Squamous Cell News
- January 27, 2010
Immune cell levels predict skin cancer risk in kidney transplant patients
The researchers measured levels of key immune cells in 116 kidney transplant recipients, 65 of whom developed squamous cell skin cancers. "We were hoping to see if there were differences in the immune systems of patients who developed skin cancer after - January 14, 2010
How sunlight causes skin cells to turn cancerous
In the new study, researchers examined a type of skin cancer, called squamous cell carcinoma, that accounts for between 200,000 and 300,000 new cases per year. Squamous cell carcinoma begins in the upper part of the epidermis, the top layer of the skin. - December 20, 2009
Heart transplant patients appear to have elevated risk for multiple skin cancers
This included 1,236 squamous cell carcinomas and 151 basal cell carcinomas (the non-melanoma skin cancers), five malignant melanomas and three other types. When evaluating the tumor burden of the 312 patients, 76 - November 15, 2009
Imaging techniques may help predict response to head and neck cancer treatment
"On the basis of this study, PET-CT performed six to eight weeks after the completion of intra-arterial chemoradiotherapy for advanced squamous cell carcinoma of the head and neck is a valuable tool for measuring treatment response and facilitating - November 4, 2009
Rice wins NIH funding for oral-cancer test
Unfortunately, the actual five-year survival rate for oral squamous cell carcinoma is only about 50 percent, among the lowest rates for all major cancers. Oral squamous cell carcinoma affects about 300,000 people per year worldwide, and most cases are - September 15, 2009
Roles of S100A2 and p63 in the carcinogenesis of esophageal squamous cell carcinoma
As a member of the S100 family, S100A2 is considered a candidate tumor-suppressor gene. Recently, p63 gene, a new member of the p53 gene family, has been studied in the fields of tumorigenesis, cell apoptosis and tissue growth. At present, few studies - July 29, 2009
Study links virus to some cases of common skin cancer
The researchers examined tissue samples from 58 people with squamous cell carcinoma (SCC), a highly curable form of skin cancer that is expected to affect more than 200,000 Americans this year. They identified the virus in more than a third of the - July 28, 2009
HPV infection may be linked to poor head and neck cancer survival rates in African-Americans
conference on new study PHILADELPHIA – A groundbreaking study in Cancer Prevention Research, a journal of the American Association for Cancer Research, suggests that having the human papillomavirus (HPV) improves survival in squamous cell carcinoma - April 27, 2009
New diagnostic advance seen for head, throat cancer
published today in PLoS ONE, a professional journal, scientists found for the first time that levels of CTIP2 were more than five times higher in the "poorly differentiated" tumor cells that caused the most deadly types of squamous cell carcinomas in the - April 22, 2009
Regulation of cell proliferation by the OGF-OGFr axis is dependent on nuclear localization signals
Experiments with a human cancer cell, a squamous cell carcinoma of the head and neck, revealed that translation of OGFr required approximately 5 hours, and transit into the nucleus took 8 hours; OGFr remained in the nucleus for up to 8 - February 20, 2009
A safe, well-tolerated, and effective treatment for metastatic esophageal cancer
esophageal squamous cell cancer has very poor prognosis. Conventional surgery is considered the most effective treatment, but many cases are inoperable at the time of diagnosis. More recently, chemotherapy has shown activity in metastatic ESCC. However, - February 18, 2009
A potential molecular target for biotherapy esophageal squamous cell carcinomas
To explore clinical pathological significance of E-cadherin and N-cadherin expressions in esophageal squamous cell carcinoma (ESCC), a research team led by Prof. Qing-Xia Fan from China detected the expression of E-cadherin and N-cadherin in 62 cases of - September 30, 2008
Saliva proteins could help detection of oral cancer
Clinicians could detect oral squamous cell carcinoma, a form of oral cancer, using a simple test that detects proteins in saliva, according to a report in the October 1, 2008, issue of Clinical Cancer Research, a journal of the American Association - September 22, 2008
A promising possibility for the treatment of the esophageal carcinoma
A research article published on 7 July 2008, in the World Journal of Gastroenterology demonstrates for the first time that lithium inhibited the proliferation of esophageal squamous cell carcinoma cells (Eca-109), which was mainly mediated by the - September 7, 2008
