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Human CD Chart
Human non-CD Chart
Table 1: Human CD Cellular Antigens
|
Human CD Cellular Antigens
|
| Antigen Name |
Other Names |
MW |
Structure |
Distribution |
Function |
eBioscience Clone |
Formats |
| CD1a
|
T6
|
49kD
|
IgSF, MHC-like
|
cortical thymocytes, Langerhans cells, DC
|
antigen presentation, w/ β2m
|
HI149
|
PU, B, F, PE, Alexa FluorŽ 488, Alexa FluorŽ 647, Pacific BlueŽ
|
| CD1b
|
T6
|
45kD
|
IgSF, MHC-like
|
cortical thymocytes, Langerhans cells, DC
|
antigen presentation, w/ β2m
|
eBioSN13
|
PU, B
|
| CD1c
|
T6
|
43kD
|
IgSF, MHC-like
|
cortical thymocytes, Langerhans cells, DC, B subset
|
antigen presentation, w/ β2m
|
|
|
| CD1d
|
|
49kD
|
IgSF, MHC-like
|
intestinal epith, B subset, monolow, DC
|
antigen presentation, w/ β2m
|
|
|
| CD1e
|
|
28kD
|
IgSF, MHC-like
|
DC
|
antigen presentation, w/ β2m
|
|
|
| CD2
|
T11, LFA-2, SRBC-R
|
50kD
|
IgSF
|
thymocytes, T, NK
|
CD58 ligand, adhesion, T cell activation
|
RPA-2.10
|
PU, FG, B, F, PE, PE-Cy5
|
| CD2R
|
T11-3
|
50kD
|
IgSF
|
Tact
|
activation-dependent form of CD2
|
|
|
| CD3γ, CD3δ
|
T3
|
|
IgSF
|
T, thymocyte subset
|
w/ TCR, TCR surface expression/signal transduction
|
|
|
| CD3ε
|
T3
|
20kD
|
IgSF
|
T, thymocyte subset
|
w/ TCR, TCR surface expression/signal transduction
|
OKT3
|
PU, FG, F, PE, Alexa FluorŽ 488, Alexa FluorŽ 647, Pacific BlueŽ
|
|
|
|
|
|
|
|
UCHT1
|
PU, FG, B, F, PE, PE-Cy5, PE-Cy7, APC, APC-Tandem
|
|
|
|
|
|
|
|
HIT3a
|
PU, FG, F, PE
|
| CD4
|
T4
|
55kD
|
IgSF
|
thymocyte subset, T subset, mono, mac
|
MHC class II coreceptor, HIV receptor,
T cell differentiation/activation
|
RPA-T4
|
PU, FG, B, F, PE, PE-Cy5, PE-Cy7, APC, APC-Tandem
|
|
|
|
|
|
|
|
OKT4
|
PU, FG, B, F, PE, PE-Cy5.5, APC, Alexa FluorŽ 488, Alexa FluorŽ 647, Alexa FluorŽ 700, Pacific BlueŽ
|
| CD5
|
T1, Tp67
|
67kD
|
Scavenger R SF
|
thymocytes, T, B subset, B-CLL
|
CD72 receptor, TCR or BCR
signaling, T-B interaction
|
UCHT2
|
PU, B, F, PE,
PE-Cy7
|
| CD6
|
T12
|
100-130kD
|
Scavenger R SF
|
thymocytes, T, B subset
|
CD166 receptor,
T cell differentiation/
costimulation
|
|
|
| CD7
|
|
40kD
|
IgSF
|
hematopoietic progenitors,
thymocytes, T, NK
|
T costimulation
|
CD7-6B7
|
PU, B, F, PE,
PE-Cy5, APC
|
| CD8a
|
T8, Leu-2
|
32-34kD
|
IgSF
|
thymocyte subset, T subset, NK
|
MHC class I coreceptor, receptor for some
mutated HIV-1, T cell differentiation/activation
|
RPA-T8
|
PU, F, PE, PE-Cy5, PE-Cy7, APC, APC-Tandem
|
|
|
|
|
|
|
|
HIT8a
|
PU, FG, B, F, PE
|
|
|
|
|
|
|
|
OKT8
|
PU, FG, B, F, PE, APC, Alexa FluorŽ 488, Alexa FluorŽ 647, Alexa FluorŽ 700, Pacific BlueŽ
|
| CD8b
|
|
30-32kD
|
IgSF
|
thymocyte subset, T subset
|
|
|
|
| CD9
|
p24, MRP-1
|
22-27kD
|
TM4SF
|
pre-B, eosinophils, basophils, platelets, Tact
|
cellular adhesion and migration
|
eBioSN4 (SN4 C3-3A2)
|
PU, B, F, PE
|
| CD10
|
CALLA, NEP, gp100
|
100kD
|
type II TM
|
B precursors, T precursors, neutrophils
|
zinc-binding metalloproteinase, B cell development
|
eBioCB-CALLA (CB-CALLA)
|
PU, B, F, PE, PE-Cy5, APC
|
| CD11a
|
LFA-1, integrin αL
|
180kD
|
Integrin family
|
lymph, gran, mono, mac
|
CD11a/CD18 receptor for ICAM-1, -2,-3, intercellular
adhesion, T costimulation
|
HI111
|
PU, FG, F, PE
|
| CD11b
|
Mac-1, integrin αM
|
170kD
|
Integrin family
|
myeloid cells, NK
|
binds CD54, ECM, iC3b
|
CBRM1/5
|
PU, FG, F, PE, Alexa FluorŽ 647, Alexa FluorŽ 700
|
|
|
|
|
|
|
|
ICRF44
|
PU, B, PE, PE-Cy7
|
| CD11c
|
p150, 95, CR4, integrin αX
|
150kD
|
Integrin family
|
DC, myeloid cells, NK, B, T subset
|
binds CD54, fibrinogen and iC3b
|
3.9
|
PU, B, F, PE, PE-Cy7, APC
|
| CDw12
|
|
90-120kD
|
|
mono, gran, platelets
|
|
|
|
| CD13
|
Aminopeptidase N, APN
|
150-170kD
|
type II TM
|
myeloid cells
|
zinc-binding metalloproteinase, antigen processing,
receptor for corona virus strains
|
WM-15
|
PU, FG, F, PE, APC
|
| CD14
|
LPS-R
|
53-55kD
|
GPI-linked
|
mono, mac, Langerhans cells, granlow
|
receptor for LPS/LBP, LPS recognition
|
61D3
|
PU, FG, B, F, PE, PE-Cy7, APC
|
| CD15
|
Lewis-x, Lex
|
|
CHO
|
neutrophils, eosinophils, mono
|
adhesion
|
HI98
|
PU, B, F
|
| CD15s
|
Sialyl Lewis X
|
|
CHO
|
neutrophils, eosinophils, mono, memory helper T, Tact
and B, NK, HEV
|
CD62L and CD62P ligand, adhesion
|
|
|
| CD15u
|
Sulfated Lewis X
|
|
CHO
|
myeloid subset
|
adhesion
|
|
|
| CD16a
|
FcγRIIIA
|
50-65kD
|
IgSF
|
neutrophils, mac, NK
|
component of low affinity Fc receptor, phagocytosis
and ADCC
|
eBioCB16 (CB16)
|
PU, FG, B, PE
|
| CD16b
|
FcγRIIIB
|
48kD
|
IgSF
|
neutrophils
|
component of low affinity Fc receptor, phagocytosis
and ADCC
|
|
|
| CDw17
|
|
|
|
neutrophils, mono, platelets
|
lactosyl ceramide
|
|
|
| CD18
|
Integrin β2
|
95kD
|
Integrin family
|
broad, all leukocytes
|
w/ CD11a, b & c, adhesion
|
CLB-LFA-1/1
|
PU, F, PE
|
| CD19
|
B4
|
95kD
|
IgSF
|
B, FDC
|
complex w/ CD21and CD81, BCR coreceptor, B cell
activation/ differentiation
|
HIB19
|
PU, FG, B, F, PE, PE-Cy5, PE-Cy7, APC, APC-Tandem, Alexa FluorŽ 488, Alexa FluorŽ 647, Alexa FluorŽ 700, Pacific BlueŽ
|
| CD20
|
B1, Bp35
|
33-37kD
|
TM4SF
|
B, T subset
|
B cell activation
|
2H7
|
PU, B, F, PE, PE-Cy5, PE-Cy7, APC, APC-Tandem, Alexa FluorŽ 488, Alexa FluorŽ 647, Alexa FluorŽ 700, Pacific BlueŽ
|
| CD21
|
C3DR, CR2, EBV-R
|
145,110kD
|
CCRSF
|
B, FDC, T subset
|
complement C3d and EBV receptor, complex w/ CD19
and CD81, BCR coreceptor
|
BU32
|
PE, PE-Cy5
|
| CD22
|
BL-CAM, Siglec-2
|
150kD
|
IgSF, sialoadhesins
|
B
|
adhesion, B-mono, B-T interactions
|
|
|
| CD23
|
FcεRII
|
45kD
|
C-type lectin
|
B, activated mac, eosinophils, FDC, platelets
|
CD19-CD21-CD81 receptor, IgE low affinity receptor,
signal transduction
|
EBVCS2
|
PU, F, PE, PE-Cy7, APC
|
| CD24
|
BA-1
|
35-45kD
|
GPI-linked
|
thymocytes, erythrocytes, peripheral lymph, myeloid
|
binds P-selectin
|
eBioSN3 (SN3 A5-2H10)
|
PU, B, F, PE
|
| CD25
|
Tac, p55
|
55kD
|
type I TM
|
Tact, Bact, lymph progenitors
|
IL-2Rα, w/ IL-2Rβ and γ to form high affinity complex
|
BC96
|
PU, B, F, PE, PE-Cy5, PE-Cy7, APC
|
| CD26
|
DPP IV
|
110kD
|
type II TM
|
thymocyte subset, Tact, soluble form
|
dipeptidyl peptidase, T costimulation, HIV entry
|
2A6
|
PU, F, PE
|
| CD27
|
T14
|
50-55kD
|
TNFRSF
|
medullary thymocytes, T, B subset, NK subset
|
CD70 receptor, T costimulation
|
O323
|
PU, B, F, PE, APC, APC-Tandem, Alexa FluorŽ 700
|
|
|
|
|
|
|
|
LG.7F9
|
PU, FG, B, F, PE, APC
|
| CD28
|
Tp44, T44
|
44kD
|
IgSF
|
most T, thymocytes, plasma cells
|
CD80, CD86 receptor, T costimulation
|
CD28.2
|
PU, FG, B, F, PE, PE-Cy7, APC
|
|
|
|
|
|
|
|
CD28.6
|
FG
|
| CD29
|
Integrin β1
|
130kD
|
Integrin family
|
lymph, mono, granlow, platelets, mast cells, fibroblasts,
endoth
|
w/ CD49a (VLA-1) receptor for VCAM-1, MAdCAM-1
and ECM
|
MEM-101A
|
PU, F, PE, PE-Cy5
|
| CD30
|
Ki-1
|
105-120kD
|
TNFRSF
|
