Mouse CD & Other Cellular Antigens
eBioscience antibodies are available conjugated to a variety of fluorophores to enable multicolor flow cytometry, functional assays, and immunohistochemistry applications. Additional antibodies to other mouse antigens including novel cell surface molecules are in our pipeline.
Antigen Name | Other Names | MW | Structure | Distribution | Function | eBioscience Clone |
---|---|---|---|---|---|---|
CD1d | CD1.1/1.2, Ly-38 | 43-49kD | IgSF | leukocytes, intestinal epith | Ag presentation, mucosal immunity, with beta2m, ligand for NKT cells | 1B1 |
CD2 | LFA-2, Ly-37, SRBC-R | 45-58kD | IgSF | thymocytes, T, NK, B, pre-B, myeloid, erythrocytes | adhesion, T activation, CD48 receptor | RM2-5 |
CD3d | T3d | 20kD | IgSF | T, thymocyte subset, NKT | TCR subunit, TCR expression & signaling | |
CD3e | T3e | 20kD | IgSF | T, thymocyte subset, NKT | TCR subunit, TCR expression & signaling | 145-2C11 |
17A2 | ||||||
500A2 | ||||||
CD3g | T3g | 25kD | IgSF | T, thymocyte subset, NKT | TCR subunit, TCR expression & signaling | |
CD4 | Ly-4, L3T4 | 55kD | IgSF | thymocyte subset, T subset, DC | TCR coreceptor, thymic differentiation, T activation, MHC class II receptor | GK1.5 |
RM4-5 | ||||||
RM4-4 | ||||||
CD5 | Ly-1 | 67kD | SRCRSF | thymocytes, T, B subset (B1) | T activation, T-B interaction, CD72 receptor | 53-7.3 |
CD6 | T12 | 100-130kD | SRCRSF | thymocytes, T, neurons, not on B | T differentiation & costimulation, CD166 receptor | |
CD7 | 40kD | IgSF | human early T marker, CD7KO has normal phenotype | |||
CD8a | Ly-2 | 32-34kD | IgSF | thymocyte subset, T subset , DC subset, not fresh NK | TCR coreceptor, MHC class I receptor, T differentiation, homodimer or heterodimer with CD8b | 53-6.7 |
CD8b | Ly-3 | 30kD | IgSF | thymocyte subset, T subset, not fresh NK | TCR coreceptor, MHC class I receptor, T differentiation, heterodimer with CD8a | CT-CD8b |
eBioH35-17.2 (H35-17.2) | ||||||
CD9 | p24 | 24-27kD | TM4SF | myeloid, platelets, Tact, B subset | cell adhesion, migration, T costimulation | eBioKMC8 |
CD10 | CALLA, NEP, Mme | 100kD | type II TM | B precursors, fibroblasts, BM stromal cells | zinc-binding metalloproteinase, neutral endopeptidase ectoenzyme, B development | |
CD11a | integrin alphaL, Ly-15, Itgal | 80kD | IntgF | T, B, NK, gran, mono, mac, DC, thymocytes | CD11a / CD18 (LFA-1) receptor for ICAM-1 and ICAM-2, intercellular adhesion, T costimulation | M17/4 |
CD11b | Mac-1, integrin alphaM, Itgam, CR3 | 170kD | IntgF | myeloid, NK, Tact, B subset | CD11b / CD18 receptor for CD54 and CD102, adhesion to ECM, fibrinogen, & complement iC3b | M1/70 |
CD11c | p150, integrin alphaX, Itgax, CR4 | 150kD | IntgF | DC, myeloid, NK, T subset | CD11c / CD18 receptor for fibrinogen & iC3b, adhesion | N418 |
CD13 | Aminopeptidase N, Lap1 | 150kD | Type II TM | myeloid, endoth, DC | zinc-binding metalloproteinase, antigen processing | mAb (please inquire) |
CD14 | LPS-R, Mo2 | 53-55kD | GPI-linked | mac, granlow | receptor for LPS/LBP, LPS recognition | Sa2-8 |
CD15 | Lewis-X | CHO | transient in brain | fucosyl transferase (Fut4) | ||
CD16 | FcgammaRIII, Ly-17, Fcgr3 | 50-60kD | IgSF | NK, neutrophils, mast cells, mac | Fcgamma low affinity receptor, phagocytosis, ADCC, NK activation | 93 |
CD18 | Integrin beta2, Itgb2 | 90-95kD | IntgF | leukocytes | with CD11a, b and c, adhesion | M18/2 |
CD19 | B4 | 95kD | IgSF | B, FDC, good B lineage marker, not plasma cells | with CD21 & CD81, BCR coreceptor, B activation / differentiation | MB19-1 |
6D5 | ||||||
eBio1D3 (1D3) | ||||||
CD20 | Ly-44, B1, Ms4a2 | 33-37kD | TM4SF | B, T subset | B differentiation / activation | AISB12 |
CD21 | CR2, CR1 | 150kD | CCRSF | B, DC | CD21 / CD35 other variants of CR2 gene, complement C3d receptor, with CD19 & CD81, BCR coreceptor | eBio4E3 |
eBio8D9 (8D9) | ||||||
CD22 | Lyb-8, Siglec-2 | 140-160kD | IgSF / sialoadhesins | B | adhesion, B-mono & B-T interactions, B activation, BM homing receptor for IgD+ B cells, CD75 counter-receptor | 2D6 |
CD23 | FcepsilonRII, Ly-42, Fcer1a | 45-49kD | C-type lectin | B, mono, mac, gran, platelets, FDC, not B1 cells | CD19/CD21/CD81 receptor, low affinity IgER, signaling | B3B4 |
CD24a | HSA, Ly-52, Nectadrin | 35-52kD | GPI-linked | B, gran, mono, mac, Tact, erythrocytes, neurons | several isoforms, B differentiation & proliferation, adhesion, T costimulation, CD62P receptor | 30-F1 |
M1/69 | ||||||
CD25 | Ly-43, p55, IL2Ralpha | 55kD | Type I TM | pre-B, pre-T, Tact, Bact, DC subset, mono, mac | low affinity IL-2 binding, with IL-2Rbeta & gamma forms IL-2 receptor high affinity, also soluble form | PC61.5 |
eBio3C7 | ||||||
eBio7D4 | ||||||
CD26 | DPP4, THAM | 110kD | Type II TM | thymocyte subset, Tact, B, NK, epith | dipeptidyl peptidase ectoenzyme, activation, adhesion | mAb (please inquire) |
CD27 | T14, Tnfrsf7 | 45kD | TNFRSF | medullary thymocytes, T, NK, B subset | CD70 receptor, T costimulation | LG.7F9 |
CD28 | Tp44 | 45kD | IgSF | T, thymocytes, NK | CD80 (B7-1) & B7-2 (CD86) receptor, T costimulation | 37.51 |
CD29 | Integrin beta1, gpIIa, Itgb1 | 130kD | IntgF | leukocytes, fibroblasts, endoth, epith | with CD49a-f (VLA-1-6), with CD51(alphavbeta1), CD29/CD49a ( VLA-1) receptor for VCAM-1, MAdCAM-1 & ECM, VLAb, adhesion, embryonic development | eBioHMb1-1 |
eBioKMI6 | ||||||
CD30 | Ki-1, Tnfrsf8 | 105-120kD | TNFRSF | Bact, Tact | CD153 receptor, lymphocyte proliferation, apoptosis, peripheral tolerance | mCD30.1 |
CD31 | PECAM-1, pgIIa | 130-140kD | IgSF | platelets, gran, endoth, DC, mono subset, T subset, B subset, LAK | multiple isoforms, CD38 receptor, signaling, platelet-endoth adhesion | 390 |
CD32 | FcgammaRII, Ly-17, Fcgr2b | 40-60kD | IgSF | mono, mac, gran, B, Tact, not NK | low affinity Fc receptor for aggregated Ig/immune complexes, ADCC | 93 |
CD33 | Siglec-3, gp67 | 67kD | IgSF, sialoadhesins | myeloid progenitors; gran | possible role in hematopoiesis, binds sialic-acid | |
CD34 | Mucosialin | 90-120kD | Sialomucin family | hematopoietic precursors, capillary endoth, BM stroma, mast cells | CD62L receptor, adhesion | RAM34 |
CD35 | Cr1, Cr2 | 190kD | SRCRSF | B, granact, FDC | CD21 & CD35 alternative splice variants of Cr2 gene, binds C3b & C4b, adhesion, phagocytosis | eBio4E3 |
eBio8D9 (8D9) | ||||||
CD36 | FAT, fatty acid translocase | 88kD | platelets, adipocytes, mono, mac, endoth, erythrocyte | oxidized LDL receptor | No. 72-1 | |
CD37 | TM4SF | mRNA: lymphoid, myeloid | T-B interaction | |||
CD38 | Cd38-rs1, T10 | 42kD | Type II TM | B, marginal zone B (high), Tact, thymocyte subset, subsets in yolk sac, in fetal liver, in BM | B activation, CD31 receptor, ectoenzyme, ADP-ribosyl cyclase/hydrolase | 90 |
