------------LEAERG-------- 80
alpha1-11(XIII)   LSLLAHFRTAELQARVLR----------------------------LEAERG-------- 80
alpha1-9(XIII)    LSLLAHFRTAELQARVLR----------------------------LEAERG-------- 80
alpha1-16(XIII)   LSLLAHFRTAELQARVLR----------------------------LEAERG-------- 80
alpha1-3(XIII)    LSLLAHFRTAELQARVLR----------------------------LEAERG-------- 80
alpha1-17(XIII)   LSLLAHFRTAELQARVLR----------------------------LEAERG-------- 80
alpha1-2(XIII)    LSLLAHFRTAELQARVLR----------------------------LEAERG-------- 80
alpha1-5(XIII)    LSLLAHFRTAELQARVLR----------------------------LEAERG-------- 80
alpha1-10(XIII)   LSLLAHFRTAELQARVLR----------------------------LEAERG-------- 80
alpha1-14(XIII)   LSLLAHFRTAELQARVLR----------------------------LEAERG-------- 80
alpha1-18(XIII)   LSLLAHFRTAELQARVLR----------------------------LEAERG-------- 80
alpha1-4(XIII)    LSLLAHFRTAELQARVLR----------------------------LEAERG-------- 80
alpha1(XXIII)     ACLLLGVQAAALQGRVAA----------------------------LEEER---ELLRRA 78
alpha1-1(XXV)     SCLYLGVKTNDLQARIAA----------------------------LESAKGAPSIHLLP 79
alpha1(XVII)      TSTAYGVKKNMPQSPAAVNTGVSTSAACTTSVQSDDLLHKDCKFLILEKDNTP------- 353
                   .    .:    *.                                **  .         

alpha1-13(XIII)   --EQQMETAILGR-------------------VNQLLDEKWKLHSRRRREAPKT------ 113
alpha1-15(XIII)   --EQQMETAILGR-------------------VNQLLDEKWKLHSRRRREAPKT------ 113
alpha1-6(XIII)    --EQQMETAILGR-------------------VNQLLDEKWKLHSRRRREAPKT------ 113
alpha1-19(XIII)   --EQQMETAILGR-------------------VNQLLDEKWKLHSRRRREAPKT------ 113
alpha1-7(XIII)    --EQQMETAILGR-------------------VNQLLDEKWKLHSRRRREAPKT------ 113
alpha1-12(XIII)   --EQQMETAILGR-------------------VNQLLDEKWKLHSRRRREAPKT------ 113
alpha1(XIII)      --EQQMETAILGR-------------------VNQLLDEKWKLHSRRRREAPKT------ 113
alpha1-8(XIII)    --EQQMETAILGR-------------------VNQLLDEKWKLHSRRRREAPKT------ 113
alpha1-11(XIII)   --EQQMETAILGR-------------------VNQLLDEKWKLHSRRRREAPKT------ 113
alpha1-9(XIII)    --EQQMETAILGR-------------------VNQLLDEKWKLHSRRRREAPKT------ 113
alpha1-16(XIII)   --EQQMETAILGR-------------------VNQLLDEKWKLHSRRRREAPKT------ 113
alpha1-3(XIII)    --EQQMETAILGR-------------------VNQLLDEKWKLHSRRRREAPKT------ 113
alpha1-17(XIII)   --EQQMETAILGR-------------------VNQLLDEKWKLHSRRRREAPKT------ 113
alpha1-2(XIII)    --EQQMETAILGR-------------------VNQLLDEKWKLHSRRRREAPKT------ 113
alpha1-5(XIII)    --EQQMETAILGR-------------------VNQLLDEKWKLHSRRRREAPKT------ 113
alpha1-10(XIII)   --EQQMETAILGR-------------------VNQLLDEKWKLHSRRRREAPKT------ 113
alpha1-14(XIII)   --EQQMETAILGR-------------------VNQLLDEKWKLHSRRRREAPKT------ 113
alpha1-18(XIII)   --EQQMETAILGR-------------------VNQLLDEKWKLHSRRRREAPKT------ 113
alpha1-4(XIII)    --EQQMETAILGR-------------------VNQLLDEKWKLHSRRRREAPKT------ 113
alpha1(XXIII)     GPPGALDAWAEPH-------------------LERLLREK-LDGLAKIRTAREA------ 112
alpha1-1(XXV)     DTLDHLKTMVQEK-------------------VERLLAQKSYEHMAKIRIAREA------ 114
alpha1(XVII)      -AKKEMELLIMTKDSGKVFTASPASIAATSFSEDTLKKEKQAAYNADSGLKAEANGDLKT 412
                       :.     :                    : *  :*            ::      

alpha1-13(XIII)   ----------------------------------------SPGCNCPPAFQGPTGRPGLP 133
alpha1-15(XIII)   ----------------------------------------SPGCNCPPAFQGPTGRPGLP 133
alpha1-6(XIII)    ----------------------------------------SPGCNCPPAFQGPTGRPGLP 133
alpha1-19(XIII)   ----------------------------------------SPGCNCPPAFQGPTGRPGLP 133
alpha1-7(XIII)    ----------------------------------------SPGCNCPPAFQGPTGRPGLP 133
alpha1-12(XIII)   ----------------------------------------SPGCNCPPAFQGPTGRPGLP 133
alpha1(XIII)      ----------------------------------------SPGCNCPPAFQGPTGRPGLP 133
alpha1-8(XIII)    ----------------------------------------SPGCNCPPAFQGPTGRPGLP 133
alpha1-11(XIII)   ----------------------------------------SPGCNCPPAFQGPTGRPGLP 133
alpha1-9(XIII)    ----------------------------------------SPGCNCPPAFQGPTGRPGLP 133
alpha1-16(XIII)   ----------------------------------------SPGCNCPPVFQ--------- 124
alpha1-3(XIII)    ----------------------------------------SPGCNCPPAFQGPTGRPGLP 133
alpha1-17(XIII)   ----------------------------------------SPGCNCPPVFQ--------- 124
alpha1-2(XIII)    ----------------------------------------SPGCNCPPAFQGPTGRPGLP 133
alpha1-5(XIII)    ----------------------------------------SPGCNCPPAFQGPTGRPGLP 133
alpha1-10(XIII)   ----------------------------------------SPGCNCPPAFQGPTGRPGLP 133
alpha1-14(XIII)   ----------------------------------------SPGCNCPPAFQGPTGRPGLP 133
alpha1-18(XIII)   ----------------------------------------SPGCNCPPAPQG-------- 125
alpha1-4(XIII)    ----------------------------------------SPGCNCPPAFQGPTGRPGLP 133
alpha1(XXIII)     ----------------------------------------PSECVCP------------- 119
alpha1-1(XXV)     ----------------------------------------PSECNCP------------- 121
alpha1(XVII)      VSTKGKTTTADIHSYGSSGGGGSGGGGGVGGAGGGPWGPAPAWCPCGSCCSWWKWLLGLL 472
                                                          .. * *              

alpha1-13(XIII)   GDKGAIG----------------------------------------------------- 140
alpha1-15(XIII)   GDKGAIG----------------------------------------------------- 140
alpha1-6(XIII)    GDKGAIG----------------------------------------------------- 140
alpha1-19(XIII)   G----------------------------------------------------------- 134
alpha1-7(XIII)    GDKGAIG----------------------------------------------------- 140
alpha1-12(XIII)   GDKGAIG----------------------------------------------------- 140
alpha1(XIII)      GDKGAIG----------------------------------------------------- 140
alpha1-8(XIII)    GDKGAIG----------------------------------------------------- 140
alpha1-11(XIII)   GDKGAIG----------------------------------------------------- 140
alpha1-9(XIII)    ------------------------------------------------------------
alpha1-16(XIII)   ------------------------------------------------------------
alpha1-3(XIII)    GDKGAI------------------------------------------------------ 139
alpha1-17(XIII)   ------------------------------------------------------------
alpha1-2(XIII)    GSPGDAG----------------------------------------------------- 140
alpha1-5(XIII)    GDKGAIG----------------------------------------------------- 140
alpha1-10(XIII)   GDKGAIG----------------------------------------------------- 140
alpha1-14(XIII)   G----------------------------------------------------------- 134
alpha1-18(XIII)   ------------------------------------------------------------
alpha1-4(XIII)    GDKGAIG----------------------------------------------------- 140
alpha1(XXIII)     ------------------------------------------------------------
alpha1-1(XXV)     ------------------------------------------------------------
alpha1(XVII)      LTWLLLLGLLFGLIALAEEVRKLKARVDELERIRRSILPYGDSMDRIEKDRLQGMAPAAG 532
                                                                                 

alpha1-13(XIII)   ---------------------MPGRVGSPGDAGLSIIGPRGPPGQPGTRGFPGFPGPIGL 179
alpha1-15(XIII)   ---------------------MPGRVGSPGDAGLSIIGPRGPPGQPGTRGFPGFPGPIGL 179
alpha1-6(XIII)    ---------------------MPGRVGSPGDAGLSIIGPRGPPGQPGTRGFPGFPGPIGL 179
alpha1-19(XIII)   --------------------------------------------QPGTRGFPGFPGPIGL 150
alpha1-7(XIII)    ---------------------MPGRVGSPGDAGLSIIGPRGPPGQPGTRGFPGFPGPIGL 179
alpha1-12(XIII)   ---------------------MPGRVGSPGDAGLSIIGPRGPPGQPGTRGFPGFPGPIGL 179
alpha1(XIII)      ---------------------MPGRVGSPGDAGLSIIGPRGPPGQPGTRGFPGFPGPIGL 179
alpha1-8(XIII)    ---------------------MPGRVGSPGDAGLSIIGPRGPPGQPGTRGFPGFPGPIGL 179
alpha1-11(XIII)   ---------------------MPGRVGSPGDAGLSIIGPRGPPGQPGTRGFPGFPGPIGL 179
alpha1-9(XIII)    -------------------------------------------GQPGTRGFPGFPGPIGL 150
alpha1-16(XIII)   -------------------------------------------GQPGTRGFPGFPGPIGL 141
alpha1-3(XIII)    -------------------------------------GMPGRVGQPGTRGFPGFPGPIGL 162
alpha1-17(XIII)   -------------------------------------------GQPGTRGFPGFPGPIGL 141
alpha1-2(XIII)    ---------------------------------LSIIGPRGPPGQPGTRGFPGFPGPIGL 167
alpha1-5(XIII)    ---------------------MPGRVGSPGDAGLSIIGPRGPPGQPGTRGFPGFPGPIGL 179
alpha1-10(XIII)   ---------------------MPGRVGSPGDAGLSIIGPRGPPGQPGTRGFPGFPGPIGL 179
alpha1-14(XIII)   ---------------------------SPGDAGLSIIGPRGPPGQPGTRGFPGFPGPIGL 167
alpha1-18(XIII)   ---------------------------SPGDAGLSIIGPRGPPGQPGTRGFPGFPGPIGL 158
alpha1-4(XIII)    ---------------------MPGRVGSPGDAGLSIIGPRGPPGQPGTRGFPGFPGPIGL 179
alpha1(XXIII)     ---------------------------------------PGPPGRRGKPGRRGDPGPPGQ 140
alpha1-1(XXV)     ---------------------------------------AGPPGKRGKRGRRGESGPPGQ 142
alpha1(XVII)      ADLDKIGLHSDSQEELWMFVRKKLMMEQENGNLRGSPGPKGDMGSPGPKGDRGFPGTPGI 592
                                                                *  *  * .*. * 

alpha1-13(XIII)   DGKPGHPGPKGDMGLTGPPGQPG--PQGQKGEKGQCGEYPHRECLSSMPAALRSSQIIAL 237
alpha1-15(XIII)   DGKPGHPGPKGDMGLTGPPGQPG--PQGQKGEKGQCGEYPHRECLSSMPAALRSSQIIAL 237
alpha1-6(XIII)    DGKPGHPGPKGDMGLTGPPGQPG--PQGQKGEKGQCGEYPHRECLSSMPAALRSSQIIAL 237
alpha1-19(XIII)   DGKPGHPGPKGDMGLTGPPGQPG--PQGQKGEKGQCGEYPHRECLSSMPAALRSSQIIAL 208
alpha1-7(XIII)    DGKPGHPGPKGDMGLTGPPGQPG--PQGQKGEKGQCGEYPHRECLSSMPAALRSSQIIAL 237
alpha1-12(XIII)   DGKPGHPGPKGDMGLTGPPGQPG--PQGQKGEKGQCGEYPHRECLSSMPAALRSSQIIAL 237
alpha1(XIII)      DGKPGHPGPKGDMGLTGPPGQPG--PQGQKGEKGQCGEYPHRECLSSMPAALRSSQIIAL 237
alpha1-8(XIII)    DGKPGHPGPKGDMGLTGPPGQPG--PQGQKGEKGQCGEYPHRECLSSMPAALRSSQIIAL 237
alpha1-11(XIII)   DGKPGHPGPKGDMGLTGPPGQPG--PQGQKGEKGQCGEYPHR------------------ 219
alpha1-9(XIII)    DGKPGHPGPKGDMGLTGPPGQPG--PQGQKGEKGQCGEYPHRECLSSMPAALRSSQIIAL 208
alpha1-16(XIII)   DGKPGHPGPKGDMGLTGPPGQPG--PQGQKGEKGQCGEYPHR------------------ 181
alpha1-3(XIII)    DGKPGHPGPKGDMGLTGPPGQPG--PQGQKGEKGQCGEYPHRECLSSMPAALRSSQIIAL 220
alpha1-17(XIII)   DGKPGHPGPKGDMGLTGPPGQPG--PQGQKGEKGQCGEYPHREC---------------- 183
alpha1-2(XIII)    DGKPGHPGPKGDMGLTGPPGQPG--PQGQKGEKGQCGEYPHRECLSSMPAALRSSQIIAL 225
alpha1-5(XIII)    DGKPGHPGPKGDMGLTGPPGQPG--PQGQKGEKGQCGEYPHRECLSSMPAALRSSQIIA- 236
alpha1-10(XIII)   DGKPGHPGPKGDMGLTGPPGQPG--PQGQKGEKGQCGEYPHR------------------ 219
alpha1-14(XIII)   DGKPGHPGPKGDMGLTGPPGQPG--PQGQKGEKGQCGEYPHR------------------ 207
alpha1-18(XIII)   DGKPGHPGPKGDMGLTGPPGQPG--PQGQKGEKGQCGEYPHR------------------ 198
alpha1-4(XIII)    DGKPGHPGPKGDMGLTGPPGQPG--PQGQKGEKGQCGEYPHRLLPLLNSVRLAPPPVIKR 237
alpha1(XXIII)     SGRDGYPGPLGLDGKPGLPGP--------KGEKGAPGDFGPR------------------ 174
alpha1-1(XXV)     PGPQGPPGPKGDKGEQGDQGPRMVFPKINHGFLSADQQLIKRR----------------- 185
alpha1(XVII)      PGPLGHPGPQGPKGQKGSVGDPG--MEGPMGQRGREGPMGPRGEAGPPGSGE-------- 642
                   *  * *** *  *  *  *          *  .       *                  

alpha1-13(XIII)   KLLPLLNSVRLAPPPVIKRRTFQGEQSQASIQGPPGPPGPPGPSGPLGHPGLPGPMGPPG 297
alpha1-15(XIII)   K----------------------GEQSQASIQGPPGPPGPPGPSGPLGHPGLPGPMGPPG 275
alpha1-6(XIII)    KLLPLLNSVRLAPPPVIKRRTFQGEQSQASIQGPPGPPGPPGPSGPLGHPGLPGPMGPPG 297
alpha1-19(XIII)   K----------------------GEQSQASIQGPPGPPGPPGPSGPLGHPGLPGPMGPPG 246
alpha1-7(XIII)    KLLPLLNSVRLAPPPVIKRRTFQGEQSQASIQGPPGPPGPPGPSGPLGHPGLPGPMGPPG 297
alpha1-12(XIII)   KLLPLLNSVRLAPPPVIKRRTFQGEQSQASIQGPPGPPGPPGPSGPLGHPGLPGPMGPPG 297
alpha1(XIII)      KLLPLLNSVRLAPPPVIKRRTFQGEQSQASIQGPPGPPGPPGPSGPLGHPGLPGPMGPPG 297
alpha1-8(XIII)    KLLPLLNSVRLAPPPVIKRRTFQGEQSQASIQGPPGPPGPPGPSGPLGHPGLPGPMGPPG 297
alpha1-11(XIII)   -LLPLLNSVRLAPPPVIKRRTFQGEQSQASIQGPPGPPGPPGPSGPLGHPGLPGPMGPPG 278
alpha1-9(XIII)    KLLPLLNSVRLAPPPVIKRRTFQGEQSQASIQGPPGPPGPPGPSGPLGHPGLPGPMGPPG 268
alpha1-16(XIII)   -LLPLLNSVRLAPPPVIKRRTFQGEQSQASIQGPPGPPGPPGPSGPLGHPGLPGPMGPPG 240
alpha1-3(XIII)    KLLPLLNSVRLAPPPVIKRRTFQGEQSQASIQGPPGPPGPPGPSGPLGHPGLPGPMGPPG 280
alpha1-17(XIII)   -LSSMPAALRSSQIIALK-----GEQSQASIQGPPGPPGPPGPSGPLGHPGLPGPMGPPG 237
alpha1-2(XIII)    KLLPLLNSVRLAPPPVIKRRTFQGEQSQASIQGPPGPPGPPGPSGPLGHPGLPGPMGPPG 285
alpha1-5(XIII)    ---------------------LKGEQSQASIQGPPGPPGPPGPSGPLGHPGLPGPMGPPG 275
alpha1-10(XIII)   -----------------------GEQSQASIQGPPGPPGPPGPSGPLGHPGLPGPMGPPG 256
alpha1-14(XIII)   -----------------------GEQSQASIQGPPGPPGPPGPSGPLGHPGLPGPMGPPG 244
alpha1-18(XIII)   -----------------------GEQSQASIQGPPGPPGPPGPSGPLGHPGLPGPMGPPG 235
alpha1-4(XIII)    -------------------RTFQGEQSQASIQGPPGPPGPPGPSGPLGHPGLPGPMGPPG 278
alpha1(XXIII)     -----------------------GDQGQDGAAGPPGPPGPPGARGPPGDTGKDGPRGAQG 211
alpha1-1(XXV)     -----------------------LIKGDQGQAGPPGPPGPPGPRGPPGDTGKDGPRGMPG 222
alpha1(XVII)      ----------------------KGERGAAGEPGPHGPPGVPGSVGPKGSSGSPGPQGPPG 680
                                           :.  .  ** **** **. ** * .*  ** *  *

alpha1-13(XIII)   LP---------------------GPPGPKGDPGIQGYHGRKGERGMPGMPGKHG------ 330
alpha1-15(XIII)   LP---------------------GPPGPKGDPGIQGYHGRKGERGMPGMPGKHG------ 308
alpha1-6(XIII)    LP---------------------GPPGPKGDPGIQGYHGRKGERGMPGMPGKHG------ 330
alpha1-19(XIII)   LP---------------------GPPGPKGDPGIQGYHGRKGERGMPGMPGKHG------ 279
alpha1-7(XIII)    LP---------------------GPPGPKGDPGIQGYHGRKGERGMPGMPGKHG------ 330
alpha1-12(XIII)   LP---------------------GPPGPKGDPGIQGYHGRKGERGMPGMPGKHG------ 330
alpha1(XIII)      LP---------------------GPPGPKGDPGIQGYHGRKGERGMPGMPGKHG------ 330
alpha1-8(XIII)    LP---------------------GPPGPKGDPGIQGYHGRKGERGMPGMPGKHG------ 330
alpha1-11(XIII)   LP---------------------GPPGPKGDPGIQGYHGRKGERGMPGMPGKHG------ 311
alpha1-9(XIII)    LP---------------------GPPGPKGDPGIQGYHGRKGERGMPGMPGKHG------ 301
alpha1-16(XIII)   LP---------------------GPPGPKGDPGIQGYHGRKGERGMPGMPGKHG------ 273
alpha1-3(XIII)    LP---------------------GPPGPKGDPGIQGYHGRKGERGMPGMPGKHG------ 313
alpha1-17(XIII)   LP---------------------GPPGPKGDPGIQGYHGRKGERGMPGMPGKHG------ 270
alpha1-2(XIII)    LP---------------------GPPGPKGDPGIQGYHGRKGERGMPGMPGKHG------ 318
alpha1-5(XIII)    LP---------------------GPPGPKGDPGIQGYHGRKGERGMPGMPGKHG------ 308
alpha1-10(XIII)   LP---------------------GPPGPKGDPGIQGYHGRKGERGMPGMPGKHG------ 289
alpha1-14(XIII)   LP---------------------GPPGPKGDPGIQGYHGRKGERGMPGMPGKHG------ 277
alpha1-18(XIII)   LP---------------------GPPGPKGDPGIQGYHGRKGERGMPGMPGKHG------ 268
alpha1-4(XIII)    LP---------------------GPPGPKGDPGIQGYHGRKGERGMPGMPGKHG------ 311
alpha1(XXIII)     PA---------------------GPKGEPGQDGEMGPKGPPG------------------ 232
alpha1-1(XXV)     VP---------------------GEPGKPGEQGLMGPLGPPGQKGSIGAPGIPGMNGQKG 261
alpha1(XVII)      PVGLQGLRGEVGLPGVKGDKGPMGPPGPKGDQGEKGPRGLTGEPGMRGLPGAVGEPGAKG 740
                                         *  *  *: *  *  *  *                  

alpha1-13(XIII)   ---------------AKGAPG------------------------IAVAGMKGEPGIPGT 351
alpha1-15(XIII)   ---------------AKGAPG------------------------IAVAGMKGEPGIPGT 329
alpha1-6(XIII)    ---------------AKGAPG------------------------IAVAGMKGEPGIPGT 351
alpha1-19(XIII)   ---------------AKGAPG------------------------IAVAGMKGEPGIPGT 300
alpha1-7(XIII)    ---------------AKGAPG------------------------IAVAGMKGEPGIPGT 351
alpha1-12(XIII)   ---------------AKGAPG------------------------IAVAGMKGEPGIPGT 351
alpha1(XIII)      ---------------AKGAPG------------------------IAVAGMKGEPGIPGT 351
alpha1-8(XIII)    ---------------AKGAPG------------------------IAVAGMKGEPGIPGT 351
alpha1-11(XIII)   ---------------AKGAPG------------------------IAVAGMKGEPGIPGT 332
alpha1-9(XIII)    ---------------AKGAPG------------------------IAVAGMKGEPGIPGT 322
alpha1-16(XIII)   ---------------AKGAPG------------------------IAVAGMKGEPGIPGT 294
alpha1-3(XIII)    ---------------AKGAPG------------------------IAVAGMKGEPGIPGT 334
alpha1-17(XIII)   ---------------AKGAPG------------------------IAVAGMKGEPGIPGT 291
alpha1-2(XIII)    ---------------AKGAPG------------------------IAVAGMKGEPGIPGT 339
alpha1-5(XIII)    ---------------AKGAPG------------------------IAVAGMKGEPGIPGT 329
alpha1-10(XIII)   ---------------AKGAPG------------------------IAVAGMKGEPGIPGT 310
alpha1-14(XIII)   ---------------AKGAPG------------------------IAVAGMKGEPGIPGT 298
alpha1-18(XIII)   ---------------AKGAPG------------------------IAVAGMKGEPGIPGT 289
alpha1-4(XIII)    ---------------AKGAPG------------------------IAVAGMKGEPGIPGT 332
alpha1(XXIII)     ---------------PKGEPG--------------------------------------V 239
alpha1-1(XXV)     EPGLPGAVGQNGIPGPKGEPGEQGEKGDAGENGPKGDTGEKGDPGSSAAGIKGEPGESGR 321
alpha1(XVII)      AMG---PAGPDGHQGPRGEQGLTGMPG-----------------IRGPPGPSGDPGKPGL 780
                                 .:*  *                                       