Protein 'switch' suppresses skin cancer development
In the first mouse model of its kind, we also found that deleting IKKα spontaneously induced squamous cell carcinomas by activating the epidermal growth factor receptor pathway," said senior author Yinling Hu, Ph.D., assistant professor in M. D. - August 25, 2008
Angiotensin inhibitors and receptor blockers linked to lower risk of nonmelanoma skin cancer
use of angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) was associated with a reduced risk of basal cell or squamous cell skin cancers in U.S. veterans, researchers report in the August 26 online issue of the Journal - August 24, 2008
Burning incense increases risk of respiratory tract cancers
The researchers also noted that the duration and intensity of incense use were associated with an increased risk of squamous cell carcinomas in the entire respiratory tract. Squamous cells cover the internal and external surfaces of the body. According - May 12, 2008
PET imaging may not improve diagnostic accuracy in early head and neck cancer
A key prognostic factor for head and neck squamous cell cancer patients is whether their disease has spread to the nearby lymph nodes. Unfortunately, some patients who appear clinically to be free of such metastases, referred to as cN0, - March 24, 2008
Other highlights in the March 25 JNCI
Ferris, M.D., Ph.D., of the University of Pittsburgh Cancer Institute and colleagues previously found that the chemokine receptor 7 (CCR7) is frequently active in metastatic squamous cell cancers of the head and neck. In the current study, Ferris and - March 3, 2008
PET/CT planning beneficial for head and neck cancer patients
CT has been the traditional choice for staging and radiation therapy treatment planning for head and neck squamous cell carcinomas, which account for approximately 5 percent of malignancies worldwide; but PET has been shown to have advantages over CT and - December 6, 2007
Lifestyle and cancer prevention: Making choices that change cancer risk
As a consequence, the male mice developed more squamous cell skin cancers, and these tumors formed faster and grew more aggressively than those that developed in the skin of female mice. These results may explain why men develop three times as - November 29, 2007
Newer radiation treatment easier for some throat cancer patients
This study will be invaluable for patients diagnosed with oropharyngeal squamous cell carcinoma who are weighing treatment options because now they know that IMRT can offer them with better quality of life. CRT aims two or three external radiation - November 12, 2007
M. D. Anderson researchers identify tumor-suppressor gene for lung cancer
Lotan and colleagues earlier had shown that Gprc5a protein is detected in the lungs more than in any other tissue and that it is underexpressed in human non-small cell lung cancer and in head and neck squamous cell carcinoma. The mouse model experiments - October 30, 2007
3-D model of esophageal cancer
This model allows us to dissect the specific genetic alterations that are important in the initiation and progression of esophageal squamous cell cancer, which holds promise for sqamous cell cancers arising in other sites, such as the skin, lung, head - August 13, 2007
Immune deficiency linked to a type of eye cancer
incidence of squamous cell eye cancer is greater among kidney transplant patients and people with human immunodeficiency virus (HIV) than the general public, which suggests the disease is associated with immune deficiency. Claire Vajdic, Ph.D., of the - August 4, 2007
Multicenter study nets new lung tumor-suppressor gene
The LKB1-deficient tumors grew more rapidly and spread more frequently than the others, and comprised all three types of non-small cell lung cancer -- squamous cell carcinoma, large-cell carcinoma, and adenocarcinoma -- rather than just one or two, - June 10, 2007
Rising skin cancer rates are more likely to affect wealthy people, says 12-year review
The figures also showed that the three most common skin cancers - basal cell carcinoma, squamous cell carcinoma and malignant melanoma - accounted for 27 per cent of all male cancers and 26 per cent of all female cancers. These findings show that many - January 29, 2007
Esophageal cancer rates climb with obesity; U-M study finds esophagectomy safe in obese patients
Esophageal cancer used to be primarily squamous cell carcinoma found in people who drank alcohol and smoked excessively. In association with the horrendous epidemic of obesity in this country, we have seen a 350 percent increase of - January 25, 2007
Novel EGFR antibody outperforms cetuximab in mouse model of lung cancer