Bact, T and NK , Reed-Sternberg cells, anaplastic large
cell lymphoma
|
CD153 receptor, lymph proliferation/ apoptosis
|
|
|
| CD31
|
PECAM-1
|
130-140kD
|
IgSF
|
mono, platelets, gran, endoth, lymph subset
|
CD38 receptor, adhesion
|
WM59
|
PU, FG, B, F, PE, APC
|
| CD32
|
FcγRII
|
40kD
|
IgSF
|
mono, gran, B, platelets
|
low affinity Fc receptor for aggregated Ig and immune
complexes
|
|
|
| CD33
|
p67, Siglec-3
|
67kD
|
IgSF, sialoadhesins
|
myeloid progenitors, mono, gran, DC, mast cells, Tact
|
adhesion
|
HIM3-4
|
PU, F, PE, PE-Cy5
|
|
|
|
|
|
|
|
WM53
|
PU, F, PE, PE-Cy5, PE-Cy7, Alexa FluorŽ 700
|
| CD34
|
|
105-120kD
|
Sialomucin, type I TM
|
hematopoietic precursors, capillary endoth,
embryonic fibroblasts
|
stem cell marker, adhesion, CD62L receptor
|
|
|
| CD35
|
CR1
|
250kD
|
CCRSF
|
erythrocytes, B, mono, neutrophils, eosinophils,
FDC, T subset
|
complement receptor 1, binds C3b and C4b,
adhesion, phagocytosis
|
|
|
| CD36
|
GPIV
|
88kD
|
|
platelets, mono, mac, endoth, early erythrocytes
|
ECM receptor, adhesion, phagocytosis
|
mAb (please inquire)
|
PU
|
| CD37
|
|
40-52kD
|
TM4SF
|
B, Tlow, granlow
|
signal transduction
|
|
|
| CD38
|
T10
|
45kD
|
|
variable levels on majority of
hematopoietic cells, high expression
on plasma cells, B and Tact
|
ecto-ADP-ribosyl cyclase,
cell activation
|
HIT2
|
PU, B, F, PE, PE-Cy5,
PE-Cy7, APC, APC-Cy5.5
|
| CD39
|
|
78kD
|
NK, mac, Langerhans
cells, DC, Bact
|
B cell adhesion,
protects activated cells
from lysis, ecto-apyrase
|
|
|
|
| CD40
|
|
48kD
|
TNFRSF
|
B, mono, mac, FDC,
endoth, T subset
|
CD154 receptor, B
differentiation/ costimulation,
isotype-switching, rescues B
cells from apoptosis
|
5C3
|
PU, FG, F, PE
|
| CD41
|
gpIIb
|
125/22kD
|
Integrin family
|
platelets, megakaryocytes
|
w/ CD61 forms GPIIb, binds fibrinogen,
fibronectin, vWF, thrombospondin, platelet activation
and aggregation
|
HIP2
|
PU, F
|
|
|
|
|
|
|
|
HIP8
|
PU, F, PE
|
| CD42a
|
GPIX
|
22kD
|
LRRF
|
platelets, megakaryocytes
|
complex w/ CD42b, c and d, receptor for vWF and
thrombin, platelet adhesion to subendothelial matrices
|
|
|
| CD42b
|
GPIba
|
145kD
|
LRRF
|
platelets, megakaryocytes
|
complex w/ CD42a, c and d, binds to vWF and
thrombin, platelet adhesion/ activation
|
HIP1
|
PU, FG, F, PE
|
| CD42c
|
GPIbb
|
24kD
|
LRRF
|
platelets, megakaryocytes
|
complex w/ CD42a, b, d
|
|
|
| CD42d
|
GPV
|
82kD
|
LRRF
|
platelets, megakaryocytes
|
complex w/ CD42a-c
|
|
|
| CD43
|
Leukosialin, sialophorin
|
115-135kD
|
Sialomucin,
type I TM
|
leukocytes, except resting B, plateletslow
|
inhibition of T cell interaction, CD54R, adhesion
|
L10
|
PU, F, PE, APC
|
| CD44
|
H-CAM, Pgp-1
|
80-95kD
|
hyaladherin family
|
hematopoietic and non-hematopoietic cells, except
platelets, hepatocytes, testis
|
binds hyaluronic acid, adhesion
|
IM7
|
PU, FG, B, F, PE, PE-Cy5, PE-Cy5.5, PE-Cy7,
APC, APC-Tandem, Alexa FluorŽ 700, Pacific BlueŽ
|
| CD44R
|
CD44v
|
|
|
CD44 variants heterogeneous expression,
constitutively on epith, mono, upregulated on activated
leukocytes
|
adhesion, metastasis
|
|
|
| CD45
|
LCA, T200, B220
|
180-240kD
|
|
hematopoietic cells, multiple isoforms from alternative
splicing
|
tyrosine phosphatase, enhanced TCR & BCR signals
|
HI30
|
PU, B, F, PE, PE-Cy5, PE-Cy5.5, PE-Cy7, APC,
APC-Tandem, Cy5
|
|
|
|
|
|
|
|
RA3-6B2
|
PU, FG, B, F, PE, PE-Cy5, PE-Cy5.5, PE-Cy7, APC, APC-Cy5.5, APC-Tandem, Cy5, Alexa FluorŽ 488, Alexa FluorŽ 647, Pacific BlueŽ
|
| CD45RA
|
|
205-220kD
|
|
B, T subset(naive), mono
|
exon A isoforms of CD45
|
HI100
|
PU, B, F, PE, PE-Cy5, APC, Pacific BlueŽ
|
|
|
|
|
|
|
|
JS-83
|
PU, B, F, PE, PE-Cy5
|
| CD45RB
|
|
190-220kD
|
|
T subset, B, mono, mac, gran
|
exon B isoforms of CD45
|
MEM-55
|
PU, F, PE, PE-Cy5
|
| CD45RO
|
|
180kD
|
|
Tact, memory T, B subset, mono, mac, gran
|
isoform of CD45 lacking A, B, C exons
|
UCHL1
|
PU, F, PE, PE-Cy5, APC
|
| CD46
|
MCP
|
56/66kD
|
CCRSF
|
nucleated cells
|
membrane cofactor protein, binds C3b & C4b allowing
degradation by Factor I, measles virus receptor
|
|
|
| CD47
|
IAP
|
47-52kD
|
IgSF
|
hematopoietic cells, epith, endoth, fibroblasts, other
tissues
|
leukocyte adhesion, migration, activation
|
|
|
| CD47R
|
|
|
|
New designation for CDw149, similar distribution as
CD47 but dimmer
|
|
|
|
| CD48
|
Blast-1
|
45kD
|
IgSF
|
broad, all leukocytes
|
cell adhesion
|
|
|
| CD49a
|
VLA-1
|
210kD
|
Integrin family
|
Tact, mono
|
integrin α1, adhesion, CD49a/CD29
binds collagen and laminin
|
|
|
| CD49b
|
VLA-2
|
165kD
|
Integrin family
|
B, mono, platelets, Tact, megakaryocytes
|
integrin α2, adhesion, CD49b/CD29
binds collagen and laminin
|
eBioY418
|
PU, FG, F
|
| CD49c
|
VLA-3
|
125kD
|
Integrin family
|
B and Tlow, most adhesive cell lines
|
integrin α3, adhesion, CD49c/CD29 binds laminin,
fibronectin and collagen
|
mAb (please inquire)
|
|
| CD49d
|
VLA-4
|
150kD
|
Integrin family
|
T, B, NK, thymocytes, mono, eosinophils, mast, DC
|
integrin α4, adhesion, CD49d/CD29 binds fibronectin,
VCAM-1 & MAdCAM-1
|
9F10
|
PU, FG, PE
|
| CD49e
|
VLA-5
|
135, 25kD
|
Integrin family
|
thymocytes, T, mono, platelets, early and Bact
|
integrin α5, adhesion, CD49e/CD29
binds fibronectin
|
|
|
| CD49f
|
VLA-6
|
125kD
|
Integrin family
|
memory T, thymocytes, mono,
platelets, megakaryocytes, epith
|
integrin α6, adhesion,
CD49f/CD29
binds laminin
|
|
|
| CD50
|
ICAM-3
|
110-120kD
|
IgSF
|
hematopoietic, endoth, epidermal Langerhans cells
|
adhesion, costimulation
|
TP1/25.1
|
PU, F, PE
|
| CD51
|
Vitronectin receptor
|
125, 24kD
|
Integrin family
|
plateletslow, endoth, osteoblasts,
melanomas
|
integrin αv, adhesion, CD51/CD61 binds
vitronectin, vWF, fibrinogen and thrombospondin
|
23C6
|
PU, FG, B, F
|
| CD52
|
CAMPATH-1
|
21-28kD
|
|
thymocytes, T, B (not plasma cells), mono, mac
|
|
|
|
| CD53
|
|
35-42kD
|
TM4SF
|
leukocytes, DC, osteoblasts, osteoclasts
|
signal transduction
|
|
|
| CD54
|
ICAM-1
|
90-110kD
|
IgSF
|
endoth, mono, lymph (high upon activation)
|
receptor for CD11a/CD18 (LFA-1), CD11b/CD18
(Mac-1) and rhinovirus
|
HA58
|
PU, FG, B, PE
|
| CD55
|
DAF
|
60-70kD
|
GPI-linked
|
hematopoietic, endoth
|
binds C3b, complement regulation
|
143-30
|
PU, B, F, PE
|
| CD56
|
NCAM
|
175-185kD
|
IgSF
|
NK, T subset, neurons, some large granular
lymphocyte leukemias, myeloid leukemias
|
adhesion
|
MEM188
|
PU, FG, F, PE, PE-Cy5.5
|
| CD57
|
HNK-1, Leu-7
|
110kD
|
|
NK subset, T subset
|
|
TB01
|
F
|
| CD58
|
LFA-3
|
55-70kD
|
IgSF
|
hematopoietic, non-hematopoietic cells
|
CD2 receptor, adhesion
|
|
|
| CD59
|
Protectin, MAC- inhibitor
|
19kD
|
GPI-linked
|
hematopoietic, non-hematopoietic cells
|
binds complement C8 and C9, blocks assembly of
membrane attack complex
|
MEM-43
|
F, PE
|
| CD60a
|
GD3
|
|
CHO
|
T subset, platelets, thymic epith, astrocytes
|
costimulation
|
|
|
| CD60b
|
9-O-sialyl GD3
|
|
CHO
|