alpha1-13(XIII)   KGEKGAEGSPGLPGLLGQKGEKGDAGN----------SIGGGRGE-----PGPPGLPGPP 396
alpha1-15(XIII)   KGEKGAEGSPGLPGLLGQKGEKGDAGN----------SIGGGRGE-----PGPPGLPGPP 374
alpha1-6(XIII)    KGEKGAEGSPGLPGLLGQKGEKGDAGN----------SIGGGRGE-----PGPPGLPGPP 396
alpha1-19(XIII)   KGEKGAEGSPGLPGLLGQKGEKGDAGN----------SIGGGRGE-----PGPPGLPGPP 345
alpha1-7(XIII)    KGEKGAEGSPGLPGLLGQKGEKGDAGN----------SIGGGRGE-----PGPPGLPGPP 396
alpha1-12(XIII)   KGEKGAEGSPGLPGLLGQKGEKGDAGN----------SIGGGRGE-----PGPPGLPGPP 396
alpha1(XIII)      KGEKGAEGSPGLPGLLGQKGEKGDAGN----------SIGGGRGE-----PGPPGLPGPP 396
alpha1-8(XIII)    KGEKGAEGSPGLPGLLGQKGEKGDAGN----------SIGGGRGE-----PGPPGLPGPP 396
alpha1-11(XIII)   KGEKGAEGSPGLPGLLGQKGEKGDAGN----------SIGGGRGE-----PGPPGLPGPP 377
alpha1-9(XIII)    KGEKGAEGSPGLPGLLGQKGEKGDAGN----------SIGGGRGE-----PGPPGLPGPP 367
alpha1-16(XIII)   KGEKGAEGSPGLPGLLGQKGEKGDAGN----------SIGGGRGE-----PGPPGLPGPP 339
alpha1-3(XIII)    KGEKGAEGSPGLPGLLGQKGEKGDAGN----------SIGGGRGE-----PGPPGLPGPP 379
alpha1-17(XIII)   KGEKGAEGSPGLPGLLGQKGEKGDAGN----------SIGGGRGE-----PGPPGLPGPP 336
alpha1-2(XIII)    KGEKGAEGSPGLPGLLGQKGEKGDAGN----------SIGGGRGE-----PGPPGLPGPP 384
alpha1-5(XIII)    KGEKGAEGSPGLPGLLGQKGEKGDAGN----------SIGGGRGE-----PGPPGLPGPP 374
alpha1-10(XIII)   KGEKGAEGSPGLPGLLGQKGEKGDAGN----------SIGGGRGE-----PGPPGLPGPP 355
alpha1-14(XIII)   KGEKGAEGSPGLPGLLGQKGEKGDAGN----------SIGGGRGE-----PGPPGLPGPP 343
alpha1-18(XIII)   KGEKGAEGSPGLPGLLGQKGEKGDAGN----------SIGGGRGE-----PGPPGLPGPP 334
alpha1-4(XIII)    KGEKGAEGSPGLPGLLGQKGEKGDAGN----------SIGGGRGE-----PGPPGLPGPP 377
alpha1(XXIII)     PGKKGDDGTPSQPGPPGPKGEPGSMGP-----------------------RGENGVDGAP 276
alpha1-1(XXV)     PGQKGEPGLPGLPGLPGIKGEPGFIGPQGEPGLPGLPGTKGERGEAGPPGRGERGEPGAP 381
alpha1(XVII)      TGPQGPQGLPGTPGRPGIKGEPGAPGK--------IVTSEGSSMLTVPGPPGPPGAMGPP 832
                   * :*  * *. **  * *** *  *                         *  *  *.*

alpha1-13(XIII)   GPKGEAGVDGQVGPPGQPGDKGERGAAGEQGPDGPKGS--------KGEPGKGE--MVDY 446
alpha1-15(XIII)   GPKGEAGVDGQVGPPGQPGDKGERGAAGEQGPDGPKGS--------KGEPGKGE--MVDY 424
alpha1-6(XIII)    GPKGEAGVDGQVGPPGQPGDKGERGAAGEQGPDGPKGS--------KGEPGKGE--MVDY 446
alpha1-19(XIII)   GPKGEAGVDGQVGPPGQPGDKGERGAAGEQGPDGPKGS--------KGEPGKGE--MVDY 395
alpha1-7(XIII)    GPKGEAGVDGQVGPPGQPGDKGERGAAGEQGPDGPKGS--------KGEPGKGE--MVDY 446
alpha1-12(XIII)   GPKGEAGVDGQVGPPGQPGDKGERGAAGEQGPDGPKGS--------KGEPGKGE--MVDY 446
alpha1(XIII)      GPKGEAGVDGQVGPPGQPGDKGERGAAGEQGPDGPKGS--------KGEPGKGE--MVDY 446
alpha1-8(XIII)    GPKGEAGVDGQVGPPGQPGDKGERGAAGEQGPDGPKGS--------KGEPGKGE--MVDY 446
alpha1-11(XIII)   GPKGEAGVDGQVGPPGQPGDKGERGAAGEQGPDGPKGS--------KGEPGKGE--MVDY 427
alpha1-9(XIII)    GPKGEAGVDGQVGPPGQPGDKGERGAAGEQGPDGPKGS--------KGEPGKGE--MVDY 417
alpha1-16(XIII)   GPKGEAGVDGQVGPPGQPGDKGERGAAGEQGPDGPKGS--------KGEPGKGE--MVDY 389
alpha1-3(XIII)    GPKGEAGVDGQVGPPGQPGDKGERGAAGEQGPDGPKGS--------KGEPGKGE--MVDY 429
alpha1-17(XIII)   GPKGEAGVDGQVGPPGQPGDKGERGAAGEQGPDGPKGS--------KGEPGKGE--MVDY 386
alpha1-2(XIII)    GPKGEAGVDGQVGPPGQPGDKGERGAAGEQGPDGPKGS--------KGEPGKGE--MVDY 434
alpha1-5(XIII)    GPKGEAGVDGQVGPPGQPGDKGERGAAGEQGPDGPKGS--------KGEPGKGE--MVDY 424
alpha1-10(XIII)   GPKGEAGVDGQVGPPGQPGDKGERGAAGEQGPDGPKGS--------KGEPGKGE--MVDY 405
alpha1-14(XIII)   GPKGEAGVDGQVGPPGQPGDKGERGAAGEQGPDGPKGS--------KGEPGKGE--MVDY 393
alpha1-18(XIII)   GPKGEAGVDGQVGPPGQPGDKGERGAAGEQGPDGPKGS--------KGEPGKGE--MVDY 384
alpha1-4(XIII)    GPKGEAGVDGQVGPPGQPGDKGERGAAGEQGPDGPKGS--------KGEPGKGE--MVDY 427
alpha1(XXIII)     GPKGEPGHRGTDG---------------AAGPRGAPGL--------KGEQGDTV--VIDY 311
alpha1-1(XXV)     GPKGKQGESGTRGPKGSKGDRGEKGDSGAQGPRGPPGQ--------KGDQGATE--IIDY 431
alpha1(XVII)      GPPGAPGPAGPAGLPGHQEVLNLQGPPGPPGPRGPPGPSIPGPPGPRGPPGEGLPGPPGP 892
                  ** *  *  *  *                 ** *. *         :*  *       . 

alpha1-13(XIII)   NGNINEALQEIRTLALMGPPGLPGQIGPPGAPGIPGQKGEIGLP---------------G 491
alpha1-15(XIII)   NGNINEALQEIRTLALMGPPGLPGQIGPPGAPGIPGQKGEIGLP---------------G 469
alpha1-6(XIII)    NGNINEALQEIRTLALMGPPGLPGQIGPPGAPGIPGQKGEIGLP---------------G 491
alpha1-19(XIII)   NGNINEALQEIRTLALMGPPGLPGQIGPPGAPGIPGQKGEIGLP---------------G 440
alpha1-7(XIII)    NGNINEALQEIRTLALMGPPGLPGQIGPPGAPGIPGQKGEIGLP---------------G 491
alpha1-12(XIII)   NGNINEALQEIRTLALMGPPGLPGQIGPPGAPGIPGQKGEIGLP---------------G 491
alpha1(XIII)      NGNINEALQEIRTLALMGPPGLPGQIGPPGAPGIPGQKGEIGLP---------------G 491
alpha1-8(XIII)    NGNINEALQEIRTLALMGPPGLPGQIGPPGAPGIPGQKGEIGLP---------------G 491
alpha1-11(XIII)   NGNINEALQEIRTLALMGPPGLPGQIGPPGAPGIPGQKGEIGLP---------------G 472
alpha1-9(XIII)    NGNINEALQEIRTLALMGPPGLPGQIGPPGAPGIPGQKGEIGLP---------------G 462
alpha1-16(XIII)   NGNINEALQEIRTLALMGPPGLPGQIGPPGAPGIPGQKGEIGLP---------------G 434
alpha1-3(XIII)    NGNINEALQEIRTLALMGPPGLPGQIGPPGAPGIPGQKGEIGLP---------------G 474
alpha1-17(XIII)   NGNINEALQEIRTLALMGPPGLPGQIGPPGAPGIPGQKGEIGLP---------------G 431
alpha1-2(XIII)    NGNINEALQEIRTLALMGPPGLPGQIGPPGAPGIPGQKGEIGLP---------------G 479
alpha1-5(XIII)    NGNINEALQEIRTLALMGPPGLPGQIGPPGAPGIPGQKGEIGLP---------------G 469
alpha1-10(XIII)   NGNINEALQEIRTLALMGPPGLPGQIGPPGAPGIPGQKGEIGLP---------------G 450
alpha1-14(XIII)   NGNINEALQEIRTLALMGPPGLPGQIGPPGAPGIPGQKGEIGLP---------------G 438
alpha1-18(XIII)   NGNINEALQEIRTLALMGPPGLPGQIGPPGAPGIPGQKGEIGLP---------------G 429
alpha1-4(XIII)    NGNINEALQEIRTLALMGPPGLPGQIGPPGAPGIPGQKGEIGLP---------------G 472
alpha1(XXIII)     DGRILDALK-----GPPGPQ------GPPGPPGIPGAKGELGLP---------------G 345
alpha1-1(XXV)     NGNLHEALQRITTLTVTGPP------GPPGPQGLQGPKGEQGSP---------------G 470
alpha1(XVII)      PGSFLSNSETFLS-GPPGPPGPPGPKGDQGPPGPRGHQGEQGLPGFSTSGSSSFGLNLQG 951
                   * : .  :        **       *  *. *  * :** * *               *

alpha1-13(XIII)   PPGHDGEKGPRGKPGDM------------------------GPPGPQGPPGKDGPP---- 523
alpha1-15(XIII)   PPGHDGEKGPRGKPGDM------------------------GPPGPQGPPGKDGPP---- 501
alpha1-6(XIII)    PPGHDGEKGPRGKPGDM------------------------GPPGPQGPPGKDGPP---- 523
alpha1-19(XIII)   PPGHDGEKGPRGKPGDM------------------------GPPGPQGPPGKDGPP---- 472
alpha1-7(XIII)    PPGHDGEKGPRGKPGDM------------------------GPPGPQGPPGKDGPP---- 523
alpha1-12(XIII)   PPGHDGEKGPRGKPGDM------------------------GPPGPQGPPGKDGPP---- 523
alpha1(XIII)      PPGHDGEKGPRGKPGDM------------------------GPPGPQGPPGKDGPP---- 523
alpha1-8(XIII)    PPGHDGEKGPRGKPGDM------------------------GPPGPQGPPGKDGPP---- 523
alpha1-11(XIII)   PPGHDGEKGPRGKPGDM------------------------GPPGPQGPPGKDGPP---- 504
alpha1-9(XIII)    PPGHDGEKGPRGKPGDM------------------------GPPGPQGPPGKDGPP---- 494
alpha1-16(XIII)   PPGHDGEKGPRGKPGDM------------------------GPPGPQGPPGKDGPP---- 466
alpha1-3(XIII)    PPGHDGEKGPRGKPGDM------------------------GPPGPQGPPGKDGPP---- 506
alpha1-17(XIII)   PPGHDGEKGPRGKPGDM------------------------GPPGPQGPPGKDGPP---- 463
alpha1-2(XIII)    PPGHDGEKGPRGKPGDM------------------------GPPGPQGPPGKDGPP---- 511
alpha1-5(XIII)    PPGHDGEKGPRGKPGDM------------------------GPPGPQGPPGKDGPP---- 501
alpha1-10(XIII)   PPGHDGEKGPRGKPGDM------------------------GPPGPQGPPGKDGPP---- 482
alpha1-14(XIII)   PPGHDGEKGPRGKPGDM------------------------GPPGPQGPPGKDGPP---- 470
alpha1-18(XIII)   PPGHDGEKGPRGKPGDM------------------------GPPGPQGPPGKDGPP---- 461
alpha1-4(XIII)    PPGHDGEKGPRGKPGDM------------------------GPPGPQGPPGKDGPP---- 504
alpha1(XXIII)     APGIDGEKGPKGQKGDP------------------------GEPGPAGLKGEAGEM---- 377
alpha1-1(XXV)     IPGMDGEQGLKGSKGDM------------------------GDPG---MTGEKGGI---- 499
alpha1(XVII)      PPGPPGPQGPKGDKGDPGVPGALGIPSGPSEGGSSSTMYVSGPPGPPGPPGPPGSISSSG 1011
                   **  * :* :*. **                         * **     *  *      

alpha1-13(XIII)   ---------------------GVKGENGHPGSPG-------------------------- 536
alpha1-15(XIII)   ---------------------GVKGENGHPGSPG-------------------------- 514
alpha1-6(XIII)    ---------------------GVKGENGHPGSPG-------------------------- 536
alpha1-19(XIII)   ---------------------GVKGENGHPGSPG-------------------------- 485
alpha1-7(XIII)    ---------------------GVKGENGHPGSPG-------------------------- 536
alpha1-12(XIII)   ---------------------GVKGENGHPGSPG-------------------------- 536
alpha1(XIII)      ---------------------GVKGENGHPGSPG-------------------------- 536
alpha1-8(XIII)    ---------------------GVKGENGHPGSPG-------------------------- 536
alpha1-11(XIII)   ---------------------GVKGENGHPGSPG-------------------------- 517
alpha1-9(XIII)    ---------------------GVKGENGHPGSPG-------------------------- 507
alpha1-16(XIII)   ---------------------GVKGENGHPGSPG-------------------------- 479
alpha1-3(XIII)    ---------------------GVKGENGHPGSPG-------------------------- 519
alpha1-17(XIII)   ---------------------GVKGENGHPGSPG-------------------------- 476
alpha1-2(XIII)    ---------------------GVKGENGHPGSPG-------------------------- 524
alpha1-5(XIII)    ---------------------GVKGENGHPGSPG-------------------------- 514
alpha1-10(XIII)   ---------------------GVKGENGHPGSPG-------------------------- 495
alpha1-14(XIII)   ---------------------GVKGENGHPGSPG-------------------------- 483
alpha1-18(XIII)   ---------------------GVKGENGHPGSPG-------------------------- 474
alpha1-4(XIII)    ---------------------GVKGENGHPGSPG-------------------------- 517
alpha1(XXIII)     ---------------------GLSG---LPGADG-------------------------- 387
alpha1-1(XXV)     ---------------------GLPG---LPGANG-------------------------- 509
alpha1(XVII)      QEIQQYISEYMQSDSIRSYLSGVQGPPGPPGPPGPVTTITGETFDYSELASHVVSYLRTS 1071
                                       *: *    **. *                          

alpha1-13(XIII)   --------------------------------EKGEKGETGQAGSP-------------- 550
alpha1-15(XIII)   --------------------------------EKGEKGETGQAGSP-------------- 528
alpha1-6(XIII)    --------------------------------EKGEKGETGQAGSP-------------- 550
alpha1-19(XIII)   --------------------------------EKGEKGETGQAGSP-------------- 499
alpha1-7(XIII)    --------------------------------EKGEKGETGQAGSPG------------- 551
alpha1-12(XIII)   --------------------------------EKGEKGETGQAGSPG------------- 551
alpha1(XIII)      --------------------------------EKGEKGETGQAGSPGE------------ 552
alpha1-8(XIII)    --------------------------------EKGEKGETGQAGSPGE------------ 552
alpha1-11(XIII)   --------------------------------EKGEKGETGQAGSPGE------------ 533
alpha1-9(XIII)    --------------------------------EKGEKGETGQAGSPGE------------ 523
alpha1-16(XIII)   --------------------------------EKGEKGETGQAGSPGE------------ 495
alpha1-3(XIII)    --------------------------------EKGEKGETGQAGSPGE------------ 535
alpha1-17(XIII)   --------------------------------EKGEKGETGQAGSPGE------------ 492
alpha1-2(XIII)    --------------------------------EKGEKGETGQAGSPGE------------ 540
alpha1-5(XIII)    --------------------------------EKGEKGETGQAGSPGE------------ 530
alpha1-10(XIII)   --------------------------------EKGEKGETGQAGSPGE------------ 511
alpha1-14(XIII)   --------------------------------EKGEKGETGQAGSPGE------------ 499
alpha1-18(XIII)   --------------------------------EKGEKGETGQAGSPGE------------ 490
alpha1-4(XIII)    --------------------------------EKGEKGETGQAGSPGE------------ 533
alpha1(XXIII)     --------------------------------LKGEKGESASDSLQES------------ 403
alpha1-1(XXV)     --------------------------------MKGEKGDSGMPGPQG------------- 524
alpha1(XVII)      GYGVSLFSSSISSEDILAVLQRDDVRQYLRQYLMGPRGPPGPPGASGDGSLLSLDYAELS 1131
                                                    * :* ..  .                

alpha1-13(XIII)   ---------------VPGLPGPE-----------------------GPPGPPGLQGVPG- 571
alpha1-15(XIII)   ---------------VPGLPGPE-----------------------GPPGPPGLQGVPG- 549
alpha1-6(XIII)    ---------------VPGLPGPE-----------------------GPPGPPGLQGVPG- 571
alpha1-19(XIII)   ---------------VPGLPGPE-----------------------GPPGPPGLQGVPG- 520
alpha1-7(XIII)    ---------------EKGEAGEK-----------------------GNPGAEGLQGVPG- 572
alpha1-12(XIII)   ---------------EKGEAGEK-----------------------GNPGAEGLQGVPG- 572
alpha1(XIII)      --KGEAGEKGNPGAEVPGLPGPE-----------------------GPPGPPGLQGVPG- 586
alpha1-8(XIII)    --KGEAGEKGNPGAEVPGLPGPE-----------------------GPPGPPGLQGVPG- 586
alpha1-11(XIII)   --KGEAGEKGNPGAEVPGLPGPE-----------------------GPPGPPGLQGVPG- 567
alpha1-9(XIII)    --KGEAGEKGNPGAEVPGLPGPE-----------------------GPPGPPGLQGVPG- 557
alpha1-16(XIII)   --KGEAGEKGNPGAEVPGLPGPE-----------------------GPPGPPGLQGVPG- 529
alpha1-3(XIII)    --KGEAGEKGNPGAEVPGLPGPE-----------------------GPPGPPGLQGVPG- 569
alpha1-17(XIII)   --KGEAGEKGNPGAEVPGLPGPE-----------------------GPPGPPGLQGVPG- 526
alpha1-2(XIII)    --KGEAGEKGNPGAEVPGLPGPE-----------------------GPPGPPGLQGVPG- 574
alpha1-5(XIII)    --KGEAGEKGNPGAEVPGLPGPE-----------------------GPPGPPGLQGVPG- 564
alpha1-10(XIII)   --KGEAGEKGNPGAEVPGLPGPE-----------------------GPPGPPGLQGVPG- 545
alpha1-14(XIII)   --KGEAGEKGNPGAEVPGLPGPE-----------------------GPPGPPGLQGVPG- 533
alpha1-18(XIII)   --KGEAGEKGNPGAEVPGLPGPE-----------------------GPPGPPGLQGVPG- 524
alpha1-4(XIII)    --KGEAGEKGNPGAEVPGLPGPE-----------------------GPPGPPGLQGVPG- 567
alpha1(XXIII)     --LAQLIV-------EPGPPGPP-----------------------GPPGPMGLQGIQG- 430
alpha1-1(XXV)     ---PSIIG-------PPGPPGPH-----------------------GPPGPMGPHGLPG- 550
alpha1(XVII)      SRILSYMSSSGISIGLPGPPGPPGLPGTSYEELLSLLRGSEFRGIVGPPGPPGPPGIPGN 1191
                                   * .*                         * **. *  *: * 