Wong, approximately 10-30 percent of patients with NSCLC and 5 percent of patients with squamous cell lung cancers have EGFR activating mutations. Some brain tumors also have EGFR activating mutations that are in animal studies responsive to the - September 13, 2006
Abnormal overexpression of p53 is a predictive molecular biomarker
overexpression of p53 is a predictive molecular biomarker of advexin efficacy in recurrent squamous cell carcinoma of the head and neck CHICAGO -- A common laboratory test that predicted poor outcome from traditional radiation and chemotherapy treatment - July 26, 2006
Skin cancer rare -- but more deadly -- in people with darker skin
They determined that while incidence rates of basal and squamous cell carcinomas and melanomas among whites have increased between 5 and 8 percent, rates among blacks for the same period remained relatively constant. More important, although fewer blacks - May 13, 2006
OHSU researcher develops first animal model to treat devasting head and neck cancers
- An Oregon Health & Science University Cancer Institute research laboratory has developed a novel mouse model designed specifically to study the often devastating head and neck squamous cell cancers. Xiao-Jing Wang, M.D., Ph.D., and colleagues report - March 13, 2006
HPV subtype associated with squamous cell skin cancers
with human papillomavirus (HPV) types called beta HPVs may be associated with an increased risk of developing a major type of skin cancer known as squamous cell carcinoma (SCC), according to a new study in the March 15 issue of the Journal of the - March 13, 2006
Researchers link human papillomavirus (HPV) to common skin cancer
NH Human papillomavirus (HPV) may be a risk factor in developing squamous cell carcinoma, a common form of skin cancer, according to research led by Dartmouth Medical School. The study, published in the March 15 issue of the Journal of the National - February 27, 2006
HPV infection a top risk factor for cervical adenocarcinoma worldwide, study says
HPV is a well-established cause of cervical squamous cell cancer, the most common type of cervical cancer worldwide. Previous studies have suggested HPV may also cause cervical adenocarcinoma, but those studies were small and did not provide - December 19, 2005
Ultraviolet B light exposure associated with increased risk of skin cancer
decreased ability to repair chromosomal damage caused by exposure to ultraviolet B (UV-B) radiation in test tubes may be associated with an increased risk of the common skin cancers basal cell carcinoma and squamous cell carcinoma, but not of melanoma, - August 8, 2005
Incidence of nonmelanoma skin cancer on the rise among young adults
The overall incidence of nonmelanoma skin cancer, consisting of squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), is increasing, according to background information in the article. This increasing incidence is most likely due to a - August 8, 2005
Skin cancers growing in young people A case for prevention
There are two common types of non-melanoma skin cancer, basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), the types evaluated in this study. Mayo Clinic investigators found that the incidence of BCC tumors increased over time (i.e., more - June 26, 2005
High-powered gene profiles provide clues to genes involved in common form of lung cancer
Our work provides a good starting point for scientists looking for others." As part of the study, investigators did microarray analyses on the two major subtypes of NSCLC, adenocarcinoma and squamous cell carcinoma, and found that their genomic profiles - June 20, 2005
Study: Harmless virus kills some cancers
PASix days is all it takes for a common, non-disease-causing virus to kill cervical, breast, prostate and squamous cell cancer cells in laboratory cultures, according to Penn State College of Medicine researchers. "Our results suggest that - December 19, 2004
Researchers report early success using saliva to detect oral cancer
Cancer Research, the scientists found they could measure for elevated levels of four distinct cancer-associated molecules in saliva and distinguish with 91 percent accuracy between healthy people and those diagnosed with oral squamous cell carcinoma. - October 25, 2004
Radiotherapy + cetuximab significantly improve disease control and survival in head and neck cancer
treatment using the monoclonal antibody cetuximab, along with high dose radiotherapy in the treatment of patients with loco-regionally advanced squamous cell carcinoma of the head and neck results in significant improvements in both loco-regional control - March 3, 2004
Innovative reconstructive surgery improves appearance, outcomes for skin cancer patients
