Greg responds...

The Desdemona and Iago names were used in our scripts to identify the characters before they got their Coldfire and Coldsteel names in "Possession". The name Othello was also used in the script to refer to Coldsteel in flashback scenes, before he became a cyborg.

None of these names were ever used in dialogue on the series. But both Desdemona and Iago were used in the credits to identify the actors (C.C.H. Pounder and Xander Berkeley) who voiced the two characters. (Othello was never used, because we simply listed Michael Dorn as Coldstone.)

So obviously, yes, we saw the relationship between the three characters as being very "OTHELLO". Particularly in their first appearance, "Legion". With Goliath in the Michael Cassio role.