alpha1-13(XIII)   ---------------PKGEAGLDGAKGEKGFQGEKGDRGPLGLP---------------- 600
alpha1-15(XIII)   ---------------PKGEAGLDGAKGEKGFQGEKGDRGPLGLP---------------- 578
alpha1-6(XIII)    ---------------PKGEAGLDGAKGEKGFQGEKGDRGPLGLPGASGLDGRP------- 609
alpha1-19(XIII)   ---------------PKGEAGLDGAKGEKGFQGEKGDRGPLGLP---------------- 549
alpha1-7(XIII)    ---------------PKGEAGLDGAKGEKGFQGEKGDRGPLGLPGASGLDGRP------- 610
alpha1-12(XIII)   ---------------PKGEAGLDGAKGEKGFQGEKGDRGPLGLP---------------- 601
alpha1(XIII)      ---------------PKGEAGLDGAKGEKGFQGEKGDRGPLGLPGASGLDGRP------- 624
alpha1-8(XIII)    ---------------PKGEAGLDGAKGEKGFQGEKGDRGPLGLP---------------- 615
alpha1-11(XIII)   ---------------PKGEAGLDGAKGEKGFQGEKGDRGPLGLP---------------- 596
alpha1-9(XIII)    ---------------PKGEAGLDGAKGEKGFQGEKGDRGPLGLPGASGLDGRP------- 595
alpha1-16(XIII)   ---------------PKGEAGLDGAKGEKGFQGEKGDRGPLGLPGASGLDGRP------- 567
alpha1-3(XIII)    ---------------PKGEAGLDGAKGEKGFQGEKGDRGPLGLPGASGLDGRP------- 607
alpha1-17(XIII)   ---------------PKGEAGLDGAKGEKGFQGEKGDRGPLGLPGASGLDGRP------- 564
alpha1-2(XIII)    ---------------PKGEAGLDGAKGEKGFQGEKGDRGPLGLPGASGLDGRP------- 612
alpha1-5(XIII)    ---------------PKGEAGLDGAKGEKGFQGEKGDRGPLGLPGASGLDGRP------- 602
alpha1-10(XIII)   ---------------PKGEAGLDGAKGEKGFQGEKGDRGPLGLPGASGLDGRP------- 583
alpha1-14(XIII)   ---------------PKGEAGLDGAKGEKGFQGEKGDRGPLGLPGASGLDGRP------- 571
alpha1-18(XIII)   ---------------PKGEAGLDGAKGEKGFQGEKGDRGPLGLPGASGLDGRP------- 562
alpha1-4(XIII)    ---------------PKGEAGLDGAKGEKGFQGEKGDRGPLGLPGASGLDGRP------- 605
alpha1(XXIII)     ---------------PKG---LDGAKGEKGASGERGPS---------------------- 450
alpha1-1(XXV)     ---------------PKG---TDGPMGPHGPAGPKGER---------------------- 570
alpha1(XVII)      VWSSISVEDLSSYLHTAGLSFIPGPPGPPGPPGPRGPPGVSGALATYAAENSDSFRSELI 1251
                                 . *     *. *  *  * :*                        

alpha1-13(XIII)   ----------------GTPGPIGVPG---------------------------------- 610
alpha1-15(XIII)   ----------------GTPGPIGVPG---------------------------------- 588
alpha1-6(XIII)    -------------GPPGTPGPIGVPG---------------------------------- 622
alpha1-19(XIII)   ----------------GTPGPIGVPG---------------------------------- 559
alpha1-7(XIII)    -------------GPPGTPGPIGVPG---------------------------------- 623
alpha1-12(XIII)   ----------------GTPGPIGVPG---------------------------------- 611
alpha1(XIII)      -------------GPPGTPGPIGVPG---------------------------------- 637
alpha1-8(XIII)    ----------------GTPGPIGVPG---------------------------------- 625
alpha1-11(XIII)   ----------------GTPGPIGVPG---------------------------------- 606
alpha1-9(XIII)    -------------GPPGTPGPIGVPG---------------------------------- 608
alpha1-16(XIII)   -------------GPPGTPGPIGVPG---------------------------------- 580
alpha1-3(XIII)    -------------GPPGTPGPIGVPG---------------------------------- 620
alpha1-17(XIII)   -------------GPPGTPGPIGVPG---------------------------------- 577
alpha1-2(XIII)    -------------GPPGTPGPIGVPG---------------------------------- 625
alpha1-5(XIII)    -------------GPPGTPGPIGVPG---------------------------------- 615
alpha1-10(XIII)   -------------GPPGTPGPIGVPG---------------------------------- 596
alpha1-14(XIII)   -------------GPPGTPGPIGVPG---------------------------------- 584
alpha1-18(XIII)   -------------GPPGTPGPIGVPG---------------------------------- 575
alpha1-4(XIII)    -------------GPPGTPGPIGVPG---------------------------------- 618
alpha1(XXIII)     ----------------GLPGPVGPPG---------------------------------- 460
alpha1-1(XXV)     ----------------GEKGAMGEP----------------------------------- 579
alpha1(XVII)      SYLTSPDVRSFIVGPPGPPGPQGPPGDSRLLSTDASHSRGSSSSSHSSSVRRGSSYSSSM 1311
                                  *  *. * *                                   

alpha1-13(XIII)   ------------------PAGPKGERG--------------------------------- 619
alpha1-15(XIII)   ------------------PAGPKGERG--------------------------------- 597
alpha1-6(XIII)    ------------------PAGPKGERG--------------------------------- 631
alpha1-19(XIII)   ------------------PAGPKGERG--------------------------------- 568
alpha1-7(XIII)    ------------------PAGPKGERG--------------------------------- 632
alpha1-12(XIII)   ------------------PAGPKGERG--------------------------------- 620
alpha1(XIII)      ------------------PAGPKGERG--------------------------------- 646
alpha1-8(XIII)    ------------------PAGPKGERG--------------------------------- 634
alpha1-11(XIII)   ------------------PAGPKGERG--------------------------------- 615
alpha1-9(XIII)    ------------------PAGPKGERG--------------------------------- 617
alpha1-16(XIII)   ------------------PAGPKGERG--------------------------------- 589
alpha1-3(XIII)    ------------------PAGPKGERG--------------------------------- 629
alpha1-17(XIII)   ------------------PAGPKGERG--------------------------------- 586
alpha1-2(XIII)    ------------------PAGPKGERG--------------------------------- 634
alpha1-5(XIII)    ------------------PAGPKGERG--------------------------------- 624
alpha1-10(XIII)   ------------------PAGPKGERG--------------------------------- 605
alpha1-14(XIII)   ------------------PAGPKGERG--------------------------------- 593
alpha1-18(XIII)   ------------------PAGPKGERG--------------------------------- 584
alpha1-4(XIII)    ------------------PAGPKGERG--------------------------------- 627
alpha1(XXIII)     ------------------LIGLPGTKG--------------------------------- 469
alpha1-1(XXV)     --------------------GPRGPYG--------------------------------- 586
alpha1(XVII)      STGGGGAGSLGAGGAFGEAAGDRGPYGTDIGPGGGYGAAAEGGMYAGNGGLLGADFAGDL 1371
                                      *  *  *                                 

alpha1-13(XIII)   -------------------------SKGDPGMTGPTGAAGL------------------- 635
alpha1-15(XIII)   -------------------------SKGDPGMTGPTGAAGL------------------- 613
alpha1-6(XIII)    -------------------------SKGDPGMTGPTGAAGL------------------- 647
alpha1-19(XIII)   -------------------------SKGDPGMTGPTGAAGL------------------- 584
alpha1-7(XIII)    -------------------------SKGDPGMTGPTGAAGL------------------- 648
alpha1-12(XIII)   -------------------------SKGDPGMTGPTGAAGL------------------- 636
alpha1(XIII)      -------------------------SKGDPGMTGPTGAAGL------------------- 662
alpha1-8(XIII)    -------------------------SKGDPGMTGPTGAAGL------------------- 650
alpha1-11(XIII)   -------------------------SKGDPGMTGPTGAAGL------------------- 631
alpha1-9(XIII)    -------------------------SKGDPGMTGPTGAAGL------------------- 633
alpha1-16(XIII)   -------------------------SKGDPGMTGPTGAAGL------------------- 605
alpha1-3(XIII)    -------------------------SKGDPGMTGPTGAAGL------------------- 645
alpha1-17(XIII)   -------------------------SKGDPGMTGPTGAAGL------------------- 602
alpha1-2(XIII)    -------------------------SKGDPGMTGPTGAAGL------------------- 650
alpha1-5(XIII)    -------------------------SKGDPGMTGPTGAAGL------------------- 640
alpha1-10(XIII)   -------------------------SKGDPGMTGPTGAAGL------------------- 621
alpha1-14(XIII)   -------------------------SKGDPGMTGPTGAAGL------------------- 609
alpha1-18(XIII)   -------------------------SKGDPGMTGPTGAAGL------------------- 600
alpha1-4(XIII)    -------------------------SKGDPGMTGPTGAAGL------------------- 643
alpha1(XXIII)     -------------------------EKGRPGEPGLDGFPGP------------------- 485
alpha1-1(XXV)     -------------------------LPGKDGEPGLDGFPGP------------------- 602
alpha1(XVII)      DYNELAVRVSESMQRQGLLQGMAYTVQGPPGQPGPQGPPGISKVFSAYSNVTADLMDFFQ 1431
                                             *  * .*  * .*                    

alpha1-13(XIII)   --PGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGL-DAPCPLGEDGLPVQGCWNK-- 690
alpha1-15(XIII)   --PGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGL-DAPCPLGEDGLPVQGCWNK-- 668
alpha1-6(XIII)    --PGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGL-DAPCPLGEDGLPVQGCWNK-- 702
alpha1-19(XIII)   --PGLHGPPGDKGNRGE------------------------------DGLPVQGCWNK-- 610
alpha1-7(XIII)    --PGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGL-DAPCPLGEDGLPVQGCWNK-- 703
alpha1-12(XIII)   --PGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGL-DAPCPLGEDGLPVQGCWNK-- 691
alpha1(XIII)      --PGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGL-DAPCPLGEDGLPVQGCWNK-- 717
alpha1-8(XIII)    --PGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGL-DAPCPLGEDGLPVQGCWNK-- 705
alpha1-11(XIII)   --PGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGL-DAPCPLGEDGLPVQGCWNK-- 686
alpha1-9(XIII)    --PGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGL-DAPCPLGEDGLPVQGCWNK-- 688
alpha1-16(XIII)   --PGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGL-DAPCPLGEDGLPVQGCWNK-- 660
alpha1-3(XIII)    --PGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGL-DAPCPLGEDGLPVQGCWNK-- 700
alpha1-17(XIII)   --PGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGL-DAPCPLGEDGLPVQGCWNK-- 657
alpha1-2(XIII)    --PGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGL-DAPCPLGEDGLPVQGCWNK-- 705
alpha1-5(XIII)    --PGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGL-DAPCPLGEDGLPVQGCWNK-- 695
alpha1-10(XIII)   --PGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGL-DAPCPLGEDGLPVQGCWNK-- 676
alpha1-14(XIII)   --PGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGL-DAPCPLGEDGLPVQGCWNK-- 664
alpha1-18(XIII)   --PGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGL-DAPCPLGEDGLPVQGCWNK-- 655
alpha1-4(XIII)    --PGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGL-DAPCPLGEDGLPVQGCWNK-- 698
alpha1(XXIII)     --RGEKGDRSERGEKGERGVPGRKGVKGQKGEPGPPGL-DQPCPVGPDGLPVPGCWHK-- 540
alpha1-1(XXV)     --RGEKGDLGEKGEKGFRGVKGEK---GEPGQPGLDGL-DAPCQLGPDGLPMPGCWQK-- 654
alpha1(XVII)      TYGAIQGPPGQKGEMGTPGPKGDRGPAGPPGHPGPPGPRGHKGEKGDKGDQVYAGRRRRR 1491
                     . :*  .::*: *                               .*  : .  .:  

alpha1-13(XIII)   ------
alpha1-15(XIII)   ------
alpha1-6(XIII)    ------
alpha1-19(XIII)   ------
alpha1-7(XIII)    ------
alpha1-12(XIII)   ------
alpha1(XIII)      ------
alpha1-8(XIII)    ------
alpha1-11(XIII)   ------
alpha1-9(XIII)    ------
alpha1-16(XIII)   ------
alpha1-3(XIII)    ------
alpha1-17(XIII)   ------
alpha1-2(XIII)    ------
alpha1-5(XIII)    ------
alpha1-10(XIII)   ------
alpha1-14(XIII)   ------
alpha1-18(XIII)   ------
alpha1-4(XIII)    ------
alpha1(XXIII)     ------
alpha1-1(XXV)     ------
alpha1(XVII)      SIAVKP 1497

MACIT Collagens Accession Numbers:

NP_005194 - (COL13A1-1; alpha1-1(XIII)) alpha 1 type XIII collagen isoform 1;
NP_542988 - (COL13A1-2; alpha1-2(XIII)) alpha 1 type XIII collagen isoform 2 ;
NP_542989 - (COL13A1-3; alpha1-3(XIII)) alpha 1 type XIII collagen isoform 3;
NP_542990 - (COL13A1-4; alpha1-4(XIII)) alpha 1 type XIII collagen isoform 4;
NP_542991 - (COL13A1-5; alpha1-5(XIII)) alpha 1 type XIII collagen isoform 5 ;
NP_542992 - (COL13A1-6; alpha1-6(XIII)) alpha 1 type XIII collagen isoform 6;
NP_542993 - (COL13A1-7; alpha1-7(XIII)) alpha 1 type XIII collagen isoform 7;
NP_542994 - (COL13A1-8; alpha1-8(XIII)) alpha 1 type XIII collagen isoform 8 ;
NP_542995 - (COL13A1-9; alpha1-9(XIII)) alpha 1 type XIII collagen isoform 9;
NP_542996 - (COL13A1-10; alpha1-10(XIII)) alpha 1 type XIII collagen isoform 10;
NP_542997 - (COL13A1-11; alpha1-11(XIII)) alpha 1 type XIII collagen isoform 11 ;
NP_542998 - (COL13A1-12; alpha1-12(XIII)) alpha 1 type XIII collagen isoform 12;
NP_542999 - (COL13A1-13; alpha1-13(XIII)) alpha 1 type XIII collagen isoform 13;
NP_543000 - (COL13A1-14; alpha1-14(XIII)) alpha 1 type XIII collagen isoform 14 ;
NP_543001 - (COL13A1-15; alpha1-15(XIII)) alpha 1 type XIII collagen isoform 15;
NP_543002 - (COL13A1-16; alpha1-16(XIII)) alpha 1 type XIII collagen isoform 16;
NP_543003 - (COL13A1-17; alpha1-17(XIII)) alpha 1 type XIII collagen isoform 17 ;
NP_543004 - (COL13A1-18; alpha1-18(XIII)) alpha 1 type XIII collagen isoform 18;
NP_543005 - (COL13A1-19; alpha1-19(XIII)) alpha 1 type XIII collagen isoform 19;
NP_000485 - (COL17A1; alpha1(XVII)) alpha 1 type XVII collagen;
NP_775736 - (COL23A1; alpha1(XXIII)) collagen, type XXIII, alpha 1;
NP_942014 - (COL25A1-1; alpha1-1(XXV)) collagen, type XXV, alpha 1 isoform 1

Multiplexins Isoform Sequence Alignment

alpha1-1(XVIII)   MAPYPCGCHILLLLFCCLAAARANLLNLNWLWFNNEDTSHAATTIPEPQGPLPVQPTADT 60
alpha1-2(XVIII)   ------------------------------------------------------------
alpha1(XV)        ------------------------------------------------------------
                                                                                 

alpha1-1(XVIII)   TTHVTPRNGSTEPATAPGSPEPPSELLEDGQDTPTSAESPDAPEENIAGVGAEILNVAKG 120
alpha1-2(XVIII)   --------------MAPRCPWP-------------------------------------- 8
alpha1(XV)        --------------MAPRRNNGQ------------------------------------- 9
                                 **                                           

alpha1-1(XVIII)   IRSFVQLWNDTVPTESLARAETLVLETPVGPLALAGPSSTPQENGTTLWPSRGIPSSPGA 180
alpha1-2(XVIII)   ------------------------------------------------WPRR-------- 12
alpha1(XV)        ------------------------------------------------------------
                                                                                 

alpha1-1(XVIII)   HTTEAGTLPAPTPSPPSLGRPWAPLTGPSVPPPSSERISE-EVGLLQLLGDPPPQQVTQT 239
alpha1-2(XVIII)   ------------RRLLDVLAPLVLLLGVRAASAEPERISE-EVGLLQLLGDPPPQQVTQT 59
alpha1(XV)        -----------CWCLLMLLSVSTPLPAVTQTRGATETASQGHLDLTQLIGVPLPSSVSFV 58
                                   :    . * .   .   .*  *: .:.* **:* * *..*: .

alpha1-1(XVIII)   DDPDVGLAYVFGPDANSGQVARYHFPSLFFRDFSLLFHIRPATEGPGVLFAITDSAQAMV 299
alpha1-2(XVIII)   DDPDVGLAYVFGPDANSGQVARYHFPSLFFRDFSLLFHIRPATEGPGVLFAITDSAQAMV 119
alpha1(XV)        TGYGGFPAYSFGPGANVGRPARTLIPSTFFRDFAISVVVKPSSTRGGVLFAITDAFQKVI 118
                   . .   ** ***.** *: **  :** *****:: . ::*::   ********: * ::

alpha1-1(XVIII)   LLGVKLSGVQDGHQDISLLYTEPGAGQTHTAASFRLPAFVGQWTHLALSVAGGFVALYVD 359
alpha1-2(XVIII)   LLGVKLSGVQDGHQDISLLYTEPGAGQTHTAASFRLPAFVGQWTHLALSVAGGFVALYVD 179
alpha1(XV)        YLGLRLSGVEDGHQRIILYYTEPGSHVSQEAAAFSVPVMTHRWNRFAMIVQGEEVTLLVN 178
                   **::****:**** * * *****:  :: **:* :*.:. :*.::*: * *  *:* *:

alpha1-1(XVIII)   CEEFQRMPLARSSRGLELEPGAGLFVAQAGGADPDKFQGVIAELKVRRDPQVSPMHCLDE 419
alpha1-2(XVIII)   CEEFQRMPLARSSRGLELEPGAGLFVAQAGGADPDKFQGVIAELKVRRDPQVSPMHCLDE 239
alpha1(XV)        CEEHSRIPFQRSSQALAFESSAGIFMGNAGATGLERFTGSLQQLTVHPDPRTPEELCDPE 238
                  ***..*:*: ***:.* :*..**:*:.:**.:. ::* * : :*.*: **:..   *  *

alpha1-1(XVIII)   EGDDSDGASGDSGSGLGDARELLREETGAALKPRLPAPPPVTTPPLAGGSSTEDSRSEEV 479
alpha1-2(XVIII)   EGDDSDGASGDSGSGLGDARELLREETGAALKPRLPAPPPVTTPPLAGGSSTEDSRSEEV 299
alpha1(XV)        ESSASGETSG--LQEADGVAEILEAVTYTQASPKEAKVEPINTPPTPSSPFEDMELSGEP 296
                  *.. *. :**   .  ... *:*.  * :  .*: .   *:.*** ....  : . * * 

alpha1-1(XVIII)   EEQTTVASLGAQTLPGSDSVS--------TWDGSVRTPGGRVKEGGLKGQKGEPGVPGPP 531
alpha1-2(XVIII)   EEQTTVASLGAQTLPGSDSVS--------TWDGSVRTPGGRVKEGGLKGQKGEPGVPGPP 351
alpha1(XV)        VPEGTLETTNMSIIQHSSPKQGSGEILNDTLEGVHSVDGDPITDSGSGAGAFLDIAEEKN 356
                    : *: : . . :  *.. .        * :*   . *. :.:.*  .      .    

alpha1-1(XVIII)   GRAGPPGSPCLPGPPGLPCPVSPLGPAGPALQTVPGPQGPPGPPGRDGTPGRDGEPGDPG 591
alpha1-2(XVIII)   GRAGPPGSPCLPGPPGLPCPVSPLGPAGPALQTVPGPQGPPGPPGRDGTPGRDGEPGDPG 411
alpha1(XV)        LAATAAGLAEVPISTAGEAEASSVPTGGPTLSMSTENPEEGVTPGPDNEERLAATAAGEA 416
                    * ..* . :* ...  . .*.: ..**:*.  .       .** *.     . ... .

alpha1-1(XVIII)   EDGKPGDTGPQGFPGTPGDVGPKGDKGDPGVGERGPPGPQGPPGPPGPSFRHDKLTFIDM 651
alpha1-2(XVIII)   EDGKPGDTGPQGFPGTPGDVGPKGDKGDPGVGERGPPGPQGPPGPPGPSFRHDKLTFIDM 471
alpha1(XV)        EALASMPGEVEASGVAPGELDLSMSAQSLGEEATVGPSSEDSLTTAAAATEVSLSTFEDE 476
                  *   .     :.   :**::. . .  . *      *..:..  ....: . .  ** * 

alpha1-1(XVIII)   EGSGFGGD-----LEALRGPRGFPGPPG--------------------PPGVPGLPGEPG 686
alpha1-2(XVIII)   EGSGFGGD-----LEALRGPRGFPGPPG--------------------PPGVPGLPGEPG 506
alpha1(XV)        EASGVPTDGLAPLTATMAPERAVTSGPGDEEDLAAATTEEPLITAGGEESGSPPPDGPPL 536
                  *.**.  *       ::   *.... **                     .* *   * * 

alpha1-1(XVIII)   RFGVNSSD---VPGPAGLPGVPGREGPPGFPG-----LPGPPGPPGREGPPGRTGQKGS- 737
alpha1-2(XVIII)   RFGVNSSD---VPGPAGLPGVPGREGPPGFPG-----LPGPPGPPGREGPPGRTGQKGS- 557
alpha1(XV)        PLPTVAPERWITPAQREHVGMKGQAGPKGEKGDAGEELPGPPEPSGPVGPTAGAEAEGSG 596
                   : . :.:   .*.     *: *: ** *  *     ***** *.*  **.. :  :** 

alpha1-1(XVIII)   LGEAGAPGHK-----GS----KGAPGPAGARGESGLAGAP------GPAGPPGPPGPPGP 782
alpha1-2(XVIII)   LGEAGAPGHK-----GS----KGAPGPAGARGESGLAGAP------GPAGPPGPPGPPGP 602
alpha1(XV)        LGWGSDVGSGSGDLVGSEQLLRGPPGPPGPPGLPGIPGKPGTDVFMGPPGSPGEDGPAGE 656
                  ** ..  *       **    :*.***.*. * .*:.* *      **.*.**  **.* 

alpha1-1(XVIII)   PGPGLPAGFDDMEGSGGPFWSTARSADGPQGPPGLPGLKGDPGVPGLPGAKGEVGADGVP 842
alpha1-2(XVIII)   PGPGLPAGFDDMEGSGGPFWSTARSADGPQGPPGLPGLKGDPGVPGLPGAKGEVGADGVP 662
alpha1(XV)        PGPPGPEGQPGVDGATG--LPGMKGEKGARGPNGSVGEKGDPGNRGLPGPPGKKGQAGPP 714
                  ***  * *  .::*: *   .  :. .*.:** *  * *****  ****. *: *  * *

alpha1-1(XVIII)   GFPGLPGREGIAGPQGP----------------------------------KGDRGSRGE 868
alpha1-2(XVIII)   GFPGLPGREGIAGPQGP----------------------------------KGDRGSRGE 688
alpha1(XV)        GVMGPPGPPGPPGPPGPGCTMGLGFEDTEGSGSTQLLNEPKLSRPTAAIGLKGEKGDRGP 774
                  *. * **  * .** **                                  **::*.** 

alpha1-1(XVIII)   KGDPGKDGVGQPGLPGPPGPPGPVVYVS-------------EQDGSVLSVPGPEGRPGFA 915
alpha1-2(XVIII)   KGDPGKDGVGQPGLPGPPGPPGPVVYVS-------------EQDGSVLSVPGPEGRPGFA 735
alpha1(XV)        KGERGMDGASIVGPPGPRGPPGHIKVLSNSLINITHGFMNFSDIPELVGPPGPDGLPGLP 834
                  **: * **..  * *** **** :  :*             .:  .::. ***:* **:.