T subset, Bact
|
|
|
|
| CD60c
|
7-O-sialyl GD3
|
|
CHO
|
T subset
|
|
|
|
| CD61
|
GPIIIa
|
105kD
|
Integrin family
|
platelets, megakaryocytes, mac, endoth
|
integrin β3, adhesion, CD41/CD61 or CD51/CD61
mediate adhesion to ECM
|
23C6
|
PU, FG, B, F
|
| CD62E
|
E-selectin, ELAM-1
|
97,107-115kD
|
Selectin
family
|
endoth
|
binds CD15s, cell rolling, metastasis
|
|
|
| CD62L
|
L-selectin, LECAM-1
|
74, 95kD
|
Selectin family
|
B, naďve and memory T, mono, gran, NK, thymocytes
|
CD34, GlyCAM, and MAdCAM-1 receptor, leukocyte
homing, tethering, rolling
|
Dreg56
|
PU, FG, F, PE, PE-Cy5, PE-Cy7, APC, APC-Tandem
|
| CD62P
|
P-selectin, PADGEM
|
140kD
|
Selectin family
|
activated platelets, endoth
|
CD162, CD15s receptor, adhesion, neutrophil rolling,
platelet-neutrophil and platelet-mono interactions
|
AK-4
|
PU, FG, F, PE
|
| CD63
|
LIMP, LAMP-3
|
53kD
|
TM4SF
|
activated platelets, mono, mac
|
lysosomal membrane protein, moves to cell surface
after activation
|
|
|
| CD64
|
FcγRI
|
72kD
|
IgSF
|
mono, mac, DC, Interferon or G-CSF activated gran
|
high affinity receptor for IgG, phagocytosis and ADCC
|
10.1
|
PU, FG, F, PE
|
| CD65
|
|
|
|
gran, mono subset, myeloid leukemias
|
|
|
|
| CD65s
|
VIM2
|
|
|
gran, mono, myeloid leukemias
|
phagocytosis
|
|
|
| CD66a
|
BGP-1, NCA-160
|
160-180kD
|
IgSF, CEA family
|
neutrophils, epith
|
cell adhesion
|
|
|
| CD66b
|
CD67, CGM6
|
95-100kD
|
IgSF, CEA family
|
gran
|
cell adhesion, neutrophil activation
|
|
|
| CD66c
|
NCA
|
90kD
|
IgSF, CEA family
|
neutrophils, colon carcinoma
|
cell adhesion
|
|
|
| CD66d
|
CGM1
|
35kD
|
IgSF, CEA family
|
neutrophils
|
|
|
|
| CD66e
|
CEA
|
180-200kD
|
IgSF, CEA family
|
colon epith, colon cancer
|
cell adhesion
|
|
|
| CD66f
|
PSG, Sp-1
|
54-72kD
|
IgSF, CEA family
|
pregnancy specific glycoprotein, placental
syncytiotrophoblasts, fetal liver
|
immune regulation, protects fetus from maternal
immune system
|
|
|
| CD68
|
Macrosialin, gp110
|
110kD
|
Sialomucin
|
intracellularly in mono, mac, neutrophils, basophils,
large lymph, mast cells, DC, myeloid progenitors, liver
|
|
eBioY1/82A
|
|
| CD69
|
AIM
|
28, 32kD
|
C-type lectin
|
Tact, B, NK and gran, thymocytes, platelets,
Langerhans cells
|
signal transduction
|
FN50
|
PU, B, F, PE, PE-Cy7, APC
|
| CD70
|
Ki-24
|
50, 70, 90, 160kD
|
TNFSF
|
Bact and Tact
|
CD27 ligand, T and B cell costimulation
|
|
|
| CD71
|
T9
|
95kD
|
|
proliferating cells, reticulocytes, erythroid precursors
|
transferrin receptor, iron uptake
|
T56/14
|
PU, F, PE
|
|
|
|
|
|
|
|
OKT9
|
PU, FG, B, F, PE
|
| CD72
|
Lyb-2
|
42kD
|
C-type lectin
|
B, FDC
|
CD5, CD100 receptor, B proliferation
|
|
|
| CD73
|
|
69kD
|
GPI-linked
|
B subset, T subset, FDC, epith
|
ecto-5-nucleotidase, nucleoside uptake,
T costimulation, lymph adhesion
|
|
|
| CD74
|
Ii, invariant chain
|
33, 35, 41, 43kD
|
|
B, mac, mono, Langerhans cells, DC, Tact
|
MHC class II traffic and function
|
|
|
| CD75
|
|
|
CHO Sialoglycan family
|
B subset, epith
|
lactosamines
|
|
|
| CD75s
|
|
|
CHO Sialoglycan family
|
B subset, T subset
|
α-2,6-sialylated lactosamines (previously CDw75
and CDw76)
|
|
|
| CD77
|
Gb3, Pk blood group
|
|
|
germinal center B, Burkitts lymphomashigh, follicular
lymphomaslow
|
apoptosis
|
|
|
| CD79a
|
Iga
|
33, 45kD
|
IgSF
|
B
|
component of BCR, BCR surface expression and
signal transduction
|
|
|
| CD79b
|
Igb
|
37kD
|
IgSF
|
B
|
component of BCR, BCR surface expression and
signal transduction
|
SN8
|
PU, F, PE
|
| CD80
|
B7, B7-1, BB1
|
60kD
|
IgSF
|
Bact and Tact, mac, DC
|
binds to CD28, CD152, T costimulation
|
2D10.4
|
PU, FG, B, F, PE, PE-Cy5
|
| CD81
|
TAPA-1
|
26kD
|
TM4SF
|
T, B, NK, thymocytes, DC, endoth, fibroblast,
neuroblastomas, melanomas
|
complex w/ CD19 & CD21, signaling, T costimulation
|
|
|
| CD82
|
R2
|
50-53kD
|
TM4SF
|
leukocytes
|
signal transduction
|
53H5
|
PU, FG, F
|
| CD83
|
HB15
|
43kD
|
IgSF
|
Bact and Tact, DC, Langerhans cells
|
|
HB15e
|
PU, B, F, PE
|
| CDw84
|
|
73kD
|
|
mono, platelets, B, T subset, mac subset
|
|
|
|
| CD85
|
|
110kD
|
IgSF, ILT/LIR family
|
DC, mono, B, NK, T subset
|
inhibition of NK, T cell cytolytic function
|
|
|
| CD86
|
B70, B7-2
|
80kD
|
IgSF
|
mono, DC, Bact and Tact
|
binds to CD28, CD152, T costimulation
|
IT2.2
|
PU, FG, B, PE, PE-Cy5
|
| CD87
|
UPA-R
|
39-66kD
|
GPI-linked
|
gran, mono, NK, Tact, endoth,
fibroblasts
|
urokinase plasminogen
activator receptor,
inflammatory cell invasion,
metastasis
|
|
|
| CD88
|
C5aR
|
40kD
|
TM7SF
|
gran, mono, DC
|
C5a receptor,
granulocyte activation
|
|
|
| CD89
|
FcαR
|
55-75kD
|
IgSF
|
mono, mac, gran, neutrophils,
B subset, T subset
|
IgA receptor, phagocytosis,
degranulation, respiratory burst
|
|
|
| CD90
|
Thy-1
|
25-35kD
|
IgSF, GPI-linked
|
CD34+ hematopoietic subset, neurons
|
hematopoietic stem cell and neuron differentiation
|
|
|
| CD91
|
|
600kD
|
LDLR family
|
mono, mac, neurons, fibroblasts
|
receptor for α-2-macroglobulin
|
|
|
| CDw92
|
|
70kD
|
|
neutrophils, mono, platelets, endoth, fibroblasts
|
|
|
|
| CD93
|
|
120kD
|
|
neutrophils, mono, endoth
|
|
mAb (please inquire)
|
PU, B, APC
|
| CD94
|
KP43
|
43kD
|
C-type lectin
|
NK, T subset
|
complex w/ NKG2, inhibits NK function
|
DX22
|
PU, F, PE
|
| CD95
|
Apo-1, Fas
|
45kD
|
TNFRSF
|
lymph (high upon activation), mono, neutrophils
|
FasL (CD178) receptor, apoptosis
|
DX2
|
PU, B, F, PE, PE-Cy5
|
|
|
|
|
|
|
|
EOS9.1
|
PU, FG
|
| CD96
|
TACTILE
|
160kD
|
IgSF
|
NK, Tact
|
adhesion of activated T and NK
|
|
|
| CD97
|
|
74, 80, 90kD
|
TM7SF
|
Bact and Tact, mono, gran
|
|
|
|
| CD98
|
4F2
|
80, 40kD
|
|
T, B, NK, gran, all human cell lines
|
cellular activation
|
|
|
| CD99
|
MIC2, E2
|
32kD
|
|
leukocytes
|
T cell activation, adhesion
|
3B2/TA8
|
PU, F, PE
|
| CD99R
|
E2
|
32kD
|
|
T, NK, myeloid cells
|
isoform of CD99
|
|
|
| CD100
|
|
150kD
|
|
hematopoietic cells except
immature bone marrow
cells, RBC and platelets
|
cell adhesion,
cellular activation
|
|
|
| CD101
|
V7, p126
|
120kD
|
IgSF
|
mono, gran, DC, Tact
|
T cell activation
|
|
|
| CD102
|
ICAM-2
|
55-65kD
|
IgSF
|
lymph, mono, platelets,
endoth
|
binds CD11a/CD18,
costimulation
|
|
|
| CD103
|
HML-1, α6, integrin αE
|
150, 25kD
|
Integrin family
|
intraepithelial lymph, lymph subset, activated lymph
|
w/ integrin β7, binds E-cadherin,
lymph homing/retention
|
B-Ly7
|
PU, F, PE
|
| CD104
|
β4 integrin
|
220kD
|
Integrin family
|
epith, Schwann cells, keratinocytes, some tumor cells
|
w/ integrin α6 (CD49f), cell adhesion,
differentiation, metastasis
|
|
|
| CD105
|
Endoglin
|
95kD
|
homodimer
|
endoth, bone marrow subset, activated mac
|
cellular response to TGF-β1
|
SN6
|
PU, FG, PE, APC
|
| CD106
|
VCAM-1
|
110kD
|
IgSF
|
activated endoth, FDC
|
VLA-4(CD49d/CD29) receptor, leukocyte adhesion,
migration, costimulation
|
STA
|
PU, B, PE
|
| CD107a
|
LAMP-1