She is one of 250,000 Americans each year who develop a form of skin cancer called squamous cell carcinoma. If caught early, squamous cell carcinoma typically doesn't spread, but if neglected or undiscovered for years, it can spread to other parts of the - September 29, 2003
Other highlights in the October 1 issue of JNCI
Ineffective for Preventing Secondary Skin Cancers, Study Shows Among individuals at high risk for nonmelanoma skin cancer, selenium supplementation does not appear to prevent basal cell carcinomas and may increase the risk of squamous cell carcinoma and - September 15, 2003
Other highlights in the September 17 issue of JNCI
Taylor, M.D., Sc.D., of the National Cancer Institute, and his colleagues measured serum á- and ã-tocopherol levels in 1,072 patients with esophageal squamous cell carcinoma, gastric cardia cancer, or gastric noncardia cancer, and 1,053 healthy - August 6, 2003
Protein profile predicts prognosis for lung cancer
with 100 percent accuracy: Lung tumor from normal lung; Primary non-small cell lung cancer (NSCLC) from normal lung; Primary NSCLC from cancer that had spread to the lungs from other organs; and Adenocarcinomas from squamous cell carcinomas, squamous - December 9, 2002
New evidence linking smoking and lung cancer in women
The Mayo Clinic study used a statistical model to compare the incidence rates of the three types of lung cancer: adenocarcinoma, squamous cell carcinoma and small cell carcinoma. "We found adenocarcinoma of the lung is more strongly associated with - August 13, 2002
Injectable gel effective in treating head and neck cancer
Head and neck squamous cell carcinoma (HNSCC) refers to this type of cancer in the head or neck. According to background information, HNSCC is diagnosed in about 40,000 Americans each year and more than - March 4, 2002
Other highlights in the March 6 issue of JNCI
Grandis, M.D., and her colleagues from the University of Pittsburgh compared the expression of GRP and its receptor, GRPR, in 25 people with squamous cell carcinoma of the head and neck and 6 people without cancer. The researchers found a five-fold - February 4, 2002
Tanning devices may contribute to incidence of common skin cancers
use of artificial tanning devices such as tanning lamps and tanning beds may contribute to the incidence of two common types of skin cancer, basal cell carcinoma and squamous cell carcinoma, conclude Margaret R. Karagas, Ph.D., of Dartmouth Medical - February 4, 2002
Tanning lamps may increase risks of skin cancers
Few studies have looked at the association between tanning devices and the more prevalent skin cancers: basal cell and squamous cell carcinoma, which together are the most common malignancy in humans. Karagas and colleagues have previously reported an - September 26, 2001
Increased risk of skin cancer for psoriasis patients given ciclosporin
The risk of squamous cell cancer of the skin is increased in patients treated for psoriasis with ciclosporin in addition to photochemotherapy, conclude authors of a study in this weeks issue of THE LANCET. Immunosuppressive treatments such as - December 26, 2000
Smoking triples risk of a common type of skin cancer
Smoking more than triples the risk of developing squamous cell carcinoma, one of the most common forms of skin cancer, researchers from the Netherlands have shown. A link between smoking and this common form of skin cancer has previously been made, - May 1, 2000
Hopkins scientists link human papillomavirus (HPV) to head and neck cancer
The investigators studied tumors of 253 patients, ages 17 to 91, with newly diagnosed or recurring squamous cell head and neck cancer. HPV was detected in 62, or 25 percent, of the tumors and, of the HPV-positive tumors, 90 percent contained a - December 19, 1999
MGH study identifies new inhibitor of tumor angiogenesis and growth
The researchers introduced TSP-2 DNA into cultured cells from human squamous cell carcinomas - tumors that do not normally produce TSP-2 - and injected the cells into the skin of immune deficient mice. As a control, another group of mice received - December 31, 1998
Medicare Policy Contradicts Preferred Treatment For Precancerous Skin Conditions, Westwood Squibb Center For Dermatology Research Reports
The policy can leave patients in pain and increase the risk that the lesions, called actinic keratoses, can develop into a form of skin cancer called squamous cell carcinoma, which can be fatal. In a paper published today by the Journal of the - February 26, 1998
Studies Underscore Link Between Nutrition And Nonmelanoma Skin Cancers
The remaining nonmelanomas are squamous cell cancers, which pose a slightly increased risk of spreading but are usually easily treated, he noted. "Clinical trials have demonstrated that a low-fat diet can reduce the