CD39 | Entpd1 | 70-100kD | lymphocyteact, microglia, endoth | ecto-nucleoside trisphosphate diphosphohydrolase | 24DMS1 | |
CD40 | gp39 receptor, Tnfrsf5 | 45-50kD | TNFRSF | B, mono, mac, T subset, DC, endoth, thymic epith, induced on cardiac myocytes | CD154 receptor, T-B interaction, B costimulation and survival, isotype-switching | 1C10 |
HM40-3 | ||||||
CD41 | gpIIb, Itga2b, CD41b | 110-125kD | IntgF | platelets, megakaryocytes | with CD61 forms GPIIb/IIIa, binds fibrinogen, fibronectin, vWF & thrombospondin, platelet activation, aggregation | eBioMWReg30 |
CD42 | Gp9, GPIX | 20kD | LRRF | platelets, megakaryocytes | platelet activation, aggregation | |
CD43 | Leukosialin, Ly-48, Spn, sialophorin | 115 & 135kD | Type I TM | T, Tact, early B, B subset, plateletslow, not resting B, not DC | isoforms, signaling, CD54R, B survival, adhesion | eBioR2/60 |
CD44 | Pgp-1, Ly-24, HERMES | 80-95 & 130kD | broad, memory T, not platelets, or hepatocytes | binds hyaluronic acid, leukocyte adhesion/homing, T activation, tumor metastasis | IM7 | |
eBioKM114 | ||||||
CD44R | variants of CD44 | restricted & varied | adhesion, metastasis, receptor for Hyaluronate | |||
CD45 | LCA, Ly-5, Ptprc | 180-240kD | PTPR family, ASV | leukocytes, not mature erythrocytes | tyrosine phosphatase, leukocyte differentiation / activation, pan-leukocyte marker | 30-F11 |
CD45.1 | Ly-5.2 strains: SJL, DA, STS/A, RIII | A20 | ||||
CD45.2 | Ly-5.1 strains: BALB/c, C3H, C57BL/6, DBA/1, DBA/2, AKR, A, 129 | 104 | ||||
CD45R/CT1 | CT1 CHO | cytotoxic Tact | ||||
CD45R | B220 | 220kD | B, NK progenitors, LAK, Tact | RA3-6B2 | ||
CD45RA | exon A isoform | |||||
CD45RB | 200-240kD | exon B isoform | T subset, B, mono, mac | C363.16A | ||
CD45RC | 200-240kD | exon C isoform | T subset, B | GL24 | ||
CD45RO | 180kD | isoform not exons A, B, or C | Tact, Bact, DC subset | |||
CD46 | MCP, membrane cofactor protein | CRRSF | broad | complement regulation, role in fertilization | ||
CD47 | IAP, Itgp | 50kD | IgSF | hematopoietic cells, epith, endoth, fibroblasts, platelets | with beta3 integrins, leukocyte adhesion, migration, activation, extravasation of PMN, binds SIRPalpha | miap301 |
CD48 | Blast-1, BCM-1, Sgp-60 | 45kD | IgSF, GPI-linked | broad on lymphocytes, not fibroblasts | adhesion, T costimulation, CD2 and Ly-9 receptor | HM48-1 |
CD49a | VLA-1, Integrin alpha1, Itga1 | 180kD | IntgF | Tact, endoth | adhesion, CD49a / CD29 binds collagen & laminin | |
CD49b | VLA-2, Integrin alpha2, Itga2 | 165kD | IntgF | platelets, T subset, megakaryocytes, NK subset | adhesion, CD49b / CD29 binds collagen & laminin | HMa2 |
DX5 | ||||||
CD49c | VLA-3, Integrin alpha3, Itga3 | 125kD | IntgF | B subset, Tlow | CD49c/CD29 binds laminin, fibronectin, collagen | |
CD49d | VLA-4, Integrin alpha4, Itga4 | 150kD | IntgF | T, B, mono | CD49d / CD29 binds fibronectin, VCAM-1, with beta7 forms LPAM-1 & binds to MAdCAM-1, homing receptor | R1-2 |
CD49e | VLA-5, Integrin alpha5, Itga5 | 135kD | IntgF | thymocytes, Tact | adhesion, CD49e / CD29 binds fibronectin | eBioHMa5-1 |
CD49f | VLA-6, Integrin alpha6, Itga6 | 120kD | IntgF | memory T, thymocytes, platelets | adhesion, CD49f / CD29 binds laminin | eBioGoH3 |
CD50 | Icam5, Ticn, Telencephalin | 130kD | IgSF | memory T, thymocytes, platelets | adhesion, CD49f / CD29 binds laminin | |
CD51 | VitronectinR, Integrin alphav, Itgav | 125, 24kD | IntgF | platelets, megakaryocytes, endoth, osteoblasts, melanoma | adhesion, CD51 / CD61 binds vitronectin, von Willebrand factor, fibrinogen & thrombospondin | RMV-7 |
CD52 | CAMPATH-1, MB7, CLS1 | 12kD | GPI-linked | mature lymphocytes | ||
CD53 | OX-44 | 35-42kD | TM4SF | leukocytes, DC, osteoblasts, osteoclasts | signaling | |
CD54 | ICAM-1, Ly-47 | 85-110kD | IgSF | endoth, mono, resting lymph (high on activation) | CD11a / CD18 (LFA-1), CD11b / CD18 (Mac-1) & CD43 receptor, adhesion, T costimulation | YN1/1.7.4 |
eBioKAT-1 (KAT-1, KAT1) | ||||||
CD55 | Decay Accelerating Factor | 60-70kD | CCRSF | broad, induced in uterus by estrogen | similar to Crry, protection from autologous complement attack | |
CD56 | NCAM | 20-185kD | IgSF | neural tissue, multiple isoforms | adhesion, neuron development, skeletal myogenesis | |
CD57 | B3GAT1 | Glucuronsyl- transferase P | ||||
CD58 (H) | LFA-3 | not defined in mouse | ||||
CD59 | Protectin, MAC-inhibitor | 19kD | GPI-linked | broad | binds complement C8 & C9, blocks membrane attack complex assembly | |
CD60 (H) | CHO | not defined in mouse | ||||
CD61 | GPIIIa, Integrin beta3, Itgb3 | 105kD | IntgF | platelets, megakaryocytes, mac, endoth | CD41 / CD61 or CD51 / CD61 complexes adhere to ECM | 2C9.G3 |
CD62E | E-selectin, ELAM-1, Sele 97 | 107-115kD | Selectin | endoth | sialyl-Lewis x receptor, leukocyte rolling & migration, tumor metastasis | |
CD62L | L-selectin, LECAM-1, sell | 74 & 95kD | Selectin | B, T, mono, gran, NK, thymocytes | CD34, GlyCAM, & MAdCAM-1 receptor, lymphocyte homing, leukocyte tethering & rolling | MEL-14 |
CD62P | P-selectin, Selp | 140kD | Selectin | plateletsact, endoth | CD162 & sialyl LewisX receptor, adhesion, neutrophil rolling, platelet-neutrophil & platelet-mono interactions, binds to CD24 | |
CD63 | MLA1 | 53kD | TM4SF | plateletsact, mono, mac | activated platelets marker, lysosomal membrane protein, translocates to surface upon activation, melanoma associated antigen | |
CD64 | FcgammaRI | 72kD | IgSF | mono, mac, DC, granact | high affinity IgG receptor, phagocytosis, trypsin-sensitive, ADCC | |
CD65 (H) | not defined in mouse | |||||
CD66a | Ceacam1, C-Cam | IgSF, CEA family | colon, liver, hematopoietic tissues | cell-cell interaction, hepatitis virus receptor | CC1 | |
CD68 | Macrosialin, gp110 | 87-115kD | Sialomucin | predominantly intracellular, tissue mac, DClow | lysosomal associated protein | |
CD69 | Activation Inducer Molecule, VEA | 35-39kD | C-type lectin | Tact, Bact, NKact, granact, thymocytes, platelets | activation, early activation marker | H1.2F3 |
CD70 | Ki-24, Tnfsf7 | 50, 70, 90, 160kD | TNFSF | Bact, Tact, cardiac myocytes | CD27 receptor, T & B costimulation | FR70 |
CD71 | T9, Trfr | 95kD | Type II TM, dimer | proliferating cells, reticulocytes, erythroid precursors | transferrin receptor, iron uptake, cell activation | R17217 |
CD72 | Lyb-2 | 40-45kD | C-type lectin, homodimer | B, FDC, T subset, polymorphic extracellular portion | CD5 & CD100 receptor, B costimulation | |
CD73 | Nt5e | 69kD | GPI-linked | ecto-5’-nucleotidase, T costimulation, adhesion | eBioTY/11.8 | |
CD74 | Ii, Ia-invariant chain | 33-43kD | Type II TM | B, mac, mono | MHC class II traffic & function, antigen presentation | mAb (please inquire) |
CD75 | BM homing of recirculating B cells, CD22 counter-receptor | |||||