|
110kD
|
|
activated platelets, T, endoth, metastatic tumors
|
a lysosomal membrane protein
|
eBioH4A3 (H4A3)
|
PU, B, F, PE-PE-Cy5, Alexa FluorŽ 488, Alexa FluorŽ 647
|
| CD107b
|
LAMP-2
|
120kD
|
|
activated platelets, T, endoth, metastatic tumors
|
a lysosomal membrane protein
|
eBioH4B4 (H4B4)
|
PU, B, F, Alexa FluorŽ 488, Alexa FluorŽ 647
|
| CD108
|
|
80kD
|
|
erythrocytes, lymphoblasts, resting lymphlow
|
|
|
|
| CD109
|
|
170kD
|
|
Tact and platelets, CD34+ subset, endoth
|
|
|
|
| CD110
|
MPL, TPO-R
|
82-84kD
|
CRSF
|
megakaryocytes, platelets, some CD34+ stem cellslow
|
thrombopoietin receptor, megakaryocyte progenitor
cell growth/differentiation
|
|
|
| CD111
|
PRR1, Nectin-1
|
64-72kD
|
IgSF
|
stem cell subset, mac, neutrophils
|
|
|
|
| CD112
|
PRR2, Nectin-2
|
64-72kD
|
IgSF
|
mono, neutrophils, CD34+ subset, megakaryocytes,
endoth, epith
|
intercellular adhesion
|
|
|
| CDw113
|
PVRL3, Nectin3
|
83kD
|
IgSF
|
testis, placenta
|
adhesion molecule that interacts with afadin
|
|
|
| CD114
|
G-CSFR
|
95, 139kD
|
CRSF
|
myeloid progenitors, endoth
|
myeloid differentiation/proliferation
|
|
|
| CD115
|
M-CSFR, c-fms
|
150kD
|
IgSF, RTK family
|
mono, mac, monocytic progenitors
|
CSF-1R, monocytic differentiation/ proliferation
|
12-3A3-1B10
|
PU, B, PE
|
| CD116
|
GM-CSFRα
|
70-85kD
|
CRSF
|
mono, gran, DC, endoth
|
w/ common β, myeloid differentiation/proliferation
|
4H1
|
PU, B, F, PE
|
| CD117
|
c-kit, SCFR
|
145kD
|
IgSF, RTK family
|
hematopoietic progenitors, mast cells
|
SCF receptor, hematopoietic progenitor development/differentiation
|
YB5.B8
|
PU, B, PE
|
| CD118
|
LIFR, gp190
|
190kD
|
Type I CRSF &
secreted forms
|
epithelial cells in adult and embryo
|
membrane-bound involved in signal transduction, soluble form inhibits activity of LIF
|
|
|
| CDw119
|
IFNγR
|
90-100kD
|
|
mac, mono, B, T, NK, neutrophils, endoth
|
IFN-γ Rα, w/ IFN-γ AF-1, host defense
|
|
|
| CD120a
|
TNFR-I
|
50-60kD
|
TNFRSF
|
hematopoietic, non-hematopoietic cells
|
receptor for both TNF-α and TNF-β
|
|
|
| CD120b
|
TNFR-II
|
75-85kD
|
TNFRSF
|
hematopoietic, non-hematopoietic cells
|
receptor for both TNF-α and TNF-β
|
|
|
| CD121a
|
IL-1R type I
|
80kD
|
IgSF
|
dimly expressed on many cells
|
binds IL-1α and IL-1β, IL-1 signaling
|
|
|
| CDw121b
|
IL-1R, type II
|
60-70kD
|
IgSF
|
B, mac, mono, T subset
|
binds IL-1α and IL-1β, negative signals
|
|
|
| CD122
|
IL-2Rβ
|
75kD
|
CRSF
|
NK, T, B, mono
|
IL-2Rβ and IL-15Rβ, signal transduction
|
|
|
| CDw123
|
IL-3R
|
70kD
|
CRSF
|
lymph subset, basophils, hematopoietic progenitors,
mac, DC, megakaryocytes
|
IL-3Rα, w/ CDw131
|
6H6
|
PU, B, PE, PE-Cy7
|
| CD124
|
IL-4R
|
140kD
|
CRSF
|
lymphlow, mono, hematopoietic
precursors, .broblast, epith
|
IL-4Rα, w/ CD132 or IL-13Rα, T cell
growth/differentiation
|
X2/45-12
|
PU, FG
|
| CDw125
|
IL-5R
|
60kD
|
CRSF
|
eosinophils, basophils
|
IL-5Rα, w/ CDw131
|
|
|
| CD126
|
IL-6R
|
80kD
|
IgSF, CRSF
|
Bact and plasma cells, most leukocyteslow, fibroblasts
|
IL-6Rα, w/ CD130
|
|
|
| CD127
|
IL-7R
|
65-75kD
|
CRSF
|
T, pro-B
|
IL-7Rα, w/ CD132, B and T cell development
|
eBioRDR5
|
PU, FG, B, F, Alexa FluorŽ 647, Pacific BlueŽ
|
| CDw128
|
see CD181 & CD182
|
|
|
|
|
|
|
| CD130
|
IL-6Rβ, gp130
|
130kD
|
CRSF
|
Bact and plasma cells, most leukocyteslow, endoth
|
IL-6Rβ, IL-6, IL-11, LIF, CNF signals
|
|
|
| CDw131
|
IL-3R common β
|
95-120kD
|
CRSF
|
mono, gran, early B
|
w/ α subunits of IL-3R, IL-5R, and
GM-CSFR, signal transduction
|
1C1
|
PU, PE
|
| CD132
|
Common γ
|
64kD
|
CRSF
|
T, B, NK, mono, gran
|
subunit of IL-2R, IL-4R, IL-7R, IL-9R, and IL-15R,
signal transduction
|
mAb (please inquire)
|
PU
|
| CD133
|
AC133, prominin-like 1
|
120kD
|
TM5SF
|
hematopoietic stem cell subset, epith, endoth
|
|
|
|
| CD134
|
OX-40
|
48-50kD
|
TNFRSF
|
Tact
|
T cell activation, differentiation, apoptosis
|
ACT35
|
PU, F, PE, APC
|
| CD135
|
Flt3/Flk2
|
130-150kD
|
RTK family
|
myelomonocytic, primitive B progenitors
|
tyrosine kinase, binds FLT3 ligand, early lymph
development
|
BV10A4H2
|
PU, B, F, PE, APC
|
| CDw136
|
MSP-R, RON
|
180kD
|
RTK family
|
epith, CNS, PNS, hematopoietic subset
|
migration, morphological change and proliferation
of different target cells
|
|
|
| CDw137
|
4-1BB
|
30kD
|
TNFRSF
|
Tact
|
T costimulation
|
|
|
| CD138
|
Syndecan-1
|
80-150kD
|
Syndecan family
|
plasma cells, pre-B, basolateral surface of epith, meurons
|
receptor for ECM, cell morphology
|
DL-101
|
PU, F, PE
|
| CD139
|
|
228kD
|
|
B, mono, gran, erythrocyteslow
|
|
|
|
| CD140a
|
PDGFRα
|
180kD
|
RTK family
|
fibroblasts, smooth muscle & glial cells, chondrocytes
|
binds PDGF A and B
|
|
|
| CD140b
|
PDGFRβ
|
180kD
|
RTK family
|
fibroblasts, smooth muscle & glial cells, chondrocytes
|
binds PDGF B
|
|
|
| CD141
|
Thrombomodulin
|
100kD
|
C-type lectin
|
mono, neutrophils, endoth, smooth muscle cells
|
initiation of protein C anticoagulant signal
|
|
|
| CD142
|
Tissue Factor
|
45kD
|
|
mono, endoth,
keratinocytes, epith
|
binds clotting factor VIIa,
initiator of clotting
|
|
|
| CD143
|
ACE
|
170kD
|
|
endoth, epith, neurons,
fibroblasts, activated mac
|
angiotensin converting
enzyme, angiotensin II
& bradykinin metabolism
|
|
|
| CD144
|
VE-Cadherin,
Cadherin-5
|
130kD
|
Cadherin family
|
endoth
|
adhesion, cell-cell
interaction
|
16B1
|
PU, B, PE
|
| CDw145
|
|
110, 90kD
|
|
endoth, some
stromal cells
|
|
|
|
| CD146
|
MUC18, S-endo
|
113-118kD
|
IgSF
|
endoth, melanomas, FDC, Tact
|
adhesion
|
|
|
| CD147
|
Neurothelin, basoglin
|
|
IgSF
|
leukocytes, erythrocytes, platelets, endoth
|
adhesion
|
|
|
| CD148
|
HPTP-eta
|
240-260kD
|
|
gran, mono, DC, T (high upon activation)
|
tyrosine phosphatase R Type III
|
|
|
| CD150
|
SLAM
|
75-95kD
|
IgSF
|
T subset (high upon activation), B, DC, endoth
|
costimulation, proliferation, Ig production, measles
virus receptor
|
A12 (7D4)
|
PU, FG, B, F, PE
|
| CD151
|
PETA-3
|
32kD
|
|
endoth, megakaryocytes, platelets, epith
|
cell adhesion
|
mAb (please inquire)
|
|
| CD152
|
CTLA-4
|
33kD
|
IgSF
|
Tact and B
|
CD80 and CD86 receptor, negative regulation of T cell
costimulation
|
14D3
|
PU, FG, B, PE
|
|
|
|
|
|
|
|
eBio20A
|
PU, FG, B, PE
|
| CD153
|
CD30L
|
40kD
|
TNFSF
|
neutrophils, B, Tact and mac
|
CD30 ligand, T costimulation
|
|
|
| CD154
|
CD40L, gp39, TRAP
|
32-39kD
|
TNFSF
|
Tact
|
CD40 ligand, B and DC costimulation
|
24-31
|
PU, FG, F, PE
|
| CD155
|
PVR
|
80-90kD
|
IgSF
|
mono, mac, CD34+ thymocytes
|
Polio virus receptor (PVR)
|
|
|
| CD156a
|
ADAM8
|
69kD
|
|
neutrophils, mono
|
leukocyte extravasation
|
|
|
| CD156b
|
TACE/ADAM 17
|
100kD
|
|
broad
|
cleaves membrane proteins (TNF, TGFα)
to generate soluble forms
|
|
|
| CDw156c
|
ADAM10
|
98kD
|
Peptidase M12B family
|
lymphoid organs, peripheral blood leukocyte,
cartilage, chondrocytes and fetal liver
|
