This month'ss guest authors review the application of solid-phase SPME to the analysis of drugs in human plasma.

Just how good are your gradients?

This month's "GC Connections" examines the various ways – and their attendant benefits and drawbacks – with which chromatographers and chromatography data-handling systems locate and measure peaks

This month'ss "Directions in Discovery" column discusses current work in the use of capillary isoelectric focusing and mass spectrometry as a multidimensional separation technique for proteomic studies.

The authors describe a sensible approach for validation and implementation of HPLC IPC assays.

The use of a silica column for HILIC is examined, including mechanistic studies of analyte retention on silica in aqueous-organic mobile phases.