CD77 (H) | not defined in mouse | |||||
CD79a | Iga, mb-1, Ly-54 | 33 & 45kD | IgSF | B | BCR subunit, BCR expression & signaling | |
CD79b | Igb, B29 | 37kD | IgSF | B | BCR subunit, BCR expression & signaling | |
CD80 | B7, B7-1, Ly-53 | 60kD | IgSF | Bact, Tact, mono, mac, DC, pancreatic beta cells | CD28 & CD152 receptor, costimulation, T-B interaction | 16-10A1 |
CD81 | TAPA-1 | 26kD | TM4SF | T, B, NK, thymocytes, DC, endoth, fibroblast, neuroblastomas, melanomas | with CD19 & CD21, signaling, T costimulation | Eat-2 |
CD82 | KAI1, C33 | 50-53kD | TM4SF, ASV | Tact, mRNA: spleen, kidney | inhibits tumor cell mobility | |
CD83 | 43kD | IgSF, Siglec family | DC, Tact, mRNA: spleen & brain | regulation of T response, binds to a ligand on B cells | Michel17 | |
CDw84 | IgSF | B, mac, mRNA: hematopoietic tissue | ||||
CD85 | MHC class I recognition | |||||
CD86 | B70, B7-2, Ly-58 | 80kD | IgSF | mono, Bact, Tact, DC | CD28/CD152 receptor, T costimulation, T-B interaction | PO3.1 |
GL1 | ||||||
CD87 | UPA-R, Plaur | GPI-linked | mRNA: muPAR1 luminal epith of gastric mucosa, muPAR2 basal epith, PAR2 secreted uPA binding protein | |||
CD88 | C5aR, C5r1 | 40kD | TM7SF | gran, neurons, astrocytes, microglia | C5a receptor, granulocyte activation, neurodegeneration | |
CD89 | FcalphaR, IgA receptor | 55-75kD | IgSF | mono, mac, neutrophils, B subset, T subset | phagocytosis, degranulation, respiratory burst | |
CD90 | Thy-1 | 18kD | IgSF, GPI-linked | thymocytes, T, hematopoietic subset, neurons, not B | hematopoietic stem cell & neuron differentiation, T activation | G7 |
CD90.1 | thy1a(thy1.1) strains: AKR & RF | HIS51 | ||||
CD90.2 | thy1b(thy1.2) all other strains | 53-2.1 | ||||
30-H12 | ||||||
CD91 | lrp1, A2mr | 600kD | LDL receptor family | mono, mac, neurons, liver, fibroblasts | receptor for a-2- macroglobulin, LDL, HSPgp96, apolipoprotein, lipoprotein metabolism | |
CDw92 (H) | not defined in mouse | |||||
CDw93 | AA4.1 antigen, C1qRp, early B lineage marker, Ly68 | 130-140kD | C-type lectin | hematopoietic progenitor marker for early B cells, endo, megakaryoblasts, platelets | phagocytic complement C1q receptor | AA4.1 |
CD94 | KP43, klrd1 | 43kD | C-type lectin | NK, T subset | with NKG2, inhibits NK function | 18d3 |
CD95 | Apo-1, Fas | 35kD | TNFRSF | thymocytes, lymphocytesact | CD95L(CD178) receptor, apoptosis induction, immune system regulation, lpr mutation | 15A7 |
CD96 | TACTILE, T cell ACTivation Increased Late Expression | 160kD | IgSF | mRNA: spleen, mammary gland | adhesion of activated T & NK | |
CD97 | TM7LN1 TM7S | lymphoid, myeloid | CD55 receptor | |||
CD98 | 4F2, Ly-10 | 80, 40kD | thymocytes, lymphocytes, mono, BM | cell activation, calcium flux | RL388 | |
CD99 | Pilr-1, D4 | |||||
CD100 | Sema4d, semaphorinH | 150kD | IgSF | mRNA: lymphoid & nervous tissues | CD72 receptor, role in immune & nervous systems | BMA-12 |
CD101 | IgSF3 | IgSF | role in susceptibility to type I diabetes | Moushi101 | ||
CD102 | ICAM-2, Ly-60 | 55-65kD | IgSF | lymphocytes, mono, platelets, endoth | binds CD11a / CD18 (LFA-1), costimulation | |
CD103 | HML-1, alphaIEL, alphaE integrin, Itgae | 150kD | IntgF | intraepithelial lymphocytes, BM mast, lymphocytesact | with integrin beta7, binds E-cadherin, lymphocyte homing | 2.00E+07 |
CD104 | beta4 integrin, Itgb4 | 220kD | IntgF | epith, endoth, immature thymocytes, Schwann cells, tumor cells, keratinocytes | with CD49f, cell adhesion / migration, differentiation, tumor metastasis, a6b4 is tumor associated Ag Tsp-180 | |
CD105 | Endoglin, Eng | 95kD | endoth, BM cell subset, macact | response to TGF-beta1, ligand for TGF-beta, adhesion | MJ7/18 | |
CD106 | VCAM-1 | 110kD | IgSF | endothact, FDC, BM myeloid | CD49d / CD29 receptor, adhesion / migration, costimulation | 429 |
CD107a | LAMP-1 | 120kD | plateletsact, Tact, endothact | adhesion, metastasis | eBio1D4B (1D4B) | |
CD107b | LAMP-2 | 110kD | plateletsact, Tact, endothact | adhesion, metastasis | eBioABL-93 (ABL-93) | |
CDw108 | Sema7a | 80kD | IgSF, GPI-linked | mRNA: nervous system(high), immune system | ||
CD109 | Gov platelet alloantigen | |||||
CD110 | TPO-R, c-mpl | 82-84kD | CRSF | megakaryocytes, platelets | thrombopoietin receptor, megakaryocyte differentiation | |
CD111 | PRR1, Nectin-1, Pvrl | 64-72kD | IgSF, ASV | fibroblasts, epithelium, neurons | polio virus receptor-related protein1, mediates entry of herpes simplex virus (HSV) strains | |
CD112 | PRR2, Pvs, Nectin-2 | 64-72kD | IgSF, ASV | mRNA: brain, spinal cord, spleen, kidney, heart, liver | intercellular adhesion, not a receptor for poliovirus | |
CDw113 | PVRL3, Nectin3 | 100kD | Ig-like, ASV | broad, epith | adhesion molecule, interacts with afadin | |
CD114 | G-CSFR, Csfgr, Csf3r | 95, 139kD | CRSF | progenitor & mature neutrophils, endoth, placenta, some myeloid leukemia | myeloid proliferation & differentiation | |
CD115 | M-CSFR, c-fms, Csf1r | 150kD | RTKF | monocytic progenitors, osteoclasts | M-CSF receptor, monocytic lineage proliferation/ differentiation, role in differentiation of osteoclasts | AFS98 |
CD116 | GM-Csf2ra | 70-85kD | CRSF | mono, gran, DC, endoth | low affinity GM-CSF receptor, with common beta AIC2B form high affinity receptor, myeloid proliferation, differentiation | |
CD117 | c-kit, Steel factor | 145kD | IgSF, RTKF | hematopoietic stem & progenitors, neural crest-derived melanocytes, primordial germ cells, mast cells | Stem Cell Factor receptor, hematopoietic progenitor development & differentiation, dominant white spotting (w) mutation | 2B8 |
ACK2 | ||||||
CD118 | LIFR | 190kD | Type I cytokine receptor family, ASV | placenta, liver, kidney, heart, lung, brain epith | membrane-bound involved in signal transduction, soluble form inhibits activity of LIF | |
CDw119 | IFNgammaR, ifgr1, Ifngr | 90-100kD | mac, mono, B, T, NK, neutrophils, endoth | Interferon-gamma receptor alpha chain, with IFNgamma AF-1, host defense, high affinity IFNgamma binding | ||
CD120a | TNFR1, p55 | 50-60kD | TNFRSF | broad | TNF receptor, binds both TNFalpha & TNFbeta, apoptosis | 55R-170 |
CD120b | TNFR2, p75 | 75-85kD | TNFRSF | broad | TNF receptor, high affinity binding to TNFalpha & TNFbeta, apoptosis | |
CD121a | IL-1R type I | 80kD | IgSF | broadlow, fibroblasts, T, brain, pancreas, cardiac endoth, epith, developing oocytes | Type I IL-1R, binds IL-1alpha & IL-1beta, IL-1 signaling | |
CDw121b | IL-1R, type II | 68kD | IgSF | B, mac, mono, T subset (Th2), epidermis, dermis, vaginal basal epith, brain | Type II IL-1R, binds IL-1alpha & IL-1beta, a decoy receptor | |
CD122 | IL-2Rbeta, p70 | 75kD | CRSF | NK, T, B, mono | IL-2R & IL-15Rbeta chain, signaling, with CD25 & CD132 form high affinity IL-2R, lymphocyte development | 5H4 |