alpha1-1(XVIII)   GFPGPAGPKGNLGSKGERGSPGPKGEKGEPGSIFSPDGGALGPAQKGAKGEPGFRGPPGP 975
alpha1-2(XVIII)   GFPGPAGPKGNLGSKGERGSPGPKGEKGEPGSIFSPDGGALGPAQKGAKGEPGFRGPPGP 795
alpha1(XV)        GFPGPRGPKGDTGLPGFPGLKGEQGEKGEPGAILTED--IPLERLMGKKGEPGMHGAPGP 892
                  ***** ****: *  *  *  * :*******:*:: *         * *****::*.***

alpha1-1(XVIII)   YGR---PGYKGEIGFPGRPGRPGMNGLKGEKGEPGDASLGFGMRGMPGPPGPPGPPGPPG 1032
alpha1-2(XVIII)   YGR---PGYKGEIGFPGRPGRPGMNGLKGEKGEPGDASLGFGMRGMPGPPGPPGPPGPPG 852
alpha1(XV)        MGPKGPPGHKGEFGLPGRPGRPGLNGLKGTKGDPG-----VIMQGPPGLPGPPGPPGPPG 947
                   *    **:***:*:********:***** **:**     . *:* ** ***********

alpha1-1(XVIII)   TPVYDS------------NVFAESSRPGPP---------GLPGNQGPPGPKGAKGEVGPP 1071
alpha1-2(XVIII)   TPVYDS------------NVFAESSRPGPP---------GLPGNQGPPGPKGAKGEVGPP 891
alpha1(XV)        AVINIKGAIFPIPVRPHCKMPVDTAHPGSPELITFHGVKGEKGSWGLPGSKGEKGDQGAQ 1007
                  : :  .            :: .::::**.*         *  *. * **.** **: *. 

alpha1-1(XVIII)   GPPGQFPFDFLQLEAEMKGEKGDRGDAGQKGERGEPG--GGGFFGSSLPGPPGPPGPRGY 1129
alpha1-2(XVIII)   GPPGQFPFDFLQLEAEMKGEKGDRGDAGQKGERGEPG--GGGFFGSSLPGPPGPPGPRGY 949
alpha1(XV)        GPPG-PPLDLAYLRHFLNNLKGENGDKGFKGEKGEKGDINGSFLMSGPPGLPGNPGPAGQ 1066
                  ****  *:*:  *.  ::. **:.** * ***:** *  .*.*: *. ** ** *** * 

alpha1-1(XVIII)   PG--IPGPKGESIRGQPGPPGPQGPPGIGYEGRQGPPGPPGPPGPPSFPGPHRQTISVPG 1187
alpha1-2(XVIII)   PG--IPGPKGESIRGQPGPPGPQGPPGIGYEGRQGPPGPPGPPGPPSFPGPHRQTISVPG 1007
alpha1(XV)        KGETVVGPQG-----PPGAPGLPGPPGFGRPGDPGPPGPPGPPGPPAILG---AAVALPG 1118
                   *  : **:*      **.**  ****:*  *  ************:: *    ::::**

alpha1-1(XVIII)   PPGPPGPPGPPGTMGASSGVRLWATRQAMLGQVHEVPEGWLIFVAEQEELYVRVQNGFRK 1247
alpha1-2(XVIII)   PPGPPGPPGPPGTMGASSGVRLWATRQAMLGQVHEVPEGWLIFVAEQEELYVRVQNGFRK 1067
alpha1(XV)        PPGPPGQPGLPGSR---NLVTAFSNMDDMLQKAHLVIEGTFIYLRDSTEFFIRVRDGWKK 1175
                  ****** ** **:    . *  ::. : ** :.* * ** :*:: :. *:::**::*::*

alpha1-1(XVIII)   VQLEARTPLPRGTDNEVAALQPPVVQLHDSNPYPRREHPHPTARPWRADDILASPPRLPE 1307
alpha1-2(XVIII)   VQLEARTPLPRGTDNEVAALQPPVVQLHDSNPYPRREHPHPTARPWRADDILASPPRLPE 1127
alpha1(XV)        LQLGELIPIP-----------------ADSPPPP----------------ALSSNPHQLL 1202
                  :**    *:*                  ** * *                 *:* *:   

alpha1-1(XVIII)   PQPYPGAPHHSSYVHLRPARPTSPPAHSHRDFQPVLHLVALNSPLSGGMRGIRGADFQCF 1367
alpha1-2(XVIII)   PQPYPGAPHHSSYVHLRPARPTSPPAHSHRDFQPVLHLVALNSPLSGGMRGIRGADFQCF 1187
alpha1(XV)        PPPNP--------------------ISSANYEKPALHLAALNMPFSGDIR----ADFQCF 1238
                  * * *                      * .  :*.***.*** *:**.:*    ******

alpha1-1(XVIII)   QQARAVGLAGTFRAFLSSRLQDLYSIVRRADRAAVPIVNLKDELLFPSWEALFSGSEGPL 1427
alpha1-2(XVIII)   QQARAVGLAGTFRAFLSSRLQDLYSIVRRADRAAVPIVNLKDELLFPSWEALFSGSEGPL 1247
alpha1(XV)        KQARAAGLLSTYRAFLSSHLQDLSTIVRKAERYSLPIVNLKGQVLFNNWDSIFSGHGGQF 1298
                  :****.** .*:******:**** :***:*:* ::******.::** .*:::***  * :

alpha1-1(XVIII)   KPGARIFSFDGKDVLRHPTWPQKSVWHGSDPNGRRLTESYCETWRTEAPSATGQASSLLG 1487
alpha1-2(XVIII)   KPGARIFSFDGKDVLRHPTWPQKSVWHGSDPNGRRLTESYCETWRTEAPSATGQASSLLG 1307
alpha1(XV)        NMHIPIYSFDGRDIMTDPSWPQKVIWHGSSPHGVRLVDNYCEAWRTADTAVTGLASPLST 1358
                  :    *:****:*:: .*:**** :****.*:* **.:.***:***  .:.** **.*  

alpha1-1(XVIII)   GRLLGQSAASCHHAYIVLCIENSFMTASK- 1516
alpha1-2(XVIII)   GRLLGQSAASCHHAYIVLCIENSFMTASK- 1336
alpha1(XV)        GKILDQKAYSCANRLIVLCIENSFMTDARK 1388
                  *::*.*.* ** :  *********** :: 

Multiplexin Collagens Accession Numbers:

NP_085059 - (COL18A1-1; alpha1-1(XVIII)) alpha 1 type XVIII collagen isoform 1 ;
NP_569712 - (COL18A1-2; alpha1-2(XVIII) alpha 1 type XVIII collagen isoform 2 ;
NP_001846 - (COL15A1; alpha1(XV)) alpha 1 type XV collagen

Short Chain Collagens Isoform Sequence Alignment

alpha1(VIII)   MAVLPGPLQLLGVLLTISLSSIRLIQAGAYYGIKPLPPQIPPQMPPQIPQYQPLGQQVPH 60
alpha2(VIII)   ---MLGTLTPLSSLLLLLL--VLVLGCG-------------------------------- 23
alpha1(X)      --MLPQIPFLLLVSLNLVHG---------------------------------------- 18
                  :      *   * :                                           

alpha1(VIII)   MPLAKDGLAMGKEMPHLQYGKEYPHLPQYMKEIQPAPRMGKEAVPKKGKEIPLASLRGEQ 120
alpha2(VIII)   -PRASSGGGAGGAAG---YAPVKYIQPMQKGPVGPPFREGKGQYLEMPLPLLPMDLKGEP 79
alpha1(X)      ----------------VFYAERYQMPTGIKGPLPNTKTQFFIPYTIKSKGIAVRGEQGTP 62
                                 *.      .     :  .              :   . :*  

alpha1(VIII)   GPRGEPGPRGPPGPPGLPG---HGIPGIKGKPGPQGYPG---VGKPGMPGMPGKPGAMGM 174
alpha2(VIII)   GPPGKPGPRGPPGPPGFPGKPGMGKPGLHGQPGPAGPPGFSRMGKAGPPGLPGKVGPPGQ 139
alpha1(X)      GPPGPAGPRGHPGPSGPPGKPGYGSPGLQGEPGLPGPPGPSAVGKPGVPGLPGKPGERGP 122
               ** * .**** ***.* **    * **::*:**  * **   :**.* **:*** *  * 

alpha1(VIII)   PGAKGEIGQKGEIGPMGIPGPQGPPGPHGLPGIGKPGGPGLPGQPGPKGDRGPKGLPGPQ 234
alpha2(VIII)   PGLRGEPGIRGDQGLRGPPGPPGLPGPSGITIPGKPGAQGVPGPPGFQGEPGPQGEPGPP 199
alpha1(X)      YGPKGDVGPAGLPGPRGPPGPPGIPGPAGISVPGKPGQQGPTGAPGPRGFPGEKGAPGVP 182
                * :*: *  *  *  * *** * *** *:.  ****  * .* ** :*  * :* **  

alpha1(VIII)   GLRGPKGDKGFGMPGAPGVKGPPGMHGPPGPVGLPGVGKPGVTGFPGPQGPLGKPGAPGE 294
alpha2(VIII)   GDRGLKGDNGVGQPGLPGAPGQGGAPGPPGLPGPAGLGKPGLDGLPGAPGDKGESGPPGV 259
alpha1(X)      GMNGQKGEMGYGAPGRPGERGLPGPQGPTGPSGPPGVGKRGENGVPGQPGIKGDRGFPGE 242
               * .* **: * * ** **  *  *  **.*  * .*:** *  *.**  *  *. * ** 

alpha1(VIII)   PGPQGPIGVPGVQGPPGIPGIGKPGQDGIPGQPGFPGGKGEQGLPGLPGPPGLPGIGKPG 354
alpha2(VIII)   PGPRGEPGAVGPKGPPGVDGVGVPGAAGLPGPQGPSGAKGEPGTRGPPGLIGPTGYGMPG 319
alpha1(X)      MGPIGPPGPQGPPGERGPEGIGKPGAAGAPGQPGIPGTKGLPGAPGIAGPPGPPGFGKPG 302
                ** *  *  *  *  *  *:* **  * **  * .* **  *  * .*  * .* * **

alpha1(VIII)   FPGPKGDRGMGGVPGALGPRGEKGPIGAPGIGGPPGEPGLPGIPGPMGPPGAIGFPGPKG 414
alpha2(VIII)   LPGPKGDRGPAGVPGLLGDRGEPGEDGEPGEQGPQGLGGPPGLPGSAGLPGRRGPPGPKG 379
alpha1(X)      LPGLKGERGPAGLPGGPGAKGEQGPAGLPGKPGLTGPPGNMGPQGPKGIPGSHGLPGPKG 362
               :** **:** .*:**  * :** *  * **  *  *  *  *  *. * **  * *****

alpha1(VIII)   EGGIVGPQGPPGPKGEPGLQGFPGKPGFLGEVGPPGMRGLPGPIGPKGEAGQKGVPGLPG 474
alpha2(VIII)   EAGPGGPPGVPGIRGDQGPSGLAGKPGVPGERGLPGAHGPPGPTGPKGEPGFTGRPGGPG 439
alpha1(X)      ETGPAGPAGYPGAKGERGSPGSDGKPGYPGKPGLDGPKGNPGLPGPKGDPGVGGPPGLPG 422
               * *  ** * ** :*: *  *  ****  *: *  * :* **  ****:.*  * ** **

alpha1(VIII)   VPGLLGPKGEPGIPGDQGLQGPPGIPGIGGPSGPIGPPGIPGPKGEPGLPGPPGFPGIGK 534
alpha2(VIII)   VAGALGQKGDLGLPGQPGLRGPSGIPGLQGPAGPIGPQGLPGLKGEPGLPGPPGEGRAGE 499
alpha1(X)      PVGPAGAKGMPGHNGEAGPRGAPGIPGTRGPIGPPGIPGFPGSKGDPGSPGPPGPAGIAT 482
                 *  * **  *  *: * :*..****  ** ** *  *:** **:** *****    . 

alpha1(VIII)   PGVAGLHGPPGKPGALGPQGQPGLPGPPGPPGPPGPPAVMPPTPPPQGEYLPDMGLGIDG 594
alpha2(VIII)   PGTAGPTGPPGVPGSPGITGP---PGPPGPPGPPGAPGAFDETG-IAGLHLPNG--GVEG 553
alpha1(X)      KGLNGPTGPPGPPGPRGHSGEPGLPGPPGPPGPPGQ-AVMPEGFIKAGQRPSLS-----G 536
                *  *  **** **. *  *    ***********  ..:       *   .       *

alpha1(VIII)   VKPPHAYGAKKGKNGGPAYEMPAFTAELTAPFPPVGAPVKFNKLLYNGRQNYNPQTGIFT 654
alpha2(VIII)   AVLGKGGKPQFGLGELSAHATPAFTAVLTSPFPASGMPVKFDRTLYNGHSGYNPATGIFT 613
alpha1(X)      TPLVSANQGVTG------MPVSAFTVILSKAYPAIGTPIPFDKILYNRQQHYDPRTGIFT 590
               .    .     *         .***. *: .:*. * *: *:: *** :. *:* *****

alpha1(VIII)   CEVPGVYYFAYHVHCKGGNVWVALFKNNEPVMYTYDEYKKGFLDQASGSAVLLLRPGDRV 714
alpha2(VIII)   CPVGGVYYFAYHVHVKGTNVWVALYKNNVPATYTYDEYKKGYLDQASGGAVLQLRPNDQV 673
alpha1(X)      CQIPGIYYFSYHVHVKGTHVWVGLYKNGTPVMYTYDEYTKGYLDQASGSAIIDLTENDQV 650
               * : *:***:**** ** :***.*:**. *. ******.**:******.*:: *  .*:*

alpha1(VIII)   FLQMPSEQAAGLYAGQYVHSSFSGYLLYPM 744
alpha2(VIII)   WVQMPSDQANGLYSTEYIHSSFSGFLLCPT 703
alpha1(X)      WLQLPNAESNGLYSSEYVHSSFSGFLVAPM 680
               ::*:*. :: ***: :*:******:*: * 

Short Chain Collagens Accession Numbers:

NP_001841 - (COL8A1; alpha1(VIII)) alpha 1 type VIII collagen;
NP_005193 - (COL8A2; alpha2(VIII)) collagen, type VIII, alpha 2;
NP_000484 - (COL10A1; alpha1(X)) collagen, type X, alpha 1

Types VI and XXVIII Collagen Isoform Sequence Alignment

alpha3-1(VI)      MRKHRHLPLVAVFCLFLSGFPTTHAQQQQADVKNGAAADIIFLVDSSWTIGEEHFQLVRE 60
alpha3-4(VI)      MRKHRHLPLVAVFCLFLSGFPTTHAQQQQADVKNGAAADIIFLVDSSWTIGEEHFQLVRE 60
alpha3-5(VI)      MRKHRHLPLVAVFCLFLSGFPTTHAQQQQAAQDS---ADIIFLIDGSNNTGSVNFAVILD 57
alpha3-2(VI)      MRKHRHLPLVAVFCLFLSGFPTTHAQQQQADVKNGAAADIIFLVDSSWTIGEEHFQLVRE 60
alpha3-3(VI)      MRKHRHLPLVAVFCLFLSGFPTTHAQQQQADVKNGAAADIIFLVDSSWTIGEEHFQLVRE 60
alpha6(VI)        ------MMLLILFLVIICSHISVNQDS------GPEYADVVFLVDSSDRLGSKSFPFVKM 48
alpha2-2C2(VI)    ------------------------------------------------------------
alpha2-2C2a(VI)   ------------------------------------------------------------
alpha1(VI)        ------------------------------------------------------------
alpha1(XXVIII)    ------------------------------------------------------------
                                                                                 

alpha3-1(VI)      FLYDVVKSLAVGENDFHFALVQFNGNPHTEFLLNTYRTKQEVLSHISN-MSYIG-GTNQT 118
alpha3-4(VI)      FLYDVVKSLAVGENDFHFALVQFNGNPHTEFLLNTYRTKQEVLSHISN-MSYIG-GTNQT 118
alpha3-5(VI)      FLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYSTKAQVLGAVKA-LGFAGGELANI 116
alpha3-2(VI)      FLYDVVKSLAVGENDFHFALVQFNGNPHTEFLLNTYRTKQEVLSHISN-MSYIG-GTNQT 118
alpha3-3(VI)      FLYDVVKSLAVGENDFHFALVQFNGNPHTEFLLNTYRTKQEVLSHISN-MSYIG-GTNQT 118
alpha6(VI)        FITKMISSLPIEADKYRVALAQYSDKLHSEFHLSTFKGRSPMLNHLRKNFGFIG-GSLQI 107
alpha2-2C2(VI)    ------------------------------------------------------------
alpha2-2C2a(VI)   ------------------------------------------------------------
alpha1(VI)        ------------------------------------------------------------
alpha1(XXVIII)    ------------------------------------------------------------
                                                                                 

alpha3-1(VI)      GKGLEYIMQSHLTKAAGSRAGDGVPQVIVVLTDGHSKDGLALPSAELKSADVNVFAIGVE 178
alpha3-4(VI)      GKGLEYIMQSHLTKAAGSRAGDGVPQVIVVLTDGHSKDGLALPSAELKSADVNVFAIGVE 178
alpha3-5(VI)      GLALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPSSDEIRYGVVALKQASVFSFGLGAQ 176
alpha3-2(VI)      GKGLEYIMQSHLTKAAGSRAGDGVPQVIVVLTDGHSKDGLALPSAELKSADVNVFAIGVE 178
alpha3-3(VI)      GKGLEYIMQSHLTKAAGSRAGDGVPQVIVVLTDGHSKDGLALPSAELKSADVNVFAIGVE 178
alpha6(VI)        GKALQEAHRTYFSAPANGRDKKQFPPILVVLASSESEDNVEEASKALRKDGVKIISVGVQ 167
alpha2-2C2(VI)    ------------------------------------------------------------
alpha2-2C2a(VI)   ------------------------------------------------------------
alpha1(VI)        ------------------------------------------------------------
alpha1(XXVIII)    ------------------------------------------------------------
                                                                                 

alpha3-1(VI)      DADEGALKEIASEPLNMHMFNLENFTSLHDIVGNLVSCVHSSVSPERAGDTETLKDITAQ 238
alpha3-4(VI)      DADEGALKEIASEPLNMHMFNLENFTSLHDIVGNLVSCVHSSVSPERAGDTETLKDIT-- 236
alpha3-5(VI)      AASRAELQHIATDDN--LVFTVPEFRSFGDLQEKLLPYIVGVAQRHIVLKPPTIVTQV-- 232
alpha3-2(VI)      DADEGALKEIASEPLNMHMFNLENFTSLHDIVGNLVSCVHSSVSPERAGDTETLKDITAQ 238
alpha3-3(VI)      DADEGALKEIASEPLNMHMFNLENFTSLHDIVGNLVSCVHSSVSPERAGDTETLKDIT-- 236
alpha6(VI)        KASEENLKAMATSQFHFNLRTVRDLSMFSQNMTHIIKDVIKYKEGAVDDIFVEACQGP-- 225
alpha2-2C2(VI)    ------------------------------------------------------------
alpha2-2C2a(VI)   ------------------------------------------------------------
alpha1(VI)        ------------------------------------------------------------
alpha1(XXVIII)    ------------------------------------------------------------
                                                                                 

alpha3-1(VI)      DSADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDT 298
alpha3-4(VI)      ------------------------------------------------------------
alpha3-5(VI)      ------------------------------------------------------------
alpha3-2(VI)      DSADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDT 298
alpha3-3(VI)      ------------------------------------------------------------
alpha6(VI)        ------------------------------------------------------------
alpha2-2C2(VI)    ------------------------------------------------------------
alpha2-2C2a(VI)   ------------------------------------------------------------
alpha1(VI)        ------------------------------------------------------------
alpha1(XXVIII)    ------------------------------------------------------------
                                                                                 

alpha3-1(VI)      YSTKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPS 358
alpha3-4(VI)      ------------------------------------------------------------
alpha3-5(VI)      ------------------------------------------------------------
alpha3-2(VI)      YSTKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPS 358
alpha3-3(VI)      ------------------------------------------------------------
alpha6(VI)        ------------------------------------------------------------
alpha2-2C2(VI)    ------------------------------------------------------------
alpha2-2C2a(VI)   ------------------------------------------------------------
alpha1(VI)        ------------------------------------------------------------
alpha1(XXVIII)    ------------------------------------------------------------
                                                                                 

alpha3-1(VI)      SDEIRYGVVALKQASVFSFGLGAQAASRAELQHIATDDNLVFTVPEFRSFGDLQEKLLPY 418
alpha3-4(VI)      ------------------------------------------------------------
alpha3-5(VI)      ------------------------------------------------------------
alpha3-2(VI)      SDEIRYGVVALKQASVFSFGLGAQAASRAELQHIATDDNLVFTVPEFRSFGDLQEKLLPY 418
alpha3-3(VI)      ------------------------------------------------------------
alpha6(VI)        ------------------------------------------------------------
alpha2-2C2(VI)    ------------------------------------------------------------
alpha2-2C2a(VI)   ------------------------------------------------------------
alpha1(VI)        ------------------------------------------------------------
alpha1(XXVIII)    ------------------------------------------------------------
                                                                                 

alpha3-1(VI)      IVGVAQRHIVLKPPTIVTQVIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIG 478
alpha3-4(VI)      -------------------VIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIG 277
alpha3-5(VI)      --------------------IEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIG 272
alpha3-2(VI)      IVGVAQRHIVLKPPTIVTQVIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIG 478
alpha3-3(VI)      ---------------------AQDSADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIG 275
alpha6(VI)        -----------------------SMADVVFLLDMSINGSEENFDYLKGFLEESVSALDIK 262
alpha2-2C2(VI)    ------------------------------------------------------------
alpha2-2C2a(VI)   ------------------------------------------------------------
alpha1(VI)        ------------------------------------------------------------
alpha1(XXVIII)    ------------------------------------------------------------
                                                                                 