proteolytic cleavage of cell-surface molecules
including Notch, TNF-α, APP and ephrin-A2
|
polyclonal
|
|
| CD157
|
BST-1
|
42-45kD
|
|
gran, mono, B progenitors, endoth
|
ADP-ribosyl-cyclic ADP-ribose hydrolase activities,
pre-B cell growth
|
eBioSY11B5 (SY11B5)
|
PU, PE
|
| CD158a
|
p58.1
|
50-58kD
|
IgSF, KIR family
|
NK subset, T subset
|
inhibition of NK cell cytolytic activity, MHC class-I
specific NK receptor
|
|
|
| CD158b
|
p58.2
|
50-58kD
|
IgSF, KIR family
|
NK subset, T subset
|
inhibition of NK cell cytolytic activity, MHC class-I
specific NK receptor
|
|
|
| CD159a
|
NKG2A
|
43kD
|
|
T subset, NK
|
w/ CD94, NK cell receptor
|
|
|
| CD159c
|
NKG2C
|
40kD
|
Type II C-Type Lectin
|
NK
|
w/ MHC class I HLA-E molecules,
forms heterodimer with CD94
|
|
|
| CD160
|
BY55
|
27kD
|
IgSF
|
NK subset, T subset
|
costimulation
|
|
|
| CD161
|
NKR-P1A
|
40kD
|
C-type lectin
|
T subset, NK
|
NK cell-mediated cytotoxicity
|
|
|
| CD162
|
PSGL-1
|
120kD
|
Mucin family
|
mono, gran, most lymph
|
CD62P, CD62L ligand, adhesion, rolling
|
|
|
| CD162R
|
PEN-5
|
|
CHO
|
NK subset
|
|
|
|
| CD163
|
130kD
|
|
Scavenger receptor SF
|
mono, mac
|
|
eBioGHI/61 (GHI/61)
|
PU, B, PE
|
| CD164
|
MGC-24
|
80kD
|
epith, mono, lymphlow, bone marrow stromal cells,
CD34+ erythroid progenitors
|
hematopoietic progenitor cell-stromal cell interaction
|
|
|
|
| CD165
|
AD2, gp37
|
42kD
|
lymph subset, mono, immature thymocytes, platelets
|
adhesion, thymocyte-thymic epith interaction
|
|
|
|
| CD166
|
ALCAM
|
105kD
|
IgSF
|
neurons, mono, epith, fibroblasts, Tact
|
CD6 ligand, adhesion
|
|
|
| CD167a
|
DDR1
|
120kD
|
RTK family
|
epith, myoblasts
|
tyrosine kinase, adhesion to collagen
|
|
|
| CD168
|
RHAMM
|
84-88kD
|
|
mono, T subset, thymocyte subset, intracellularly in
breast cancer cells
|
adhesion, tumor migration, metastasis
|
|
|
| CD169
|
sialoadhesin, Siglec-1
|
185kD
|
IgSF,
sialoadhesins
|
tissue mac subset
|
adhesion, cell-cell and cell-matrix interactions, binds
CD227 on breast cancer cells and CD43 on T cells
|
|
|
| CD170
|
Siglec-5, CD33-like2
|
140kD
|
IgSF, sialoadhesins
|
Mac subset, neutrophils
|
adhesion
|
|
|
| CD171
|
L1
|
200-210kD
|
IgSF
|
CNS, PNS, glial cells, mono, T subset, B, DC, several
human tumor cells
|
kidney morphogenesis, lymph node architecture, T
costimulation, neurohistogenesis, homotypic
interaction, binds CD9, CD24, CD56, CD142,
CD166, integrins
|
|
|
| CD172a
|
SIRPγ
|
110kD
|
|
mono, T subset, stem cells
|
adhesion, complex w/ CD47
|
|
|
| CD172b
|
SIRPβ, SIRB1
|
50kD
|
IgSF
|
mono and DC
|
negative regulation of RTK-coupled signaling
|
|
|
| CD172g
|
SIRPγ, SIRPB2
|
45-50kD
|
IgSF, ASV
|
mRNA: liver and at lower levels in many tissues
|
binds CD47
|
|
|
| CD173
|
Blood group H type 2
|
|
CHO
|
erythrocytes, stem cell subset, platelets
|
|
|
|
| CD174
|
Lewis Y
|
|
CHO
|
stem cells subset, epith
|
|
|
|
| CD175
|
Tn
|
|
CHO
|
stem cells subset
|
|
|
|
| CD175s
|
Sialyl-Tn
|
|
CHO
|
erythroblasts
|
|
|
|
| CD176
|
Thomson Friedrenreich Ag
|
|
CHO
|
stem cell subset
|
|
|
|
| CD177
|
NB1
|
56-62kD
|
|
neutrophil subset
|
|
|
|
| CD178
|
FasL, CD95L
|
38-42kD
|
TNFSF
|
Tact, testis
|
CD95 ligand, apoptosis, immune privilege, soluble
form in serum
|
NOK-1
|
PU, FG, B, PE
|
| CD179a
|
V pre B
|
16-18kD
|
IgSF
|
Pro- and Pre-B
|
B cell differentiation/signaling, w/ IgM
|
|
|
| CD179b
|
Lambda 5
|
22kD
|
IgSF
|
Pro- and Pre-B
|
B cell differentiation/signaling, w/ IgM
|
|
|
| CD180
|
RP-105
|
95-105kD
|
LRRF, TLR family
|
B subset, mono, DC
|
B cell activation, LPS signaling, w/ MD-1
|
MHR73-11
|
PU, FG, B, PE
|
| CD181
|
CXCR1, IL-8RA
|
39kD
|
GPCR1 family
|
neutrophils, basophils, NK, T subset, mono
|
binding of IL-8 induces chemotaxis of neutrophils
|
mAb (please inquire)
|
|
| CD182
|
CXCR2, IL-8RB
|
40kD
|
GPCR1 family
|
neutrophils, basophils, NK, T subset, mono
|
binding of IL-8 induces chemotaxis of neutrophils
|
mAb (please inquire)
|
|
| CD183
|
CXCR3
|
40kD
|
TM7SF
|
eosinophils, Tact and NK, GM-CSF activated CD34+
progenitors
|
IP-10 , Mig and I-TAC receptor, T cell recruitment to
inflammatory sites, enhancement of Th1 response
|
|
|
| CD184
|
CXCR4, fusin
|
45kD
|
TM7SF
|
B, DC, T subset, mono, endoth
|
SDF-1 receptor, X4 HIV-1 coreceptor
|
12G5
|
PU, FG, B, PE, PE-Cy5, PE-Cy7, APC
|
| CD185
|
CXCR5, BLR1
|
45kD
|
GPCR1 family
|
mature B and Burkitt Lymphoma cells
|
w/ chemokine BLC, possible regulatory
function in Burkitt Lymphomagenesis and/or B
differentiation, activation of mature B
|
|
|
| CDw186
|
CXCR6, BONZO
|
40kD
|
GPCR1 family
|
Tact
|
receptor for CXCL16 and coreceptor for SIV, strains of
HIV-2 and m-tropic HIV-1
|
polyclonal
|
|
| CD191
|
CCR1, MIP-1αR, RANTES-R
|
39kD
|
GPCR1 family
|
T, mono, stem cell subset
|
binds C-C type chemokines and
transduces signal by increasing
intracellular calcium ion levels
|
|
|
| CD192
|
CCR2, MCP-1-R
|
40kD
|
GPCR1 family
|
activated NK and mononuclear
phagocytes, T subset, B, endoth
|
binds MCP-1, MCP-3 & MCP-4, alternative
coreceptor with CD4 for HIV-1 infection
|
|
|
| CD193
|
CCR3, CKR3
|
45kD
|
GPCR1 family
|
eosinophils, lower expression in neutrophils
and mono, T subset
|
binds eotaxin, eotaxin-3, MCP-3, MCP-4,
RANTES & MIP-1δ, alternative coreceptor
w/ CD4 for HIV-1 infectiongg
|
mAb (please inquire)
|
|
| CD195
|
CCR5
|
45kD
|
|
mono, T subset
|
MIP-1α, MIP-1β and RANTES receptor, R5 HIV-1
coreceptor
|
eBioT21/8 (T21/8)
|
PU, B, PE
|
|
|
|
|
|
|
|
R22/7
|
PU, FG, B, PE
|
|
|
|
|
|
|
|
V14/2
|
PU, FG, B, PE
|
|
|
|
|
|
|
|
polyclonal
|
|
| CD196
|
CCR6, LARC receptor, DRY6
|
45kD
|
GPCR1 family
|
T subset, B, DC subset
|
binds MIP-3α/LARC
|
|
|
| CD197
|
CCR7
|
45kD
|
|
T subset, DC Subset
|
6Ckine and MIP-2β receptor
|
CCR7.6B3
|
PU
|
| CDw198
|
CCR8, GPRCY6, TER1
|
50kD
|
GPCR1 family
|
T, high expression in Th2, NK, mono
|
allergic inflammation, alternative coreceptor
with CD4 for HIV-1 infection
|
polyclonal
|
|
| CDw199
|
CCR9, GPR-9-6
|
43kD
|
GPCR1 family
|
subset of memory T, lamina propria mononuclear cells
|
binds SCYA25/TECK, alternative coreceptor with
CD4 for HIV-1 infection
|
|
|
| CD200
|
OX-2
|
45-50kD
|
|
thymocytes, endoth, B, Tact
|
inhibition of immune response
|
|
|
| CD201
|
EPC-R
|
50kD
|
|
endoth subset
|
activated protein C receptor
|
|
|
| CD202b
|
Tie2, Tek
|
150kD
|
RTK family
|
stem cells, endoth
|
angiopoietin-1 receptor
|
|
|
| CD203c
|
NPP3/PDNP3, ENpp1, PD-1b
|
130-150kD
|
type II TM
|
basophils, mast cells, glioma cells, megakaryocytes
|
ectoenzyme, binding to and clearance of extracellular
nucleotides
|
|
|
| CD204
|
Macrophage scavenger-R
|
220kD
|
|
mac
|
endocytosis of macromolecules
|
|
|
| CD205
|
DEC-205
|
205kD
|
|
DC, thymic epith
|
DC, thymic epith
|
MG38
|
PU, B, F, PE
|
| CD206
|
macrophage mannose-R
|
180kD
|
|
DC subset, mac, mono
|
phagocytosis and pinocytosis of mannose containing