TM-b1 | ||||||
CDw123 | IL-3Ralpha | 70kD | CRSF | lymphocyte subset, basophils, hematopoietic progenitors, mac, DC, megakaryocytes | IL-3R alpha chain, low affinity binding to IL-3, with CDw131 form high affinity IL3 binding | 5B11 |
CD124 | IL-4Ralpha | 140kD | CRSF | lymphocyteslow, mono, hematopoietic precursors, fibroblast, epith | IL-4Ralpha chain, with CD132 or IL-13Ralpha chain, with CD132 forms high affinity IL-4R, T growth & differentiation, soluble form | |
CDw125 | IL-5Ralpha | 60kD | CRSF | eosinophils, basophils | IL-15Ralpha chain, with CDw131 for low affinity IL-5 binding, with beta subunit for high affinity IL-15 binding | |
CD126 | IL-6Ralpha | 80kD | IgSF, CRSF | Bact, plasma cells, most leukocyteslow, fibroblasts | IL-6Ralpha subunit, low affinity IL-6 binding, with CD130 for high affinity IL-6 binding, soluble form | D7715A7 |
CD127 | IL-7Ralpha | 65-75kD | CRSF | pro-B, T | IL-7Ralpha chain, with CD132 for high affinity IL-7 binding, T & B development | A7R34 |
eBioSB/199 | ||||||
CDw128 | see CD181 and CD182 | |||||
CD130 | IL-6Rbeta, gp130 | 130kD | CRSF | broad in adult & embryonic cells | Common beta chain of IL-6R, IL-11R, LIFR, OSMR | KGP130 |
CDw131 | IL-3R, AIC2B/A, common beta, Csf2rb1, Csf2rb2 | 95-120kD | CRSF | mono, gran, early B | 2 genes in mouse, signaling, with alpha subunits of IL-3, IL-5, GM-CSF receptors | |
CD132 | IL-2R Common beta | 64kD | CRSF | T, B, NK, mono, gran, DC | Subunit of IL-2, IL-4, IL-7, IL-13, & IL-15R, signaling, mutation: X-linked SCID | mAb (please inquire) |
CD133 | Prominin-1, AC133 | 115-120kD | TM5 glycoprotein | primitive cells like hematopoietic progenitors, neural, endoth stem cells, retina, retinoblastoma, developing epith (apical surface) | unknown | 13A4 |
CD134 | OX-40, Ly-70, Txgp1 | 48-50kD | TNFRSF | Tact | OX-40L receptor, apoptosis, T activation / differentiation | OX-86 |
CD135 | Flt3/Flk2, EMS-like tyr kinase 3 | 130-150kD | RTK family | hematopoietic progenitors: myeloid & primitive B progenitors | binds FLT3 ligand, myeloid & lymphoid development, expands hematopoietic progenitors & DC | A2F10 |
CDw136 | STK, Mst1r, RON | 180kD | RTK family | hematopoietic cells | macrophage stimulatory 1 receptor | |
CDw137 | 4-1BB, Tnfrsf9 | 30kD | TNFRSF | Tact | T costimulation, binds to 4-1BBL, fibronectin, vitronectin, laminin, collagen VI | 17B5 |
CD138 | syndecan-1, Sdc1 | 80-150kD | Syndecan | epith, plasma cells, pre-B, neurons | receptor for ECM, cell morphology, B differentiation | mAb (please inquire) |
CD139 (H) | not defined in mouse | |||||
CD140a | PDGF receptor alpha | 180kD | RTK family | fibroblasts, smooth muscle, glial cells, chondrocytes | PDGFRaa binds PDGF AA, AB, BB, PDGFRab binds AB, BB, PDGFRbb binds PDGFBB, embryonic development, signaling | APA5 |
CD140b | PDGF receptor beta | 180kD | RTK family | fibroblasts, smooth muscle, glial cells, chondrocytes | see CD140a for ligands, signaling | APB5 |
CD141 | Thrombomodulin | 100kD | C-type lectin | mono, neutrophils, endoth, smooth muscle | initiation of protein C anticoagulant pathway | |
CD142 | Tissue Factor, factorIII, F3 | 45kD | mRNA: broad | binds clotting factor VIIa, embryonic development | ||
CD143 | ACE | 170kD | endoth, epith, neuron, fibroblasts, macact | peptidyl-peptidase, angiotensin converting enzyme | ||
CD144 | Cadherin5, VECadherin | 130kD | Cadherins | endoth | adhesion, intercellular interaction | BV13 |
BV14 | ||||||
CD146 | MUC18, S-endo, mcom | IgSF | embryonic tissue, mammary tumors | cell adhesion during development | ||
CD147 | Neurothelin, basigin, Bsg | IgSF | leukocytesact, erythrocytes, platelets, endoth | adhesion, blood-brain barrier | RL73 | |
CD148 | HPTP-eta, M4, M56 | 240-260kD | mRNA: broad, high in brain, kidney | tyrosine phosphatase R Type III | ||
CD150 | SLAM, IPO-3 | 75kD | IgSF | T, B, maintained on Th1 | costimulation, proliferation, Ig production | 9D1 |
CD151 | PETA-3, SFA-1 | 32kD | TM4SF | endoth, megakaryocytes, platelets | adhesion, signaling | |
CD152 | CTLA-4, Ly-56 | 33kD | IgSF | Tact | CD80, CD86 receptor, negative T stimulation | 9H10 |
UC10-4B9 | ||||||
CD153 | CD30L, Tnfsf8 | 40kD | TNFSF | Tact, macact, neutrophil, B, induced on cardiac myocyte | CD30 receptor, T costimulation | RM153 |
CD154 | CD40L, gp39, Ly-62, Tnfsf5 | 32-39kD | TNFSF | transiently on Tact, B subset (intracellular), platelets | CD40 receptor, B & DC costimulation, T activation | MR1 |
CD155 | PVR | 80-90kD | IgSF | mono, mac | Polio virus receptor | |
CD156a | ADAM8, MS2 | 69kD | Type I TM | neutrophils, mono | metalloprotease, leukocyte extravasation | |
CD156b | TACE/ ADAM 17 | 100kD | broad | zinc metalloprotease, TNF converting enzyme | ||
CDw156c | ADAM10, kuz, kuzbanian, Madm | 60kD | Peptidase M12B family | neural precursors, fibroblasts | proteolytic cleavage of cell-surface molecules including Notch, TNF-alpha, APP & ephrin-A2 | polyclonal |
CD157 | BST-1, Ly-65, Bp3 | 38-48kD | GPI-linked | gran, mono, early B, T subset, BM stroma | ADP-ribosyl-cyclic ADP-ribose hydrolase, pre-B growth | |
CD158 (H) | KIR | not defined in mouse | ||||
CD159a | NKG2A, Klrc1 | 43kD | NK & NKT cells | with CD94, Qa-1(b) receptor, inhibitory signaling | 20d5 | |
CD159c | NKG2C | C-type lectin | NK & NKT cells | with CD94, Qa-1(b) receptor, stimulatory signaling | 20d5 | |
CD160 | BY55 | 27kD | IgSF | NK subset, T subset | costimulation | eBioCNX46-3 |
CD161c | NKR-P1c, Ly-55, NK1.1 | 40kD | C-type lectin | NK, T subset | NK cell-mediated cytotoxicity | PK136 |
CD162 | PSGL-1, Slp1 | 120kD | Mucin family | myeloid cells, lymphocyte subset | CD62P & CD62L receptor, adhesion, leukocyte rolling | |
CD162R (H) | PEN-5 | not defined in mouse | ||||
CD163 | 100-130kD | SRCRSF | peritoneal mac | |||
CD164 | MGC-24, A115, A24 | 80kD | Sialomucin | mRNA: broad various adult & embryonic tissues | hematopoietic progenitor-stroma interaction | |
CD165 | AD2, gp37 | not defined in mouse | ||||
CD166 | ALCAM | 120kD | IgSF | neurons, Tact, mono, epith, fibroblasts | CD6 receptor, adhesion, T development, T-B interaction, role in nervous system | eBioALC48 |
CD167a | DDR1 | 120kD | RTK family | epith, myoblasts, brain, early marker neuroectoderma | discoidin domain receptor, tyrosine kinase, adhesion | |
CD168 | RHAMM, Hmmr | 70-73kD | broad | hyaluronan-mediated motility receptor, adhesion, cell locomotion, tumor metastasis (intracellular in human breast cancer) | ||
CD169 | sialoadhesin, Sn, Siglec-1 | 185kD | IgS | tissue mac subset | adhesion, cell-cell & cell-matrix interactions, binds alpha2,3-sialylated ligands CD43, CD227, SRBC-R | |
CD170 (H) | Siglec-5, CD33-like2 | 140kD | IgSF, sialoadhesins | mac subset, neutrophils | adhesion | |