alpha3-1(VI)      QDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFT 538
alpha3-4(VI)      QDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFT 337
alpha3-5(VI)      QDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFT 332
alpha3-2(VI)      QDLIQVAVAQYADTVRPEFYFNTHPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFT 538
alpha3-3(VI)      TQQIRVGVVQFSDEPRTMFSLDTYSTKAQVLGAVKALGFAGGELANIGLALDFVVENHFT 335
alpha6(VI)        ENCMRVGLVAYSNETKVINSLSMGINKSEVLQHIQNLSPRTG-KAYTGAAIKKLRKEVFS 321
alpha2-2C2(VI)    ------------------------------------------------------------
alpha2-2C2a(VI)   ------------------------------------------------------------
alpha1(VI)        ------------------------------------------------------------
alpha1(XXVIII)    ------------------------------------------------------------
                                                                                 

alpha3-1(VI)      SSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFD 598
alpha3-4(VI)      SSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFD 397
alpha3-5(VI)      SSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFD 392
alpha3-2(VI)      SSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFD 598
alpha3-3(VI)      RAGGSRVEEGVPQVLVLISAGPSSDEIRYGVVALKQASVFSFGLGAQAASRAELQHIATD 395
alpha6(VI)        ARNGSRKNQGVPQIAVLVTHRDSEDNVTKAAVNLRREGVTIFTLGIEGASDTQLEKIASH 381
alpha2-2C2(VI)    ------------------------------------------------------------
alpha2-2C2a(VI)   ------------------------------------------------------------
alpha1(VI)        ------------------------------------------------------------
alpha1(XXVIII)    ------------------------------------------------------------
                                                                                 

alpha3-1(VI)      SSLVFIPAEFR-----AAPLQGMLPGLLAPLRTLSG----------TPEVHSNKRDIIFL 643
alpha3-4(VI)      SSLVFIPAEFR-----AAPLQGMLPGLLAPLRTLSG----------TPEVHSNKRDIIFL 442
alpha3-5(VI)      SSLVFIPAEFR-----AAPLQGMLPGLLAPLRTLSG----------TPEVHSNKRDIIFL 437
alpha3-2(VI)      SSLVFIPAEFR-----AAPLQGMLPGLLAPLRTLSG----------TPEVHSNKRDIIFL 643
alpha3-3(VI)      DNLVFTVPEFRSFGDLQEKLLPYIVGVAQRHIVLKPPTIV------TQVIEVNKRDIVFL 449
alpha6(VI)        PAEQYVSKLKT-FADLAAHNQTFLKKLRNQITHTVSVFSERTETLKSGCVDTEEADIYLL 440
alpha2-2C2(VI)    ------------------------------------------------------------
alpha2-2C2a(VI)   ------------------------------------------------------------
alpha1(VI)        ------------------------------------------------------------
alpha1(XXVIII)    ------------------------------------------------------------
                                                                                 

alpha3-1(VI)      LDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDIL 703
alpha3-4(VI)      LDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDIL 502
alpha3-5(VI)      LDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDIL 497
alpha3-2(VI)      LDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQTKSDIL 703
alpha3-3(VI)      VDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFNTHPTKREVI 509
alpha6(VI)        IDGSGSTQATDFHEMKTFLSEVVGMFNIAPHKVRVGAVQYADSWDLEFEINKYSNKQDLG 500
alpha2-2C2(VI)    ------------------------------------------------------------
alpha2-2C2a(VI)   ------------------------------------------------------------
alpha1(VI)        ------------------------------------------------------------
alpha1(XXVIII)    ------------------------------------------------------------
                                                                                 

alpha3-1(VI)      GHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDSYLQAA 763
alpha3-4(VI)      GHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDSYLQAA 562
alpha3-5(VI)      GHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDSYLQAA 557
alpha3-2(VI)      GHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDSYLQAA 763
alpha3-3(VI)      TAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPA 569
alpha6(VI)        KAIENIRQMGGN-TNTGAALNFTLS--LLQKAKKQRGNKVPCHLVVLTNGMSKDSILEPA 557
alpha2-2C2(VI)    ------------------------------------------------------------
alpha2-2C2a(VI)   ------------------------------------------------------------
alpha1(VI)        ------------------------------------------------------------
alpha1(XXVIII)    ------------------------------------------------------------
                                                                                 

alpha3-1(VI)      NALTRAGILTFCVGASQANKAELEQIAFNPSLVYLMDDF--SSLPALPQQLIQPLTTYVS 821
alpha3-4(VI)      NALTRAGILTFCVGASQANKAELEQIAFNPSLVYLMDDF--SSLPALPQQLIQPLTTYVS 620
alpha3-5(VI)      NALTRAGILTFCVGASQANKAELEQIAFNPSLVYLMDDF--SSLPALPQQLIQPLTTYVS 615
alpha3-2(VI)      NALTRAGILTFCVGASQANKAELEQIAFNPSLVYLMDDF--SSLPALPQQLIQPLTTYVS 821
alpha3-3(VI)      QELKRSSIMAFAIGNKGADQAELEEIAFDSSLVFIPAEFRAAPLQGMLPGLLAPLRTLSG 629
alpha6(VI)        NRLREEHIRVYAIGIKEANQTQLREIAGEEKRVYYVHDF--DALKDIRNQVVQEICTEEA 615
alpha2-2C2(VI)    ------------------------------------------------------------
alpha2-2C2a(VI)   ------------------------------------------------------------
alpha1(VI)        ------------------------------------------------------------
alpha1(XXVIII)    ------------------------------------------------------------
                                                                                 

alpha3-1(VI)      GGVEEVPLAQPESKRDILFLFDGSANLVGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYS 881
alpha3-4(VI)      GGVEEVPLAQPESKRDILFLFDGSANLVGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYS 680
alpha3-5(VI)      GGVEEVPLAQPESKRDILFLFDGSANLVGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYS 675
alpha3-2(VI)      GGVEEVPLAQPESKRDILFLFDGSANLVGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYS 881
alpha3-3(VI)      --------TPEESKRDILFLFDGSANLVGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYS 681
alpha6(VI)        CK---------EMKADIMFLVDSSGSIG-------------------------------- 634
alpha2-2C2(VI)    ------------------------------------------------------------
alpha2-2C2a(VI)   ------------------------------------------------------------
alpha1(VI)        ------------------------------------------------------------
alpha1(XXVIII)    ------------------------------------------------------------
                                                                                 

alpha3-1(VI)      DDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVL 941
alpha3-4(VI)      DDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVL 740
alpha3-5(VI)      DDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVL 735
alpha3-2(VI)      DDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVL 941
alpha3-3(VI)      DDVKVESRFDEHQSKPEILNLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVL 741
alpha6(VI)        ------------------------------------------------------------
alpha2-2C2(VI)    ------------------------------------------------------------
alpha2-2C2a(VI)   ------------------------------------------------------------
alpha1(VI)        ------------------------------------------------------------
alpha1(XXVIII)    ------------------------------------------------------------
                                                                                 

alpha3-1(VI)      QFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAESLPK 1001
alpha3-4(VI)      QFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAESLPK 800
alpha3-5(VI)      QFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAESLPK 795
alpha3-2(VI)      QFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAESLPK 1001
alpha3-3(VI)      QFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAESLPK 801
alpha6(VI)        ------------------------------------------------------------
alpha2-2C2(VI)    ------------------------------------------------------------
alpha2-2C2a(VI)   ------------------------------------------------------------
alpha1(VI)        ------------------------------------------------------------
alpha1(XXVIII)    ------------------------------------------------------------
                                                                                 

alpha3-1(VI)      IGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGVRSGFPLLKEFVQRVVESLDVG 1061
alpha3-4(VI)      IGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGVRSGFPLLKEFVQRVVESLDVG 860
alpha3-5(VI)      IGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGVRSGFPLLKEFVQRVVESLDVG 855
alpha3-2(VI)      IGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGVRSGFPLLKEFVQRVVESLDVG 1061
alpha3-3(VI)      IGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGVRSGFPLLKEFVQRVVESLDVG 861
alpha6(VI)        ---------------------------------------PENFSKMKTFMKNLVSKSQIG 655
alpha2-2C2(VI)    ------------------------------------------------------------
alpha2-2C2a(VI)   ------------------------------------------------------------
alpha1(VI)        ------------------------------------------------------------
alpha1(XXVIII)    ------------------------------------------------------------
                                                                                 

alpha3-1(VI)      QDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILV 1121
alpha3-4(VI)      QDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILV 920
alpha3-5(VI)      QDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILV 915
alpha3-2(VI)      QDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILV 1121
alpha3-3(VI)      QDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTLLGGPTPNTGAALEFVLRNILV 921
alpha6(VI)        PDRVQIGVVQFSDINKEEFQLNRFMSQSDISNAIDQMAHIG-QTTLTGSALSFVSQYFSP 714
alpha2-2C2(VI)    ------------------------------------------------------------
alpha2-2C2a(VI)   ------------------------------------------------------------
alpha1(VI)        ------------------------------------------------------------
alpha1(XXVIII)    ------------------------------------------------------------
                                                                                 

alpha3-1(VI)      SSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFI 1181
alpha3-4(VI)      SSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFI 980
alpha3-5(VI)      SSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFI 975
alpha3-2(VI)      SSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFI 1181
alpha3-3(VI)      SSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFI 981
alpha6(VI)        TKG---ARPNIRKFLILITDGEAQDIVKEPAVVLRQEGVIIYSVGVFGSNVTQLEEISGR 771
alpha2-2C2(VI)    --------------------------------MLQGTCSVLLLWGILGAIQAQQQEVISP 28
alpha2-2C2a(VI)   --------------------------------MLQGTCSVLLLWGILGAIQAQQQEVISP 28
alpha1(VI)        ----------------------------------MRAARALLPLLLQACWTAAQDEPETP 26
alpha1(XXVIII)    -------------------------------MWNRYFVFYLLLLSAFTSQTVSGQRKKGP 29
                                                                  .  .  :     

alpha3-1(VI)      PDFAVAIPTFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSPGVGGKRDVVFLIDGS 1241
alpha3-4(VI)      PDFAVAIPTFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSPGVGGKRDVVFLIDGS 1040
alpha3-5(VI)      PDFAVAIPTFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSPGVGGKRDVVFLIDGS 1035
alpha3-2(VI)      PDFAVAIPTFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSPGVGGKRDVVFLIDGS 1241
alpha3-3(VI)      PDFAVAIPTFRQLGTVQQVISERVTQLTREELSRLQPVLQPLPSPGVGGKRDVVFLIDGS 1041
alpha6(VI)        PEMVFYVENFDILQRIEDDLVFGICSPREECKR--------------IEVLDVVFVIDSS 817
alpha2-2C2(VI)    DTTERNNNCPEKT----------------------------------DCPIHVYFVLDTS 54
alpha2-2C2a(VI)   DTTERNNNCPEKT----------------------------------DCPIHVYFVLDTS 54
alpha1(VI)        RAVAFQ-----------------------------------------DCPVDLFFVLDTS 45
alpha1(XXVIII)    KSNLLARKSDVQG---------------------------------SICFIDIVFIVDSS 56
                                                                     .: *::* *

alpha3-1(VI)      QSAG-PEFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLN----AHSSKDEVQ 1296
alpha3-4(VI)      QSAG-PEFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLN----AHSSKDEVQ 1095
alpha3-5(VI)      QSAG-PEFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLN----AHSSKDEVQ 1090
alpha3-2(VI)      QSAG-PEFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLN----AHSSKDEVQ 1296
alpha3-3(VI)      QSAG-PEFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLN----AHSSKDEVQ 1096
alpha6(VI)        GSIDYDEYNIMKDFMIGLVKKADVGKNQVRFGALKYADDPEVLFYLD----DFGTKLEVI 873
alpha2-2C2(VI)    ESVT------------MQS-PTDILLFHMKQFVPQFISQLQNEFYLD----QVALSWRYG 97
alpha2-2C2a(VI)   ESVT------------MQS-PTDILLFHMKQFVPQFISQLQNEFYLD----QVALSWRYG 97
alpha1(VI)        ESVA------------LRLKPYGALVDKVKSFTKRFIDNLRDRYYRC----DRNLVWNAG 89
alpha1(XXVIII)    ESSK------------------IALFDKQKDFVDSLSDKIFQLTPGRSLEYDIKLA---- 94
                   *                           :  .    ..                     

alpha3-1(VI)      NAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGK--SDDEVDD 1354
alpha3-4(VI)      NAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGK--SDDEVDD 1153
alpha3-5(VI)      NAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGK--SDDEVDD 1148
alpha3-2(VI)      NAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGK--SDDEVDD 1354
alpha3-3(VI)      NAVQRLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGK--SDDEVDD 1154
alpha6(VI)        SVLQNDQAMGG--STYTAEALGFSDHMFTEARGSRLNKGVPQVLIVITDGESHDADKLNA 931
alpha2-2C2(VI)    ------------------------------------------------------------
alpha2-2C2a(VI)   ------------------------------------------------------------
alpha1(VI)        ------------------------------------------------------------
alpha1(XXVIII)    ------------------------------------------------------------
                                                                                 

alpha3-1(VI)      PAVELKQFGVAPFTIARN-ADQEELVKISLSPEYVFSVSTFRELPSLEQKLLTPITTLTS 1413
alpha3-4(VI)      PAVELKQFGVAPFTIARN-ADQEELVKISLSPEYVFSVSTFRELPSLEQKLLTPITTLTS 1212
alpha3-5(VI)      PAVELKQFGVAPFTIARN-ADQEELVKISLSPEYVFSVSTFRELPSLEQKLLTPITTLTS 1207
alpha3-2(VI)      PAVELKQFGVAPFTIARN-ADQEELVKISLSPEYVFSVSTFRELPSLEQKLLTPITTLTS 1413
alpha3-3(VI)      PAVELKQFGVAPFTIARN-ADQEELVKISLSPEYVFSVSTFRELPSLEQKLLTPITTLTS 1213
alpha6(VI)        TAKALRDKGILVLAVGIDGANPVELLAMAGSSDKYFFVETFGGLKGIFSDVTASVCNSS- 990
alpha2-2C2(VI)    ---------------GLHFSDQVEVFS--------------------------------- 109
alpha2-2C2a(VI)   ---------------GLHFSDQVEVFS--------------------------------- 109
alpha1(VI)        ---------------ALHYSDEVEIIQGL------------------------------- 103
alpha1(XXVIII)    ---------------ALQFSSSVQIDP--------------------------------- 106
                                 . . :.  ::                                   

alpha3-1(VI)      EQIQKLLASTRYPPPAVESDAADIVFLIDSSEGVRPDGFAHIRDFVSRIVRRLNIGPSKV 1473
alpha3-4(VI)      EQIQKLLASTRYPPPAVESDAADIVFLIDSSEGVRPDGFAHIRDFVSRIVRRLNIGPSKV 1272
alpha3-5(VI)      EQIQKLLASTRYPPPAVESDAADIVFLIDSSEGVRPDGFAHIRDFVSRIVRRLNIGPSKV 1267
alpha3-2(VI)      EQIQKLLASTRYPPP--------------------------------------------- 1428
alpha3-3(VI)      EQIQKLLASTRYPPPAVESDAADIVFLIDSSEGVRPDGFAHIRDFVSRIVRRLNIGPSKV 1273
alpha6(VI)        ------------------------------------------------------------
alpha2-2C2(VI)    ------------------------------------------------------------
alpha2-2C2a(VI)   ------------------------------------------------------------
alpha1(VI)        ------------------------------------------------------------
alpha1(XXVIII)    ------------------------------------------------------------
                                                                                 

alpha3-1(VI)      RVGVVQFSNDVFPEFYLKTYRSQAPVLDAIRRLRLRGGSPLNTGKALEFVARNLFVKSAG 1533
alpha3-4(VI)      RVGVVQFSNDVFPEFYLKTYRSQAPVLDAIRRLRLRGGSPLNTGKALEFVARNLFVKSAG 1332
alpha3-5(VI)      RVGVVQFSNDVFPEFYLKTYRSQAPVLDAIRRLRLRGGSPLNTGKALEFVARNLFVKSAG 1327
alpha3-2(VI)      ------------------------------------------------------------
alpha3-3(VI)      RVGVVQFSNDVFPEFYLKTYRSQAPVLDAIRRLRLRGGSPLNTGKALEFVARNLFVKSAG 1333
alpha6(VI)        ------------------------------------------------------------
alpha2-2C2(VI)    ------------------------------------------------------------
alpha2-2C2a(VI)   ------------------------------------------------------------
alpha1(VI)        ------------------------------------------------------------
alpha1(XXVIII)    ------------------------------------------------------------
                                                                                 

alpha3-1(VI)      SRIEDGVPQHLVLVLGGKSQDDVSRFAQVIRSSGIVSLGVGDRNIDRTELQTITNDPRLV 1593
alpha3-4(VI)      SRIEDGVPQHLVLVLGGKSQDDVSRFAQVIRSSGIVSLGVGDRNIDRTELQTITNDPRLV 1392
alpha3-5(VI)      SRIEDGVPQHLVLVLGGKSQDDVSRFAQVIRSSGIVSLGVGDRNIDRTELQTITNDPRLV 1387
alpha3-2(VI)      ------------------------------------------------------------
alpha3-3(VI)      SRIEDGVPQHLVLVLGGKSQDDVSRFAQVIRSSGIVSLGVGDRNIDRTELQTITNDPRLV 1393
alpha6(VI)        ------------------------------------------------------------
alpha2-2C2(VI)    ------------------------------------------------------------
alpha2-2C2a(VI)   ------------------------------------------------------------
alpha1(VI)        ------------------------------------------------------------
alpha1(XXVIII)    ------------------------------------------------------------
                                                                                 

alpha3-1(VI)      FTVREFRELPNIEERIMNSFGPSAATPAPPGVDTPPPSRPEKKKADIVFLLDGSINFRRD 1653
alpha3-4(VI)      FTVREFRELPNIEERIMNSFGPSAATPAPPGVDTPPPSRPEKKKADIVFLLDGSINFRRD 1452
alpha3-5(VI)      FTVREFRELPNIEERIMNSFGPSAATPAPPGVDTPPPSRPEKKKADIVFLLDGSINFRRD 1447
alpha3-2(VI)      --VREFRELPNIEERIMNSFGPSAATPAPPGVDTPPPSRPEKKKADIVFLLDGSINFRRD 1486
alpha3-3(VI)      FTVREFRELPNIEERIMNSFGPSAATPAPPGVDTPPPSRPEKKKADIVFLLDGSINFRRD 1453
alpha6(VI)        ------------------------------------KVDCEIDKVDLVFLMDGSTSIQPN 1014
alpha2-2C2(VI)    --------------------------------------PPGSDRASFIKNLQGISSFRRG 131
alpha2-2C2a(VI)   --------------------------------------PPGSDRASFIKNLQGISSFRRG 131
alpha1(VI)        -------------------------------------TRMPGGRDALKSSVDAVKYFGKG 126
alpha1(XXVIII)    ------------------------------------PFSSWKDLQTFKQKVKSMNLIGQG 130
                                                                :   :..   :  .

alpha3-1(VI)      SFQEVLRFVSEIVDTVYEDGDSIQVGLVQYNSDPTDEFFLKDFSTKRQIIDAINKVVYKG 1713
alpha3-4(VI)      SFQEVLRFVSEIVDTVYEDGDSIQVGLVQYNSDPTDEFFLKDFSTKRQIIDAINKVVYKG 1512
alpha3-5(VI)      SFQEVLRFVSEIVDTVYEDGDSIQVGLVQYNSDPTDEFFLKDFSTKRQIIDAINKVVYKG 1507
alpha3-2(VI)      SFQEVLRFVSEIVDTVYEDGDSIQVGLVQYNSDPTDEFFLKDFSTKRQIIDAINKVVYKG 1546
alpha3-3(VI)      SFQEVLRFVSEIVDTVYEDGDSIQVGLVQYNSDPTDEFFLKDFSTKRQIIDAINKVVYKG 1513
alpha6(VI)        DFKKMKEFLASVVQDFDVSLNRVRIGAAQFSDTYHPEFPLGTFIGEKEISFQIENIKQIF 1074
alpha2-2C2(VI)    TFTDCALAN---------------------------------------------MTEQIR 146
alpha2-2C2a(VI)   TFTDCALAN---------------------------------------------MTEQIR 146
alpha1(VI)        TYTDCAIKK---------------------------------------------GLEQLL 141
alpha1(XXVIII)    TFSYYAISN-------------------------------ATRLLKR------------- 146
                   :                                                          

alpha3-1(VI)      GRHANTKVGLEHLRVN-HFVPEAGSRLDQRVPQIAFVITGGKSVEDAQDVSLALTQRGVK 1772
alpha3-4(VI)      GRHANTKVGLEHLRVN-HFVPEAGSRLDQRVPQIAFVITGGKSVEDAQDVSLALTQRGVK 1571
alpha3-5(VI)      GRHANTKVGLEHLRVN-HFVPEAGSRLDQRVPQIAFVITGGKSVEDAQDVSLALTQRGVK 1566
alpha3-2(VI)      GRHANTKVGLEHLRVN-HFVPEAGSRLDQRVPQIAFVITGGKSVEDAQDVSLALTQRGVK 1605
alpha3-3(VI)      GRHANTKVGLEHLRVN-HFVPEAGSRLDQRVPQIAFVITGGKSVEDAQDVSLALTQRGVK 1572
alpha6(VI)        G---NTHIGAALREVEHYFRPDMGSRINTGTPQVLLVLTDGQSQDEVAQAAEALRHRGID 1131
alpha2-2C2(VI)    QD-----------------------RSKG-TVHFAVVITDGHVTG---SPCGGIKLQAER 179
alpha2-2C2a(VI)   QD-----------------------RSKG-TVHFAVVITDGHVTG---SPCGGIKLQAER 179
alpha1(VI)        VG-----------------------GSHLKENKYLIVVTDGHPLEGYKEPCGGLEDAVNE 178
alpha1(XXVIII)    -------------------------EGRKDGVKVVLLMTDG----IDHPKNPDVQSISED 177
                                                  :  .::*.*            :      