molecules
|
|
|
| CD207
|
Langerin
|
40kD
|
|
Langerhans cells
|
endocytic receptor
|
|
|
| CD208
|
DC-LAMP
|
70-90kD
|
|
DCact, interdigitating DC
|
|
|
|
| CD209
|
DC-SIGN
|
44kD
|
|
DC subset
|
ICAM-3 receptor, HIV-1 binding protein
|
eB-h209
|
PU, B, F, PE, APC
|
|
|
|
|
|
|
|
polyclonal
|
|
| CDw210
|
IL-10-R
|
90-110kD
|
|
T, B, NK, mono, mac
|
IL-10 receptor, signal transduction
|
|
|
| CD212
|
IL-12-R β1
|
100kD
|
|
Tact and NK
|
binds IL-12 w/ high affinity, associates
w/ IL-12 receptor β2
|
|
|
| CD213a1
|
IL-13-R α1
|
65kD
|
|
B, mono, fibroblasts, endoth
|
binds IL-13 w/ low affinity, w/ CD124
|
|
|
| CD213a2
|
IL-13-R α2
|
65kD
|
|
B, mono
|
binds IL-13 w/ high affinity
|
|
|
| CDw217
|
IL-17-R
|
120kD
|
|
broad
|
IL-17 receptor
|
|
|
| CDw218a
|
IL-18Rα, IL-1Rrp
|
70kD
|
IL-1R family
|
T, NK, DCs
|
binds IL-18, activation of NF-κB
|
H44
|
PU, B, F, PE
|
| CDw218b
|
IL-18Rβ, IL18RAP
|
70kD
|
IL-1R family
|
T, NK and DCs
|
heterodimeric receptor with IL-18Rα to enhance IL-18 binding
|
|
|
| CD220
|
Insulin-R
|
140, 70kD
|
|
broad
|
insulin receptor
|
|
|
| CD221
|
IGF-1 R
|
140, 70kD
|
|
broad
|
binds IGF w/ high affinity, signaling, cell proliferation/
differentiation
|
|
|
| CD222
|
IGF-II R,
mannose-6
phosphate-R
|
250kD
|
Type I TM
|
broad, 90-95%
intracellular
|
adhesion,
tumor growth,
a receptor for
TGFβ-LAP,
plasminogen,
proliferin,
truncated
form (220kD)
found in serum
|
|
|
| CD223
|
LAG-3
|
70kD
|
IgSF
|
Tact and NK
|
an MHC class II ligand
|
mAb (please inquire)
|
|
| CD224
|
GGT
|
27, 68kD
|
|
leukocytes, stem cells
|
|
|
|
| CD225
|
Leu-13
|
17kD
|
|
broad
|
|
|
|
| CD226
|
DNAM-1, PTA-1, TLiSA1
|
65kD
|
IgSF
|
T, NK, mono, platelets, activated HUVEC
|
activation of cell-mediated cytotoxicity, soluble form
(50kD) found in normal serum
|
|
|
| CD227
|
MUC1, EMA
|
300kD
|
Mucin family, type I TM
|
epith, stem cell subset, FDC, mono, B subset, some
myelomas
|
adhesion, signaling, binds CD169, CD54, & selectins
|
mAb (please inquire)
|
|
| CD228
|
Melanotransferrin
|
80-95kD
|
|
stem cells, melanomas
|
|
|
|
| CD229
|
Ly-9
|
95, 110kD
|
IgSF
|
T, B
|
adhesion
|
|
|
| CD230
|
Prion protein
|
35kD
|
broad
|
|
|
|
|
| CD231
|
TALLA-1, A15
|
30-45kD
|
TM4SF
|
T leukemias, neuroblastomas, brain neurons
|
marker for T cell acute lymphoblastic leukemia
|
|
|
| CD232
|
VESP-R
|
200kD
|
|
broad
|
|
|
|
| CD233
|
Band 3, SLC4A1
|
90kD
|
Anion exchanger family
|
erythrocytes
|
anion exchanger pump, transport of CO2, linking red
cell membrane to cytoskeleton
|
|
|
| CD234
|
Duffy, DARC
|
35-45kD
|
|
erythrocytes
|
Duffy antigen chemokine receptor
|
|
|
| CD235a
|
Glycophorin A
|
36kD
|
|
erythrocytes
|
|
HIR2 (also GA-R2)
|
PU, B, F, PE
|
| CD235ab
|
Glycophorin A/B
|
20kD
|
|
erythrocytes
|
|
mAb (please inquire)
|
|
| CD235b
|
Glycophorin B
|
20kD
|
|
erythrocytes
|
|
|
|
| CD236
|
Glycophorin C/D
|
32, 23kD
|
|
erythrocytes, stem cell subset
|
|
|
|
| CD236R
|
Glycophorin C
|
32kD
|
|
erythrocytes, stem cell subset
|
|
|
|
| CD238
|
Kell
|
93kD
|
|
erythrocytes, stem cell subset
|
|
|
|
| CD239
|
B-CAM
|
78-85kD
|
|
erythrocytes, stem cell subset
|
|
|
|
| CD240CE
|
Rh30CE
|
30-32kD
|
|
erythrocytes
|
|
|
|
| CD240D
|
Rh30D
|
30-32kD
|
TM12SF
|
erythrocytes
|
|
|
|
| CD241
|
RhAg, Rh50
|
50kD
|
TM12SF
|
erythrocytes
|
complex w/ CD47, LW, glycophorin B
|
|
|
| CD242
|
ICAM-4
|
42kD
|
IgSF
|
erythrocytes
|
adhesion, Landsteiner-Wiener blood group
|
|
|
| CD243
|
MDR-1, p170, P-gp
|
180kD
|
|
stem cells, small intestine, kidneystem cells, small intestine, kidney
|
ion pump
|
|
|
| CD244
|
2B4
|
70kD
|
type II TM
|
T subset, mono, basophils, NK
|
NK activation, CD48 ligand
|
eBioDM244
|
F, Alexa FluorŽ 647
|
|
|
|
|
|
|
|
eBioC1.7 (C1.7)
|
PU, FG, B, PE
|
| CD245
|
p220/240
|
220-240kD
|
|
T subset
|
|
|
|
| CD246
|
ALK, Ki-1
|
80kD
|
|
anaplastic T cell leukemias, small intestine, testis,
brain, not on normal lymph
|
brain development, implicated in ALK lymphomas
|
|
|
| CD247
|
TCRz
|
16kD
|
RTK family
|
T, NK
|
TCR complex subunit, coupling of antigen recognition
to signaling
|
|
|
| CD248
|
TEM1, Endosialin
|
175kD
|
C-Type Lectin
|
endothelial tissue, stromal fibroblasts
|
tumor progression and angiogenesis
|
|
|
| CD249
|
Aminopeptidase A
|
160kD
|
Peptidase M1 family
|
epith, endoth
|
renin-angiotensin system
|
|
|
| CD252
|
OX-40Ligand, gp34
|
34kD
|
TNFSF
|
Bact, cardiac myocytes
|
T costimulation
|
|
|
| CD253
|
TRAIL, Apo-2L, TL2, TNFSF10
|
|
TNFSF
|
Tact, many tissues
|
death
|
RIK-2
|
PU, FG, B, PE
|
|
|
|
|
|
|
|
polyclonal
|
|
| CD254
|
TRANCE, RANKL, OPGL
|
35kD
|
TNFSF
|
lymph node & BM stroma Tact
|
binds OPG and RANK, osteoclast differentiation,
enhances DC to stimulate naďve-T proliferation
|
MIH23
|
PU
|
|
|
|
|
|
|
|
MIH24
|
PU, B, PE
|
| CD256
|
APRIL, TALL-2
|
16kD
|
TNFSF
|
mono, mac
|
binds TACI & BCMA, B proliferation
|
polyclonal
|
|
| CD257
|
BLyS, BAFF, TALL-1
|
|
TNFSF
|
monoact, soluble form
|
B cell growth factor & costimulator
of Ig production
|
1D6
|
PU, B, F, PE
|
|
|
|
|
|
|
|
polyclonal
|
|
| CD258
|
LIGHT, HVEM-L
|
28kD
|
TNFSF
|
Tact, immature DC
|
binds LTBR,
T proliferation,
receptor for HVEM
|
|
|
| CD261
|
TRAIL-R1, DR4
|
57kD
|
TNFRSF
|
Tact, peripheral blood
leukocytes
|
contains death domain,
apoptosis via FADD & caspase-8
|
DJR1
|
PU, B, PE
|
|
|
|
|
|
|
|
polyclonal
|
|
| CD262
|
TRAIL-R2, DR5
|
60kD
|
TNFRSF
|
widely expressed, peripheral blood lymphocytes
|
contains death domain, apoptosis via
FADD and caspase-8
|
DJR2-4
|
PU, B, PE
|
|
|
|
|
|
|
|
DJR2-2
|
PU
|
|
|
|
|
|
|
|
2A7
|
PU, FG
|
|
|
|
|
|
|
|
polyclonal
|
|
| CD263
|
TRAIL-R3, DcR1, LIT
|
65kD
|
TNFRSF
|
peripheral blood lymphocytes
|
receptor for TRAIL but lacks death domain
|
DJR3
|
PU, B, PE
|
|
|
|
|
|
|
|
polyclonal
|
|
| CD264
|
TRAIL-R4, TRUNDD, DcR2
|
35kD
|
TNFRSF
|
peripheral blood leukocytes
|
binds TRAIL but contains truncated death domain
|
DJR4-1
|
PU, B, PE
|
|
|
|
|
|
|
|
polyclonal
|
|
| CD265
|
RANK, TRANCE-R, ODFR
|
97kD
|
TNFRSF
|
broad expression
|
binds TRANCE, osteoclastogenesis,
T-DC interactions
|
9A725
|
PU
|
| CD266
|
TWEAK-R, FGF-inducible 14
|
14kD
|
TNFRSF
|
heart, placenta and kidney, HUVEC
|
TWEAK receptor, cell-matrix interactions and endoth
growth and migration
|
ITEM-1
|
PU, PE
|
|
|
|
|
|
|
|
ITEM-2
|
PU, FG
|
|
|
|
|
|
|
|
ITEM-4
|
PU, B, PE
|
| CD267
|
TACI,
TNFR SF13B
|
|
|
B, Tact
|
binds BAFF
& APRIL
|
11H3
|
PU, FG, B, PE
|
|
|
|
|
|
|
|
polyclonal
|
|
| CD268
|
BAFFR, TR13C
|
25kD
|
TNFRSF
|
B
|
binds BLyS, mature B survival
|
8A7
|
PU, FG, B, F, PE
|
|
|
|
|
|
|
|
polyclonal
|
|
| CD269
|
BCMA, TNFRSF13B
|
20kD
|
TNFRSF
|
mature B (membrane and perinuclear)
|
APRIL & BAFF receptor, B survival & proliferation
|
|
|
| CD271
|
NGFR, p75 (NTR)
|
45kD
|
TNFRSF
|
neurons (schwann cells, growing neurites), BM