CD171 | L1, cell adhesion molecule | 200-210kD | IgSF | CNS, PNS, glial cells, mono, T subset, B, DC, lymph node reticular fibroblasts, some epith | homotypic adhesion, T co-stimulation, integrin binding, KO has neuropathologies similar to CRASH disorder | |
CD172a | SIRPalpha, Ptpns1 | 110kD | IgSF | mono, mac, DC, T subset, stem cells | adhesion, with CD47, SHP substrate-1 | |
CD172b | SIRPbeta | 60-90kD | Ig-like Type I cell surface receptor | mac and other hematopoietic lineages | engagement of SIRPbeta promotes phagocytosis in mac | |
CD172g (H) | SIRPgamma | not defined in mouse | ||||
CD173-CD175 (H) | CHO | |||||
CD176 | Trf, transferring, Tfn, HP | CHO | ||||
CD177 | NB1 | 56-62kD | GPI-linked | neutrophil subset (surface & intracellular) | ||
CD178 | Fas Ligand, CD95L,TNFSF6 | 38-42kD | TNFSF | Tact, testis | apoptosis of CD95+ cells, immune privilege, soluble form in serum, gld mutation nonfunctional FasL | MFL3 |
MFL4 | ||||||
CD179a | V pre B | 16kD | IgSF | pro- & early pre-B | B differentiation, signaling, pre-BCR with IgM/CD79alpha/beta | |
CD179b | Lambda 5 | 22kD | IgSF | pro- & early pre-B | B differentiation, signaling, pre-BCR with IgM/CD79alpha/beta | |
CD180 | RP105, Ly-78 | 95-105kD | LRRF, TLRSF | B, mono, DC | B recognition & signaling of LPS, with MD-1 | RP/14 |
CD181 | CXCR1, IL8Ralpha | 39kD | GPCR family | neutrophils, basophils, NK, T subset, mono | binding of IL-8 induces chemotaxis of neutrophils | |
CD182 | CXCR2, IL8Rbeta | 40kD | GPCR family | neutrophils, basophils, NK, T subset, mono | binding of IL-8 induces chemotaxis of neutrophils, also binds GRO and NAP-2 | |
CD183 | CXCR3, Cmkar3, gpr9 | 40kD | TM7SF | Tact (Th1), NK, eosinophils, GM-CSF activated hematopoietic progenitors | 6Ckine, IP-10 , Mig & I-TAC receptor, T recruitment to inflammatory sites,Th1 response, allograft destruction | CXCR3-173 |
CD184 | CXCR4, Cmkar4, Fusin/LESTR | 45kD | TM7SF | T subset, B, DC, mono, endoth | SDF-1 receptor, embryogenesis, (human: X4 HIV-1 coreceptor) | eBiomCXCR4 |
polyclonal | ||||||
CD185 | CXCR5, BLR1 | 45kD | GPCR family | spleen, resting B, T, skin-derived DC | binds BLC, involved in B-cell migration into B-cell follicles of spleen and Peyer’s patches | |
CDw186 | CXCR6, BONZO | 40kD | GPCR family | memory T | chemokine receptor for CXCL16, also a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1 | |
CD191 | CCR1, MIP-1alphaR, RANTES-R | 39kD | GPCR family | neutrophils, mono, lymph, eosinophils & osteoclasts | receptor for C-C type chemokines MIP-1alpha, RANTES, MIP-1beta, MCP-1 | |
CD192 | CCR2, MIP-1alphaR | 40kD | GPCR family | T subset, mono, B | receptor for the MCP-1, MCP-3 & MCP-4 chemokines | |
CD193 | CCR3, MIP-1alphaRL2 | 45kD | GPCR family | skeletal muscle & low amounts in leukocytes, T subset | receptor for C-C type chemokines eotaxin, MCP-3, MCP-4 and RANTES | |
CD195 | CCR5, Cmkbr5 | 45kD | TM7SF | T subset, NK, monolow | MIP-1alpha, MIP-1beta & RANTES receptor, (human: R5 HIV-1 coreceptor) | HM-CCR5 (7A4) |
CD196 | CCR6, KY411 | 45kD | GPCR family | mainly B, T and DC subset | receptor for C-C type chemokines MIP-3alpha/LARC | |
CD197 | CCR7, Cmkbr7 | 45kD | TM7SF | T, DC subset | 6Ckine & MIP-2beta receptor | 4B12 |
CDw198 | CCR8, TER1 | 50kD | GPCR family | mono, mac, neutrophils, T subset | receptor for TCA-3/I-309 | |
CDw199 | CCR9, CMKBR10 | 43kD | GPCR family | high in thymus, immature and mature T | receptor for chemokine SCYA25/TECK, role in T development | eBioCW-1.2 (CW-1.2) |
CD200 | OX-2 | 45-50kD | IgSF | thymocytes, B, Tact, DC, endoth, neurons | T costimulation, regulation of oxidoreductase pathway | |
CD201 | Procr, EPCR | 50kD | endoth & stem cell subset | activated protein C receptor | eBio1560 (1560) | |
CD202b | Tie2, Tek | 140kD | RTK family | stem cells, endoth from early development | angiogenesis, Angiopoietin-1 receptor | TEK4 |
CD203c | ENpp1, PC-1, TWY | 115kD | Type II TM | antibody secreting B, basophils, mast cells, megakaryocytes, glioma | plasma cell alloantigen, ectoenzyme, binding/clearance of extracellular nucleotides | |
CD204 | Macrophage scavenger-R, Scvr | 220kD | mac | endocytosis of macromolecules | ||
CD205 | DEC-205, Ly75 | 205kD | mac mannose receptor SF | DC, thymic epith, Blow, BM stromal, pulmonary epith, brain capillaries | antigen up-take/presentation, immune inhibition | 205yekta |
CD206 | macrophage mannose-R, Mrc1 | 180kD | mac, mono, DC subset | phagocytosis / pinocytosis mannose containing molecules | ||
CD207 | Langerin | 40kD | Type II TM | Langerhans cells | Ag capture & endocytic receptor, with Birbeck granules | eBioRMUL.2 |
CD208 (H) | DC-LAMP, Lamp3 | 70-90kD | DCact, interdigitating DC | |||
CD209 | DC-SIGN, CIRE | 44kD | DC subset | ICAM-3 receptor, HIV-1 binding protein, T-DC interaction | 5H10 | |
LWC06 | ||||||
CDw210 | IL-10R | 90-110kD | Th1, B, NK, mono, mast cells, mac | IL-10 receptor, signaling, related to IFN receptors | ||
CD212 | IL-12Rbeta1 | 100kD | dimer & oligomer Type I TM | Tact, NKact | high affinity binding to IL-12, with IL-12 receptor beta2, signaling, T & NK response to IL-12 | |
CD213a1 | IL-13Ralpha1, NR4 | 65kD | CRSF | mono, NK, fibroblasts, endoth | binds IL-13 low affinity, with CD124 | |
CD213a2 | IL-13Ralpha2 | 65kD | CRSF | B, mono | binds IL-13 high affinity | |
CDw217 | IL-17R | 120kD | broad | IL-17 receptor | ||
CDw218a | IL-18Ralpha, IL1Rrp | 70kD | IL-1R family | T, NK & DCs | IL-18 binding leads to the activation of NF-kappaB | |
CDw218b | IL-18Rbeta, IL18Rap | 70kD | IL-1R family | T, NK and DCs | forms heterodimeric receptor with IL-18Ralpha to enhance IL-18 binding | |
CD220 | InsulinR, Insr | 140 & 70kD | RTK family | broad | Insulin receptor, regulation of metabolism | |
CD221 | IGF-1R | 140 & 70kD | RTK family | broad | binds IGF high affinity, prolif/differentiation | |
CD222 | IGF-II R, M6P/IGF2R | 220-250kD | Type I TM | broad, 90-95% intracellular | cation-independent mannose 6-phosphate receptor, TGFbeta-LAP, plasminogen & proliferin receptor | |
CD223 | LAG-3 | 70kD | IgSF | Tact, Nkact | MHC class II ligand, role in natural killing | eBioC9B7W |
polyclonal | ||||||
CD224 | GGT, Ggtp | 27, 68kD | yolk sac, protoplasmic astrocytes, endoth, embryonic stem cell lines | gamma-glutamyl transpeptidase | ||
CD225 | Ifitm1, fragilis2, Mil2 | primordial germ cells | adhesion, differentiation, interferon-induced transmembrane protein 1 | |||
CD226 | DNAM-1, PTA-1, TLiSA1 | IgSF | Th1, CD8 T, platelets | platelet activation, T differentiation, costimulation, Th1 function | eBio10E5 | |
CD227 | Muc1, EMA | 300kD | Mucin family type I TM | lymphocytes, tumors, epith, increased in pregnancy | epithelial membrane antigen, organogensis | |