alpha3-1(VI)      VFAVGVRNIDSEEVGKIASNSATAFRVGNVQELSELSEQVLETLHDAMHETLCPGVTDAA 1832
alpha3-4(VI)      VFAVGVRNIDSEEVGKIASNSATAFRVGNVQELSELSEQVLETLHDAMHETLCPGVTDAA 1631
alpha3-5(VI)      VFAVGVRNIDSEEVGKIASNSATAFRVGNVQELSELSEQVLETLHDAMHETLCPGVTDAA 1626
alpha3-2(VI)      VFAVGVRNIDSEEVGKIASNSATAFRVGNVQELSELSEQVLETLHDAMHETLCPGVTDAA 1665
alpha3-3(VI)      VFAVGVRNIDSEEVGKIASNSATAFRVGNVQELSELSEQVLETLHDAMHETLCPGVTDAA 1632
alpha6(VI)        IYSVGIGDVDDQQLIQITGTAEKKLTVHNFDELKKVNKRIVRNICTTAGE---------- 1181
alpha2-2C2(VI)    AREEGIR----------------LFAVAPNQNLKEQGLRDIAS----------------- 206
alpha2-2C2a(VI)   AREEGIR----------------LFAVAPNQNLKEQGLRDIAS----------------- 206
alpha1(VI)        AKHLGVK----------------VFSVAITPDHLEPRLSIIATDH--------------- 207
alpha1(XXVIII)    ARISGIS----------------FITIALSTVVNEAKLRLISG----------------- 204
                      *:                  : :       :     :                   

alpha3-1(VI)      KACNLDVILGFDGSRD---QNVFVAQKGFESKVDAILNRISQMHRVSCSGGRSPTVRVSV 1889
alpha3-4(VI)      KACNLDVILGFDGSRD---QNVFVAQKGFESKVDAILNRISQMHRVSCSGGRSPTVRVSV 1688
alpha3-5(VI)      KACNLDVILGFDGSRD---QNVFVAQKGFESKVDAILNRISQMHRVSCSGGRSPTVRVSV 1683
alpha3-2(VI)      KACNLDVILGFDGSRD---QNVFVAQKGFESKVDAILNRISQMHRVSCSGGRSPTVRVSV 1722
alpha3-3(VI)      KACNLDVILGFDGSRD---QNVFVAQKGFESKVDAILNRISQMHRVSCSGGRSPTVRVSV 1689
alpha6(VI)        SNCFVDVVVGFDVSTQEKGQTLLEGQPWMETYLQDILRAISSLNGVSCEVGTETQVSVAF 1241
alpha2-2C2(VI)    ------------------------------------------------------------
alpha2-2C2a(VI)   ------------------------------------------------------------
alpha1(VI)        ------------------------------------------------------------
alpha1(XXVIII)    ------------------------------------------------------------
                                                                                 

alpha3-1(VI)      VANTPSGPVEAFDFDEYQPEMLEKFRNMRSQHPYVLTEDTLKVYLNKFRQSSPDSVKVVI 1949
alpha3-4(VI)      VANTPSGPVEAFDFDEYQPEMLEKFRNMRSQHPYVLTEDTLKVYLNKFRQSSPDSVKVVI 1748
alpha3-5(VI)      VANTPSGPVEAFDFDEYQPEMLEKFRNMRSQHPYVLTEDTLKVYLNKFRQSSPDSVKVVI 1743
alpha3-2(VI)      VANTPSGPVEAFDFDEYQPEMLEKFRNMRSQHPYVLTEDTLKVYLNKFRQSSPDSVKVVI 1782
alpha3-3(VI)      VANTPSGPVEAFDFDEYQPEMLEKFRNMRSQHPYVLTEDTLKVYLNKFRQSSPDSVKVVI 1749
alpha6(VI)        QVTN-AMEKYSPKFEIYSENILNSLKDITVKGPSLLNANLLDSLWDTFQNKSAARGKVVL 1300
alpha2-2C2(VI)    ------------------------------------------------------------
alpha2-2C2a(VI)   ------------------------------------------------------------
alpha1(VI)        ------------------------------------------------------------
alpha1(XXVIII)    ------------------------------------------------------------
                                                                                 

alpha3-1(VI)      HFTDGADGDLADLHRASENLRQEGVRALILVGLERVVN---LERLMHLEFGRGFMYDRPL 2006
alpha3-4(VI)      HFTDGADGDLADLHRASENLRQEGVRALILVGLERVVN---LERLMHLEFGRGFMYDRPL 1805
alpha3-5(VI)      HFTDGADGDLADLHRASENLRQEGVRALILVGLERVVN---LERLMHLEFGRGFMYDRPL 1800
alpha3-2(VI)      HFTDGADGDLADLHRASENLRQEGVRALILVGLERVVN---LERLMHLEFGRGFMYDRPL 1839
alpha3-3(VI)      HFTDGADGDLADLHRASENLRQEGVRALILVGLERVVN---LERLMHLEFGRGFMYDRPL 1806
alpha6(VI)        LFSDGLDDDVEKLEQKSDELRKEGLNALITVALDGPADSSDLADLPYIEFGKGFEYRTQL 1360
alpha2-2C2(VI)    TPHELYRNDYATMLPDSTEIDQDTINRIIKVMKHEAYG---------------------- 244
alpha2-2C2a(VI)   TPHELYRNDYATMLPDSTEIDQDTINRIIKVMKHEAYG---------------------- 244
alpha1(VI)        TYRRNFTAADWGQSRDAEEAISQTIDTIVDMIKNNVEQ---------------------- 245
alpha1(XXVIII)    ------DSSSEPTLLLSDPTLVDKIQDRLDILFEKKCER--------------------- 237
                                  :     : :   : :  .                          

alpha3-1(VI)      RLNLLDLDYELAEQLDNIAEKACCGVPCKCS-GQRGDRGPIGSIGPKGIPGEDGYRGYPG 2065
alpha3-4(VI)      RLNLLDLDYELAEQLDNIAEKACCGVPCKCS-GQRGDRGPIGSIGPKGIPGEDGYRGYPG 1864
alpha3-5(VI)      RLNLLDLDYELAEQLDNIAEKACCGVPCKCS-GQRGDRGPIGSIGPKGIPGEDGYRGYPG 1859
alpha3-2(VI)      RLNLLDLDYELAEQLDNIAEKACCGVPCKCS-GQRGDRGPIGSIGPKGIPGEDGYRGYPG 1898
alpha3-3(VI)      RLNLLDLDYELAEQLDNIAEKACCGVPCKCS-GQRGDRGPIGSIGPKGIPGEDGYRGYPG 1865
alpha6(VI)        SIGMRELGSRLSKQLVNVAERTCCCLFCKCI-GGDGTMGDPGPPGKRGPPGFKGSEGYLG 1419
alpha2-2C2(VI)    ---------------------ECYKVSCLEIPGPSGPKGYRGQKGAKGNMGEPGEPGQKG 283
alpha2-2C2a(VI)   ---------------------ECYKVSCLEIPGPSGPKGYRGQKGAKGNMGEPGEPGQKG 283
alpha1(VI)        ---------------------VCCSFECQPARGPPGLRGDPGFEGERGKPGLPGEKGEAG 284
alpha1(XXVIII)    -------------------------KICECEKGDPGDPGPPGTHGNPGIKGERGPKGNPG 272
                                             *    *  *  *  *  *  *  *  *  *  *

alpha3-1(VI)      --DEGGPGERGPPGVNGTQGFQGCPGQRGVKGSRGFPGEKGEVGEIGLDGLDGEDGDKGL 2123
alpha3-4(VI)      --DEGGPGERGPPGVNGTQGFQGCPGQRGVKGSRGFPGEKGEVGEIGLDGLDGEDGDKGL 1922
alpha3-5(VI)      --DEGGPGERGPPGVNGTQGFQGCPGQRGVKGSRGFPGEKGEVGEIGLDGLDGEDGDKGL 1917
alpha3-2(VI)      --DEGGPGERGPPGVNGTQGFQGCPGQRGVKGSRGFPGEKGEVGEIGLDGLDGEDGDKGL 1956
alpha3-3(VI)      --DEGGPGERGPPGVNGTQGFQGCPGQRGVKGSRGFPGEKGEVGEIGLDGLDGEDGDKGL 1923
alpha6(VI)        --EEGIAGERGAPGPVGEQGTKGCYGTKGPKGNRGLNGQEGEVGENGIDGLNGEQGDNGL 1477
alpha2-2C2(VI)    --RQGDPGIEGPIGFPGPKGVPGFKGEKGEFGADGRKGAPGLAGKNGTDGQKGKLGRIGP 341
alpha2-2C2a(VI)   --RQGDPGIEGPIGFPGPKGVPGFKGEKGEFGADGRKGAPGLAGKNGTDGQKGKLGRIGP 341
alpha1(VI)        --DPGRPGDLGPVGYQGMKGEKGSRGEKGSRGPKGYKGEKGKRGIDGVDGVKGEMGYPGL 342
alpha1(XXVIII)    NAQKGEAGERGPGGIPGYKGDKGERGECGKPGIKGDKGSPGPYGPKGPRGIQGITGPPGD 332
                      * .*  *. *  * :*  *  *  *  *  *  *  *  *  *  * .*  *  * 

alpha3-1(VI)      PGSSGEKGNPGRRGDKGPRGEKGER--GDVGIRGDPGNPGQDSQERGPKGETGDLGPMGV 2181
alpha3-4(VI)      PGSSGEKGNPGRRGDKGPRGEKGER--GDVGIRGDPGNPGQDSQERGPKGETGDLGPMGV 1980
alpha3-5(VI)      PGSSGEKGNPGRRGDKGPRGEKGER--GDVGIRGDPGNPGQDSQERGPKGETGDLGPMGV 1975
alpha3-2(VI)      PGSSGEKGNPGRRGDKGPRGEKGER--GDVGIRGDPGNPGQDSQERGPKGETGDLGPMGV 2014
alpha3-3(VI)      PGSSGEKGNPGRRGDKGPRGEKGER--GDVGIRGDPGNPGQDSQERGPKGETGDLGPMGV 1981
alpha6(VI)        PGRKGEKGDEGSQGSPGKRGTPGDR--GAKGLRGDPGAPGVDSSIEGPTGLKGERGRQGR 1535
alpha2-2C2(VI)    PGCKGDPGNRGPDGYPGEAGSPGER--GDQGGKGDPGRPGR----RGPPGEIGAKGSKGY 395
alpha2-2C2a(VI)   PGCKGDPGNRGPDGYPGEAGSPGER--GDQGGKGDPGRPGR----RGPPGEIGAKGSKGY 395
alpha1(VI)        PGCKGSPGFDGIQGPPGPKGDPGAF--GLKGEKGEPGADGE----AGRPGSSGPSGDEGQ 396
alpha1(XXVIII)    PGPKGFQGNKGEPGPPGPYGSPGAPGIGQQGIKGERGQEGR----PGAPGPIG-VGEPGQ 387
                  ** .*  *  *  *  *  *  *    *  * :*: *  *      *  *  *  *  * 

alpha3-1(VI)      PGRDGVPGGPGETGKNGGFGRRGPPGAKGNKGGPGQPGFEGEQGTRGAQGPAGPAGPPGL 2241
alpha3-4(VI)      PGRDGVPGGPGETGKNGGFGRRGPPGAKGNKGGPGQPGFEGEQGTRGAQGPAGPAGPPGL 2040
alpha3-5(VI)      PGRDGVPGGPGETGKNGGFGRRGPPGAKGNKGGPGQPGFEGEQGTRGAQGPAGPAGPPGL 2035
alpha3-2(VI)      PGRDGVPGGPGETGKNGGFGRRGPPGAKGNKGGPGQPGFEGEQGTRGAQGPAGPAGPPGL 2074
alpha3-3(VI)      PGRDGVPGGPGETGKNGGFGRRGPPGAKGNKGGPGQPGFEGEQGTRGAQGPAGPAGPPGL 2041
alpha6(VI)        RGWPGPPGTPGSRRKTAAHGRRGHTGPQGTAGIPGPDGLEGSLGLKGPQGPRGEAGVKGE 1595
alpha2-2C2(VI)    QGNSGAPGSPGVKGAKGGPGPRGPKGEPGRRGDPGTKGSPGSDGPKGEKGDPGPEGPRGL 455
alpha2-2C2a(VI)   QGNSGAPGSPGVKGAKGGPGPRGPKGEPGRRGDPGTKGSPGSDGPKGEKGDPGPEGPRGL 455
alpha1(VI)        PGEPGPPGEKGEAGDEGNPGPDGAPGERGGPGERGPRGTPGTRGPRGDPGEAGPQGDQGR 456
alpha1(XXVIII)    PGPRGPEGVPGERGLPGE-GFPGPKGEKGSEGPTGPQGLQG-LSIKGEKGDIGPVGPQGP 445
                   *  *  *  *     .  *  *  *  *  *  *  *  *  . :*  *  *  *  * 

alpha3-1(VI)      IGEQGISGPRGSGGAAGAPGERGRTGPLGRKGEPGEPGPKGGIGNRGPRGETGDDGRDGV 2301
alpha3-4(VI)      IGEQGISGPRGSGGAAGAPGERGRTGPLGRKGEPGEPGPKGGIGNRGPRGETGDDGRDGV 2100
alpha3-5(VI)      IGEQGISGPRGSGGAAGAPGERGRTGPLGRKGEPGEPGPKGGIGNRGPRGETGDDGRDGV 2095
alpha3-2(VI)      IGEQGISGPRGSGGAAGAPGERGRTGPLGRKGEPGEPGPKGGIGNRGPRGETGDDGRDGV 2134
alpha3-3(VI)      IGEQGISGPRGSGGAAGAPGERGRTGPLGRKGEPGEPGPKGGIGNRGPRGETGDDGRDGV 2101
alpha6(VI)        KGGVGSKGPQGPPGPGGEAGNQGRLGSQGNKGEPGDLGEKGAVGFPGPRGLQGNDGSPGY 1655
alpha2-2C2(VI)    AGEVGNKGAKGDRGLPGPRGPQGALGEPGKQGSRGDPGDAGPRGDSGQPGPKGDPGRPGF 515
alpha2-2C2a(VI)   AGEVGNKGAKGDRGLPGPRGPQGALGEPGKQGSRGDPGDAGPRGDSGQPGPKGDPGRPGF 515
alpha1(VI)        EGPVGVPGDPGEAGPIGPKGYRGDEGPPGSEGARGAPGPAGPPGDPGLMGERGEDGPAGN 516
alpha1(XXVIII)    MGIPG-IGSQGEQGIQGPIGPPGPQGPAG-QGLPGSKGEVGQMGPTGPRGPVGIGVQGPK 503
                   *  *  *  *  *  *  *  *  *  * :*  *  *  *  *  *  *  *       

alpha3-1(VI)      GSEGRRGKKGERGFPGYPGPKGNPGEPGLNGTTGPKGIRGRR-GNSGPPGIVGQKGDPGY 2360
alpha3-4(VI)      GSEGRRGKKGERGFPGYPGPKGNPGEPGLNGTTGPKGIRGRR-GNSGPPGIVGQKGDPGY 2159
alpha3-5(VI)      GSEGRRGKKGERGFPGYPGPKGNPGEPGLNGTTGPKGIRGRR-GNSGPPGIVGQKGDPGY 2154
alpha3-2(VI)      GSEGRRGKKGERGFPGYPGPKGNPGEPGLNGTTGPKGIRGRR-GNSGPPGIVGQKGDPGY 2193
alpha3-3(VI)      GSEGRRGKKGERGFPGYPGPKGNPGEPGLNGTTGPKGIRGRR-GNSGPPGIVGQKGDPGY 2160
alpha6(VI)        GSVGRKGAKGQEGFPGESGPKGEIGDPGGPGETGLKGARGKM-ISAGLPGEMGSPGEPGP 1714
alpha2-2C2(VI)    SYPGPRGAPGEKGEPGPRGPEGGRGDFGLKGEPGRKGEKGEP-ADPGPPGEPGPRGPRGV 574
alpha2-2C2a(VI)   SYPGPRGAPGEKGEPGPRGPEGGRGDFGLKGEPGRKGEKGEP-ADPGPPGEPGPRGPRGV 574
alpha1(VI)        GTEGFPGFPGYPGNRGAPGINGTKGYPGLKGDEGEAGDPGDDNNDIAPRGVKGAKGYRGP 576
alpha1(XXVIII)    GEPGSIGLPGQPGVPGEDGAAGKKGEAGLPGARGPEGPPGKG--QPGPKGDEGKKGSKGN 561
                  .  *  *  *  *  *  *  *  *  *  *  *  *  *    . .  *  *  *  * 

alpha3-1(VI)      PGPAGPKGNRGDS--IDQCALIQSIKDKCPCCYGPLECPVFPTELAFALDTSEGVNQDTF 2418
alpha3-4(VI)      PGPAGPKGNRGDS--IDQCALIQSIKDKCPCCYGPLECPVFPTELAFALDTSEGVNQDTF 2217
alpha3-5(VI)      PGPAGPKGNRGDS--IDQCALIQSIKDKCPCCYGPLECPVFPTELAFALDTSEGVNQDTF 2212
alpha3-2(VI)      PGPAGPKGNRGDS--IDQCALIQSIKDKCPCCYGPLECPVFPTELAFALDTSEGVNQDTF 2251
alpha3-3(VI)      PGPAGPKGNRGDS--IDQCALIQSIKDKCPCCYGPLECPVFPTELAFALDTSEGVNQDTF 2218
alpha6(VI)        PGRKGVKGAKGLAS-FSTCELIQYVRDRSPGRHGKPECPVHPTELVFALDHSRDVTEQEF 1773
alpha2-2C2(VI)    PGPEGEPGPPGDPG-LTECDVMTYVRETCGCCDCEKRCGALD--VVFVIDSSESIGYTNF 631
alpha2-2C2a(VI)   PGPEGEPGPPGDPG-LTECDVMTYVRETCGCCDCEKRCGALD--VVFVIDSSESIGYTNF 631
alpha1(VI)        EGPQGPPGHQGPPG-PDECEILDIIMKMCSCCECK--CGPID--LLFVLDSSESIGLQNF 631
alpha1(XXVIII)    QGQRGLPGPEGPKGEPGIMGPFGMPGTSIPGPPGPKGDRGGPGIPGFKGEPGLSIRGPKG 621
                   *  *  *  *          :                        *  : . .:     

alpha3-1(VI)      GRMRDVVLSIVNDLTIAESN--CPRGARVAVVTYNNEVTTEIRFADSKRKSVLLDKIKNL 2476
alpha3-4(VI)      GRMRDVVLSIVNDLTIAESN--CPRGARVAVVTYNNEVTTEIRFADSKRKSVLLDKIKNL 2275
alpha3-5(VI)      GRMRDVVLSIVNDLTIAESN--CPRGARVAVVTYNNEVTTEIRFADSKRKSVLLDKIKNL 2270
alpha3-2(VI)      GRMRDVVLSIVNDLTIAESN--CPRGARVAVVTYNNEVTTEIRFADSKRKSVLLDKIKNL 2309
alpha3-3(VI)      GRMRDVVLSIVNDLTIAESN--CPRGARVAVVTYNNEVTTEIRFADSKRKSVLLDKIKNL 2276
alpha6(VI)        ERMKEMMAFLVRDIKVRENS--CPVGAHIAILSYNSHARHLVRFSDAYKKSQLLREIETI 1831
alpha2-2C2(VI)    TLEKNFVINVVNRLGAIAKDPKSETGTRVGVVQYSHEGTFEAIQLDDERIDSLSSFKEAV 691
alpha2-2C2a(VI)   TLEKNFVINVVNRLGAIAKDPKSETGTRVGVVQYSHEGTFEAIQLDDERIDSLSSFKEAV 691
alpha1(VI)        EIAKDFVVKVIDRLSRDELVKFEPGQSYAGVVQYSHSQMQEHVSLRSPSIRNVQELKEAI 691
alpha1(XXVIII)    VQGPRGPVGAPGLKGDGYPGVPGPRGLPGPPGPMGLRGVGDTGAKGEPGVRGPPGPSGPR 681
                                                       .                         

alpha3-1(VI)      QVALTSKQQSLETAMSFVARNTFKRVRNGFLMRKVAVFFSNTPTRASPQLREAVLKLSDA 2536
alpha3-4(VI)      QVALTSKQQSLETAMSFVARNTFKRVRNGFLMRKVAVFFSNTPTRASPQLREAVLKLSDA 2335
alpha3-5(VI)      QVALTSKQQSLETAMSFVARNTFKRVRNGFLMRKVAVFFSNTPTRASPQLREAVLKLSDA 2330
alpha3-2(VI)      QVALTSKQQSLETAMSFVARNTFKRVRNGFLMRKVAVFFSNTPTRASPQLREAVLKLSDA 2369
alpha3-3(VI)      QVALTSKQQSLETAMSFVARNTFKRVRNGFLMRKVAVFFSNTPTRASPQLREAVLKLSDA 2336
alpha6(VI)        PYERSSASREIGRAMRFISRNVFKRTLPGAHTRKIATFFSSGQSADAHSITTAAMEFGAL 1891
alpha2-2C2(VI)    KNLEWIAGGTWTPSALKFAYDRLIKESRRQKTRVFAVVITDGR-HDPRDDDLNLRALCDR 750
alpha2-2C2a(VI)   KNLEWIAGGTWTPSALKFAYDRLIKESRRQKTRVFAVVITDGR-HDPRDDDLNLRALCDR 750
alpha1(VI)        KSLQWMAGGTFTGEALQYTRDQLLPPSPNNR---IALVITDGR-SDTQRDTTPLNVLCSP 747
alpha1(XXVIII)    GVGTQGPKGDTGQKGLPGPPGPPGYGSQGIKGEQGPQGFPGPKGTMGHGLPGQKGEHGER 741
                                    . .              .  :..                   

alpha3-1(VI)      GITPLFLTRQEDRQLINALQINNTAVGHALVLPAGRDLTDFLENVLTCHVCLDICNIDPS 2596
alpha3-4(VI)      GITPLFLTRQEDRQLINALQINNTAVGHALVLPAGRDLTDFLENVLTCHVCLDICNIDPS 2395
alpha3-5(VI)      GITPLFLTRQEDRQLINALQINNTAVGHALVLPAGRDLTDFLENVLTCHVCLDICNIDPS 2390
alpha3-2(VI)      GITPLFLTRQEDRQLINALQINNTAVGHALVLPAGRDLTDFLENVLTCHVCLDICNIDPS 2429
alpha3-3(VI)      GITPLFLTRQEDRQLINALQINNTAVGHALVLPAGRDLTDFLENVLTCHVCLDICNIDPS 2396
alpha6(VI)        EIIPVVITFSNVPSVRRAFAIDDTGTFQVIVVPSGADYIPALERLQRCTFCYDVCKPDAS 1951
alpha2-2C2(VI)    DVTVTAIGIGDMFHEKHESENLYSIACDKPQQVRNMTLFSDLVAEKFIDDMEDVLCPDPQ 810
alpha2-2C2a(VI)   DVTVTAIGIGDMFHEKHESENLYSIACDKPQQVRNMTLFSDLVAEKFIDDMEDVLCPDPQ 810
alpha1(VI)        GIQVVSVGIKDVFDFIPGSDQLNVISCQGLAPSQGRPGLS-LVKENYAELLEDAFLKNVT 806
alpha1(XXVIII)    GDVGKKGDKGE----------IGEPGSPGKQGLQGPKGDLGLTKEEIIKLITEICGCGPK 791
                            :                       .      *          :    .  