mesencymal cells
|
NGF, BDNF, NT-3, & NT-4 receptor, tumor suppressor,
cell survival and death
|
|
|
| CD272
|
BTLA
|
33kD
|
IgSF
|
Tact, B , remains on Th1
|
HVEM receptor, inhibitory response
|
MIH26
|
PU, FG, B, PE
|
| CD273
|
B7DC, PD-L2, PDCD1L2
|
25kD
|
IgSF
|
DC subset, mono, mac
|
PD-1 receptor, costimulation or suppression of T
proliferation
|
MIH18
|
PU, FG, B, PE
|
| CD274
|
B7-H1, PD-L1
|
33kD
|
IgSF
|
leukocytes, broad
|
PD-1 receptor, costimulation of lymphocytes
|
MIH1
|
PU, FG, B, PE, PE-Cy7, APC
|
| CD275
|
B7-H2, ICOSL, B7-RP1, GL50
|
60kD
|
B7 Family
|
B, DC, mono
|
costimulation, cytokine production
|
eBioMIH39
|
PU
|
|
|
|
|
|
|
|
MIH12
|
PU, FG, B, PE
|
| CD276
|
B7-H3
|
40-45kD
|
B7 Family, ASV
|
in vitro cultured DC and mono, Tact, mammary tissue
|
costimulation, T activation
|
M3.2D7
|
PU, FG, B, PE
|
| CD277
|
BT3.1, butyrophilin SF3 A1, BTF5
|
56kD
|
B7/BT family, ASV
|
T, B, NK, mono, DC, endoth, CD34+ cells,
tumor cell lines
|
T activation
|
eBioBT3.1 (20.1, BT3.1)
|
PU, B, PE
|
| CD278
|
ICOS, AILIM
|
55-60kD
|
CD28 family
|
Tact, Th2
|
binds ICOS-L, T costimulation
|
ISA-3
|
PU, FG, B, F, PE
|
| CD279
|
PD1, SLEB2
|
55kD
|
|
Tact and Bact
|
B7-H1 & B7-DC receptor, autoimmune
disease and peripheral tolerance
|
J116
|
PU, FG
|
|
|
|
|
|
|
|
MIH4
|
PU, F, PE, Alexa FluorŽ 647
|
| CD280
|
ENDO180, UPARAP
|
180kD
|
C-type lectin SF
|
chondrocytes, fibroblasts, endothelial, mac
|
mannose receptor, collagen matrix remodeling and
endocytic recycling
|
|
|
| CD281
|
TLR1
|
90kD
|
TLR family
|
low levels in PBMC, mono and possibly DC
|
innate immunity, w/ TLR2
|
GD2.F4
|
PU, FG, PE
|
| CD282
|
TLR2
|
90kD
|
TLR family
|
mono, neutrophil, upregulated in mac
|
binds dsRNA, response to bacterial lipoproteins,
innate immunity
|
TL2.1
|
PU, FG, B, F, PE, APC, Alexa FluorŽ 488, Alexa FluorŽ 647, Alexa FluorŽ 700
|
|
|
|
|
|
|
|
TL2.3
|
PU
|
|
|
|
|
|
|
|
T2.5
|
PU, FG, B, PE, PE-Cy7, Alexa FluorŽ 488, Alexa FluorŽ 647, Pacific BlueŽ
|
|
|
|
|
|
|
|
polyclonal
|
|
| CD283
|
TLR3
|
100kD
|
TLR family, ASV
|
derived moDC (may be intracellular)
|
binds dsRNA, innate immunity
|
TLR3.7
|
PU, FG, B, PE
|
| CD284
|
TLR4
|
100kD
|
TLR family, ASV
|
PBMC (weak in mono, immature DC & neutro)
|
binds LPS, innate immunity
|
HTA125
|
PU, FG, B, PE, PE-Cy5, PE-Cy7, APC, Alexa FluorŽ 488, Alexa FluorŽ 647, Alexa FluorŽ 700, Pacific BlueŽ
|
|
|
|
|
|
|
|
polyclonal
|
|
| CD289
|
TLR9
|
120kD
|
TLR family
|
pDC (intracellular)
|
binds CpG-DNA, innate immunity
|
eB72-1665
|
PU, PE
|
| CD292
|
BMPR1A, ALK3
|
57kD
|
Type I
|
bone progenitor
|
BMP 2 & 4 receptor, bone development
|
|
|
| CDw293
|
BMPR1B, ALK6
|
57kD
|
Type I, ASV
|
bone progenitor
|
BMP receptor, bone development
|
|
|
| CD294
|
CRTH2. GPR44
|
55-70kD
|
GPCR-7TM
|
Th2, eosinophils, basophils
|
binds prostaglandin D2, stimulatory effects on Th2,
allergic inflammation
|
|
|
| CD295
|
LeptinR, LEPR
|
132kD
|
Type I cytokine-like
receptor
|
broad
|
adipose metabolism, immune dysfunction in obesity
|
|
|
| CD296
|
ART1, RT6, ART2
|
37kD
|
ADP-ribosyltransferase
|
heart and skeletal muscle, peripheral T, NK subset
|
modifies integrins during differentiation,
ADP ribosylation of target proteins
|
|
|
| CD297
|
ART4, dombrock blood group
|
38kD
|
ADP-ribosyltransferase
|
erythroid, monoact
|
ADP ribosylation of target proteins
|
|
|
| CD298
|
Na+/K+-ATPase β3 subunit
|
52kD
|
|
broad
|
transport sodium & potassium ions across membrane
|
|
|
| CD299
|
DC-SIGN-related, LSIGN, DC-SIGN2
|
45kD
|
Type II, similar to CD209, ASV
|
endothelial subset
|
binds ICAM3, HIV-1 gp120, coreceptor w/
DC-SIGN, HIV infection
|
|
|
| CD300a
|
CMRF35H, IRC1, IRp60
|
60kD
|
IgSF, ASV
|
NK, mono, neutrophils, T and B subset and
lymphocytic cell lines, AML
|
unknown
|
|
|
| CD300c
|
CMRF35A, LIR
|
|
IgSF
|
mono, neutrophils, monocytic cell lines, B & T subsets
|
unknown
|
|
|
| CD300e
|
CMRF35L
|
|
IgSF CMRF family
|
|
unknown
|
|
|
| CD301
|
MGL, HML
|
38kD
|
C type lectin SF, ASV
|
immature DC
|
binds Tn antigen, uptake of
glycosylated antigens
|
|
|
| CD302
|
DCL1, BIMLEC
|
19-28kD
|
Type I TM C-type
lectin receptor
|
some myeloid and
Hodgkins cell lines
|
a fusion protein in
Hodgkins lymphoma w/
DEC-205
|
|
|
| CD303
|
BDCA2, HECL
|
38kD
|
C-type lectin SF
ASV
|
plasmacytoid dendritic cells
|
inhibit IFN-α production
|
|
|
| CD304
|
BDCA4, neuropilin 1
|
130kD
|
semaphorin family
|
neurons, CD4+/CD25+ Treg, DC, endothelial and
tumor cells
|
interacts w/ VEGF165 & semaphorins, co-receptor
with plexin, axonal guidance, angiogenesis, cell
survival, migration
|
|
|
| CD305
|
LAIR1
|
32-40kD
|
IgSF, ASV
|
NK, B, T, mono
|
inhibitory receptor on NK and T cells
|
|
|
| CD306
|
LAIR2
|
|
IgSF, ASV
|
unknown
|
soluble, mucosal tolerance
|
|
|
| CD307
|
IRTA2
|
55-105kD
|
IgSF (Fc receptor), ASV
|
B subset, B lymphoma
|
B cell development, translocation in some lymphomas
|
|
|
| CD309
|
VEGFR2, KDR
|
230kD
|
Type III TM tyr kinase
|
endothelial, angiogenic precursor cells, hemangioblast
|
binds VEGF, regulates adhesion and cell signaling
|
|
|
| CD312
|
EMR2
|
90kD
|
EGFR-7TM ASV
|
mono, mac, moDC, granslow
|
cell adhesion and migration for phagocytosis
|
|
|
| CD314
|
NKG2D, KLR
|
42kD
|
Type II lectin-like receptor
|
NK, CD8+ activated, NK1.1+ T, some myeloid cells
|
binds MHC class I, MICA, MICB, Rae1 & ULBP4,
activates cytolysis and cytokine production,
costimulation
|
1D11
|
PU, FG, B, F, PE, APC
|
|
|
|
|
|
|
|
5C6
|
PU, FG, B, PE
|
| CD315
|
CD9P1, SMAP6, FPRP, PTGFRN
|
135kD
|
IgSF
|
B subset, monoact
|
w/ CD81 and CD9
|
|
|
| CD316
|
EWI2, PGRL, CD81P3, KASP
|
63-75kD
|
IgSF8
|
B, T cells, low on NK cells
|
w/ CD81 & CD9; involved in cell migration
|
|
|
| CD317
|
BST2, HM1.24
|
30-36kD
|
Type II
|
B, T, NK, mono, DC, fibroblast cell line, myeloma
|
pre-B cell growth, overexpressed in multiple myeloma
|
|
|
| CD318
|
CDCP1, SIMA135
|
135kD
|
Type I, ASV
|
HSC (subset of CD34+), tumors
|
cell adhesion with ECM
|
|
|
| CD319
|
CRACC, SLAMF7
|
66kD
|
Ig TM
|
T, B and DC subset, NK, upregulated in DC
|
regulate T and NK cells
|
|
|
| CD320
|
8D6A, 8D6
|
30kD
|
LDL receptor
|
follicular DC, germinal centers
|
B proliferation, tumor formation
|
|
|
| CD321
|
JAM1, F11 receptor
|
35kD
|
IgSF, Type I, ASV
|
platelet receptor, epithelia and endothelial, platelets
|
tight junctions
|
|
|
| CD322
|
JAM2, VE-JAM
|
43kD
|
IgSF
|
HEV, other endoth
|
cell adhesion, lymphocyte homing to secondary
lymphoid organs
|
|
|
| CD324
|
E-Cadherin, Uvomorulin
|
120kD
|
cadherin SF
|
non-neural epith
|
cell adhesion, homotypic interaction & binds αE/β7
|
|
|
| CDw325
|
N-Cadherin,
NCAD
|
140kD
|
cadherin SF
|
brain, skeletal and
cardiac muscle
|
cell adhesion, neuronal recognition
|
|
|
| CD326
|
Ep-CAM, Ly74
|
35-40kD
|
|
most epith cell membranes
|
growth factor receptor?