CD228 | Melanotransferrin, Mfi2 | 80-95kD | TransferrinSF | mRNA: cartilage(high), testis(moderate) | ||
CD229 | Ly-9, Lgp100 | 95, 110kD | IgSF | thymocytes, T, B, BM subset, not erythrocytes | adhesion | Ly9ab3 |
CD230 | Prion protein, PrnP | 35kD | neurons, lymphocytes, other cells | Scrapie-associated fibril protein | ||
CD231 | TALLA-1, A15 | 30-45kD | TM4SF | mRNA: brain, colon, muscle, heart, kidney, spleen | T cell acute lymphoblastic leukemia marker, neuronal function | |
CD232 | VESP-R, PlexinC1 | 200kD | broad | viral-encoded semaphorin protein receptor | ||
CD233 | Band3, SLC4A1 | 90kD | Anion exchanger F | erythrocytes, mRNA: epith, other tissues | anion pump, CO2 transport, linking membrane to cytoskeleton | |
CD234 | Duffy, Dfy, DARC | 36-37kD | mRNA: spleen, BM, liver, brain, not erythrocytes | Duffy blood group antigen chemokine receptor | ||
CD235a | Glycophorin A, Gypa | 36kD | erythrocytes | one gene only in mouse for Glycophorin A | ||
CD236R | Glycophorin C | 32kD | erythrocytes | |||
CD238 | Kell blood group, Kel | 110kD | erythrocytes, mRNA: spleen | |||
CD239 (H) | B-CAM, Lu | 78-85kD | IgSF | mRNA: broad, erythrocytes | Lutheran blood group, B adhesion to laminin | |
CD240CE (H) | Rhesus 30CE | 30-32kD | erythrocytes | Rh30CE & RH30D is one gene in the mouse: RH30 | ||
CD241 | Rhesus 50, RhAg | 50kD | TM12SF | erythrocytes | Rh antigens with CD47 & LW | |
CD242 (H) | ICAM-4, LW blood group | 42kD | IgSF | erythrocytes | adhesion, Landsteiner-Wiener blood group | |
CD243 | MDR-1, Abcb1, Pgp | 170kD | T subset, stem cells, small intestine, kidney | ion pump, cytokine export, CTL function | ||
CD244 | 2B4, Ly-90, Nmrk | 78kD | Type II TM, IgSF | NK, NKT, LAK | NK activation, CD48 receptor, MHC-unrestricted killing | eBio244F4 |
CD246 | ALK, Ki-1 | 200kD | RTK family | mRNA: brain, not normal lymphocytes | anaplastic lymphoma kinase, brain development | |
CD247 | TCR zeta, cd3z | 16kD | RTK family | T, NK subset | TCR subunit, signaling, low level impaired immune function | |
CD248 | TEM1, Endosialin | 175kD | C-Type Lectin | endoth tissue | may function in tumor progression and angiogenesis | |
CD249 (H) | Aminopeptidase A | not defined in mouse | ||||
CD252 | OX-40 Ligand, gp34 | 35kD | TNFSF | Bact, cardiac myocytes | T-B interaction, T costimulation | RM134L |
CD253 | TRAIL, APO-2L | TNFSF | NKact, liver NK | apoptosis | N2B2 | |
CD254 | TRANCE, RANKL, OPGL | ~35kD | TNFSF | Tact, osteoblasts | T-DC communication, osteoclast differentiation | IK22/5 |
CD256 | APRIL, TALL-2 | 16kD | TNFSF | Tact, mono, mac | binds TACI and BCMA | polyclonal |
CD257 | BLyS, BAFF, TALL-1 | 45kD | TNFSF | mono | binds TACI, BCMA & BAFFR to induce B proliferation | polyclonal |
CD258 | LIGHT, HVEM-L | 28kD | TNFSF | Tact, immature DC | binds LTBR to induce T proliferation, also binds HVEM | mAb (please inquire) |
CD261 (H) | TRAIL-R1 | not defined in mouse | ||||
CD262 | TRAIL-R2, DR5, Apo2, TRICK2, KILLER | TNFRSF | broad | ligand for TRAIL, activates NF-kappaB & mediates apoptosis, p53-dependent expression | MD5-1 | |
polyclonal | ||||||
CD263 (H) | TRAIL-R3 | not defined in mouse | Polyclonal | |||
CD264 (H) | TRAIL-R4 | not defined in mouse | Polyclonal | |||
CD265 | RANK, TRANCE-R, ODFR | 97kD | TNFRSF | broad expression | binding of TRANCE mediates osteoclastogenesis & T-DC interactions | R12-31 |
CD266 | TWEAK Receptor, Fn14 | 14kD | TNFRSF | mRNA in liver regeneration, Colon 26 cell line | cell migration, proliferation, angiogenesis, activates NF-kappaB pathway | ITEM-2 |
ITEM-4 | ||||||
CD267 | TACI, TNFRSF13b | 32kD | TNFRSF | Tact and B | binding of APRIL or BLyS stimulates B and T function | eBio8F10-3 |
CD268 | BAFFR, Bcmd | 25kD | TNFRSF | B | BLyS binding promotes survival of mature B & B response | polyclonal |
eBio7H22-E16 | ||||||
CD269 | BCMA, TNFRSF13B | 20kD | Type III TM, TNFRSF | mature B (membrane and perinuclear) | binds APRIL, BAFF, survival and proliferation | |
CD271 | NGFR, TNFRSF16, p75 (NTR), Bex3, Ngfrap1 | 45kD | TNFRSF | neurons, mesenchymal stem cells | binds NGF, BDNF, NT-3 and NT-4, tumor supressor mediate cell survival and death | |
CD272 | BTLA, B & T Lymphocyte Associated | 33kD | IgSF | T, B , BM, splenic macs, BM derived DC | binds HVEM, negative regulation | 6F7 (blocking) |
3F9.D12 | ||||||
6H6 | ||||||
6G3 | ||||||
8F4 (non-blocking) | ||||||
CD273 | B7DC, PD-L2, PDCD1L2 | 25kD | IgSF | DC subset, mono, mac | binds PD-1, co-stimulation or supression of T cell proliferation | TY25 |
122 | ||||||
CD274 | B7-H1, PD-L1, PDCD1LG1 | 33kD | IgSF | leukocytes, decrease in mature thymic T cells | binds PD-1, proliferation and cytokine production | MIH5 |
1-111A | ||||||
CD275 | B7-H2, GL50, ICOS-L, B7h, B7RP-1 | 60kD | B7 family | APC, B, DC, mac | lymphocyte costimulation, receptor for ICOS | HK5.3 |
CD276 | B7-H3, B7RP-2 | 40-45kD | B7 family | in vitro cultured DC and mono | negative regulator of T cell activation | M3.2D7 |
CD277 (H) | BT3.1 | not defined in mouse | ||||
CD278 | ICOS, Inducible T cell COStimulator , Ly115 | 55-60kD | CD28 family | Tact, Th2 | T costimulation, B7-H2 receptor, cytokine production | 7E.17G9 |
C398.4A | ||||||
15F9 | ||||||
CD279 | PD-1, programmed death-1 | 55kD | IgSF | Tact, Bact | negatively regulates lymphocytes, T cell development | J43 |
RMP1-14 | ||||||
RMP1-30 | ||||||
CD280 | ENDO180, UPARAP, MRC2 | 180kD | CD28 family | chondrocytes | binds uPAR, mannose receptor, collagen matrix remodeling & endocytic recycling | |
CD281 | TLR1 | 90kD | TLR family | low levels in leukocytes | innate immunity, with TLR2 | eBioTR23 |
eBioLD5 | ||||||
CD282 | TLR2 | 90kD | TLR family | myeloid lineage: mac & DC in spleen | response to bacterial lipoproteins | 6C2 |
T2.5 | ||||||
mT2.7 | ||||||
polyclonal | ||||||
CD283 | TLR3 | 100kD | TLR family | DC subset, mac, fibroblasts, induced by LPS | binds dsRNA, activation of NK-kappaB | T3.7C3 |
polyclonal | ||||||
CD284 | TLR4, Ly87, Rasl2-8 | 100kD | TLR family, ASV | thioglycolate-elicited peritoneal mac | binds LPS, innate immunity | MTS510 |
UT41 | ||||||
UT12 | ||||||
UT18 | ||||||
polyclonal | ||||||
CD289 | TLR9 | 120kD | TLR family | DC subset (intracellular) | binds CpG-DNA | m9.D6 |
polyclonal | ||||||
CD292 | BMPR1A, ALK3 | 57kD | Type I, BMP receptor | bone progenitor, broad | binds BMP 2 & 4, bone development, germ layer specification | |
CDw293 | BMPR1B, ALK6 | 57kD | Type I, BMP receptor | bone progenitor, developing retina | binds BMP, bone development, neurogenesis | |
CD294 | CRTH2, GPR44 | 55-70kD | GPCR-7TM | Th2, eosinophils, basophils | binds prostaglandin D2, chemotaxis | |