alpha3-1(VI)      CGFGSWRPSFRDRRAAGSDVDIDMAFILDSAETTTLFQFNEMKKYIAYLVRQLDMSPDPK 2656
alpha3-4(VI)      CGFGSWRPSFRDRRAAGSDVDIDMAFILDSAETTTLFQFNEMKKYIAYLVRQLDMSPDPK 2455
alpha3-5(VI)      CGFGSWRPSFRDRRAAGSDVDIDMAFILDSAETTTLFQFNEMKKYIAYLVRQLDMSPDPK 2450
alpha3-2(VI)      CGFGSWRPSFRDRRAAGSDVDIDMAFILDSAETTTLFQFNEMKKYIAYLVRQLDMSPDPK 2489
alpha3-3(VI)      CGFGSWRPSFRDRRAAGSDVDIDMAFILDSAETTTLFQFNEMKKYIAYLVRQLDMSPDPK 2456
alpha6(VI)        CDQARPPP---------VQSYMDAAFLLDASRNMGSAEFEDIRAFLGALLDHFEITPEPE 2002
alpha2-2C2(VI)    IVCPDLPCQTELSVAQCTQRPVDIVFLLDGSERLGEQNFHKARRFVEQVARRLTLA-RRD 869
alpha2-2C2a(VI)   IVCPDLPCQTDAPWPGGEP-PVTFLRTEEGPD----ATFPRTIPLIQQLLN--------- 856
alpha1(VI)        AQICIDKKCPDYTCPITFSSPADITILLDGSASVGSHNFDTTKRFAKRLAERFLTA-GRT 865
alpha1(XXVIII)    CKET----------------PLELVFVIDSSESVGPENFQIIKNFVKTMADRVALDLATA 835
                                              :..       *         :           

alpha3-1(VI)      ASQHFARVAVVQHAPSESVDNASMPPVKVEFSLTDYGSKEKLVDFLSRGMTQLQGTRALG 2716
alpha3-4(VI)      ASQHFARVAVVQHAPSESVDNASMPPVKVEFSLTDYGSKEKLVDFLSRGMTQLQGTRALG 2515
alpha3-5(VI)      ASQHFARVAVVQHAPSESVDNASMPPVKVEFSLTDYGSKEKLVDFLSRGMTQLQGTRALG 2510
alpha3-2(VI)      ASQHFARVAVVQHAPSESVDNASMPPVKVEFSLTDYGSKEKLVDFLSRGMTQLQGTRALG 2549
alpha3-3(VI)      ASQHFARVAVVQHAPSESVDNASMPPVKVEFSLTDYGSKEKLVDFLSRGMTQLQGTRALG 2516
alpha6(VI)        TSVTGDRVALLSHAPPDFLPNTQKSPVRAEFNLTTYRSKRLMKRHVHESVKQLNGDAFIG 2062
alpha2-2C2(VI)    DDPLNARVALLQFGGPGEQQVAFPLSHNLTAIHEALETTQYLNSFSHVGAGVVH------ 923
alpha2-2C2a(VI)   ----------------------------------ATELTQDPAAYSQLVAVLVY------ 876
alpha1(VI)        DPAHDVRVAVVQYSGTGQQRPERASLQFLQN-YTALASAVDAMDFINDATDVND------ 918
alpha1(XXVIII)    RIGIINYSHKVEKVANLKQFSSKDDFKLAVDNMQYLGEGTYTATALQAANDMFEDAR--- 892
                                                                                 

alpha3-1(VI)      SAIEYTIENVFESAPNPRDLKIVVLMLTGEVPEQQLEEAQRVILQAKCKGYFFVVLGIGR 2776
alpha3-4(VI)      SAIEYTIENVFESAPNPRDLKIVVLMLTGEVPEQQLEEAQRVILQAKCKGYFFVVLGIGR 2575
alpha3-5(VI)      SAIEYTIENVFESAPNPRDLKIVVLMLTGEVPEQQLEEAQRVILQAKCKGYFFVVLGIGR 2570
alpha3-2(VI)      SAIEYTIENVFESAPNPRDLKIVVLMLTGEVPEQQLEEAQRVILQAKCKGYFFVVLGIGR 2609
alpha3-3(VI)      SAIEYTIENVFESAPNPRDLKIVVLMLTGEVPEQQLEEAQRVILQAKCKGYFFVVLGIGR 2576
alpha6(VI)        HALQWTLDNVFLSTPNLRRNKVIFVISAGETSHLDGEILKKESLRAKCQGYALFVFSLGP 2122
alpha2-2C2(VI)    --AINAIVRSPRGGARRHAELSFVFLTDGVTGNDS---LHESAHSMRKQNVVPTVLALGS 978
alpha2-2C2a(VI)   --TAERAK-----------------FATGVERQD------------WMELFIDTFKLVHR 905
alpha1(VI)        --ALGYVTRFYREASSGAAKKRLLLFSDGNSQGATPAAIEKAVQEAQRAGIEIFVVVVGR 976
alpha1(XXVIII)    -PGVKKVALVITDGQTDSRDKEKLTEVVKNASDTNVEIFVIGVVKKNDPNFEIFHKEMNL 951
                                                                           :  

alpha3-1(VI)      KVNIKEVYTFASEPNDVFFKLVDKSTELNEEPLMRFGRLLPSFVSSENAFYLSPDIRKQC 2836
alpha3-4(VI)      KVNIKEVYTFASEPNDVFFKLVDKSTELNEEPLMRFGRLLPSFVSSENAFYLSPDIRKQC 2635
alpha3-5(VI)      KVNIKEVYTFASEPNDVFFKLVDKSTELNEEPLMRFGRLLPSFVSSENAFYLSPDIRKQC 2630
alpha3-2(VI)      KVNIKEVYTFASEPNDVFFKLVDKSTELNEEPLMRFGRLLPSFVSSENAFYLSPDIRKQC 2669
alpha3-3(VI)      KVNIKEVYTFASEPNDVFFKLVDKSTELNEEPLMRFGRLLPSFVSSENAFYLSPDIRKQC 2636
alpha6(VI)        IWDDKELEDLASHPLDHHLVQLGRIHKPDHSYGVKFVKSFINSIRRAINKYPPINLKIKC 2182
alpha2-2C2(VI)    DVDMDVLTTLSLGDRAAVFHEKDYDSLAQPGFFDRFIRWIC------------------- 1019
alpha2-2C2a(VI)   DIVGDPETALALC----------------------------------------------- 918
alpha1(VI)        QVNEPHIRVLVTGKTAEYDVAYGESHLFRVPSYQALLRGVFHQTVSRKVALG-------- 1028
alpha1(XXVIII)    IATDPEHVYQFDDFFTLQDTLKQKLFQKICEDFDSYLVQIFGSSSPQPGFGMSGEE---- 1007
                                                                                 

alpha3-1(VI)      DWFQGDQPTKNLVKFGHKQVNVPNNVTSSPTSNPVTTTKPVTTTKPVTTTTKPVTTTTKP 2896
alpha3-4(VI)      DWFQGDQPTKNLVKFGHKQVNVPNNVTSSPTSNPVTTTKPVTTTKPVTTTTKPVTTTTKP 2695
alpha3-5(VI)      DWFQGDQPTKNLVKFGHKQVNVPNNVTSSPTSNPVTTTKPVTTTKPVTTTTKPVTTTTKP 2690
alpha3-2(VI)      DWFQGDQPTKNLVKFGHKQVNVPNNVTSSPTSNPVTTTKPVTTTKPVTTTTKPVTTTTKP 2729
alpha3-3(VI)      DWFQGDQPTKNLVKFGHKQVNVPNNVTSSPTSNPVTTTKPVTTTKPVTTTTKPVTTTTKP 2696
alpha6(VI)        NRLNSIDPKQ-------------------------------------------------- 2192
alpha2-2C2(VI)    ------------------------------------------------------------
alpha2-2C2a(VI)   ------------------------------------------------------------
alpha1(VI)        ------------------------------------------------------------
alpha1(XXVIII)    ------------------------------------------------------------
                                                                                 

alpha3-1(VI)      VTIINQPSVKPAAAKPAPAKPVAAKPVATKMATVRPPVAVKPATAAKPVAAKPAAVRPPA 2956
alpha3-4(VI)      VTIINQPSVKPAAAKPAPAKPVAAKPVATKMATVRPPVAVKPATAAKPVAAKPAAVRPPA 2755
alpha3-5(VI)      VTIINQPSVKPAAAKPAPAKPVAAKPVATKMATVRPPVAVKPATAAKPVAAKPAAVRPPA 2750
alpha3-2(VI)      VTIINQPSVKPAAAKPAPAKPVAAKPVATKMATVRPPVAVKPATAAKPVAAKPAAVRPPA 2789
alpha3-3(VI)      VTIINQPSVKPAAAKPAPAKPVAAKPVATKMATVRPPVAVKPATAAKPVAAKPAAVRPPA 2756
alpha6(VI)        -----------------PPRPFRSFVPGPLKATLKEDVLQKAKFFQDKKYLSRVARSGRD 2235
alpha2-2C2(VI)    ------------------------------------------------------------
alpha2-2C2a(VI)   ------------------------------------------------------------
alpha1(VI)        ------------------------------------------------------------
alpha1(XXVIII)    ---------------LSESTPEPQKEISESLSVTRDQDEDDKAPEPTWADDLPATTSSEA 1052
                                                                                 

alpha3-1(VI)      AAAAKPVATKPEVPRPQAAKPAATKPATTKPMVKMSREVQVFEITENSAKLHWERAEPPG 3016
alpha3-4(VI)      AAAAKPVATKPEVPRPQAAKPAATKPATTKPMVKMSREVQVFEITENSAKLHWERAEPPG 2815
alpha3-5(VI)      AAAAKPVATKPEVPRPQAAKPAATKPATTKPMVKMSREVQVFEITENSAKLHWERAEPPG 2810
alpha3-2(VI)      AAAAKPVATKPEVPRPQAAKPAATKPATTKPMVKMSREVQVFEITENSAKLHWERAEPPG 2849
alpha3-3(VI)      AAAAKPVATKPEVPRPQAAKPAATKPATTKPMVKMSREVQVFEITENSAKLHWERAEPPG 2816
alpha6(VI)        DAIQNFMRSTSHTFKNGRMIESAPKQHD-------------------------------- 2263
alpha2-2C2(VI)    ------------------------------------------------------------
alpha2-2C2a(VI)   ------------------------------------------------------------
alpha1(VI)        ------------------------------------------------------------
alpha1(XXVIII)    TTTPRPLLSTPVDGAEDPRCLEALKPGNCG------------------------------ 1082
                                                                                 

alpha3-1(VI)      PYFYDLTVTSAHDQSLVLKQNLTVTDRVIGGLLAGQTYHVAVVCYLRSQVRATYHGSFST 3076
alpha3-4(VI)      PYFYDLTVTSAHDQSLVLKQNLTVTDRVIGGLLAGQTYHVAVVCYLRSQVRATYHGSFST 2875
alpha3-5(VI)      PYFYDLTVTSAHDQSLVLKQNLTVTDRVIGGLLAGQTYHVAVVCYLRSQVRATYHGSFST 2870
alpha3-2(VI)      PYFYDLTVTSAHDQSLVLKQNLTVTDRVIGGLLAGQTYHVAVVCYLRSQVRATYHGSFST 2909
alpha3-3(VI)      PYFYDLTVTSAHDQSLVLKQNLTVTDRVIGGLLAGQTYHVAVVCYLRSQVRATYHGSFST 2876
alpha6(VI)        ------------------------------------------------------------
alpha2-2C2(VI)    ------------------------------------------------------------
alpha2-2C2a(VI)   ------------------------------------------------------------
alpha1(VI)        ------------------------------------------------------------
alpha1(XXVIII)    ------------------------------------------------------------
                                                                                 

alpha3-1(VI)      KKSQPPPPQPARSASSSTINLMVSTEPLALTETDICKLPKDEGTCRDFILKWYYDPNTKS 3136
alpha3-4(VI)      KKSQPPPPQPARSASSSTINLMVSTEPLALTETDICKLPKDEGTCRDFILKWYYDPNTKS 2935
alpha3-5(VI)      KKSQPPPPQPARSASSSTINLMVSTEPLALTETDICKLPKDEGTCRDFILKWYYDPNTKS 2930
alpha3-2(VI)      KKSQPPPPQPARSASSSTINLMVSTEPLALTETDICKLPKDEGTCRDFILKWYYDPNTKS 2969
alpha3-3(VI)      KKSQPPPPQPARSASSSTINLMVSTEPLALTETDICKLPKDEGTCRDFILKWYYDPNTKS 2936
alpha6(VI)        ------------------------------------------------------------
alpha2-2C2(VI)    ------------------------------------------------------------
alpha2-2C2a(VI)   ------------------------------------------------------------
alpha1(VI)        ------------------------------------------------------------
alpha1(XXVIII)    ----------------------------------------------EYVVRWYYDKQVNS 1096
                                                                                 

alpha3-1(VI)      CARFWYGGCGGNENKFGSQKECEKVCAPVLAKPGVISVMGT 3177
alpha3-4(VI)      CARFWYGGCGGNENKFGSQKECEKVCAPVLAKPGVISVMGT 2976
alpha3-5(VI)      CARFWYGGCGGNENKFGSQKECEKVCAPVLAKPGVISVMGT 2971
alpha3-2(VI)      CARFWYGGCGGNENKFGSQKECEKVCAPVLAKPGVISVMGT 3010
alpha3-3(VI)      CARFWYGGCGGNENKFGSQKECEKVCAPVLAKPGVISVMGT 2977
alpha6(VI)        -----------------------------------------
alpha2-2C2(VI)    -----------------------------------------
alpha2-2C2a(VI)   -----------------------------------------
alpha1(VI)        -----------------------------------------
alpha1(XXVIII)    CARFWFSGCNGSGNRFNSEKECQETCIQG------------ 1125

Types VI and XXVIII Collagen Accession Numbers:

NP_001839 - (COL6A1; alpha1(VI)) collagen, type VI, alpha 1;
NP_001840 - (COL6A2-2C2; alpha2-2C2(VI)) alpha 2 type VI collagen isoform 2C2;
NP_478054 - (COL6A2-2C2a; alpha2(2C2a(VI)) alpha 2 type VI collagen isoform 2C2a;
NP_004360 - (COL6A3; alpha3-1(VI)) alpha 3 type VI collagen isoform 1 ;
NP_476505 - (COL6A3-2; alpha3-2(VI)) alpha 3 type VI collagen isoform 2 precursor ;
NP_476506 - (COL6A3-3; alpha3-3(VI)) alpha 3 type VI collagen isoform 3;
NP_476507 - (COL6A3-4; alpha3-4(VI)) alpha 3 type VI collagen isoform 4;
NP_476508 - (COL6A3-5; alpha3-5(VI)) alpha 3 type VI collagen isoform 5;
NP_001096078 - (COL6A6; alpha6(VI)) collagen type VI alpha 6
NP_001032852 - (COL28A1; alpha1(XXVIII) collagen, type XXVIII alpha 1

Type VII Collagen Species Alignment

Human MTLRLLVAALCAG-ILAEAPRVRAQHRERVTCTRLYAADIVFLLDGSSSIGRSNFREVRS 59
Dog   MRLPLLVAALCAG-ILAGALRVRAQQRERVTCTRLYAADIVFLLDGSSSIGRGNFREVRG 59
Mouse MRLRLLVAALCAAEILMGAPEVWAQPRDRVTCTRLYAADIVFLLDGSSSIGRSNFREVRG 60
      * * ********. **  * .* ** *:************************.******.

Human FLEGLVLPFSGAASAQGVRFATVQYSDDPRTEFGLDALGSGGDVIRAIRELSYKGGNTRT 119
Dog   FLEGLVWPFSGAASAQGVRFAAVQYSDDPRTEFGLGALGSGGDVIRAIRELSYKGGNTRT 119
Mouse FLEGLVLPFSGAASAQGVRFATVQYSDDPQTEFGLDTLGSGSDTIRAIRELSYKGGNTRT 120
      ****** **************:*******:*****.:****.*.****************

Human GAAILHVADHVFLPQLARPGVPKVCILITDGKSQDLVDTAAQRLKGQGVKLFAVGIKNAD 179
Dog   GAAILHVADHVFLPQLARPGVPKVCILITDGKSQDLVDTAAQRLKGQGVKLFAVGIKNAD 179
Mouse GAALHHVSDRVFLPRLTRPGVPKVCILITDGKSQDLVDTAAQKLKGQGVKLFAVGIKNAD 180
      ***: **:*:****:*:*************************:*****************

Human PEELKRVASQPTSDFFFFVNDFSILRTLLPLVSRRVCTTAGGVPVTRPPDDSTSAPRDLV 239
Dog   PEELKRVASQPTSDFFFFVNDFSILRTLLPLVSRRVCTTAGGVPVTLPADDLTSGPRDLV 239
Mouse PEELKRVASQPTSDFFFFVNDFSILRTLLPLISRRVCTTAGGVPVTLPSDDTPSGPRDLV 240
      *******************************:************** *.** .*.*****

Human LSEPSSQSLRVQWTAASGPVTGYKVQYTPLTGLGQPLPSERQEVNVPAGETSVRLRGLRP 299
Dog   LSEAGSQSLRVQWTAASGPVTGYKVQYTPLTGLGQPLPSERREVSVPAGETSTQLQGLRP 299
Mouse LSEPSSQSLRVQWTAASGPVTGYKVQYTPLTGLGQPLPSERQEVNIPAGETSTRLQGLRP 300
      ***..************************************:**.:******.:*:****

Human LTEYQVTVIALYANSIGEAVSGTARTTALEGPELTIQNTTAHSLLVAWRSVPGATGYRVT 359
Dog   LTEYQVTVVALYANSIGEAVSGTARTTALEGPELTIQNTTTHSLLVAWRSVPGATGYRVT 359
Mouse LTDYQVTVVALYANSIGEAVSGTARTTAKEGLELSLQNITSHSLLVAWRRVPGANGYRVT 360
      **:*****:******************* ** **::** *:******** ****.*****

Human WRVLSGGPTQQQELGPGQGSVLLRDLEPGTDYEVTVSTLFGRSVGPATSLMARTDASVEQ 419
Dog   WRVLSGGVTQQQELGPGQGSVLLRDLEPGTDYEVTVSSLLGRSIGSASSLTARTDTSVEQ 419
Mouse WRDLSGGPTQQQDLSPGQGSVFLDHLEPGTDYEVTVSALFGHSVGPAASLTARTASSVEQ 420
      ** **** ****:*.******:* .************:*:*:*:*.*:** *** :****

Human TLRPVILGPTSILLSWNLVPEARGYRLEWRRETGLEPPQKVVLPSDVTRYQLDGLQPGTE 479
Dog   TLRPVILGPTSILVSWNLVPEARGYRLEWRRESGLGVPQKVVLPSDVTRYQLDGLQPGTE 479
Mouse TLHPIILSPTSILLSWNLVPEARGYRLEWRRESGLETPQKVELPPDVTRHQLDGLQPGTE 480
      **:*:**.*****:******************:**  **** **.****:**********

Human YRLTLYTLLEGHEVATPATVVPTGPELPVSPVTDLQATELPGQRVRVSWSPVPGATQYRI 539
Dog   YRLTLYTLLEGREVATPATVVPTGPELPVGPVTDLQATELPGQRVRVSWSPVPGATEYRI 539
Mouse YRLTLYTLLEGREVATPATVVPTGLEQLVSPVMNLQAIELPGQRVRVSWNPVPGATEYRF 540
      ***********:************ *  *.** :*** ***********.******:**:

Human IVRSTQGVERTLVLPGSQTAFDLDDVQAGLSYTVRVSARVGPREGSASVLTVRREPETPL 599
Dog   TVRSAQGVERTLVLPGSQTAFDLDDVRAGLSYTVRVSARVGTREGGASILTVRRELEAPL 599
Mouse TVRTTQGVERTLLLPGSQTTFDLDDVRAGLSYTVRVSARVGAQEGDASILTIHRDPEAPL 600
       **::*******:******:******:**************.:**.**:**::*: *:**

Human AVPGLRVVVSDATRVRVAWGPVPGASGFRISWSTGSGPESSQTLPPDSTATDITGLQPGT 659
Dog   AIPGLRVVASDATRVRVAWGPVPGASGFRISWRTDGGPESSQTLPPESTATDILGLRPGT 659
Mouse VVPGLRVVASDATRIRVAWGLVPGASGFRISWRTGSGPESSRTLTPDSTVTDILGLQPST 660
      .:******.*****:***** *********** *..*****:**.*:**.*** **:*.*

Human TYQVAVSVLRGREEGPAAVIVARTDPLGPVRTVHVTQASSSSVTITWTRVPGATGYRVSW 719
Dog   SYQVAVSALRGREESPPVVIVAQTDPLGPVRTVHVTQTSSSSVTIAWNRVPGATGYRVSW 719
Mouse SYQVAVSALRGREEGPPVVIVARTDPLGPVRRVHLTQAGSSSVSITWTGVPGATGYRVSW 720
      :******.******.*..****:******** **:**:.****:*:*. ***********

Human HSAHGPEKSQLVSGEATVAELDGLEPDTEYTVHVRAHVAGVDGPPASVVVRTAPEPVGRV 779
Dog   HSGHGPEKSQLVSGEATVAELDGLEPDTEYRVHVRAHVAGVDGTPASVVVRTDPAPVGSV 779
Mouse HSGHGPEKSLLVSGDATVAEIDGLEPDTEYIVRVRTHVAGVDGAPASVVVRTAPEPVGSV 780
      **.****** ****:*****:********* *:**:*******.******** * *** *

Human SRLQILNASSDVLRITWVGVTGATAYRLAWGRSEGGPMRHQILPGNTDSAEIRGLEGGVS 839
Dog   SKLQILNASSDVLRVTWVGVTGATAYRLAWGRSEGGPTRQQMLPGNTDSAEIRGLEGGVS 839
Mouse SKLQILNASSDVLRVTWVGVPGATSYKLAWGRSEGGPMKHRILPGNKESAEIRDLEGGVS 840
      *:************:*****.***:*:********** ::::****.:*****.******

Human YSVRVTALVGDREGTPVSIVVTTPPEAPPALGTLHVVQRGEHSLRLRWEPVPRAQGFLLH 899
Dog   YSVRVTALVGDREGAPVSIVVTTPPEAPPALETLRVVQRGEHSLRLRWRPVPGARGFRLR 899
Mouse YSVRVTALVGDREGAPVSIVITTPPATPALLETLQVVQSGEHSLRLRWEPVPGAPGFRLH 900
      **************:*****:**** :*. * **:*** *********.*** * ** *:

Human WQPEGGQEQSRVLGPELSSYHLDGLEPATQYRVRLSVLGPAGEGPSAEVTARTESPRVPS 959
Dog   WRPEGGQEQSRVLGPDLSSYELDGLEPATLYRMWLSVLGPAGEGPPMEVTAYTESLRVPS 959
Mouse WQPEGGQEQSLTLGPESNSYNLVGLEPATKYQVWLTVLGQTGEGPPRKVTAYTEPSHIPS 960
      *:******** .***: .**.* ****** *:: *:*** :****. :*** **. ::**

Human IELRVVDTSIDSVTLAWTPVSRASSYILSWRPLRGPGQEVPGSPQTLPGISSSQRVTGLE 1019
Dog   SELRVVDTSVDSVTLAWTPVSGVSSYILSWRPLGRPGQDIPGASQTLPGISSSQQVTGLE 1019
Mouse TELRVVDTSIDSVTLTWTPVSGASSYILSWRPLRGTGQEVPRAPQTLPGTSSSHRVTGLE 1020
       ********:*****:***** .**********  .**::* :.***** ***::*****

Human PGVSYIFSLTPVLDGVRGPEASVTQTPVCPRGLADVVFLPHATQDNAHRAEATRRVLERL 1079
Dog   PGISYTFSLTPIREGVRGPEASLTQKPVCPRGLMDVVFLLHTTQDNAHRAEAAKRALERL 1079
Mouse PGISYVFSLTPIQSGVRGSEISVTQTPACSHGPVDVVFLLHATRDNAHNAEAVRRVLERL 1080
      **:** *****: .****.* *:**.*.*.:*  ***** *:*:****.***.:*.****

Human VLALGPLGPQAVQVGLLSYSHRPSPLFPLNGSHDLGIILQRIRDMPYMDPSGNNLGTAVV 1139
Dog   VSALGPLGPQAVQVGLLSYSHRPSPLFPLNSSYNPDVILQKIHSIPYVDPSGNNLGTAVV 1139
Mouse VSALGPLGPQAAQVGLLTYSHRPSPLFPLNSSHDLGIILRKIRDIPYVDPSGNNLGTAVT 1140
      * *********.*****:************.*:: .:**::*:.:**:***********.