|
|
|
| CDw327
|
SIGLEC6
|
|
IgSF
|
placenta, spleen, B
. sialic-acid dependent
|
adhesion, membrane-
bound & secreted forms
|
|
|
| CDw328
|
SIGLEC7,
AIRM-1
|
75kD
|
IgSF
|
resting and activated
NK, placenta, liver,
spleen, lower in gran & mono
|
sialic-acid dependent adhesion,
inhibit NK activation, hemopoiesis
|
|
|
| CDw329
|
SIGLEC9
|
|
IgSF
|
neutrophils and mono
|
sialic-acid dependent adhesion molecule
|
|
|
| CD331
|
FGFR1, Fms-like tyrosine kinase-2, KAL2,
N-SAM
|
30kD
|
TM tyr kinase
|
fibroblasts, epithelial
|
binds FGF, high affinity receptor for fibroblast
growth factors
|
|
|
| CD332
|
FGFR2, BEK, KGFR
|
115-135kD
|
TM RTK family
|
fibroblasts, epithelial
|
binds FGF, high affinity receptor for fibroblast
growth factors
|
|
|
| CD333
|
FGFR3, ACH, CEK2
|
115kD
|
TM RTK family
|
fibroblasts, epithelial
|
binds FGF, high affinity receptor for fibroblast
growth factors
|
|
|
| CD334
|
FGFR4, JTK2, TKF
|
110kD
|
TM RTK family
|
fibroblasts, epithelial
|
binds FGF, high affinity receptor for fibroblast
growth factors
|
|
|
| CD335
|
NKp46, Ly-94 homolog
|
46kD
|
IgSF
|
NK
|
activates NK cells upon non-MHC ligand binding
|
|
|
| CD336
|
NKp44, Ly-95 homolog
|
44kD
|
IgSF
|
NK
|
activates NK cells upon non-MHC ligand binding
|
|
|
| CD337
|
NKp30, Ly117
|
30kD
|
IgSF
|
NK
|
activates NK cells upon non-MHC ligand binding
|
|
|
| CDw338
|
ABCG2, BCRP, Bcrp1, MXR
|
73kD
|
GPCR 7TM
|
stem cell subset (side population)
|
multi-drug resistance transporter
|
5D3
|
PU, FG, B, PE
|
| CD339
|
Jagged-1, JAG1, JAGL1, hJ1
|
135kD
|
EGF TM
|
stromal cells, epithelial, AML
|
binds Notch, hematopoiesis
|
|
|
Table 2: Human non-CD Cellular Antigens
|
Human non-CD Cellular Antigens
|
| Antigen Name |
Other Names |
MW |
Structure |
Distribution |
Function |
eBioscience Clone |
Formats |
| 4-1BB Ligand
|
CD137L
|
|
TNFSF
|
Bact, DC, carcinoma cell lines
|
T costimulation
|
|
|
| AID
|
|
|
RNA-editing deaminase family
|
Bact, Germinal Center B
|
Activation-Induced Deaminase, Ig class
switch recombination
|
hAID
|
PU
|
| AITR
|
TNFRSF18, GITR
|
|
|
Treg, Tact
|
costimulation
|
eBioAITR
|
PU, APC, Alexa FluorŽ 488
|
| AITRL
|
TNFSF18, TL6, GITRL
|
|
|
APC
|
|
eBioAITR-L
|
PU
|
| B7 family
|
see CD273-276
|
|
|
|
|
|
|
| B7-H4
|
B7-S1, B7x
|
|
B7 family
|
|
may interact with BTLA (?),
inhibition
|
H74
|
PU, FG, B, PE
|
| BAMBI
|
TGFBR
|
29kD
|
TGFBR
|
carcinoma cell
|
pseudoreceptor for TGF-β
(short cytoplasmic domain),
growth inhibition
|
4E8
|
PU, B, PE
|
| BCMA
|
see CD269
|
|
|
|
|
|
|
| BLyS
|
see CD257
|
|
|
|
|
|
|
| BR3
|
see CD268
|
|
|
|
|
|
|
| BTLA
|
see CD272
|
|
|
|
|
|
|
| CCR7
|
see CD197
|
|
|
|
|
|
|
| c-Met
|
HGFR/SFR
|
190kD
|
heterodimer, PTK
|
epith, hematopoietic progenitors, early thymocytes
|
tumor growth/metastasis, Hepatocyte Growth
Factor/Scatter Factor receptor, T development,
hematopoiesis
|
eBioclone 97
|
PU, B, F
|
| CMKLR1
|
chemokine-like receptor 1
|
42kD
|
GPCR 7TM,
chemokine receptor
|
pDC (CD123+), in vitro derived moDC
|
binds chemerin, pDC recruitment, bone development
|
BZ332
|
PU, B, F, PE, Alexa FluorŽ 488, Alexa FluorŽ 647
|
| DcR3
|
TR6, TNFRSF6B
|
|
Soluble
|
tumors
|
Fas decoy receptor, tumor evasion
|
37A565
|
PU
|
|
|
|
|
|
|
|
polyclonal
|
|
| DEC-205
|
see CD205
|
|
|
|
|
|
|
| DR3
|
TRAMP, Apo-3, WSL-1, LARD, TR3
|
|
TNFRSF
|
Tact, leukocytes
|
lymphocyte homeostasis
|
JD3
|
PU, B, PE
|
|
|
|
|
|
|
|
polyclonal
|
|
| DR6
|
TR7
|
|
TNFRSF
|
|
death, Th2 response
|
polyclonal
|
|
| FcεRIα
|
high-affinity IgE receptor
|
|
tetramer complex
|
mast cells, basophils
|
triggers IgE-mediated allergic reactions
|
AER-37 (CRA1)
|
PU, FG, B, F, PE, APC
|
| Foxp3
|
SCURFIN
|
50kD
|
Fox family forkhead
|
T subsets (CD4+/CD25+ subset and CD8+ subset)
|
transcription factor, upregulated in T regs
|
PCH101
|
PU, B, F, PE, PE-Cy5, APC, Alexa FluorŽ 488, Alexa FluorŽ 647, Alexa FluorŽ 700, Pacific BlueŽ
|
|
|
|
|
|
|
|
236A/E7
|
PU, B, F, PE, APC, Alexa FluorŽ 488, Alexa FluorŽ 647, Pacific BlueŽ
|
|
|
|
|
|
|
|
eBio7979
|
PU, PE, Alexa FluorŽ 488, Alexa FluorŽ 647
|
|
|
|
|
|
|
|
150D/E4
|
PU, PE, Alexa FluorŽ 488, Alexa FluorŽ 647
|
| Granzyme B
|
Granzyme-2, CTLA-1
|
30kD
|
Peptidase
S1 family
|
Cytotoxic T, NK
|
target cell apoptotic lysis, cell-mediated immune
responses
|
eBioGrB
|
PU, PE
|
| HLA-ABC
|
|
45, 11-12kD
|
|
nucleated cells
|
cell-mediated immune response & tumor surveillance
|
W6/32
|
PU, FG, B, F, PE, PE-Cy5
|
| HLA-DR
|
|
|
|
APC, Tact
|
presentation of peptides to CD4+ T lymphocytes
|
LN3
|
PU, B, PE, PE-Cy5, PE-Cy7, APC, Alexa FluorŽ 700
|
| HVEM
|
TNFRSF14, TR2
|
60kD
|
TNFRSF
|
broad expression
|
receptor for LIGHT, LT-α, BTLA, Herpes Simplex
Virus, lymphocyte activation
|
eBioHVEM-122
|
PU
|
| ICOS
|
see CD278
|
|
|
|
|
|
|
| ICOSL
|
see CD275
|
|
|
|
|
|
|
| IL-15Rα
|
|
|
|
monoact
|
binds to IL-15, w/ IL-2RB and common γ, IL-15 trans-presentation
|
mAb (please inquire)
|
|
| Integrin β5
|
|
100kD
|
|
carcinoma cell lines, fibroblast lines
|
w/ αv subunit, vitronectin receptor
|
KN52
|
PU, FG, F, PE
|
| MD-2
|
|
30KD
|
|
w/ TLR4 distribution and LPS recognition
|
|
9B4
|
PU
|
| MICA/MICB
|
|
70kD
|
MHC Class I-related proteins
|
intestinal epith, some tumors
|
unregulated on epith after shock, NKG2D receptors
|
6D4
|
PU, FG, PE, Alexa FluorŽ 488
|
| Nanog
|
|
34kD
|
|
ES cells
|
transcription factor, self renewal of ES cells
|
hNanog.1
|
PU, B, F
|
|
|
|
|
|
|
|
hNanog.2
|
PU, F
|
| NKG2D
|
see CD314
|
|
|
|
|
|
|
| NOD2
|
CARD-15, IBD1
|
|
|
monocytes, intracellular
|
|
2D9
|
PU
|
| Notch-1
|
Lin-12, Tan 1
|
|
|
developing embryo, variety of adult tissues
|
cell-cell interaction, cell fate determination
|
mN1A
|
PU, B, PE
|
| OPG
|
TRAIL-R5, TR1,
TNFRSF11B
|
|
|
binds TRAIL?
|
bone resorption
|
|
|
| OX-40
|
see CD134
|
|
|
|
|
|
|
| OX-40 Ligand
|
see
CD252
|
|
|
|
|
|
|
| p38
|
|
38kD
|
SAP/MAP kinase
|
NK, CD8+ T subset, upregulated on CD8+T
|
role in cytolytic activity
|
eBioC1.7 (C1.7)
|
PU, FG, B, PE
|
| PD-1
|
see CD279
|
|
|
|
|
|
|
| PD-L1
|
see CD274
|
|
|
|
|
|
|
| PD-L2
|
see CD273
|
|
|
|
|
|
|
| Perforin
|
|
70-75kD
|
|
CTL, NK
|
cytolytic protein
|
eBioBOR21
|
PU
|
|
|
|
|
|
|
|
dG9
|
PU, F, PE
|
| RP105
|
see CD180
|
|
|
|
|
|
|
| RANK
|
see CD265
|
|
|
|
|
|
|
| RANKL
|
see CD254
|
|
|
|
|
|
|
| SAP
|
SLAM-associated protein
|
14kD
|
adaptor protein
|
T, NK
|
negatively regulates SLAM- family receptors
|
mAb (please inquire)
|
|
| SLP-76
|
|
76kD
|
|
T, Blow
|
T cell receptor mediated signaling
|
HS76
|
PU, F
|
| SSEA-1
|
stage-specific embryonic antigen-1
|
|
|
ES cells, embryonic carcinomas, germ cells
|
down regulated by differentiation
|
eBioMC-631 (MC-631)
|
PU, B, PE, Alexa FluorŽ 488
|
| SSEA-3
|
stage-specific embryonic antigen-3
|
|
|
|
|
eBioMC-813-70 (MC-813-70)
|
PU, B, PE, Alexa FluorŽ 488
|
| SSEA-4
|
stage-specific embryonic antigen-4
|
|
|
|
|
eBioMC-813-70 (MC-813-70)
|
PU, B, PE, Alexa FluorŽ 488
|
| Stro-1
|
|
|
|
BM stroma, erythroid progenitors
|
surface marker for immature mesenchymal cells
|
eBioStro-1
|
|
| TACI
|
see CD267
|
|
|
|
|
|
|
| T-bet
|
|
|
|
Th1 cells
|
transcription factor, T development/differentiation
|
mAb (please inquire)
|
|
| TCL1
|
|
|
|
B cell tumors, lymphoid lineages in a developmentally controlled manner, pDC
|
intracellular, lymphoid proto-oncogene
|
eBio1-21 (1-21)
|
PU, B, PE
|
| TCR αβ
|
|
|
|
peripheral T subset
|
antigen recognition
|
IP26
|
PU, B, F, PE, PE-Cy5, APC
|
| TCR γδ
|
|
|
|
T subset
|
antigen recognition
|
B1.1
|
PU, FG, B, F, PE
|
| TLR1 - TLR4
|
see CD281 - CD284
|
|
|
|
|
|
|
| TLR5
|
TIL3
|
|
TLR family
|
mRNA: leukocytes, prostate, ovary, liver, lung
|
interacts w/ microbial lipoproteins, NF-κB, responds to
Salmonella
|
|
|
| TLR6
|
|
|
TLR family
|
mRNA: leukocytes, ovary, lung
|
interacts w/ microbial
lipoproteins, protein sequence
similar to hTLR1; regulates TLR2
response
|
hPer6
|
PU, B
|
| TLR7
|
|
|
TLR family
|
mRNA: spleen, placenta,
lung; upregulated on mac
|
|
polyclonal
|
|
| TLR8
|
|
|
TLR family
|
mRNA: leukocytes,
lung
|
|
polyclonal
|
|
| TLR9
|
see CD289
|
|
|
|
|
|
|
| TLR10
|
|
|
TLR family
|
mRNA: lymphoid
tissues
|
most closely
related to TLR1 and
TLR6
|
|
|
| TNFRI
|
see CD120a
|
|
|
|
|
|
|
| TRAIL
|
see CD253
|
|
|
|
|
|
|
| TSLPR
|
|
50kD
|
heterodimer with IL-7Rα/CD127
|
monocytes, DC, B
|
binds TSLP (Thymic Stromal Lymphopoietin) to activate DC
|
eBio1A6 (1A6)
|
PU, B, PE
|
| TWEAK
|
TNFSF12, APO3L
|
|
TNFSF
|
activated mono
|
death
|
CARL-1
|
PU, FG, B, PE
|
|
|
|
|
|
|
|
CARL-2
|
PU
|
| TWEAK Receptor
|
see CD266
|
|
|
|
|
|
|
| ULBPs
|
|
|
MHC class I-related protiens, GPI-linked
|
tumors
|
NKG2D receptors, NK activation
|
family of ULBP-1-6 (please inquire)
|
|
| ZAP-70
|
TCRζ-associated kinase
|
70kD
|
Syk family
|
Intracellular T, NK
|
TCR signaling & development
|
1E7.2
|
PU, B, F, PE, PE-Cy5.5
|
References:
Alexa FluorŽ and Pacific BlueŽ are registered trademarks of and licensed under patents assigned to Molecular Probes, Inc. for research use only.
|