CD295 | LeptinR, LEPR | 132kD | Type I cytokine-like receptor, ASV | broad | adipose metabolism, may be involved in immune dysfunction in obesity | |
CD296 | ART1, RT6, ART2 | 37kD | ADP- ribosyltransferase | heart and skeletal muscle, peripheral T, NK subset | GPI linked protein modifies integrin during differentiation | |
CD297 | ART4, dombrock blood group | 38kD | ADP- ribosyltransferase | heart, lung, liver, and spleen, erythroid, monoact | ||
CD298 | Na+/K+-ATPase beta3 subunit, ATP1B3 | 52kD | broad | transporter | ||
CD299 (H) | DC-SIGN-related | not defined in mouse | ||||
CD301-302 (H) | not defined in mouse | |||||
CD303 | Clecsf10, dectin-2 | C-type lectin domain family 4 | tissue mac, DC, upregulated on blood mono | inflammatory lesion, UV-induced tolerance | ||
CD304 | BDCA4, | |||||
neuropilin 1, | ||||||
Nrp, NP-1 | 130kD | semaphorin family | DC, neurons, endoth & tumor cells, CD4+/CD25+ Treg | binds VEGF165, semaphorins, coreceptor with plexin, axonal guidance, angiogenesis, cell survival, migration | polyclonal | |
CD305 | LAIR1 | 32-40kD | IgSF, ASV | broad, NK, B, T, mono | inhibitory receptor on NK and T cells | 113 |
CD306-307 (H) | not defined in mouse | |||||
CD309 | VEGFR2, Flk-1, KDR | 230kD | Type III TM tyr kinase | endoth, angiogenic precursor cells; hemangioblast | binds VEGF, regulates adhesion and cell signaling | Avas12a1 |
CD312 (H) | EMR2 | not defined in mouse | ||||
CD314 | NKG2D, KLRK1 | 42kD | Type II lectin-like receptor | NK, CD8+ activated, not CD4+ in the periphery, macact | binds MHC class I, Rae1 & ULBP4, cytolysis and cytokine production; costimulatory | CX5 (blocking) |
MI6 (blocking) | ||||||
C7 (blocking) | ||||||
A10 (activating) | ||||||
CD315 | CD9P1, SMAP6, FPRP, PTGFRN | 135kD | IgSF | B subset, monoact | with CD81 and CD9 | |
CD316 | EWI2, PGRL, KASP | 63-75kD | TM4SF, IgSF8 | B, T, low on NK cells | with CD81 & CD9; involved in cell migration | |
CD317 | BST2 | 30-36kD | Type II | BM stromals, fibroblasts, plasmacytoid DC | pre-B cell growth, overexpressed in multiple myeloma | eBio129c1 |
eBio927 | ||||||
CD318 | CDCP1, CUB domain containing protein 1 | |||||
CD319 | CRACC, SLAMF7 | 66kD | Ig TM | predicted: T, B and DC subset, NK, upregulated in DC | regulate T and NK cells | |
CD320 | 8D6, VLDL | |||||
CD321 | JAM1, F11 receptor, KAR | 12.5kD | IgSF, Type I, AVS | epith and endoth, platelets | tight junction, binds reovirus & LFA1, platelet receptor | |
CD322 | JAM2, VE-JAM | 45kD | IgSF | HEV and other endothelia | mediates transendothelial migration of lymphocytes | |
CD324 | E-Cadherin, Uvomorulin | 120kD | cadherin SF | non-neural epith | binding to integrin alphaE/beta7 & homotypic interactions mediate cell adhesion | DECMA-1 |
CDw325 | N-Cadherin, Cadherin-2 | 140kD | cadherin SF | brain, skeletal & cardiac muscle | adhesion, may be involved in neuronal recognition mechanism | |
CD326 | Ep-CAM, EGP, Ly-74 | 40kD | thymocytes, epith, DC | may function as growth factor receptor or adhesion molecule | ||
CDw327 (H) | siglec6 | not defined in mouse | ||||
CDw328 (H) | siglec7 | not defined in mouse | ||||
CDw329 | siglec9, siglecl1 | IgSF | monocyte/myeloid cells | mediates sialic-acid dependent binding to cells | ||
CD331 | FGFR1, FLT2, N-SAM | 30kD | TM tyr kinase | fibroblasts, epithelial | binds FGF, wound healing, bone development | |
CD332 | FGFR2, KGFR, KSAM | 115-135kD | TM tyr kinase | fibroblasts, epithelial, ectoderm of embryo | binds FGF, embryonic limb development, AER | |
CD333 | FGFR3, ACH, CEK2 | 115kD | TM tyr kinase, ASV | fibroblasts, epithelial, astrocytes | binds FGF, bone & CNS development | |
CD334 | FGFR4, TKF | 110kD | TM tyr kinase | fibroblasts, epithelial, hepatocytes | binds FGF, bone development | |
CD335 | NKp46, Ly-94 homolog | 46kD | IgSF | NK | binds non-MHC, NK activation | 29A1.4 |
CD336 (H) | NKp44 | not defined in mouse | ||||
CD337 (H) | Ncr3, IC7, Ly117 | mouse IC7 mRNA in liver | ||||
CDw338 | ABCG2, Mxr, ABC15, BCRP1 | 73kD | GPCR 7TM | stem cell subset (side population) | Multi-drug resistance transporter | |
CD339 | Jagged-1, Serrate1 | 135kD | EGF TM | BM stromal & mac, stromal cell lines | receptor for Notch-1, 2, & 3, hematopoiesis, Th2 fate |
Antigen Name | Other Names | MW | Structure | Distribution | Function | eBioscience Clone |
---|---|---|---|---|---|---|
B2D | ||||||
4-1BBL | Tnfsf9 | TNFSF | Bact, DCact, peritoneal macact | DC activation, cytokine production | TKS-1 | |
33D1 antigen | DC-specific marker | DC subpopulations | upregulated by GM-CSF, downregulated by IL-4 | 33D1 | ||
AA4.1 antigen | see CDw93 | |||||
ABCG2 | see CDw338 | |||||
AC133 | see CD133 | |||||
AID | Aicda | RNA-editing deaminase family | Germinal Center B (low to undetectable levels) | Activation-Induced Deaminase, Ig class switch recombination | eBio961 | |
eBio911 | ||||||
B7-DC | see CD273 | |||||
B7-H1 | see CD274 | |||||
B7-H2 | see CD275 | |||||
B7-H3 | see CD276 | |||||
B7-H4 | B7S1, B7x, GPI-linkedF3 | T, B, mono, DC subsets | lymphocyte costimulation | eBioMIH29 (MIH29) | ||
clone 9 | ||||||
188 | ||||||
BP-1 | Ly-51, 6C3, Enpep | 120-160kD | Type II TM | early B progenitors, BM stromal cells, thymic epith | zinc metalloproteinase, glutamyl aminopeptidase | 6C3 |
FG35.4 | ||||||
BTLA | see CD272 | |||||
CCR7 | see CD197 | |||||
CIRE | see CD209 | |||||
c-Met | Met, HGFR/SFR, Par4 | 190kD | heterodimer, PTK | epith, hematopoietic progenitors, early thymocytes, not detected in adult tissues | tumor growth/matastasis, Hepatocyte Growth Factor/Scatter Factor receptor, T development, hematopoiesis | eBioclone 4 |
eBioclone 7 | ||||||
CMKLR1 | chemokine-like receptor 1 | 42kD | GPCR 7TM | pDC (CD123+), in vitro derived moDC | binds chemerin, pDC reruitment, may be involved in bone development | mAb (please inquire) |
DC maturation marker | mature DC, B, intracellular granules | eBio2A1 | ||||
DR5 | see CD262 | |||||
DX5 | see CD49b | |||||
F4/80 antigen | Emr1, pan-macrophage marker | 125kD | TM7 | resident tissue mac, liver Kupffer cells, not blood mono, distinguishes mono/mac from fibroblasts | macrophage maturation | BM8 |
FIRE | emr4 | 90-100kD | EGF-7TM | mac, neutrophilsact, BM derived DC | myeloid-B cell interaction | 6F12 |
Flk-1 | see CD309 | |||||
Flt-4 | VEGFR3 | 170kD | RTK family | lymphatic endoth | endoth growth factor receptor, binds VEGF-C | AFL4 |
Foxp3 | SCURFIN | 50kD | Fox family forkhead | T cells (CD4+/CD25+ subset and CD8+ subset) | transcription factor, may be upregulated in T regs | FJK-16s |
eBio7979 | ||||||
NRRF-30 | ||||||
150D/E4 | ||||||
GITR | AITR, Tnfrsf18 | 30kD | TNFRSF | T subset, Tact | costimulator for CD4+CD25+ Treg subset, induction of apoptosis, regulation of Treg and mucosal immunity | DTA-1 |