Human TAHRYMLAPDAPGRRQHVPGVMVLLVDEPLRGDIFSPIREAQASGLNVVMLGMAGADPEQ 1199
Dog   TAHRHLLAPDAPGRRQHIPGIMVLLVDEPLRGDIFNPIREAQAAGLKVMILGQAGADPEQ 1199
Mouse TAHRYLLASNAPGRRQQVPGVMVLLVDEPLRGDILSPIREAQTSGLKVMALSLVGADPEQ 1200
      ****::**.:******::**:*************:.******::**:*: *. .******

Human LRRLAPGMDSVQTFFAVDDGPSLDQAVSGLATALCQASFTTQPRPEPCPVYCPKGQKGEP 1259
Dog   LRRLVPGMDPVQTFFAVDDGSSLDRAVSGLATSLCQIGSTIQPQPEPCTVHCPKGQKGEP 1259
Mouse LRRLAPGTDPIQNFFAVDNGPGLDRAVSDLAVALCQAAVTIEPQTGPCAVHCPKGQKGEP 1260
      ****.** *.:*.*****:*..**:***.**.:*** . * :*:. **.*:*********

Human GEMGLRGQVGPPGDPGLPGRTGAPGPQGPPGSATAKGERGFPGADGRPGSPGRAGNPGTP 1319
Dog   GEMGLKGQAGPPGPPGLPGRIGVPGPQGPPGGTVAKGERGFPGADGPPGSPGRPGTPGTP 1319
Mouse GVTGLQGQAGPPGPPGLPGRTGAPGPQGPPGSTQAKGERGFPGPEGPPGSPGLPGVPGSP 1320
      *  **:**.**** ****** *.********.: *********.:* ***** .* **:*

Human GAPGLKGSPGLPGPRGDPGERGPRGPKGEPGAPGQVIGGEGPGLPGRKGDPGPSGPPGPR 1379
Dog   GS---MGSPGWPGPRGETGERGPRGPKGEPGEPGRVIGGGGPGLPGQKGDPGLPGLPGSR 1376
Mouse GI---KGSTGRPGPRGEQGERGPQGPKGEPGEPGQITGGGGPGFPGKKGDPGPSGPPGSR 1377
      *     **.* *****: *****:******* **:: ** ***:**:***** .* **.*

Human GPLGDPGPRGPPGLPGTAMKGDKGDRGERGPPGPGEGGIAPGEPGLPGLPGSPGPQGPVG 1439
Dog   GPLGDPGPRGPPGLPGTAVKGDKGDRGERGPPGPGDGSTAPGEPGLPGLPGSPGPQGPVG 1436
Mouse GPVGDPGPRGPPGLPGISVKGDKGDRGERGPPGPGIGASEQGDPGLPGLPGSPGPQGPAG 1437
      **:************* ::**************** *.   *:***************.*

Human PPGKKGEKGDSEDGAPGLPGQPGSPGEQGPRGPPGAIGPKGDRGFPGPLGEAGEKGERGP 1499
Dog   PSGEKGEKGDCEDGAPGLPGQPGSPGEQGLRGPSGDIGPKGDRGPKGAVGDTGEKGERGS 1496
Mouse RPGEKGEKGDCEDGGPGLPGQPGPPGEPGLRGAPGMTGPKGDRGLTGTPGEPGVKGERGH 1497
       .*:******.***.********.*** * **..*  *******  *. *:.* ***** 

Human PGPAGSRGLPGVAGRPGAKGPEGPPGPTGRQGEKGEPGRPGDPAVVGPAVAGPKGEKGDV 1559
Dog   PGPVGPQGLPGVAGRPGAEGPEGPPGPVGRRGEKGEPGRPGDPAVG-PDGTGAKGEKGDV 1555
Mouse PGPVGPQGLPGAAGHPGVEGPEGPPGPTGRRGEKGEPGRPGDPAVG-PGGAGAKGEKGEA 1556
      ***.*.:****.**:**.:********.**:**************  *  :*.*****:.

Human GPAGPRGATGVQGERGPPGLVLPGDPGPKGDPGDRGPIGLTGRAGPPGDSGPPGEKGDPG 1619
Dog   GPTGPRGAAGVKGERGPPGLVLPGDPGPKGDPGDRGPIGLSGRAGPPGDSGPPGEKGDPG 1615
Mouse GLPGPRGASGSKGEQGAPGLALPGDPGPKGDPGDRGPIGLTGRAGPTGDSGPPGEKGEPG 1616
      * .*****:* :**:*.***.*******************:*****.**********:**

Human RPGPPGPVGPRGRDGEVGEKGDEGPPGDPGLPGKAGERGLRGAPGVRGPVGEKGDQGDPG 1679
Dog   RPGSPGPIGPRGRDGEVGEKGDEGPPGDPGLPGKAGERGLRGAPGARGPVGEKGDQGDPG 1675
Mouse RPGSPGPVGPRGRDGEAGEKGDEGIPGEPGLPGKAGERGLRGAPGPRGPVGEKGDQGDPG 1676
      ***.***:********.******* **:***************** **************

Human EDGRNGSPGSSGPKGDRGEPGPPGPPGRLVDTGPGAREKGEPGDRGQEGPRGPKGDPGLP 1739
Dog   EDGRNGSPGPSGPKGDRGEPGPPGLPGRLVDSGLGAGEKGEPGDRGQEGPRGPKGDPGPP 1735
Mouse EDGRNGSPGSSGPKGDRGEPGPPGPPGRLVDAGIESRDKGEPG---QEGPRGPKGDPGPP 1733
      *********.************** ******:*  : :*****   ************ *

Human GAPGERGIEGFRGPPGPQGDPGVRGPAGEKGDRGPPGLDGRSGLDGKPGAAGPSGPNGAA 1799
Dog   GASGERGVSGLRGPPGPQGDPGVRGPTGEKGDRGPPGLDGRSGLDGKPGAPGPPGPHGAT 1795
Mouse GVSGERGIDGLRGPPGPQGDPGVRGPAGDKGDRGPPGLDGRSGLDGKPGAPGPPGLHGAS 1793
      *..****:.*:***************:*:*********************.**.* :**:

Human GKAGDPGRDGLPGLRGEQGLPGPSGPPGLPGKPGEDGKPGLNGKNGEPGDPGEDGRKGEK 1859
Dog   GKAGDPGRDGLPGLRGEHGPPGPPGPPGIQGKPGEDGKPGLNGKNGEPGDPGEDGRKGEK 1855
Mouse GKAGDPGRDGLPGLRGEHGPPGPPGPPGVPGKAGDDGKPGLNGKNGDPGDPGEDGRKGEK 1853
      *****************:* ***.****: **.*:***********:*************

Human GDSGASGREGRDGPKGERGAPGILGPQGPPGLPGPVGPPGQGFPGVPGGTGPKGDRGETG 1919
Dog   GDSGAPGREGHDGPKGERGAPGSPGLQGPPGLPGQMGPSGQGFPGVPGNTGPKGDRGDTG 1915
Mouse GDSGAPGREGPDGPKGERGAPGNPGLQGPPGLPGQVGPPGQGFPGVPGITGPKGDRGETG 1913
      *****.**** ***********  * ******** :**.********* ********:**

Human SKGEQGLPGERGLRGEPGSVPNVDRLLETAGIKASALREIVETWDESSGSFLPVPERRRG 1979
Dog   PKGEQGLPGERGLRGDPGSVGNVERLLETIGIKTSALREIVETWDESSGSFLPMPERRRG 1975
Mouse SKGEQGLPGERGLRGEPGSLPNAERLLETAGIKVSALREIVDTWDESSGSFLPVPERRPG 1973
      .**************:***: *.:***** ***.*******:***********:**** *

Human PKGDSGEQGPPGKEGPIGFPGERGLKGDRGDPGPQGPPGLALGERGPPGPSGLAGEPGKP 2039
Dog   PKGDPGERGPPGKEGPIGFSGERGLKGERGDPGPQGPPGLALGERGPPGPPGLAGEPGKP 2035
Mouse PKGDPGDRGPPGKEGLIGFPGERGLKGERGDPGPQGPPGLALGERGPPGPPGLAGEPGKP 2033
      ****.*::******* ***.*******:**********************.*********

Human GIPGLPGRAGGVGEAGRPGERGERGEKGERGEQGRDGPPGLPGTPGPPGPPGPKVSVDEP 2099
Dog   GIPGLPGRAGGAGEAGRPGERGERGEKGERGEQGRDGPPGLP---GPPGPPGPKVAVDEP 2092
Mouse GIPGLPGRAGGSGEAGRPGERGERGEKGERGDQGRDGLPGLP---GPPGPPGPKVAIEEP 2090
      *********** *******************:***** ****   **********:::**

Human GPGLSGEQGPPGLKGAKGEPGSNGDQGPKGDRGVPGIKGDRGEPGPRGQDGNPGLPGERG 2159
Dog   GPGLSGVQGPPGFKGAKGEPGSDGDQGPKGDRGMPGIKGDRGEPGQKGLDGSPGLPGERG 2152
Mouse GPGLAREQGPPGLKGAKGEPGSDGDPGPKGDRGVPGIKGDVGEPGKRGHDGNPGLPGERG 2150
      ****:  *****:*********:** *******:****** **** :* **.********

Human MAGPEGKPGLQGPRGPPGPVGGHGDPGPPGAPGLAGPAGPQGPSGLKGEPGETGPPGRGL 2219
Dog   VAGPEGKPGLQGPRGTPGPVGGHGDPGPPGAPGLAGPAGPQGPSGLKGEPGETGPPGRGL 2212
Mouse VAGPEGKPGLQGPRGTPGPVGSHGDPGPPGAPGLAGPAGPQGPSGLKGEPGETGPPGRGL 2210
      :**************.*****.**************************************

Human TGPTGAVGLPGPPGPSGLVGPQGSPGLPGQVGETGKPGAPGRDGASGKDGDRGSPGVPGS 2279
Dog   PGPTGAVGLPGPPGPSGLVGPQGAPGLPGQVGETGKPGAPGRDGAGGKDGDRGAPGVPGS 2272
Mouse PGPVGAVGLPGPPGPSGLVGPQGSPGLPGQVGETGKPGPPGRDGSSGKDGDRGSPGVPGS 2270
      .**.*******************:**************.*****:.*******:******

Human PGLPGPVGPKGEPGPTGAPGQAVVGLPGAKGEKGAPGGLAGDLVGEPGAKGDRGLPGPRG 2339
Dog   PGLPGPVGPKGEPGQTGTPGQAVVGPPGAKGEKGAPGGLAGDLVGEPGAKGDRGLPGPRG 2332
Mouse PGLPGPVGPKGEPGPVGAPGQVVVGPPGAKGEKGAPGDLAGALLGEPGAKGDRGLPGPRG 2330
      ************** .*:***.*** ***********.*** *:****************

Human EKGEAGRAGEPGDPGEDGQKGAPGPKGFKGDPGVGVPGSPGPPGPPGVKGDLGLPGLPGA 2399
Dog   EKGEAGRAGEPGDPGEDGQKGAPGLKGNKGDPGVGVEGPPGPAGLPGVKGDVGPPGSPGA 2392
Mouse EKGEAGRAGGPGDPGEDGQKGAPGLKGLKGEPGIGVQGPPGPSGPPGMKGDLGPPGAPGA 2390
      ********* ************** ** **:**:** *.***.* **:***:* ** ***

Human PGVVGFPGQTGPRGEMGQPGPSGERGLAGPPGREGIPGPLGPPGPPGSVGPPGASGLKGD 2459
Dog   PGVVGFPGQTGPRGEMGQPGPSGERGLAGLPGREGPPGPLGPPGPPGSTGVPGASGPKGD 2452
Mouse PGVVGFPGQTGPRGETGQPGPVGERGLAGPPGREGAPGPLGPPGPPGSAGAPGASGLKGD 2450
      *************** ***** ******* ***** ************.* ***** ***

Human KGDPGVGLPGPRGERGEPGIRGEDGRPGQEGPRGLTGPPGSRGERGEKGDVGSAGLKGDK 2519
Dog   KGDSGVGLPGARGERGEPGVRGEDGRPGQEGPRGLTGPPGSRGERGEKGDAGTSGLKGDK 2512
Mouse KGDPGAGLPGPRGERGEPGVRGEDGHPGQEGPRGLVGPPGSRGEQGEKGAAGAAGLKGDK 2510
      ***.*.****.********:*****:*********.********:**** .*::******

Human GDSAVILGPPGPRGAKGDMGERGPRGLDGDKGPRGDNGDPGDKGSKGEPGDKGSAGLPGL 2579
Dog   GDAALAMGAPGPRGAKGDMGERGLPGIDGDKGPRGDTGNPGEKGTKGEPGDKGSAGLLGA 2572
Mouse GDSAVIEGPPGPRGAKGDMGERGPRGIDGDKGPRGESGNPGDKGSKGEPGDKGSAGSIGV 2570
      **:*:  *.**************  *:********:.*:**:**:***********  * 

Human RGLLGPQGQPGAAGIPGDPGSPGKDGVPGIRGEKGDVGFMGPRGLKGERGVKGACGLDGE 2639
Dog   RGLTGPKGEPGAAGIPGDPGSPGKDGTPGVRGDKGDTGFMGPRGLKGERGVKGACGLDGE 2632
Mouse RGLTGPKGEPGAAGIPGEPGAPGKDGIPGFRGDKGDIGFMGPRGLKGEKGIKGTCGRDGE 2630
      *** **:*:********:**:***** **.**:*** ***********:*:**:** ***

Human KGDKGEAGPPGRPGLAGHKGEMGEPGVPGQSGAPGKEGLIGPKGDRGFDGQPGPKGDQGE 2699
Dog   KGDKGEGGPPGRPGLAGRKGDMGEPGVPGQSGAPGKEGLIGPKGDRGFDGQPGSKGDQGE 2692
Mouse RGDKGEAGFPGRPGLAGKKGDMGEPGLPGQSGAPGKEGLIGPKGDRGFDGQSGPKGDQGE 2690
      :*****.* ********:**:*****:************************.*.******

Human KGERGTPGIGGFPGPSGNDGSAGPPGPPGSVGPRGPEGLQGQKGERGPPGERVVGAPGVP 2759
Dog   KGERGPPGIGGFPGPRGNDGSSGPPGPPGSVGPKGPEGLQGQKGERGPPGERMVGAPGAP 2752
Mouse KGERGPPGVGGFPGPRGNDGSSGPPGPPGGVGPKGPEGLQGQKGERGPPGESVVGAPGAP 2750
      *****.**:****** *****:*******.***:***************** :*****.*

Human GAPGERGEQGRPGPAGPRGEKGEAALTEDDIRGFVRQEMSQHCACQGQFIASGSRPLPSY 2819
Dog   GTPGERGEQGRPGPAGPRGEKGEAALTEDDIRAFVRQEMSQHCACQGQFIASGSRPLPSY 2812
Mouse GTPGERGEQGRPGPAGPRGEKGEAALTEDDIRDFVRQEMSQHCACQGQFIASGSRPLPGY 2810
      *:****************************** *************************.*

Human AADTAGSQLHAVPVLRVSHAEEEERVPPED-DEYSEYSEYSVEEYQDPEAPWD------- 2871
Dog   AADTAGPQLPPVPVLRVSHAEEEGQVPPED-DEY-EYSEYSVEEYQDPEAPQD------- 2863
Mouse AADTAGSQLHHVPVLRVSHVEEEGQVPPEDDDDFSEYSVYSVEDYQEPEVPWDGEAEIKG 2870
      ******.**  ********.*** :***** *:: *** ****:**:**.* *       

Human ----SDDPCSLPLDEGSCTAYTLRWYHRAVTGSTEACHPFVYGGCGGNANRFGTREACER 2927
Dog   ----GNDPCLLPLDEGSCTAYTLRWYHRAVASGTEACHPFVYGGCGGNANRFGTREACEH 2919
Mouse WDQRGSDLCSLPLDEGSCTAYTLRWYHRAVPGG-TACHPFVYGGCGGNANRFGTREACER 2929
          ..* * ********************...  ************************:

Human RCPPRVVQSQGTGTAQD 2944
Dog   RCRPHMVQNQGTGAARS 2936
Mouse RCPPQGVHSQKTGAA-- 2944
      ** *: *:.* **:*  

Type VII Collagen Accession Numbers:  NP_000085 - Human alpha 1 type VII collagen; NP_031764 - Mouse alpha 1 type VII collagen; NP_001002980- Dog alpha 1 type VII collagen

Predicted General Properties of Collagen alpha1(I)  (Homo sapiens) - Primary Sequence Analysis (with ProtParam) ^b

Number of amino acids: 1464  Molecular weight: 138911.4  Theoretical pI: 5.60

Amino acid composition: 
Ala (A) 140 9.6% Arg (R) 71 4.8% Asn (N) 28 1.9% Asp (D) 66 4.5% Cys (C) 18 1.2% Gln (Q) 49 3.3% Glu (E) 75 5.1% Gly (G) 391 26.7% His (H) 9 0.6% Ile (I) 24 1.6% Leu (L) 48 3.3% Lys (K) 57 3.9% Met (M) 13 0.9% Phe (F) 27 1.8% Pro (P) 278 19.0% Ser (S) 60 4.1% Thr (T) 44 3.0% Trp (W) 6 0.4% Tyr (Y) 13 0.9% Val (V) 47 3.2% Asx (B) 0 0.0% Glx (Z) 0 0.0% Xaa (X) 0 0.0%

Total number of negatively charged residues (Asp + Glu): 141 Total number of positively charged residues (Arg + Lys): 128 Atomic composition: Carbon C 5978 Hydrogen H 9285 Nitrogen N 1835 Oxygen O 1941 Sulfur S 31 Formula: C₅₉₇₈H₉₂₈₅N₁₈₃₅O₁₉₄₁S₃₁ Total number of atoms: 19070 Extinction coefficients: Extinction coefficients are in units of M^-1 cm^-1, at 280 nm measured in water. Ext. coefficient 53495 Abs 0.1% (=1 g/l) 0.385, assuming ALL Cys residues appear as half cystines Ext. coefficient 52370 Abs 0.1% (=1 g/l) 0.377, assuming NO Cys residues appear as half cystines Estimated half-life: The N-terminal of the sequence considered is M (Met). The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro). >20 hours (yeast, in vivo). >10 hours (Escherichia coli, in vivo). Instability index: The instability index (II) is computed to be 30.62 This classifies the protein as stable. Aliphatic index: 38.05 Grand average of hydropathicity (GRAVY): -0.786

 

Bioinformatics References

^a Higgins D., Thompson J., Gibson T. Thompson J. D., Higgins D. G., Gibson T. J.(1994). CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting,position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22:4673-4680.

^b Gasteiger E., Hoogland C., Gattiker A., Duvaud S., Wilkins M.R., Appel R.D., Bairoch A.; Protein Identification and Analysis Tools on the ExPASy Server;
(In) John M. Walker (ed): The Proteomics Protocols Handbook, Humana Press (2005). pp. 571-607  Full text - Copyright Humana Press.

Bookmark this page

Recent Articles on the Collagen Protein

Effect of VP12 and viperistatin on inhibition of collagen receptors-dependent melanoma metastasis.

Staniszewska I, Walsh EM, Rothman VL, Gaathon A, Tuszynski GP, Calvete JJ, Lazarovici P, Marcinkiewicz C

Cancer Biol Ther

Collagen IX is Required for the Integrity of Collagen II Fibrils and the Regulation of Vascular Plexus Formation in Zebrafish Caudal Fins.

Huang CC, Wang TC, Lin BH, Wang YW, Johnson SL, Yu J

Dev Biol

Electrophysiological characterization of embryonic hippocampal neurons cultured in a 3D collagen hydrogel.

Xu T, Molnar P, Gregory C, Das M, Boland T, Hickman JJ

Biomaterials

Collagen modified based membranes for tissue engineering: influence of type and molecular weight of GAGs on cell proliferation.

Ruozi B, Parma B, Croce MA, Tosi G, Bondioli L, Vismara S, Forni F, Vandelli MA

Int J Pharm

TGF-beta signaling and collagen deposition in chronic rhinosinusitis.

Van Bruaene N, Derycke L, Perez-Novo CA, Gevaert P, Holtappels G, De Ruyck N, Cuvelier C, Van Cauwenberge P, Bachert C

J Allergy Clin Immunol

Effects of Mechanical Stretch on Collagen and Cross-linking in Engineered Blood Vessels.

Solan A, Dahl SL, Niklason LE

Cell Transplant

Macromoleculeinsights Home   Privacy Policy