GITRL | AITRL, Tnfsf18 TNFSF | DC, Mac, B | costimulation for T subset | eBioYGL386 | ||
Granzyme B | CCP1, Ctla1, Gzmb | 30kD | cytotoxic granules of NK & CTL (CD8+) | proteolysis, induction of perforin-mediated apoptosis | 16G6 | |
GB11 | ||||||
HVEM | TNFRSF14, TR2 | 60kD | TNFRSF | broad expression | receptor for LIGHT, LTalpha, BTLA, Herpes Simplex Virus, involved in lymphocyte activation | mAb (please inquire) |
ICOS | see CD278 | |||||
IgD | peripheral mature B cells | 11-26c | ||||
activating polyclonal | ||||||
IgE Receptor high affinity | FcepsilonRIalpha | basophils, eosinophils, mono, mast, & Langerhans cells | high affinity binding to IgE | 38776 | ||
IgM | surface expression by mature B cells | II/41 | ||||
eB121-15F9 | ||||||
IL-15R\alpha | Tact, dim expression | binds to IL-15, w/ IL-2Rbeta and common gamma, IL-15 trans-presentation | mAb (please inquire) | |||
IL-21R | broad on T, B, NK, DC | induction of apoptosis in B, expansion of CD3 activated T, NK activation, inhibition of DC | eBio4A9 | |||
Jagged-1 | see CD339 | |||||
JAML | JAM family | IgSF | neutrophils, mono | junctional adhesion molecule 1-like protein, cell contact, neutrophil migration, binds to CAR (coxsackie and adenovirus receptor) | eBio4E10 | |
KLRG1 | MAFA | 30-38kD | NK & T subset | inhibition of cytokine production and cytotoxicity | 2F1 | |
LT\betaR | Tnfrsf3 | 47kD | TNFRSF | mast, stromal cells, epith | lymphoid organ development | eBio3C8 |
Ly-6A/E | Sca-1 | 18kD | GPI-linked | hematopoietic progenitors, myeloid subset, peripheral lymphoid, mast cells | T activation | D7 |
Ly-6B | ||||||
Ly-6C | 14-17kD | GPI-linked | endoth, T, NK, mono, mac | |||
Ly-6D | ThB, Ly-61 | 15kD | GPI-linked | B, T, thymic epith | ||
Ly-6F | ||||||
Ly-6G | Gr-1 | 21-25kD | GPI-linked | myeloid cells, upregulated in gran | RB6-8C5 | |
Ly-49A | A1, Klra1 | 85kD | Type II TM C-type lectin | T subset, NK subset | regulation of cytotoxicity, binds MHC class I | eBio12A8 |
Ly-49B | Klra2 | |||||
Ly-49C | Klra3, 5E6 | 110kD | Type II TM C-type lectin | T subset, NK subset | regulation of cytotoxicity, binds MHC class I | 14B11 |
Ly-49D | Klra4 | Type II TM C-type lectin | NK subset | NK activation | eBio12A8 | |
eBio4E5 | ||||||
Ly-49E | Klra5 | |||||
Ly-49F | Klra6 | 14B11 | ||||
Ly-49G | LGL1, Klra7 | 85kD | Type II TM C-type lectin | T subset, NK subset | regulation of cytotoxicity | AT8 |
eBio4D11 | ||||||
Ly-49H | Klra8 | Type II TM C-type lectin | 14B11 | |||
Ly-49I | Klra9 | Type II TM C-type lectin | 14B11 | |||
YLI-90 | ||||||
Mac-3 | 93-110kD | mac (surface & intracellular) related to CD107b | M3/84 | |||
MAdCAM-1 | 50kD | IgSF, Type I TM | endoth subset | mucosal vascular addressin cell adhesion molecule, adhesion, lymph homing, binds CD49d & CD62L | MECA-367 | |
MCP-1 | monocyte chemoattractant protein; CCL2 | 16kD | splenocytes | chemoattractant for mac and basophils | 400 | |
2H5 | ||||||
MD-1 | Ly86 | 28kD | mature B, mono/mac, DC | w/ RP105 (CD180), regulates CD180 surface expression & B cell response to LPS, also secreted | MD14 | |
MD113 | ||||||
Nanog | embryonic stem cells | transcription factor, ES self renewal | eBioM320 | |||
NKG2A | see CD159a | |||||
NKG2A^{B6^} | CD159a, Klrc1 | 38kD | C-type lectin | C57BL/6 mouse strain | w/ CD94, Qa-1(b) receptor, inhibitory signaling | 16a11 |
NKG2B | C-type lectin | splice variant of NKG2A | ||||
NKG2C | see CD159c | |||||
NKG2D | see CD314 | |||||
NKG2E | C-type lectin | NK & NKT cells | w/ CD94, Qa-1(b) receptor, stimulatory signaling | 20d5 | ||
Notch-1 | Lin-12, Tan1 | developing embryo, variety of adult tissues | cell-cell interaction, cell fate determination | mN1A | ||
OX-40 Ligand | see CD252 | |||||
PD-1 | see CD279 | |||||
Perforin | Perforin1, Pfp, Prf1 | 70kD | intracellular, NK and CTL (CD8+) | cytolysis, apoptosis | eBioOMAK-D | |
Plexin B2 | Plxnb2, Debt | Semaphorin/Plexin Family | mRNA in nervous system | eBio3E7 | ||
Prominin-1 | see CD133 | |||||
RAE-1\gamma | mRNA in early embryo, not adult tissues; upregulated by retinoic acid or certain disease conditions, RAE-1alpha, -beta, and -gamma are expressed in BALB/c mice, but not in C57BL/6, whereas RAE-1delta and -epsilon are expressed in C57BL/6 mice | ligand for NKG2D | CX1 | |||
RANK | see CD265 | |||||
ROR\gamma(t) | 58kD | ROR family Transcription Factor | Th17 cells, thymus | transcriptional regulation | AFKJS-9 | |
SAP | SLAM-associated protein | 14kD | adaptor protein | T, NK | negatively regulates SLAM-family receptors | eBio5G8 |
eBio1B2 | ||||||
Sca-1 | see Ly6-A/E | |||||
Sema4A | Sema b, SemB | semaphorin family | DC, B, Tact | T constimulation, may not be ligand for Tim-2? | KL-1 (aka SK31) | |
SLP-76 | 76kD | T, low in B | T cell receptor mediated signaling | MS76 | ||
SSEA-1 | stage-specific embryonic antigen-1 | mouse ES cells, embryonic carcinomas, germ cells | down regulated by differentiation | eBioMC-480 (MC-480) | ||
T-bet | Th1 cells | transcription factor, T development / differentiation | eBioT422 | |||
TCR \alpha\beta | T subset | antigen recognition | H57-597 | |||
TCR \gamma\delta | T subset | antigen recognition | GL3 | |||
UC7-13D5 | ||||||
TCR-HY | Transgenic H-Y T cells | T3.70 | ||||
Ter-119 | Ly-76 | early proerythroblast to mature erythrocyte | w/ glycophorinA, but not a typical glycophorin | TER-119 | ||
Tie2 | see CD202b | |||||
TIM-1 | Timd1, Havcr1 | Type I TM, IgSF | mRNA activated T cells | RMT1-4 | ||
RMT1-10 | ||||||
TIM-2 | Timd2 | Type I TM, IgSF | mRNA activated T cells | receptor for Sema4A | RMT2-1 | |
RMT2-14 | ||||||
TIM-3 | Th1-speci.c marker, Havcr2 | Type I TM | late stage of T cell differentiation, CD4+ Th1, CD8+ Tc1 | effector function of Th1, macrophage activation, regulation of autoimmunity, hepatitis A virus cellular receptor 2 | 8B.2C12 | |
RMT3-23 | ||||||
TLR1 - TLR4 | see CD281 - CD284 | |||||
TLR5 | mRNA: liver, lung, lower level in MOLF/Ei mice | Gram-negative bacterial infection | ||||
TLR6 | mRNA: spleen, thymus, ovary, lung | activation of NF-kappaB & JunK | ||||
TLR7 | PRO285 | 125kD | TLR family | many tissues, DC subset | innate immune response to microbial agents | polyclonal |
TLR8 | PRO286 | 126kD | TLR family | many tissues, DC subset | innate immune response to microbial agents | polyclonal |
TLR9 | see CD289 | |||||
TLR11 | polyclonal | |||||
TLR13 | mAb (please inquire) | |||||
TRAIL | see CD253 | |||||
TRANCE | see CD254 | |||||
TWEAK | TNF-related weak inducer of apoptosis | TNFSF, Type II TM | mRNA in many adult and fetal tissues | membrane-bound and secreted forms, apoptosis, binds Fn14 | MTW-1 | |
TWEAK Receptor | see CD266 | |||||
ZAP-70 | TCR zeta-associated kinase | 70kD | Syk family | T (intracellular), NK | TCR signaling & development | 1E7.2 |